Molecular Biology Of The Arterial Wall
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Molecular Biology Of The Arterial Wall
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Author : Gotthard Schettler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular Biology Of The Arterial Wall written by Gotthard Schettler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The outstanding contributions to this volume are designed to shed light on some fields of cell biology and cellular pathology, including newly observed phenomena of cell-cell interactions, which might be applicable in studying the pathological process of atherosclerosis. The topics included cover: lipoproteins and lipoprotein receptors; growth factors; endocytosis and exocytosis; ONC Genes and proliferative disease; white blood cells; prostaglandins and leukotrienes; and the biology of smooth muscle and endothelium. The volume provides a complete summary of the most important developments in the field with great impact for arteriosclerosis research.
Biology Of The Arterial Wall
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Author : Bernard I. Levy
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-23
Biology Of The Arterial Wall written by Bernard I. Levy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-23 with Medical categories.
Biology of the Arterial Wall is intended as a general reference text concerned with the biology of the vascular cells and the blood vessel wall under physiological and pathological conditions. One of the major functions of the arteries is to maintain a continuous blood flow to the organs whatever the pressure conditions, thanks to the vasomotor tone of the smooth muscle cells. Great advances have been made over the last decade in the understanding of the endothelial cells as integrators and transducers of signals originating from the blood stream. The pluripotent control functions of the endothelial cells in the vessel wall are now well recognized. A review of endothelial functions and dysfunctions is presented. Cell biology and molecular genetic studies have now identified an array of molecules elaborated by endothelial cells and vascular smooth muscle cells and by the blood-borne elements which interact with artery cells, defending the artery against injury and modulating evolving abnormal processes. Molecules which induce or inhibit endothelial and/or smooth muscle cells are currently under great scrutiny. Angiogenesis, which plays a major role in tumor growth, but may also be beneficial as a healing process in muscle ischemia, is discussed. Apoptosis, or programmed cell death, has only recently been recognized as an essential process in blood vessel modeling and remodeling. An overview of apoptosis in the vascular system is presented. It is increasingly evident that the adjustments of the blood vessel wall are made in the presence of deforming disease processes such as hypertension and atherosclerosis. The second part of the book is concerned with the blood vessel wall in disease conditions. Several chapters review the role of the vessel and vascular cells in inflammation, and vascular remodeling during arterial hypertension and aging. One chapter is devoted to atherogenesis, atheroma and plaque instability, followed by the pathophysiology of post-angioplasty restenosis, which is a crucial issue in modern interventional cardiology.
Atherosclerosis
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Author : Sergey Fedoroff
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Atherosclerosis written by Sergey Fedoroff and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This volume contains the papers which were presented at the First Altschul Symposium, Atherosclerosis: Cellular and Molecular Interactions in the Artery Wall. The symposium was held in Saskatoon, at the University of Saskatchewan in May 1990 in memory of Dr. Rudolph Altschul, a pioneer in the field of vascular biology and the prevention of atherosclerosis. Dr. Altschul was Professor and Head of the Department of Anatomy at the University of Saskatchewan from 1955 to 1963. The challenge for biomedical scientists is to unravel the multifactorial etiology of atherosclerosis. For the last hundred and sixty years, anatomical pathologists have carefully studied the morphological changes of the human vascular wall during the initiation and evolution of the fibrofatty atherosclerotic plaque. Based on these elegant morphological observations, theories on atherogenesis were put forth by pathologists in the 1840's. Rudolf Virchow suggested that the movement of substances from the blood into the vessel wall was important for atherogenesis while Carl von Rokitansky felt that the deposition of substances on the lumenal surface of the artery resulted in the formation of atherosclerotic plaque. Since these original theories, it has become apparent that the pathogenesis of atherosclerosis is multifactorial and the disease evolves in stages. It is also likely that not all plaques arise through the same sequence of events and that many steps are involved in the development of each plaque. Today, our understanding of the complicated processes of atherogenesis is still incomplete.
Blood Vessels
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Author : Walter John Cliff
language : en
Publisher: CUP Archive
Release Date : 1976-04
Blood Vessels written by Walter John Cliff and has been published by CUP Archive this book supported file pdf, txt, epub, kindle and other format this book has been release on 1976-04 with Science categories.
Cellular Metabolism Of The Arterial Wall And Central Nervous System
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Author : Gotthard Schettler
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Cellular Metabolism Of The Arterial Wall And Central Nervous System written by Gotthard Schettler and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
International experts review the molecular biology of ion channels, diseases of the central nervous system including Alzheimer's disease, the molecular biology of atherogenesis, plasma lipproteins, lipid transport, long chain fatty acid transport and metabolism, and lipoprotein receptors. Future directions and perspectives and common features in these important areas are discussed.
