Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases
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Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases
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Author : Mohammadreza Hajjari
language : en
Publisher: Frontiers Media SA
Release Date : 2016-12-14
Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases written by Mohammadreza Hajjari and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-14 with Genetics categories.
Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.
Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases
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Author :
language : en
Publisher:
Release Date : 2016
Molecular Function And Regulation Of Non Coding Rnas In Multifactorial Diseases written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with categories.
Our understanding of the mechanisms underlying the development of multifactorial diseases such as diabetes, autism, Alzheimer's disease, and cancer has been greatly advanced. Non-coding RNAs (ncRNAs), generally including microRNAs and long non-coding RNAs, have recently been found to have potential roles in these diseases, and provide new opportunities for developing both specific biomarkers and therapeutic targets. However, the molecular function and regulation of these RNAs still remains challenging. Numerous studies are focusing on this field in order to fully appreciate the role and regulation of these molecules in human medicine and biology. This e-book aims to bring together new findings on Non-coding RNAs in different complex diseases. It will highlight the characterization, roles, mechanism, and mode of action of these RNAs in complex disorders. We believe that the publications on this topic would be exponentially extended in future. The improved approaches at multiple levels may pave the way for designing and applying new biomarker and therapeutic targets for specific diseases based on these attractive molecules.
New Drug Targets For Proteotoxicity In Cardiometabolic Diseases
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Author : Jun Ren
language : en
Publisher: Frontiers Media SA
Release Date : 2021-11-02
New Drug Targets For Proteotoxicity In Cardiometabolic Diseases written by Jun Ren and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-11-02 with Science categories.
Impact Of System Biology And Molecular Medicine On The Management Of Complex Immune Mediated Respiratory Diseases
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Author : Blanca Cárdaba
language : en
Publisher: Frontiers Media SA
Release Date : 2021-10-21
Impact Of System Biology And Molecular Medicine On The Management Of Complex Immune Mediated Respiratory Diseases written by Blanca Cárdaba and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-21 with Medical categories.
Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications
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Author : Gautam Sethi
language : en
Publisher: World Scientific
Release Date : 2023-03-14
Non Coding Rna Transcripts In Cancer Therapy Pre Clinical And Clinical Implications written by Gautam Sethi and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-03-14 with Medical categories.
'Non-coding RNA Transcripts in Cancer Therapy: Pre-clinical and Clinical Implications' provides a new insight towards role of non-coding RNAs molecules including microRNAs, long non-coding RNAs and circular RNAs in cancer. The reason of focusing on cancer is that this malignant disease is responsible for high death around the world and after cardiovascular diseases, it is a leading cause of death. In the current book, the basic information and knowledge about ncRNAs, their biogenesis and their biological functions are covered. It is shown that ncRNAs can regulate expression level of genes at transcriptional and post-transcriptional levels and therefore, ncRNAs are master and key players in molecular pathways. Then, the impact of regulation of molecular pathways by ncRNAs on important molecular mechanisms such as proliferation, metastasis, epithelial-to-mesenchymal transition, apoptosis and autophagy are described. All of these aspects are integrated in cancer and for treatment of this disease. In case of miRNAs, their biogenesis and biological functions in physiological conditions are described. Then, impact of miRNAs on proliferation, metastasis, therapy response (drug resistance and radio-resistance) is described. For lncRNAs and circRNAs, a same way is followed and their biogenesis and functional roles in cells are discussed. At the next step, function of lncRNAs and circRNAs in regulating proliferation, metastasis and therapy response (chemoresistance and radio-resistance) is introduced. These subjects are discussed based on pre-clinical studies and in order to make the book more comprehensive and broaden its scope, the function of exosomal ncRNAs in diagnosis and prognosis of cancer patients is described.
Long Non Coding Rnas In Human Disease
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Author : Kevin V. Morris
language : en
Publisher: Springer
Release Date : 2016-04-13
Long Non Coding Rnas In Human Disease written by Kevin V. Morris and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-04-13 with Medical categories.
