Sex Hormone Receptor Signals In Human Malignancies
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Sex Hormone Receptor Signals In Human Malignancies
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Author : Hiroshi Miyamoto
language : en
Publisher: MDPI
Release Date : 2019-10-01
Sex Hormone Receptor Signals In Human Malignancies written by Hiroshi Miyamoto and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-01 with Science categories.
Sex steroids, including androgens, estrogens, and progestogens, are known to have widespread physiological actions beyond the reproductive system via binding to the sex hormone receptors. Meanwhile, emerging evidence has indicated that sex hormone receptor signals are involved in the outgrowth of some malignancies, such as prostate and breast carcinomas, as well as others that have not traditionally been considered as endocrine-related neoplasms. This Special Issue “Sex Hormone Receptor Signals in Human Malignancies” covers various aspects of the potential role of sex hormone receptors and related signals in prostate cancer, breast cancer, and other neoplastic conditions by depicting promising findings derived from in vitro and in vivo experiments as well as the analyses of surgical specimens. The current observations described may thus provide a unique insight into novel or known functions of sex hormone receptors and related molecules.
Sex Hormone Receptor Signals In Human Malignancies
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Author : Hiroshi Miyamoto
language : en
Publisher:
Release Date : 2019
Sex Hormone Receptor Signals In Human Malignancies written by Hiroshi Miyamoto and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Electronic books categories.
Sex steroids, including androgens, estrogens, and progestogens, are knownto have widespread physiological actions beyond the reproductive systemvia binding to the sex hormone receptors. Meanwhile, emerging evidence hasindicated that sex hormone receptor signals are involved in the outgrowth ofsome malignancies, such as prostate and breast carcinomas, as well as othersthat have not traditionally been considered as endocrine-related neoplasms. ThisSpecial Issue "Sex Hormone Receptor Signals in Human Malignancies" coversvarious aspects of the potential role of sex hormone receptors and related signalsin prostate cancer, breast cancer, and other neoplastic conditions by depictingpromising findings derived from in vitro and in vivo experiments as well as theanalyses of surgical specimens. The current observations described may thusprovide a unique insight into novel or known functions of sex hormone receptorsand related molecules.
Ar Signaling In Human Malignancies Prostate Cancer And Beyond
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Author : Emmanuel S. Antonarakis
language : en
Publisher: MDPI
Release Date : 2018-03-23
Ar Signaling In Human Malignancies Prostate Cancer And Beyond written by Emmanuel S. Antonarakis and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-23 with Medicine (General) categories.
This book is a printed edition of the Special Issue "AR Signaling in Human Malignancies: Prostate Cancer and Beyond" that was published in Cancers
Molecular Basis Of Sex Hormone Receptor Function
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Author : Hinrich Gronemeyer
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Molecular Basis Of Sex Hormone Receptor Function written by Hinrich Gronemeyer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
How sex hormone receptors and all the other members of the nuclear receptor superfamily do such a remarkable job has fascinated scientists for decades. A series of discoveries in the past few years has dramatically enlightened our understanding of the molecular mechanisms that govern nuclear receptor action. The elucidation of the 3D structures of several nuclear receptor ligand binding domains in the presence of agonists or antagonists has provided an allosteric concept of ligand action, and the discovery of a plethora of ligand-dependent protein interactions has linked this transconformation with the ability of nuclear receptors to act as transcriptional activators and repressors and the enzymatic modification of chromatin and factors of the basal transcriptional machinery.
Breast Cancer And Surgery
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Author : Nilufer Bulut
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-11-21
Breast Cancer And Surgery written by Nilufer Bulut and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-11-21 with Medical categories.
The book 'Breast Cancer and Surgery' summarizes the treatment options from the onset of breast carcinogenesis to early-local advanced and metastatic breast cancer. Chemotherapy alternatives, drug resistance and local and surgical treatment preferences are extensively discussed and this information is especially directed at clinicians, researchers, and students. This book includes a comparison between different chemotherapy agents and targeted therapies with published phase II-III studies. The importance of palliative care and dietary supplements administered during the treatment course in reducing the comorbidity of patients is emphasized. Photodynamic treatments have been included in this book. A comprehensive and up-to-date information exchange that can be accessed through a single source is provided to all researchers interested in breast cancer.
Hormone Signaling
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Author : Vincent Goffin
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-03-31
Hormone Signaling written by Vincent Goffin and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-31 with Medical categories.
