Molecular Determinants Of Different Gating Mechanisms In Inwardly Rectifying Potassium Channels
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Molecular Determinants Of Different Gating Mechanisms In Inwardly Rectifying Potassium Channels
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Author : Xinyang Huang
language : en
Publisher:
Release Date : 2012
Molecular Determinants Of Different Gating Mechanisms In Inwardly Rectifying Potassium Channels written by Xinyang Huang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Molecular Determinants Of Gating At The Potassium Channel Selectivity Filter
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Author : Julio F. Cordero-Morales
language : en
Publisher:
Release Date : 2008
Molecular Determinants Of Gating At The Potassium Channel Selectivity Filter written by Julio F. Cordero-Morales and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
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Molecular Gating Dynamics Of The Cytoplasmic Domains Of Inwardly Rectifying Potassium Kir Channels
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Author : Scott Dusan Pegan
language : en
Publisher:
Release Date : 2006
Molecular Gating Dynamics Of The Cytoplasmic Domains Of Inwardly Rectifying Potassium Kir Channels written by Scott Dusan Pegan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
My research focuses on understanding the mechanisms of eukaryotic inwardly rectifying potassium channels (Kir), which are responsible for creating membrane potential stability. N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two crystal structures of the cytoplasmic domains of Kir2.1 (Kir2.1L) and the G protein-sensitive Kir3.1 (Kir3.1S) channels in the absence of PIP2 show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central pore (G-loop). Significant flexibility of the pore-facing G-loop of Kir2.1L and Kir3.1S suggest a possible role as a diffusion barrier between cytoplasmic and transmembrane pores. Consistent with this, mutations of the G-loop disrupted gating or inward rectification. Structure comparison reveals a di-aspartate cluster on the distal end of the cytoplasmic pore of Kir2.1L that is important for modulating inward rectification. The Kir2.1L structural allows us the first structural look at the potential causes of Andersen's Syndrome, which is caused by defects in the inwardly rectifying potassium channel 2.1 (Kir2.1). We have characterized individual Andersen's Syndrome mutants R218Q, G300V, E303K, and [delta]314-315 and have shown that they have multiple affects on the ability of Kir2.1 channel's cytoplasmic domains to assemble into proper tetrameric assemblies. The 2.0 Å x-ray crystal structure of the N- and C-terminal cytoplasmic domains of Kir2.1 R218Q combined with T309K, reveals the G-loop and CD loop disruptions by the R218Q mutation. We show that E303 plays an important role in gating. Moreover, we demonstrate a novel DE loop stabilizing 2-methyl-2,4-pentanediol binding site, and cytoplasmic bound potassium ion, the first identified for this class of K channels. We have also conducted NMR studies on the last 58 residues of Kir2.1 to show the flexibility of this region and binding footprint of PSD95 PDZ domains, which tethers the channels to the cell's cytoskeleton. Taken together, these results demonstrate that cytoplasmic domains of Kir channels are structurally significant components of the channel and undergo structural changes to modulate gating and inward rectification.
Pharmacology Of Potassium Channels
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Author : Nikita Gamper
language : en
Publisher: Springer Nature
Release Date : 2021-09-27
Pharmacology Of Potassium Channels written by Nikita Gamper and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-27 with Medical categories.
The aim of the present book is to comprehensively review current advances in understanding of genetics, structural biology, pharmacology of potassium channels and their roles in disease as well as to identify current gaps in knowledge. The ultimate goal is to provide a scientific foundation for better understanding of modulatory mechanisms and pharmacology of potassium channels and to use this understanding to drive future drug discovery. This book will be a must-have for academic and industrial scientists interested in physiology, pharmacology, pathology and structure-functional relationships of ion channels. The book will also be helpful for lecturers and students in the college and university classrooms, as well as for anyone interested in the state-of-the art in modern cell biology, physiology and pharmacology.
Potassium Ion Channels Molecular Structure Function And Diseases
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Author :
language : en
Publisher: Academic Press
Release Date : 1999-05-04
Potassium Ion Channels Molecular Structure Function And Diseases written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-05-04 with Medical categories.
This book is the first to focus on potassium ion channels and covers the recent remarkable progress made in research on these proteins. Many diseases are caused by the abnormalities of potassium ion channels. They include diabetes mellitus, life-threatening hereditary cardiac arrhythmia, epilepsy, neural degeneration, and renal hypertension. Written by leading scientists in the field, this volume offers readers a comprehensive update of this field in the understanding of the genes, molecular structure, function and diseases of potassium ion channels. Key Features * The first comprehensive volume on potassium ion channels in all aspects of genes, molecular structure, function, and diseases * Completely up-to-date information * Written by leading scientists in the field
Structure And Dynamics Of Protein In The Permeation And Gating Of Potassium Ion Channels
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Author : Salvatore M. Cosseddu
language : en
Publisher:
Release Date : 2013
Structure And Dynamics Of Protein In The Permeation And Gating Of Potassium Ion Channels written by Salvatore M. Cosseddu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Biological Membranes
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Author : Kenneth M. Merz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Biological Membranes written by Kenneth M. Merz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The interface between a living cell and the surrounding world plays a critical role in numerous complex biological processes. Sperm/egg fusion, virus/cell fusion, exocytosis, endocytosis, and ion permeation are a few examples of processes involving membranes. In recent years, powerful tools such as X-ray crystal lography, electron microscopy, nuclear magnetic resonance, and infra-red and Raman spectroscopy have been developed to characterize the structure and dy namics of biomembranes. Despite this progress, many of the factors responsible for the function of biomembranes are still not well understood. The membrane is a very complicated supramolecular liquid-crystalline structure that is largely composed of lipids, forming a bilayer, to which proteins and other biomolecules are anchored. Often, the lipid bilayer environment is pictured as a hydropho bic structureless slab providing a thermodynamic driving force to partition the amino acids of a membrane protein according to their solubility. However, much of the molecular complexity of the phospholipid bilayer environment is ignored in such a simplified view. It is likely that the atomic details of the polar head group region and the transition from the bulk water to the hydrophobic core of the membrane are important. An understanding of the factors responsible for the function of biomembranes thus requires a better characterization at the molec ular level of how proteins interact with lipid molecules, of how lipids affect protein structure and of how lipid molecules might regulate protein function.
Molecular Mechanisms Of Gating And Selectivity In The Potassium Channel Kcsa
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Author : Ameer Naphtali Thompson
language : en
Publisher:
Release Date : 2011
Molecular Mechanisms Of Gating And Selectivity In The Potassium Channel Kcsa written by Ameer Naphtali Thompson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with categories.
Molecular Mechanisms Of Inwardly Rectifying Kir2 Potassium Channels Modulation
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Author : Nicoleta Oana Ureche
language : en
Publisher:
Release Date : 2008
Molecular Mechanisms Of Inwardly Rectifying Kir2 Potassium Channels Modulation written by Nicoleta Oana Ureche and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Molecular Dynamics Studies Of Permeation And Gating Mechanisms In Potassium Channels
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Author : Chun Kei Lam
language : en
Publisher:
Release Date : 2023
Molecular Dynamics Studies Of Permeation And Gating Mechanisms In Potassium Channels written by Chun Kei Lam and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023 with categories.
Potassium (K+) channels contribute to diverse physiological activities, representing an indispensable part of living organisms. A thorough understanding of different aspects of permeation mechanisms and gating in K+ channels is of crucial importance. Since only static information can be inferred from the available high-resolution structures of K+ channels, the dynamical nature of ion permeation calls for a systematic investigation into the collective behavior of ions during permeation using computer simulations. In the first part of the thesis, we use molecular dynamics simulations and Mark...