Molecular Genetics Of Inflammatory Bowel Disease
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Molecular Genetics Of Inflammatory Bowel Disease
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Author : Mauro D'Amato
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-10-05
Molecular Genetics Of Inflammatory Bowel Disease written by Mauro D'Amato and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-10-05 with Medical categories.
Research in Crohn’s disease (CD) and ulcerative colitis (UC), together known as the inflammatory bowel diseases (IBD), has truly seen a revolution in the last 5-10 years. This book examines how these genetic discoveries have led to the identification of biological functions not previously associated with IBD pathophysiology (e.g. autophagy), how multiple genetic risk factors for IBD converge on given biological functions and that together the identified variants in these genes have predisposing and protective roles (e.g. the multiple variants in the receptor for the IL23 cytokine and its signaling cascade), and how having such a large number of known genetic risk factors has changed our understanding not only about the genetic and molecular overlap between CD and UC, but also between these diseases and other chronic inflammatory diseases (e.g. psoriasis, multiple sclerosis, type 1 diabetes and many others).
Molecular Genetics Of Inflammatory Bowel Disease
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Author :
language : en
Publisher:
Release Date : 2019
Molecular Genetics Of Inflammatory Bowel Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Inflammatory bowel diseases categories.
Inflammatory bowel disease (IBD) affects 1% of people worldwide. This condition is partly inherited, and genetic research has made enormous progress during the last few years, providing important insight into disease pathogenesis. This book provides a concise but complete overview of existing knowledge, with particular focus on the molecular and genetic mechanisms at the basis of IBD. Invited experts, at the frontline of IBD research, introduce basic concepts in the pathophysiology of IBD and its two major forms Crohn's disease and ulcerative colitis, provide a historical perspective and highlight latest discoveries of IBD genetic research, describe how this information has helped to unravel novel pathogenetic pathways, and formulate a vision for future investigations and their clinical application in IBD. State-of-the-art information contained in this book is an exceptional resource for all those in the biomedical field with a specific interest in IBD, including basic scientists, gastroenterologists, GI specialist doctors and research nurses, but also medical and biomedical students.
Kirsner S Inflammatory Bowel Diseases
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Author : Joseph B. Kirsner
language : en
Publisher: Elsevier Health Sciences
Release Date : 2004
Kirsner S Inflammatory Bowel Diseases written by Joseph B. Kirsner and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.
This comprehensive New Edition describes all of the latest scientific and clinical advances in the field of inflammatory bowel disease (IBD). A new editorial team-joined by a superb group of international authorities-examine every aspect of IBD-including etiology and pathogenesis, diagnosis and evaluation, medical and surgical therapy, and more. A wealth of expanded coverage, additional international contributors, extensive updating throughout, and numerous diagnostic and therapeutic algorithms make this an essential resource. Emphasizes evidence-based medicine in the section on medical therapy. Features a detailed description of inflammatory and immunologic pathways, allowing the reader to fully understand the contributing influences to the inflammation of IBD. Presents separate chapters on molecular genetics and clinical genetics for more in-depth coverage of each aspect of inflammatory bowel disease genetics. Provides a comprehensive review of IBD through abundant, high-quality endoscopic, radiographic, and histologic photographs-placing the various diagnostic modalities in perspective. Offers extensive coverage of postoperative recurrence of Crohn's disease · pouchitis · microscopic colitis · perianal disease · and osteoporosis. Includes up-to-the-minute guidance (including many 2003 references). Features a new editorial team, joined by numerous new contributors who provide fresh, global perspectives. Includes nine new chapters. Offers expanded coverage throughout, and through revisions of all pre-existing chapters. With over 75 additional contributing experts.
Inflammatory Bowel Disease
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2005-06-10
Inflammatory Bowel Disease written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-06-10 with Science categories.
Inflammatory bowel disease (IBD) comprises a group of idiopathic diseases of the intestine characterized by chronic inflammation of the bowel with periods of exacerbation and remission. Although the exact cause of IBD remains undetermined, the condition appears to be related to a combination of genetic and environmental factors resulting in an aberrant activation of the mucosal immune system. This book contains a series of interdisciplinary discussions between clinical and basic scientists focusing on key issues such as: Epithelial cell and molecular biology, including apoptosis, necrosis and cell survival The role of bacterial milieu and mucosal bacteria in the IBD and of prebiotic and probiotic therapy The progress towards the identification of susceptibility genes and phenotype-determining genes The pharmacogenetics of IBD Mucosal immunology and therapeutic strategies stemming therefrom
Trends In Inflammatory Bowel Disease Therapy 1996
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Author : R.S. McLeod
language : en
Publisher: Springer
Release Date : 1997-03-31
Trends In Inflammatory Bowel Disease Therapy 1996 written by R.S. McLeod and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-03-31 with Medical categories.
This book is the proceedings of an international symposium held in Ottawa, Ontario, Canada, June 12-15 1996, and sponsored by Axcan Pharma, the Canadian Association of Gastroenterology and the Canadian Society of Colon and Rectal Surgeons. While the etiology and cure of inflammatory bowel disease (IBD) remain elusive, it is safe to say that there have been exciting advances in the field since the last symposium was held two years ago. A faculty of international experts from a range of disciplines - including molecular genetics, physiology, epidemiology, pediatrics, gastroenterology and surgery - was assembled and provided updates on the most current and controversial areas. The first part of the book is devoted to a review of advances in determining the etiology of IBD with focus on mucosal inflammation and genetics. The clinical part of the book includes sessions on ileal pouches, new therapies for the treatment of Crohn's disease, controversies related to the management of ulcerative colitis, cancer risk in IBD and management of IBD in the pediatric population. This volume will be of interest to both gastroenterologists and colon and rectal surgeons, whether concerned with basic science or clinical practice.
