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Molecular Biology Of Long Non Coding Rnas


Molecular Biology Of Long Non Coding Rnas
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Molecular Biology Of Long Non Coding Rnas


Molecular Biology Of Long Non Coding Rnas
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Author : Ahmad M. Khalil
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-09-20

Molecular Biology Of Long Non Coding Rnas written by Ahmad M. Khalil and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-09-20 with Medical categories.


​Long non-coding RNAs (lnc)RNAs have emerged as a new paradigm in epigenetic regulation of the genome. Thousands of lncRNAs have been identified and observed in a wide range of organisms. Unlike mRNA, lncRNA have no protein-coding capacity. ​So, while their function is not entirely clear, they may serve as key organizers of protein complexes that allow for higher order regulatory events. Discovering these functions has been the result of intense research done of the last few years, and lncRNA research has had several critical developments during that time. This book will consolidate these ideas and models to better examine the most important issues in lncRNA biology. This will include critical studies that have led to the discovery and annotation of lncRNAs in numerous species, and the molecular mechanisms for a few lncRNA that have begun to emerge.



Computational Biology Of Non Coding Rna


Computational Biology Of Non Coding Rna
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Author : Xin Lai
language : en
Publisher: Humana
Release Date : 2025-02-03

Computational Biology Of Non Coding Rna written by Xin Lai and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-03 with Science categories.




Long Noncoding Rnas In Plants


Long Noncoding Rnas In Plants
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Author : Santosh Kumar Upadhyay
language : en
Publisher: Academic Press
Release Date : 2020-11-13

Long Noncoding Rnas In Plants written by Santosh Kumar Upadhyay and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-13 with Science categories.


The growth of human population has increased the demand for improved yield and quality of crops and horticultural plants. However, plant productivity continues to be threatened by stresses such as heat, cold, drought, heavy metals, UV radiations, bacterial and fungal pathogens, and insect pests. Long noncoding RNAs are associated with various developmental pathways, regulatory systems, abiotic and biotic stress responses and signaling, and can provide an alternative strategy for stress management in plants. Long Noncoding RNAs in Plants: Roles in development and stress provides the most recent advances in LncRNAs, including identification, characterization, and their potential applications and uses. Introductory chapters include the basic features and brief history of development of lncRNAs studies in plants. The book then provides the knowledge about the lncRNAs in various important agricultural and horticultural crops such as cereals, legumes, fruits, vegetables, and fiber crop cotton, and their roles and applications in abiotic and biotic stress management. - Includes the latest advances and research in long noncoding RNAs in plants - Provides alternative strategies for abiotic and biotic stress management in horticultural plants and agricultural crops - Focuses on the application and uses of long noncoding RNAs



Computational Non Coding Rna Biology


Computational Non Coding Rna Biology
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Author : Yun Zheng
language : en
Publisher: Academic Press
Release Date : 2018-09-14

Computational Non Coding Rna Biology written by Yun Zheng and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-09-14 with Science categories.


Computational Non-coding RNA Biology is a resource for the computation of non-coding RNAs. The book covers computational methods for the identification and quantification of non-coding RNAs, including miRNAs, tasiRNAs, phasiRNAs, lariat originated circRNAs and back-spliced circRNAs, the identification of miRNA/siRNA targets, and the identification of mutations and editing sites in miRNAs. The book introduces basic ideas of computational methods, along with their detailed computational steps, a critical component in the development of high throughput sequencing technologies for identifying different classes of non-coding RNAs and predicting the possible functions of these molecules. Finding, quantifying, and visualizing non-coding RNAs from high throughput sequencing datasets at high volume is complex. Therefore, it is usually possible for biologists to complete all of the necessary steps for analysis. - Presents a comprehensive resource of computational methods for the identification and quantification of non-coding RNAs - Introduces 23 practical computational pipelines for various topics of non-coding RNAs - Provides a guide to assist biologists and other researchers dealing with complex datasets - Introduces basic computational methods and provides guidelines for their replication by researchers - Offers a solution to researchers approaching large and complex sequencing datasets



Non Coding Rnas


Non Coding Rnas
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Author : Jan Barciszewski
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-08-31

Non Coding Rnas written by Jan Barciszewski and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-08-31 with Science categories.


General inspection of a role performed in the cell by RNAs allows us to distinguish three major groups of transcripts: I. protein-coding mRNAs, II. non-coding housekeeping and III. regulatory RNAs. The housekeeping RNAs include RNA classes that are generally, constitutively expressed and whose presence is required for normal function and viability of the cells. On the other hand, a group of regulatory RNAs includes RNA species that are expressed at certain stages of organism development or cell differentiation or as a response to external stimuli and can affect expression of other genes on the levels of transcription or translation. Non-coding RNA transcripts form a heterogeneous class of RNAs that can not be characterized by a single specific function. Initially, the term non-coding RNA (ncRNA) was used primarily to describe polyadenylated and a capped eukaryotic RNAs transcribed by RNA polymerase II, but lacking long open reading frames. Now, this definition can be extended to cover all RNA transcripts that do not show protein-coding capacity and is sometimes used to describe any RNA that does not encode protein, including introns. This book is an in-depth look at the function of Non-Coding RNAs and their relationship to Molecular Biology and Molecular Biology.



