Molecular Biology Of Steroid And Nuclear Hormone Receptors
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Molecular Biology Of Steroid And Nuclear Hormone Receptors
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Author : Leonard Freedman
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology Of Steroid And Nuclear Hormone Receptors written by Leonard Freedman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Intracellular Receptors: New Instruments for a Symphony of Signals In the late eighteenth century, it was proposed on theoretical grounds that each of the body's organs, beginning with the brain, must be "a factory and laboratory of a specific humor which it returns to the blood", and that these circulating signals "are indispensable for the life of the whole" (Bordeu 1775). During the nineteenth cen tury, some remarkable physiological experiments revealed the actions of humoral factors that affected the for and function of multiple tissues, organs and organ sys tems within the body (Berthold 1849); much later, the chemical and molecular na ture of some of those factors was determined. Against this deep historical backdrop of the founding studies of intercellular signaling, molecular biology sprang into existence a mere forty years ago, rooted in the revelation of regulable gene expression in bacteria. But contemporaneous with those classical analyses of transcriptional regulation of the lactose operon, the mod em era of signal transduction was inaugurated by the identification of cAMP as a second messenger -- an intracellular mediator of hormonal activation of glycogen catabolism (Sutherland and RaIl 1960). Later in that same decade, it emerged that cAMP is a critical signal not only in metazoans, but even in bacteria, where it serves an analogous function as a critical switch that activates expression of genes re quired for catabolism of complex carbon sources, including those of the lactose operon.
Molecular Biology Of Steroid And Nuclear Hormone Receptors
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Author : Leonard P. Freedman
language : en
Publisher:
Release Date : 1998
Molecular Biology Of Steroid And Nuclear Hormone Receptors written by Leonard P. Freedman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998 with Hormone receptors categories.
This text presents the topic of endocrinology viewed from the perspective of molecular biology.
Molecular Biology Of Steroid And Nuclear Hormone Receptors
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Author : Leonard Freedman
language : en
Publisher:
Release Date : 1998-01-01
Molecular Biology Of Steroid And Nuclear Hormone Receptors written by Leonard Freedman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-01-01 with categories.
Nuclear Receptors
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Author : Didier Picard
language : en
Publisher: OUP Oxford
Release Date : 1999-07-08
Nuclear Receptors written by Didier Picard and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-07-08 with Science categories.
The steroid / nuclear receptor superfamily is a large and growing group of transcription factors that are studied by a large and varied number of basic and clinical researchers. The first two chapters describe the evolutionary biology of the superfamily and explain how to clone and characterize new receptors. Chapter 3 shows how to identify the ligands of novel receptors and chapter 4 explains the kinetic analysis of receptor interactions. In chapter 5, the reader is guided through the functional characterization of coactivators using microinjection. The next section covers receptor phosphorylation, ligand regulated transcription, and hormone resistance syndromes. Chapter 9 describes the in vitro assembly of Hsp90 complexes and chapter 10 explains yeast as a model system for looking at receptor function. The final chapter shows how heterologous proteins can be regulated by fusion to the hormone binding domain of a receptor. Nuclear Receptors: A Practical Approach is a comprehensive guide to studying members of the superfamily and will be invaluable to all researchers old and new.
Steroid Hormone Action
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Author : Malcolm G. Parker
language : en
Publisher: IRL Press
Release Date : 1993
Steroid Hormone Action written by Malcolm G. Parker and has been published by IRL Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Genetic regulation categories.
Steroid Hormone Action is a comprehensive overview of the molecular mechanisms by which these hormones regulate the expression of specific target genes. The book covers the structure of steroid receptors, transcriptional activation and repression, and also contains chapters on steroid bindingproteins and steroidogenesis. Steroid receptors represent one of the best characterized transcription factors so that the book will be of general interest to Molecular Biologists studying eucaryotic gene regulation. Chapters on the mechanisms of action of steoid antagonists and defective receptorsin target cells will be of particular interest to Endocrinologists and Clinicians. In such a rapidly progressing field it is difficult to keep up with all the literature but this book, written by international experts, focuses on the most important advances that have been made recently.
Nuclear Receptor Coregulators
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Author :
language : en
Publisher: Academic Press
Release Date : 2004-08-11
Nuclear Receptor Coregulators written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-08-11 with Science categories.
