Molecular Biology And Prevention Of Endometrial Cancer
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Author :
language : en
Publisher:
Release Date : 2001
written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with categories.
Molecular Biology And Prevention Of Endometrial Cancer
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Author :
language : en
Publisher:
Release Date : 2006
Molecular Biology And Prevention Of Endometrial Cancer written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
To increase our understanding of the molecular aberrations associated with endometrial carcinogenesis and the biologic mechanisms underlying the protective effect of oral contraceptive (OC) therapy. 1) Oligonucleotide microarray analysis was performed on a panel of endometrial cancers. 2) A subset of adenocarcinoma cases from the International DES Registry (IDESR) was analyzed for MSI 3) A case-control study of the CASH database was performed to evaluate the relationship between progestin potency and endometrial cancer risk. 4) An analysis of endometrium samples from cymologous macaques that were exposed to long term progestins was performed. 5) A clinical trial comparing progestin versus placebo is underway that will facilitate investigation of the effects of progestin exposure on the endometrial lining. 1) Different histological types of endometrial cancer have unique genomic expression patterns. 2) The poor quality DNA from the majority of IDESR samples prohibited an adequate analysis of the case set. 3) A case-control study has suggested higher progestin- potency OCs may be more protective than lower progestin potency OCs among women with a larger body habitus. 4) Macaque studies have suggested that induction of apoptosis may be a mechanism underlying the chemoprotective effects of progestin on the endometrium. 5) Regulatory hurdles have resulted in delays in initiation of the clinical trial. Final FDA approval is expected within the next 3-4 months and the original objectives in the statement of work will be addressed.
Precision Molecular Pathology Of Uterine Cancer
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Author : Michael T. Deavers
language : en
Publisher: Springer
Release Date : 2017-10-28
Precision Molecular Pathology Of Uterine Cancer written by Michael T. Deavers and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-10-28 with Medical categories.
This text provides a comprehensive review for practicing pathologists to understand the molecular biology, diagnostics, and predictive markers and implications for therapy of uterine cancer. While molecular based therapeutic strategies for uterine cancer are not as well developed as for some other organ sites, these are the most common gynecologic malignancies and there have been many important recent developments that are discussed in this volume. Comprehensive chapters address essential information about endometrial carcinoma, uterine mesenchymal tumors, and cervical carcinoma and include the pathogenesis of carcinoma and discuss molecular based classification, biomarkers, therapy, prevention, and hereditary cancers of the uterus. Precision Molecular Pathology of Uterine Cancer is a unique and one of a kind resource for practicing pathologists, pathologists in training and gynecologists.
Cell And Molecular Biology Of Endometrial Carcinoma
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Author : H. Kuramoto
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cell And Molecular Biology Of Endometrial Carcinoma written by H. Kuramoto and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The 15th International Symposium of the Japan Human Cell Society on Cell and Molecular Biology of Endometrial Carcinoma brought together leading researchers from Japan and around the world. The papers collected here are the work of twenty-two leaders in their field and are organized in ten major categories. The first section, in vitro experimental systems, takes up the pioneering work by Kuramoto in 1968 and Nishida in 1980 in establishing, respectively, the HEC-1 and hormone-responsive endometrial carcinoma cell lines. Other topics include apoptosis, proliferation, and growth factors; cell cycle regulators; signaling pathways; angiogenesis; carcinogenesis; hormones and hormone receptors; genes and gene expression; endometrial receptivity; and chemo-resistance and -sensitivity. Presenting the latest work in the cell and molecular biology of endometrial carcinoma, this volume is a valuable resource for gynecologists, pathologists, and molecular biologists.
Molecular Diagnosis And Targeting For Gynecologic Malignancy
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Author : Seiji Isonishi
language : en
Publisher: Springer Nature
Release Date : 2021-03-05
Molecular Diagnosis And Targeting For Gynecologic Malignancy written by Seiji Isonishi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-05 with Medical categories.
This book summarizes the important developments in the field of cancer research, specifically uterine cervical/endometrial cancer and ovarian cancer. It highlights the recent advances in gynecologic cancer, such as next generation models of genetically engineered animal models or cancer cell lines, focusing on their significance for advancing our understanding of gynecologic cancer biology, prevention and treatment, and drug response and resistance. Cancer research in the area of gynecologic tumors has undergone an enormous transformation over the past decade, with a greater understanding of tumor biology, elucidation of novel targets for therapeutic intervention, and better recognition of genetic predisposition syndromes. At the same time, the recent advances in basic cancer research have provided key insights into all aspects of gynecologic cancer biology, including developmental pathways and the impact of lineage plasticity, understanding metastatic progression, uncovering the roles of the tumor microenvironment , exploring tumor evolution, and discovering new therapeutic approaches and mechanisms of drug sensitivity and adaptive response. Molecular Diagnosis and Targeting for Gynecologic Malignancy appeals to investigators, clinicians, residents and postdocs who are curious about new research on gynecologic malignancies. It not only presents basic and translational research, but also explores the generalizability of the evidence covering the interface between basic and clinical science. Furthermore, a number of the topics offer the basis for new ideas that have the potential to advance into the gynecologic malignancies. This book provides readers with state-of-the-art information that will help improve the lives of patients with these challenging diseases.
