Molecular Genetics Of Sex Determination
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Molecular Genetics Of Sex Determination
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Author : Stephen S. Wachtel
language : en
Publisher: Academic Press
Release Date : 2014-07-23
Molecular Genetics Of Sex Determination written by Stephen S. Wachtel and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-07-23 with Science categories.
In this era of accelerated discovery and prolific output, Molecular Genetics of Sex Determination keeps readers abreast of this fields fast-moving biology. Its chapters were completed by experts in eacharea only months before publication. The text is organized into two parts. First, it reviews the basic biology of sex determination and summarizes ground-breaking work in mouse, marsupial, and Drosophila systems. Second, it covers current human genetics, clinical studies, and the syndromes of abnormal sex differentiation. With chapters by preeminent reproductive biologists, this is a capital work. Ohno's law is described by Ohno; the Lyon hypothesis, by Lyon; Sinclair tells how he cloned the testis-determining gene; and so on. Molecular Genetics of Sex Determination is authoritative, comprehensive, and current. It is prime reading for geneticists, developmental biologists, graduate students in these and related fields, clinical researchers, physicians, and medical students. Reviews the genetics of sex determination in 19 up-to-date chapters Features research on sex chromosomes and sex-determining genes Includes abnormalities of sex determination and clinical genetics Written by scientists who pioneered work in this field
The Genetics And Biology Of Sex Determination
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Author : Derek J. Chadwick
language : en
Publisher: John Wiley & Sons
Release Date : 2002-04-26
The Genetics And Biology Of Sex Determination written by Derek J. Chadwick and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-04-26 with Science categories.
Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms. By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.
Genetics Of Sex Determination
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Author : R.S. Verma
language : en
Publisher: Elsevier
Release Date : 1996-04-23
Genetics Of Sex Determination written by R.S. Verma and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-23 with Medical categories.
The Genetical Theory of Natural Selection by R.A. Fisher (1930) dictated that sexual dimorphisms may depend upon a single medelian factor. This could be true for some species but his suggestion could not take off the ground as gender in Drosophila is determined by the number of X chromosomes. Technical advances in molecular biology have revived the initial thinking of Fisher and dictate that TDF or SRY genes in humans or Tdy in mice are sex determining genes. The fortuitous findings of XX males and XY female, which are generally termed sex reversal phenomenon, are quite bewildering traits that have caused much amazement concerning the pairing mechanism(s) of the pseudoautosomal regions of human X and Y chromosomes at meiosis. These findings have opened new avenues to explore further the genetic basis of sex determination at the single gene level.The aim of the fourth volume, titled Genetics of Sex Determination is to reflect on the latest advances and future investigative directions, encompassing 10 chapters. Commissioned several distinguished scientists, all pre-eminent authorities in each field to shed their thoughts concisely but epitomise their chapters with an extended bibliography. Obviously, during the past 60 years, the metoric advances are voluminous and to cover every account of genes, chromosomes, and sex in a single volume format would be a herculean task. Therefore, a few specific topics are chosen, which may be of great interest to scientists and clinicians. The seasoned scientists who love to inquire about the role of genes in sex determination should find the original work of these notable contributors very enlightening. This volume is intended for advanced students who want to keep abreast as well as for those who indulge in the search for genes of sex determination.
The Genetics And Biology Of Sex Determination Novartis Foundation Symposia Book 244
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Author : Derek'' J. Chadwic'k
language : en
Publisher:
Release Date : 2021-04-29
The Genetics And Biology Of Sex Determination Novartis Foundation Symposia Book 244 written by Derek'' J. Chadwic'k and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-29 with categories.
Nature employs a wide variety of sex determining mechanisms and it is only comparatively recently that the tools have become available for these to be explored at the cellular and molecular levels. A major landmark was the discovery in 1990 of the SRY gene and the subsequent demonstration of its key role in triggering male sex determination in transgenic mice. This book reviews and discusses our current understanding of the molecular genetic pathways of sex determination, with special emphasis on vertebrates. It features comparisons with other modes of sex determination, consideration of the biology of sexual development and discussion of the evolution of sex-determining mechanisms.By bringing together an international and interdisciplinary group of experts who study many different aspects of the problem, the book highlights much new and exciting work in this area and serves to identify and stimulate promising new research directions.