Multicellular organisms require a means of intracellular communication to organize and develop the complex body plan that occurs during embryogenesis and then for cell and organ systems to access and respond to an ever changing environmental milieu. Mediators of this constant exchange of information are growth factors, neurotransmmitters, peptide and protein hormones which bind to cell surface receptors and transduce their signals from the extracellular space to the intracellular compartment. Via multiple signaling pathways, receptors of this general class affect growth, development and differentiation. Smaller hydrophobic signaling molecules, such as steroids and non-steroid hormones, vitamins and metabolic mediators interact with a large family of nuclear receptors. These receptors function as transcription factors affecting gene expression, to regulate the multiple aspects of animal and human physiology, including development, reproduction and homeostasis. The aim of this book is to cover various aspects of intracellular signaling involving hormone receptors.
Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance
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Author : Andrew Freywald
language : en
Publisher: Academic Press
Release Date : 2020-12-02
Biological Mechanisms And The Advancing Approaches To Overcoming Cancer Drug Resistance written by Andrew Freywald and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-12-02 with Science categories.
Biological Mechanisms and the Advancing Approaches to Overcoming Cancer Drug Resistance, Volume 12, discusses new approaches that are being undertaken to counteract tumor plasticity, understand and tackle the interactions with the microenvironment, and disrupt the rewiring of malignant cells or bypass biological mechanism of resistance by using targeted radionuclide therapies. This book provides a unique opportunity to the reader to understand the fundamental causes of drug resistance and how different approaches are applied. It is a one-stop-shop to understand why it is so difficult to treat cancer, and why only a very few patients respond to therapy and a significant portion develop resistance. Despite a rapid development of more effective anti-cancer drugs and combination therapies, cancer remains the leading cause of lethality in the developed world. The main reason for this is the ability of heterogeneous subpopulations of tumor cells interacting with constantly evolving tumor microenvironment to resist elimination and eventually, trigger cancer relapse. In this book, experts review current concepts explaining molecular and biological mechanisms of cancer drug resistance and discussing advancing approaches for overcoming these therapeutic challenges. Provides the most updated knowledge on the mechanisms of cancer drug resistance and the emerging therapeutic approaches reviewed by experts in the field Brings detailed analyses of most important recently reported developments related to drug resistance and their relevance to overcoming it in cancer patients Discusses in-depth molecular mechanisms and novel concepts of cancer resistance to conventional and advanced therapies
Diagnosis And Management Of Ovarian Disorders
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Author : Albert Altchek
language : en
Publisher: Elsevier
Release Date : 2003-09-04
Diagnosis And Management Of Ovarian Disorders written by Albert Altchek and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-09-04 with Medical categories.
This updated second edition of Diagnosis and Management of Ovarian Disorders provides thorough, yet succinct insight into the ever-changing realm of ovarian disorders. It presents a novel multidisciplinary approach to the subject as described by clinicians, surgeons, pathologists, basic scientists and related medical researchers. Topics covered include reproductive technology, early diagnosis of ovarian cancer, and management of menopause among others. The breadth of information provided by this book will appeal to clinicians and researchers involved in the study and treatment of ovarian disorders. KEY FEATURES * Includes updated information on early diagnosis of ovarian cancer * Reviews new diagnostic techniques for ovarian disorders * Discusses latest information on reproductive technology * Presents translational treatment linking laboratory research with clinical medicine
Gonadotropin Releasing Hormone Receptor Signaling And Functions
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Author : Ivana Bjelobaba
language : en
Publisher: Frontiers Media SA
Release Date : 2018-05-10
Gonadotropin Releasing Hormone Receptor Signaling And Functions written by Ivana Bjelobaba and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-10 with categories.
This eBook provides a comprehensive overview of our current knowledge on Gonadotropin-releasing hormone receptor evolution, structure, signaling and functions. Apart from review articles, it comprises exciting new research, as well as hypotheses and perspectives, all of which are valuable in guiding our further research in this field.
Sex Differences In Physiology
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Author : Gretchen Neigh
language : en
Publisher: Academic Press
Release Date : 2016-05-10
Sex Differences In Physiology written by Gretchen Neigh and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-10 with Medical categories.
Sex Differences in Physiology is an all-encompassing reference that details basic science research into sex differences in all physiological fields. It includes scientific discoveries concerning sex differences in cardiovascular, respiratory, renal, gastrointestinal, and musculoskeletal physiology. In addition, coverage of the development, endocrinology, neurophysiology, immunity, and metabolism is included, making this important reference a resource that will meet the needs of investigators interested in incorporating sex differences into their research programs, while also providing clinicians with the basis for providing the best sex-based medical treatment options available. Provides a sweeping, organ-by-organ review of currently observed sex differences in animal models and human disease Explains how sex differences influence physiology and disease Provides the critical knowledge on sex differences for better understanding of prevention and treatment of diseases