This volume focuses on the roles of long non-coding RNAs (lncRNAs) in contexts ranging from human cancers to cardiovascular disease and ageing. The role of lncRNAs in X-inactivation and those lncRNAs derived from pseudogenes, past retroelements integrated within the human genome, as well as the role these pseudogene-derived lncRNAs play in cancer development are discussed in detail. Further, the book examines the function of lncRNAs in diseases such as diabetes, in smooth muscle formation, and in the modulation of nuclear receptors, as well as in connection with perspectives on the development of personalized therapeutics. It offers an appealing and insightful resource for scientists and clinicians alike.
Polypharmacology
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Author : Zhiguo Wang
language : en
Publisher: Springer Nature
Release Date : 2022-08-01
Polypharmacology written by Zhiguo Wang and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-08-01 with Medical categories.
There is a growing interest in unmet needs for the development of a new discipline in drug discovery and in university education on polypharmacology. However, there has not been a book with the comprehensive compilation of basic knowledge and advanced methodology that is needed. This book aims to meet the needs making Polypharmacology a new sub-discipline of Pharmacology, not only being a hot area of pharmacological research and education but also a new paradigm for drug discovery. It contains the contents covering the entire scope of Polypharmacology including systemic in-depth exposition of basic knowledge, novel concepts, innovative technologies, and translational and clinical applications by showcasing state-of-the-art strategies and step-by-step instructions of cutting-edge methods. The contents of this book targets broad readerships including scientists in pharmacology research and drug development, and university teachers and graduates in medical school or school of pharmacy.
Molecular Advances And Applications Of Machine Learning In Understanding Autism And Comorbid Psychiatric Disorders
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Author : Salam Salloum-Asfar
language : en
Publisher: Frontiers Media SA
Release Date : 2023-07-24
Molecular Advances And Applications Of Machine Learning In Understanding Autism And Comorbid Psychiatric Disorders written by Salam Salloum-Asfar and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-24 with Science categories.
Novel Roles Of Non Coding Brain Rnas In Health And Disease
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Author : Hermona Soreq
language : en
Publisher: Frontiers E-books
Release Date : 2014-10-23
Novel Roles Of Non Coding Brain Rnas In Health And Disease written by Hermona Soreq and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-23 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
Non-coding RNAs (ncRNAs), and in particular microRNAs are rapidly becoming the focus of research interest in numerous basic and translational fields, including brain research; and their importance for many aspects in brain functioning merits special discussion. The wide-scope, multi-targeted and highly efficient manner of ncRNA regulatory activities draws attention to this topic by many, but the available research and analysis tools and experimental protocols are still at their infancy, and calls for special discussion given their importance for many aspects in brain functioning. This eBook is correspondingly focused on the search for, identification and exploration of those non-coding RNAs whose activities modulate the multi-leveled functions of the eukaryotic brain. The different articles strive to cover novel approaches for identifying and establishing ncRNA-target relationships, provide state of the art reports of the affected neurotransmission pathways, describe inherited and acquired changes in ncRNA functioning and cover the use of ncRNA mimics and blockade tools for interference with their functions in health and disease of the brain. Non-coding RNAs are here to stay, and this exciting eBook provides a glimpse into their impact on our brain’s functioning at the physiology, cell biology, behavior and immune levels.
Long Non Coding Rna
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Author : Syed Mudasir Andrabi
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2020-09-03
Long Non Coding Rna written by Syed Mudasir Andrabi and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09-03 with Science categories.
Long non-coding RNAs (LncRNAs) were originally regarded as “noise” in the genome due to their lack of protein-encoding capacity. However, their roles are now understood to cover various biological functions like gene regulation, cell proliferation, survival, differentiation, and chromatin remodeling. As an emerging group of non-coding RNA molecules, LncRNAs are involved in diverse diseases like cancer, cardiovascular, autoimmune, hormonal disorders, neurodegeneration, and infection, among others. However, knowledge of the mechanisms by which they act is still ambiguous. As such, this book meets the essential need for a textbook dedicated to this topic and provides a comprehensive and captivating account of lncRNA research.