Molecular Diversity And Combinatorial Chemistry
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Molecular Diversity And Combinatorial Chemistry
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Author : Michael C. Pirrung
language : en
Publisher: Elsevier
Release Date : 2004-10-17
Molecular Diversity And Combinatorial Chemistry written by Michael C. Pirrung and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-10-17 with Language Arts & Disciplines categories.
Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.
Combinatorial Chemistry And Molecular Diversity In Drug Discovery
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Author : Eric M. Gordon
language : en
Publisher: Wiley-Liss
Release Date : 1998-08-27
Combinatorial Chemistry And Molecular Diversity In Drug Discovery written by Eric M. Gordon and has been published by Wiley-Liss this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-08-27 with Medical categories.
Increasing pressure to identify, optimize, develop, and commercialize novel drugs more rapidly and more cost-effectively has led to an urgent demand for technologies that can reduce the time to market for new products. Molecular diversity, of both natural and synthetic materials, provides a valuable source of compounds for identifying and optimizing new drug leads. Through the rapidly evolving technology of combinatorial chemistry, it is now possible to produce libraries of small molecules to screen for novel bioactivities. This powerful new technology has begun to help pharmaceutical companies find new drug candidates quickly, save significant dollars in preclinical development costs, and ultimately change their fundamental approach to drug discovery. Included among the many topics: Historical background. Library strategy and design. Solid-phase synthesis. Small molecular libraries. Automation, analytical, and computational methodology. Biological diversity. Strategies for screening combinatorial libraries. Combinatorial drug screening and development. Combinatorial chemistry information management.
Molecular Diversity And Combinatorial Chemistry
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Author : Michael C. Pirrung
language : en
Publisher: Elsevier
Release Date : 2004-11-09
Molecular Diversity And Combinatorial Chemistry written by Michael C. Pirrung and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-11-09 with Business & Economics categories.
Written for advanced undergraduate and graduate students, this textbook makes the main concepts of combinatorial chemistry accessible to the non-specialist.
Molecular Diversity And Combinatorial Chemistry
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Author : Irwin M. Chaiken
language : en
Publisher:
Release Date : 1996
Molecular Diversity And Combinatorial Chemistry written by Irwin M. Chaiken and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Reports progress on chemical, enzymatic, phage, and cell-derived libra ries. Discusses synergy between structure-based design and combinatori al libraries. Presents applications of combinatorial libraries to drug discovery and new synthetic catalysis. Reports library screening appr oaches, including the use of NMR. Presents recent advances in solid-ph ase organic synthesis, liquid-phase organic synthesis, and high-throug hput combinatorial organic synthesis. Discusses automation of organic synthesis as well as new methodologies for monitoring solid-phase orga nic synthesis.
Annual Reports In Combinatorial Chemistry And Molecular Diversity
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Author : M.R. Pavia
language : en
Publisher: Springer
Release Date : 2010-12-06
Annual Reports In Combinatorial Chemistry And Molecular Diversity written by M.R. Pavia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-06 with Science categories.
Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.
Annual Reports In Combinatorial Chemistry And Molecular Diversity
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Author : W.H. Moos
language : en
Publisher: Springer Science & Business Media
Release Date : 1997-04-30
Annual Reports In Combinatorial Chemistry And Molecular Diversity written by W.H. Moos and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-04-30 with Medical categories.
Combinatorial chemistry and molecular diversity approaches to scientific inquiry and novel product R&D have exploded in the 1990s! For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed, more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. This first volume covers: (i) combinatorial chemistry, (ii) combinatorial biology and evolution, and (iii) informatics and related topics. Within each section chapters are prepared by experts in the field, including, for example, in Section I: Coverage of mixture pools vs. parallel individual compound synthesis, solution vs. solid-phase synthesis, analytical tools, and automation. Section II highlights selection strategies and library-based evolution, phage display, peptide and nucleic acid libraries. Section III covers databases and library design, high through-put screening, coding strategies vs. deconvolutions, intellectual property issues, deals and collaborations, and successes to date.
Molecular Diversity In Drug Design
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Author : P.M. Dean
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-05-08
Molecular Diversity In Drug Design written by P.M. Dean and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-05-08 with Science categories.
