Molecular Mechanisms Of Inwardly Rectifying Kir2 Potassium Channels Modulation
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Molecular Mechanisms Of Inwardly Rectifying Kir2 Potassium Channels Modulation
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Author : Nicoleta Oana Ureche
language : en
Publisher:
Release Date : 2008
Molecular Mechanisms Of Inwardly Rectifying Kir2 Potassium Channels Modulation written by Nicoleta Oana Ureche and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Molecular Gating Dynamics Of The Cytoplasmic Domains Of Inwardly Rectifying Potassium Kir Channels
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Author : Scott Dusan Pegan
language : en
Publisher:
Release Date : 2006
Molecular Gating Dynamics Of The Cytoplasmic Domains Of Inwardly Rectifying Potassium Kir Channels written by Scott Dusan Pegan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with categories.
My research focuses on understanding the mechanisms of eukaryotic inwardly rectifying potassium channels (Kir), which are responsible for creating membrane potential stability. N- and C-terminal cytoplasmic domains of inwardly rectifying K (Kir) channels control the ion-permeation pathway through diverse interactions with small molecules and protein ligands in the cytoplasm. Two crystal structures of the cytoplasmic domains of Kir2.1 (Kir2.1L) and the G protein-sensitive Kir3.1 (Kir3.1S) channels in the absence of PIP2 show the cytoplasmic ion-permeation pathways occluded by four cytoplasmic loops that form a girdle around the central pore (G-loop). Significant flexibility of the pore-facing G-loop of Kir2.1L and Kir3.1S suggest a possible role as a diffusion barrier between cytoplasmic and transmembrane pores. Consistent with this, mutations of the G-loop disrupted gating or inward rectification. Structure comparison reveals a di-aspartate cluster on the distal end of the cytoplasmic pore of Kir2.1L that is important for modulating inward rectification. The Kir2.1L structural allows us the first structural look at the potential causes of Andersen's Syndrome, which is caused by defects in the inwardly rectifying potassium channel 2.1 (Kir2.1). We have characterized individual Andersen's Syndrome mutants R218Q, G300V, E303K, and [delta]314-315 and have shown that they have multiple affects on the ability of Kir2.1 channel's cytoplasmic domains to assemble into proper tetrameric assemblies. The 2.0 Å x-ray crystal structure of the N- and C-terminal cytoplasmic domains of Kir2.1 R218Q combined with T309K, reveals the G-loop and CD loop disruptions by the R218Q mutation. We show that E303 plays an important role in gating. Moreover, we demonstrate a novel DE loop stabilizing 2-methyl-2,4-pentanediol binding site, and cytoplasmic bound potassium ion, the first identified for this class of K channels. We have also conducted NMR studies on the last 58 residues of Kir2.1 to show the flexibility of this region and binding footprint of PSD95 PDZ domains, which tethers the channels to the cell's cytoskeleton. Taken together, these results demonstrate that cytoplasmic domains of Kir channels are structurally significant components of the channel and undergo structural changes to modulate gating and inward rectification.
Molecular Mechanisms Underlying The Inward Rectification And Pharmacological Modulation Of The Kir2 1 Channel
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Author : 黃烱瑋
language : en
Publisher:
Release Date : 2013
Molecular Mechanisms Underlying The Inward Rectification And Pharmacological Modulation Of The Kir2 1 Channel written by 黃烱瑋 and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with categories.
Molecular Determinants Of Different Gating Mechanisms In Inwardly Rectifying Potassium Channels
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Author : Xinyang Huang
language : en
Publisher:
Release Date : 2012
Molecular Determinants Of Different Gating Mechanisms In Inwardly Rectifying Potassium Channels written by Xinyang Huang and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with categories.
Heart Physiology And Pathophysiology
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Author : Yoshihisa Kurachi
language : en
Publisher: Elsevier
Release Date : 2000-10-09
Heart Physiology And Pathophysiology written by Yoshihisa Kurachi and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000-10-09 with Science categories.