Diseases Of The Arterial Wall
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Author : Jean-Pierre Camilleri
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Diseases Of The Arterial Wall written by Jean-Pierre Camilleri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This text combines extensive coverage of normal structure and function of the arterial wall with detailed accounts of the changes that occur in disease. These data are presented in a comprehensive way not found elsewhere; they are essential for the proper understanding of arterial disease and for its investigation using modern methodology. Development and the factors controlling vessel form and structure are first discussed; and the normal cellular populations, functions and interactions are then considered. Particular topics, such as pulmonary hypertension, the effects of trauma on vessels, and diabetic vascular disease, are reviewed in detail. This book will be of interest to all involved in the management of vascular disease.
Endothelial Cell Biology In Health And Disease
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Author : M. Simionescu
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Endothelial Cell Biology In Health And Disease written by M. Simionescu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
Although blood capillaries were first observed through a flea-lens microscope by Malpighi in 1661,200 more years elapsed before the cellular nature of the vessel wall was conclusively demonstrated. Beginning with the middle of the 19th cen tury, our knowledge of the histological organization of blood vessels has steadily increased. However, the endothelium, which for a long time was considered to be just an inert barrier lining, had been barely explored until three decades ago. Since then, there has been an upsurge of interest in the fine structure and function of endothelial cells. Intense in vivo and in vitro investigations have revealed that the endothelial cell is a key element in a wide variety of normal activities and diseases. A large number of investigators and laboratories have been attracted to endothelial cell research, thus supporting the expansion of the continuously grow ing and diversifying field of endotheliology. The number of articles published annually on this subject has increased from a few score at the beginning of the 1970s to more than a thousand in recent years, and an increasing number of journals, books, societies, and symposia focused primarily on the vascular en dothelium have marked the last decade.
Atherogenesis
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Author : Sampath Parthasarathy
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-11
Atherogenesis written by Sampath Parthasarathy and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-11 with Medical categories.
This monograph will bring out the state-of-the-art advances in the dynamics of cholesterol transport and will address several important issues that pertain to oxidative stress and inflammation. The book is divided into three major sections. The book will offer insights into the roles of specific cytokines, inflammation, and oxidative stress in atherosclerosis and is intended for new researchers who are curious about atherosclerosis as well as for established senior researchers and clinicians who would be interested in novel findings that may link various aspects of the disease.
Vascular Engineering
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Author : Kazuo Tanishita
language : en
Publisher: Springer
Release Date : 2016-03-17
Vascular Engineering written by Kazuo Tanishita and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-03-17 with Medical categories.
This book describes the fundamental biology and mechanics of the vasculature and examines how this knowledge has underpinned the development of new clinical modalities, including endovascular treatment and vascularization of reconstructed tissue for regenerative medicine. Vascular engineering is a multidisciplinary field integrating vascular biology, hemodynamics, biomechanics, tissue engineering, and medicine. Each chapter offers insights into the dynamics of the circulatory system and explains how the impact of related disease conditions — atherosclerosis, hypertension, myocardial ischemia, and cerebral infarction — has generated a focus on developing expertise to both maintain and treat the vascular system. As a comprehensive book in this expanding area, Vascular Engineering serves as a valuable resource for clinicians as well as academics and professionals working in biophysics, biomedical engineering, and nano and microrheology. Graduate students in these subject areas will also find this volume insightful.
Vascular Disease
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Author : Andrew H. Baker
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-01
Vascular Disease written by Andrew H. Baker and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-01 with Medical categories.
Molecular biology has revolutionized research into vascular disease. Over the past 20 years molecular techniques have enabled us to both elucidate - lecular mechanisms in vascular disease and identify appropriate therapies. The vast explosion in technical knowledge and the array of protocols that become more advanced and intricate by the day lead us into new and exciting areas of research that were previously unobtainable. Vascular Disease: Molecular Biology and Gene Transfer Protocols - scribes today’s most powerful molecular methods for the investigation of the pathogenesis of vascular disease. The protocols are highly detailed, allowing beginners who have little experience in either vascular biology or molecular biology to embark on new molecular projects. This book is also suited to more experienced molecular biologists who wish to grasp new methods for stu- ing the involvement of genes in normal vascular physiology and in diseased states. It is well established that cardiovascular disease progression has a s- stantial genetic influence. Part I describes three methods that have been used successfully to identify specific mutations in candidate genes involved in c- diovascular disorders. These mutations include both single-stranded conf- mational polymorphism analysis and heteroduplex detection methods. In addition, technology to map new genes to specific regions of chromosomes by high-resolution mapping is described.