High-throughput screening and combinatorial chemistry are two of the most potent weapons ever to have been used in the discovery of new drugs. At a stroke, it seems to be possible to synthesise more molecules in a month than have previously been made in the whole of the distinguished history of organic chemistry, Furthermore, all the molecules can be screened in the same short period. However, like any weapons of immense power, these techniques must be used with care, to achieve maximum impact. The costs of implementing and running high-throughput screening and combinatorial chemistry are high, as large dedicated facilities must be built and staffed. In addition, the sheer number of chemical leads generated may overwhelm the lead optimisation teams in a hail of friendly fire. Mother nature has not entirely surrendered, as the number of building blocks that could be used to build libraries would require more atoms than there are in the universe. In addition, the progress made by the Human Genome Project has uncovered many proteins with different functions but related binding sites, creating issues of selectivity. Advances in the new field of pharmacogenomics will produce more of these challenges. There is a real need to make hi- throughput screening and combinatorial chemistry into 'smart' weapons, so that their power is not dissipated. That is the challenge for modellers, computational chemists, cheminformaticians and IT experts. In this book, we have broken down this grand challenge into key tasks.
Annual Reports In Combinatorial Chemistry And Molecular Diversity
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Author : M.R. Pavia
language : en
Publisher: Springer
Release Date : 1999-06-30
Annual Reports In Combinatorial Chemistry And Molecular Diversity written by M.R. Pavia and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-06-30 with Science categories.
Combinatorial chemistry and molecular diversity approaches to scientific and novel product R & D have exploded in the 1990s. For example, in the preparation of drug candidates, the automated, permutational, and combinatorial use of chemical building blocks now allows the generation and screening of unprecedented numbers of compounds. Drug discovery - better, faster, cheaper? Indeed more compounds have been made and screened in the 1990s than in the last hundred years of pharmaceutical research. The second volume in this series includes contributions on methods, solid phases, purification, analysis, carbohydrates, patent strategies and tactics, diversity profiling and combinatorial series design, and finishes with a survey of chemical libraries yielding biologically active agents and a compendium of solid phase chemistry publications. Each contribution is prepared by a recognized expert resulting in a high quality account of the recent advances in the field.
Molecular Diversity In Drug Design
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Author : P.M. Dean
language : en
Publisher: Springer Science & Business Media
Release Date : 1999-10-31
Molecular Diversity In Drug Design written by P.M. Dean and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-10-31 with Medical categories.
This book focuses on the theoretical problems associated with molecular diversity as it is being applied in the pharmaceutical industry. Therefore, this book deals with algorithms that are involved in understanding chemical space and selection of diverse sets of structures. The algorithms also deal with the problem of focused diversity where chemical libraries are being created within a structured physical volume. Diversity is necessarily connected to combinational chemistry, although this book is limited to the application of diversity methods to combinational chemistry and does not deal with synthetic methods. It is this focus on algorithms and strategies for exploiting molecular diversity that makes it different from books on combinational chemistry. The intended readership of the book falls into two categories: those actively engaged in applying molecular diversity in the chemical industry and those in academia who are developing strategies to embrace, understand and accept the many problems thrown up by this new research field of molecular diversity.
Chemoinformatics
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Author : Jürgen Bajorath
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-04
Chemoinformatics written by Jürgen Bajorath and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-04 with Medical categories.
In the literature, several terms are used synonymously to name the topic of this book: chem-, chemi-, or chemo-informatics. A widely recognized de- nition of this discipline is the one by Frank Brown from 1998 (1) who defined chemoinformatics as the combination of “all the information resources that a scientist needs to optimize the properties of a ligand to become a drug. ” In Brown’s definition, two aspects play a fundamentally important role: de- sion support by computational means and drug discovery, which distinguishes it from the term “chemical informatics” that was introduced at least ten years earlier and described as the application of information technology to ch- istry (not with a specific focus on drug discovery). In addition, there is of course “chemometrics,” which is generally understood as the application of statistical methods to chemical data and the derivation of relevant statistical models and descriptors (2). The pharmaceutical focus of many developments and efforts in this area—and the current popularity of gene-to-drug or si- lar paradigms—is further reflected by the recent introduction of such terms as “discovery informatics” (3), which takes into account that gaining kno- edge from chemical data alone is not sufficient to be ultimately successful in drug discovery. Such insights are well in accord with other views that the boundaries between bio- and chemoinformatics are fluid and that these d- ciplines should be closely combined or merged to significantly impact b- technology or pharmaceutical research (4).