Molecular Biology Of Long Non Coding Rnas


Molecular Biology Of Long Non Coding Rnas
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Author : Ahmad M. Khalil
language : en
Publisher:
Release Date : 2019

Molecular Biology Of Long Non Coding Rnas written by Ahmad M. Khalil and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Molecular biology categories.


This book examines key issues in lncRNA biology, including critical studies that have led to the discovery and annotation of lncRNAs in numerous species and the molecular mechanisms for a few lncRNA that have begun to emerge.



Molecular Biology Of Rna


Molecular Biology Of Rna
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Author : David Elliott
language : en
Publisher: Oxford University Press
Release Date : 2017-01-31

Molecular Biology Of Rna written by David Elliott and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-31 with Science categories.


RNA plays a central, and until recently, somewhat underestimated role in the genetics underlying all forms of life on earth. This versatile molecule not only plays a crucial part in the synthesis of proteins from a DNA template, but is also intrinsically involved in the regulation of gene expression, and can even act as a catalyst in the form of a ribozyme. This latter property has led to the hypothesis that RNA - rather than DNA - could have played an essential part in the origin of life itself. This landmark text provides a systematic overview of the exciting and rapidly moving field of RNA biology. Key pioneering experiments, which provided the underlying evidence for what we now know, are described throughout, while the relevance of the subject to human disease is highlighted via frequent boxes. For the second edition of Molecular Biology of RNA, more introductory material has been incorporated at the beginning of the text, to aid students studying the subject for the first time. Throughout the text, new material has been included - particularly in relation to RNA binding domains, non-coding RNAs, and the connection between RNA biology and epigenetics. Finally, a new closing chapter discusses how exciting new technologies are being used to explore current topical areas of research.



Long Non Coding Rnas


Long Non Coding Rnas
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Author : Yi Feng
language : en
Publisher: Humana
Release Date : 2016-01-01

Long Non Coding Rnas written by Yi Feng and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-01 with Medical categories.


This volume assembles a broad spectrum of methods used in long non-coding RNAs (lncRNA) research, ranging from computational annotation of lncRNA genes to molecular and cellular analyses of the function of individual lncRNA. Long Non-Coding RNAs: Methods and Protocols also discusses methods used to study circular RNAs and RNA splicing, as well as influential findings on lncRNA in human diseases. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Thorough and cutting-edge, Long Non-Coding RNAs: Methods and Protocols is a must-have for molecular biologists, cell and developmental biologists, specialists who conduct disease-oriented research, and bioinformatics experts who seek a better understanding on lncRNA expression and function by computational analysis of the massive sequencing data that are rapidly accumulating in recent years.



Long Non Coding Rnas In Cancer


Long Non Coding Rnas In Cancer
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Author : Alfons Navarro
language : en
Publisher: Humana
Release Date : 2021-06-24

Long Non Coding Rnas In Cancer written by Alfons Navarro and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-24 with Medical categories.


This volume presents techniques needed for the study of long non-coding RNAs (lncRNAs) in cancer from their identification to functional characterization. Chapters guide readers through identification of lncRNA expression signatures in cancer tissue or liquid biopsies by RNAseq, single Cell RNAseq, Phospho RNAseq or Nanopore Sequencing techniques; validation of lncRNA signatures by Real time PCR, digital PCR or in situ hybridization; and functional analysis by siRNA or CRISPR based methods for lncRNA silencing or overexpression. Lipid based nanoparticles for delivery of siRNAs in vivo, lncRNA-protein interactions, viral lncRNAs and circRNAs are also treated in this volume. Written in the format of the highly successful Methods in Molecular Biology series, each chapter includes an introduction to the topic, lists necessary materials and reagents, includes tips on troubleshooting and known pitfalls, and step-by-step, readily reproducible protocols. Authoritative and practical, Long Non-Coding RNAs in Cancer aims to provide a collection of laboratory protocols, bioinformatic pipelines, and review chapters to further research in this vital field.



Long Non Coding Rna Biology


Long Non Coding Rna Biology
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Author : M.R.S. Rao
language : en
Publisher: Springer
Release Date : 2017-08-16

Long Non Coding Rna Biology written by M.R.S. Rao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-16 with Medical categories.


This contributed volume offers a comprehensive and detailed overview of the various aspects of long non-coding RNAs and discusses their emerging significance. Written by leading experts in the field, it motivates young researchers around the globe, and offers graduate and postgraduate students fascinating insights into genes and their regulation in eukaryotes and higher organisms.