Cancer Prevention
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Author : Alexandros G. Georgakilas
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-04-20
Cancer Prevention written by Alexandros G. Georgakilas and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-04-20 with Medical categories.
This unique synthesis of chapters from top experts in their fields targets the unique and significant area of cancer prevention for different types of cancers. Perspective readers are invited to go through novel ideas and current developments in the field of molecular mechanisms for cancer prevention, epidemiological studies, antioxidant therapies and diets, as well as clinical aspects and new advances in prognosis and avoidance of cancer. The primary target audience for the book includes PhD students, researchers, biologists, medical doctors and professionals who are interested in mechanistic studies on cancer prevention and translational benefits for optimized cancer treatment.
Molecular Genetics Of Endometrial Carcinoma
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Author : Lora Hedrick Ellenson
language : en
Publisher: Springer
Release Date : 2016-12-01
Molecular Genetics Of Endometrial Carcinoma written by Lora Hedrick Ellenson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-01 with Medical categories.
This comprehensive text provides a much-needed review of a disease that is currently garnering the interest of molecular biologists, translational scientists, and clinicians. The volume includes emerging developments in the molecular genetics of endometrial carcinoma. In addition to covering the basic genetics of endometrial carcinoma, chapters also cover a wide range of signaling pathways implicated in endometrial carcinoma. A section of the book includes a number of genetically engineered mouse models, which contribute to understanding the role of various genetic alterations in the development and progression of endometrial carcinoma. These models also provide preclinical models for developing effective targeted therapeutic approaches. Endometrial carcinoma is the most common malignancy of the female genital tract in the United States and the number of cases continues to increase around the world. This book is a meant to serve as a resource for a wide range of scientists, from molecular geneticists to signal transduction biologists, as well as to both clinicians and scientists interested in developing targeted therapeutic approaches for women with endometrial carcinoma.
Management Of Endometrial Cancer
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Author : Mansoor R. Mirza
language : en
Publisher: Springer
Release Date : 2019-08-26
Management Of Endometrial Cancer written by Mansoor R. Mirza and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-26 with Medical categories.
This practical reference book provides up-to-date, evidence-based multidisciplinary guidelines on the epidemiology, biology, diagnosis, and treatment of endometrial cancer. Individual chapters focus on topics such as hormonal interactions, cancer prevention, genetic classification and its clinical applications. Recent advances in diagnostic methods are described. The treatment-oriented chapters include coverage of the roles of lymphadenectomy and sentinel node dissection, surgical complications, radiation techniques, and chemotherapy in early-stage disease. Treatment options in advanced disease, including hormonal therapy and targeted therapy, are considered separately, as is the management of rare tumor types. The authors are international key opinion leaders. Summaries of the ESMO/ESGO/ESTRO guidelines on management are included. Each clinical chapter ends with a summary of recommendations with the level of evidence.
New Insights Into Endometrial Cancer 2022
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Author : Laura Paleari
language : en
Publisher:
Release Date : 2023
New Insights Into Endometrial Cancer 2022 written by Laura Paleari and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with Cancer categories.
This open access Special Issue brings together original research and review articles on molecular oncology, with attention given to endometrial cancer. It highlights new findings, methods, and technical advances in molecular cancer research. The main feature of this Special Issue is that it is a platform for open-source sharing of significant works in the field of molecular oncology that can increase our understanding of endometrial cancer development, which may lead to the discovery of new molecular diagnostic technologies and targeted therapeutics. Topics include: Molecular methods to personalize endometrial cancer screening and detection; Identification and new aspects of cellular signaling molecules and pathways for target discovery, drug design, and personalized and gender medicine; DDI discovery in endometrial cancer management; Drug repurposing for endometrial cancer prevention/treatment; Molecular modeling studies.
Mechanisms In Carcinogenesis And Cancer Prevention
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Author : Harri U. Vainio
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-04-17
Mechanisms In Carcinogenesis And Cancer Prevention written by Harri U. Vainio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Medical categories.
A large proportion of cancers is preventable. External factors, discovered by epidemiological studies during the last 50 years, account for a majority of all cancer deaths. However, still rather little is known, about how environmental and genetic factors interact, how they may regulate gene activation etc. And it is a long way from the discovery of a basic regulatory mechanism to practical patient treatment. This volume describes the present state of the art in carcinogenesis, possibilities for cancer prevention, and gives genetic background in cancer development. Attention is given to the host-environment interaction, considering how this interaction may lead to cancer formation and how it can be utilised in cancer prevention. The molecular basis for cancer development and the molecular basis for prevention are described.