First published in 1943, Vitamins and Hormones is the longest-running serial published by Academic Press. In the early days of the Serial, the subjects of vitamins and hormones were quite distinct. The Editorial Board now reflects expertise in the field of hormone action, vitamin action, X-ray crystal structure, physiology, and enzyme mechanisms. Under the capable and qualified editorial leadership of Dr. Gerald Litwack, Vitamins and Hormones continues to publish cutting-edge reviews of interest to endocrinologists, biochemists, nutritionists, pharmacologists, cell biologists, and molecular biologists. Others interested in the structure and function of biologically active molecules like hormones and vitamins will, as always, turn to this series for comprehensive reviews by leading contributors to this and related disciplines. *First published in 1943, Vitamins and Hormones is AP's longest running serial *Each volume contains cutting edge reviews by leading contributors
Gene Regulation By Steroid Hormones Iii
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Author : Arun K. Roy
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Gene Regulation By Steroid Hormones Iii written by Arun K. Roy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The field of steroid hormone action has continued to expand into the realm of molecular biology at a pace even faster than most of us ever imagined. techniques of molecular biology have made it possible to clone The hormone-regulated genes and to examine steroid-receptor interactions with these genes. Nucleotide sequences of these genes, which show preferential binding of steroid receptors, have been identified. These results are complemented by the identification of chromatin acceptor proteins, which also show preferential binding for steroid-receptor complexes. Thus, one can envision the day when cloned genes, purified acceptor proteins, and receptor-steroid complexes will be recombined in vitro to form a functional unit. Cellular localization of steroid receptors has undergone recent revision, and it now appears that receptors are localized primarily in the nuclear compartment. These findings, although controversial, will lead to a reassessment of many of the previous concepts of steroid-receptor interactions and regulation. The way in which these observations at the of physiology, molecular and cellular levels fit into the overall scheme development, and evolution are continuing to progress, and the future promises some very exciting syntheses of understanding at all levels of biological organization. The third Meadow Brook Conference on hormones was held in order to bring together investigators who will undoubtedly contribute heavily to this future synthesis and to permit a free exchange of ideas and concepts as they relate to the current state-of-the-art in molecular endocrinology. Spring 1986 ARUN K. Roy JAMES H. CLARK Contents Preface. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . v Contributors . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
Steroid Receptors
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Author : Gabriella Castoria
language : en
Publisher:
Release Date : 2014
Steroid Receptors written by Gabriella Castoria and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Cancer categories.
Steroid Receptors: Methods and Protocols presents a selection of techniques that have been recently applied to the analysis of steroid receptors, powerful tools for the advancement of our understanding of both the mechanisms regulating gene transcription and the rapid signaling responses of tissues to signals. Research in this area has generated a wealth of data allowing the elucidation of steroid receptor mechanisms and improving the treatment of many endocrine disorders, above all cancers. Chapters cover methods to analyze gene transcription, chromatin and proteomic modifications, extra-nuclear signaling regulation, development of cell and animal models, and preparation of new antibodies. Written in the successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and easily accessible, Steroid Receptors: Methods and Protocols offers an updated view on a variety of modern methods that will hopefully contribute to improving our knowledge on the integration of steroid receptors in single or different functionally connected cellular contexts under a variety of physiological and pathological conditions, above all tumors.
Steroid And Sterol Hormone Action
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Author : Thomas C. Spelsberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Steroid And Sterol Hormone Action written by Thomas C. Spelsberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The purpose of this book is to focus attention on recent developments in steroid and sterol hormone action. Many authors have generously contributed to the book. As a result, there is a great diversity of opinion! A majority of the chapters deal with steroid or sterol hormone receptors. This is not meant to imply that receptor-mediated mechanisms are the sole or even the most important mechanisms by which steroid hormones act in the cell. There is wealth of evidence showing that other, non-receptor events, are important also. Steroid hormone recep tor research and the study of nuclear events mediated by steroids are presently the most intensely studied aspects of sterol hormone action and our selection of topics reflects this trend. We have also included chapters on vitamin 0 sterols and thyroid hormone in the book, as there is pood evidence that these hormones act in a manner similar to other classical steroids. 1 IMMUNOCHARACTERIZATION OF THE NUCLEAR ACCEPTOR SITES FOR THE AVIAN OVIDUCT PROGESTERONE RECEPTOR A. GOLDBERGER, M. HORTON, T. C. SPELSBERG Department of Biochemistry and Molecular Biology, Mayo Clinic and Mayo Graduate School of Medicine, Rochester, MN 55905 INTRODUCTION It is well known that steroid hormones, certain vitamins and sterols, enter target cells and bind to specific protein receptors in the cyto plasm or nucleus (1-4). This binding is saturable, high affinity, and steroid specific.
Nuclear Hormone Receptors
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Author : Malcolm G. Parker
language : en
Publisher:
Release Date : 1991
Nuclear Hormone Receptors written by Malcolm G. Parker and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Cell receptors categories.
An overview of the supergene family made up of those nuclear hormone receptors which recognize thyroid and steroid hormones, vitamen D and retinoic acid and which are characterized by their ability to bind both ligands and the genes which respond to them.