Heart Physiology and Pathophysiology, 4E, provides the foundation for the scientific understanding of heart function and dysfunction, and bridges the gap between basic cardiovascular science and clinical cardiology. This comprehensive text covers all the important aspects of the heart and vascular system. The most important and relevant disorders are presented, with emphasis on the mechanisms involved. The first three editions of this book developed a reputation as the leading reference in cardiovascular science for researchers and academic cardiologists. This recent edition has been updated, expanded, and includes a number of new contributors. It has also been remodeled to expand its usage as a text reference for cardiology residents, practicing cardiologists, and graduate students. Key Features* The most comprehensive book available on this topic* Clear, concise, and complete coverage of all important aspects of cardiovascular physiology/pathophysiology* Completely updated version of the foremost reference on cardiovascular science, including new information on pathophysiology and electrophysiology* Useful tool in bridging the gap between basic science, pathophysiology, and clinical cardiology
Patient Specific Induced Pluripotent Stem Cell Models
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Author : Andras Nagy
language : en
Publisher: Humana
Release Date : 2015-11-08
Patient Specific Induced Pluripotent Stem Cell Models written by Andras Nagy and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-11-08 with Science categories.
This volume captures the rapid developments in the field of induced pluripotent stem (iPS) cells, which have provided novel opportunities and approaches both for better understanding a number of human diseases and for developing new platforms for drug development and screening for such diseases. Specifically, representative protocols on various disease models have been collected from labs around the world. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Patient-Specific Induced Pluripotent Stem Cell Models: Generation and Characterization is an ideal reference for scientists working on furthering iPS research.
Ion Channels In Health And Sickness
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Author : Fatima Shad Kaneez
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-10-10
Ion Channels In Health And Sickness written by Fatima Shad Kaneez and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-10-10 with Science categories.
Ion channels are proteins that make pores in the membranes of excitable cells present both in the brain and the body. These cells are not only responsible for converting chemical and mechanical stimuli into the electrical signals but are also liable for monitoring vital functions. All our activities, from the blinking of our eyes to the beating of our heart and all our senses from smell to sight, touch, taste and hearing are regulated by the ion channels. This book will take us on an expedition describing the role of ion channels in congenital and acquired diseases and the challenges and limitations scientist are facing in the development of drugs targeting these membrane proteins.
Cardiac Repolarization
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Author : Ihor Gussak
language : en
Publisher: Springer Science & Business Media
Release Date : 2003-03-13
Cardiac Repolarization written by Ihor Gussak and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-03-13 with Medical categories.
A comprehensive review of all the latest developments in cardiac electrophysiology, focusing on both the clinical and experimental aspects of ventricular repolarization, including newly discovered clinical repolarization syndromes, electrocardiographic phenomena, and their correlation with the most recent advances in basic science. The authors illuminate the basic electrophysiologic, molecular, and pharmacologic mechanisms underlying ventricular repolarization, relate them to specific disease conditions, and examine the future of antiarrhythmic drug development based on both molecular and electrophysiological properties. They also fully review the clinical presentation and management of specific cardiac repolarization conditions.
Structure To Function Of G Protein Gated Inwardly Rectifying Girk Channels
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Author :
language : en
Publisher: Academic Press
Release Date : 2015-09-23
Structure To Function Of G Protein Gated Inwardly Rectifying Girk Channels written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-23 with Science categories.
This volume in the International Review of Neurobiology series is a comprehensive overview of the state-of-the-art research into GIRK Potassium Channels. It reviews current knowledge and understanding and provides a starting point for researchers and practitioners entering the field. Presents a comprehensive overview of the latest research into GIRK potassium channels Serves as a perfect starting point for researchers and practitioners entering the field Expands the literature and field of neurobiology
The Endothelium
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Author : Michel Félétou
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2011
The Endothelium written by Michel Félétou and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Science categories.
The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in direct contact with the blood/lymph and the circulating cells. The endothelium is a major player in the control of blood fluidity, platelet aggregation and vascular tone, a major actor in the regulation of immunology, inflammation and angiogenesis, and an important metabolizing and an endocrine organ. Endothelial cells controls vascular tone, and thereby blood flow, by synthesizing and releasing relaxing and contracting factors such as nitric oxide, metabolites of arachidonic acid via the cyclooxygenases, lipoxygenases and cytochrome P450 pathways, various peptides (endothelin, urotensin, CNP, adrenomedullin, etc.), adenosine, purines, reactive oxygen species and so on. Additionally, endothelial ectoenzymes are required steps in the generation of vasoactive hormones such as angiotensin II. An endothelial dysfunction linked to an imbalance in the synthesis and/or the release of these various endothelial factors may explain the initiation of cardiovascular pathologies (from hypertension to atherosclerosis) or their development and perpetuation. Table of Contents: Introduction / Multiple Functions of the Endothelial Cells / Calcium Signaling in Vascular Cells and Cell-to-Cell Communications / Endothelium-Dependent Regulation of Vascular Tone / Conclusion / References