On Genes And Inflammatory Bowel Disease
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Author : Pieter Cornelis Frans Stokkers
language : en
Publisher:
Release Date : 1999
On Genes And Inflammatory Bowel Disease written by Pieter Cornelis Frans Stokkers and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with categories.
Ulcerative Colitis
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Author : Mustafa Shennak
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-01-18
Ulcerative Colitis written by Mustafa Shennak and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-18 with Medical categories.
Ulcerative Colitis (UC) is a rapidly evolving medical field, and will continue to be very exiting in the next few decades. Although the underlying cause of this disease is still unknown, results in research dealing with various issues related to this disease are published every day. Chapters included in this book review the most recent literature on related advancements in regard to this chronic disease, which is controllable but not curable. Aspects like epidemiology, pathophysiology, genetics, incriminated etiologies, clinical aspects, complications, and disease management, including advancements in the diagnostic and therapeutic options, were documented by well known clinicians, researchers, and world wide authorities in their fields. This book on UC will be a valuable addition to each doctor's library interested in this subject, or for physicians dealing with patients suffering from this disease. Authors have also included figures and diagrams to depict their point, and to easily reach the minds of the readers in the simplest way.
Origins And Directions Of Inflammatory Bowel Disease
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Author : Joseph B. Kirsner
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Origins And Directions Of Inflammatory Bowel Disease written by Joseph B. Kirsner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Few human illnesses today are so challenging, medically, scientifically, and socio-economically, as the "nonspecific" inflammatory bowel diseases (IBD): ulcerative colitis and Crohn's disease. Originating several centuries ago but essentially diseases of the 20th century, often attacking children and young adults, involving all bodily systems as well as the gastrointestinal tract, ulcerative colitis and Crohn's disease have emerged in recent decades as among the more "glamorous" unsolved diseases, presenting unusual opportunities for insightful clinical and investigative study. Many of the prevailing concepts originated during the early and mid 20th century. The purpose of Origins and Directions of Inflammatory Bowel Disease is to review these earlier studies and their evolution "from the mystical to the molecular," and guide investigators and physicians through the challenging clinical and scientific maze of IBD.
Crohn S Disease
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Author : Alessandro Fichera
language : en
Publisher: Springer
Release Date : 2015-08-20
Crohn S Disease written by Alessandro Fichera and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-20 with Medical categories.
Crohn’s Disease: Basic Principles provides a comprehensive and state-of-the-art overview of the current diagnosis and treatment strategies for Crohn’s disease. Care of these patients and clinical conditions can be quite complex and often require a multidisciplinary approach. Sections of the book are based on the most current, evidenced-based resources and have been structured to review the etiology and diagnosis of Crohn’s disease, discuss advances in medical and surgical treatment, illustrate emerging technologies impacting the care of patients with Crohn’s disease, and examine functional and quality of life outcomes in this patient population. The text reviews our understanding of the influence of molecular and genetic factors in the development and pattern of Crohn’s disease. Current methods of diagnosis and strategies in the medical management of patients with Crohn’s disease are evaluated including the use of biologic agents. Resection and bowel sparing techniques for primary and recurrent disease as well as advances in endoscopy and laparoscopy are discussed in detail. In addition, factors influencing the quality of life of patients with Crohn’s disease are examined including nutrition, enterostomal care, fertility, and sexual function. Written by recognized experts in their field, Crohn’s Disease: Basic Principles highlights the integrated multidimensional aspect of caring for patients with Crohn’s disease and will be of great value to colon and rectal surgeons, general surgeons, gastroenterologists, internists, as well as fellows and upper level residents in training training.
Diagnostic And Treatment Methods For Ulcerative Colitis And Colitis Associated Cancer
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Author : Pandurangan, Ashok Kumar
language : en
Publisher: IGI Global
Release Date : 2021-03-29
Diagnostic And Treatment Methods For Ulcerative Colitis And Colitis Associated Cancer written by Pandurangan, Ashok Kumar and has been published by IGI Global this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-29 with Medical categories.
In recent years, epidemiological studies have shown a significant increase of incidences regarding ulcerative colitis (UC) in most regions of the world. At present, a common therapeutic modality for inflammatory bowel disorders is the use of anti-inflammatory agents, including sulfasalazine and acetylsalicylic acid, steroid hormone, and other immunosuppressive agents. Most of these treatments are symptomatic and palliative because the etiology of the disease is not yet established. As a result of no proper drug available to treat UC, patients with UC are at a high risk of developing colitis-associated cancer (CAC). It is necessary to understand the genetic and molecular mechanisms involved in the pathogenesis of UC and CAC that lead to the path of new drug discoveries. Diagnostic and Treatment Methods for Ulcerative Colitis and Colitis-Associated Cancer provides innovative insights that describe the fundamental understanding of UC and CAC and the molecular mechanisms behind the etiology as well as modern diagnostic methods that are employed in UC and CAC. Current prevention and therapeutic strategies practiced in the pre-clinical level are also discussed. The content within this publication examines alternative medicine and dietary intervention and drug delivery techniques. It is designed for healthcare professionals, physicians, academicians, researchers, R&D organizations, and medical students involved in drug discovery and clinical and therapeutic research.