Molecular Genetic Mechanisms Of Sex Determination In Animals
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Author : Aleksandr F. Smirnov
language : en
Publisher: Scientific Research Publishing, Inc. USA
Release Date :
Molecular Genetic Mechanisms Of Sex Determination In Animals written by Aleksandr F. Smirnov and has been published by Scientific Research Publishing, Inc. USA this book supported file pdf, txt, epub, kindle and other format this book has been release on with Science categories.
Gender (sex) is a set of morphological and physiological characteristics of the organism underlying sexual reproduction, the essence of which is reduced to fertilization, i.e. the fusion of male and female gametes (gametes) zygote, which develops into a new organism.Sexual reproduction of a species is considered as one of the mechanisms of its homeostasis. Thanks to this mechanism, numerous species have an evolutionary advantage. In the book, two authors will discuss the types of genetic sex determination and differentiation, mostly in multicellular animal organisms. Sex determination is both genetic and environmental process, the sex of an individual being established through an alternative physiological solution. There are two main postulated mechanisms of sex determination: genetic (GSD, Genetical Sex Determination) and environmental (ESD, Environmental Sex Determination).
The Evolution Of Sex Determination
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Author : Leo W. Beukeboom
language : en
Publisher:
Release Date : 2014
The Evolution Of Sex Determination written by Leo W. Beukeboom and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with Medical categories.
Sexual reproduction is a fundamental aspect of life. It is defined by the occurrence of meiosis and the fusion of two gametes of different sexes or mating types. Sex-determination mechanisms are responsible for the sexual fate and development of sexual characteristics in an organism, be it a unicellular alga, a plant, or an animal. In many cases, sex determination is genetic: males and females have different alleles or different genes that specify their sexual morphology. In animals, this is often accompanied by chromosomal differences. In other cases, sex may be determined by environmental (e.g. temperature) or social variables (e.g. the size of an organism relative to other members of its population). Surprisingly, sex-determination mechanisms are not evolutionarily conserved but are bewilderingly diverse and appear to have had rapid turnover rates during evolution. Evolutionary biologists continue to seek a solution to this conundrum. What drives the surprising dynamics of such a fundamental process that always leads to the same outcome: two sex types, male and female? The answer is complex but the ongoing genomic revolution has already greatly increased our knowledge of sex-determination systems and sex chromosomes in recent years. This novel book presents and synthesizes our current understanding, and clearly shows that sex-determination evolution will remain a dynamic field of future research. The Evolution of Sex Determination is an advanced, research level text suitable for graduate students and researchers in genetics, developmental biology, and evolution.
Genes And Mechanisms In Vertebrate Sex Determination
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Author : Gerd Scherer
language : en
Publisher: Birkhäuser
Release Date : 2013-04-17
Genes And Mechanisms In Vertebrate Sex Determination written by Gerd Scherer and has been published by Birkhäuser this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-17 with Science categories.
Following an opening chapter by the late Susumu Ohno on paralogues of sex-determining genes, the five best-studied genes essential for early mammalian gonadal development are portrayed in detail: SF-1 and WT1 and their roles in early events in gonadal development, SRY and SOX9 in testis determination, and the anti-testis gene DAX-1. Subsequent chapters look at the roles of these genes in sex determination in marsupial mammals, birds, reptiles, amphibians and fish, and review the different sex-determining mechanisms, genetic and environmental, that operate in these different vertebrate classes. Two insights emerge: one, that the same basic set of genes appears to operate during early gonadal development in all vertebrates, despite the differences in mechanisms; the other, that sex determination in vertebrates results from a complex network of regulatory interactions and not from a simple hierarchical cascade of gene actions.
Sex Chromosomes And Sex Determination In Vertebrates
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Author : Alberto J. Solari
language : en
Publisher: CRC Press
Release Date : 1993-10-22
Sex Chromosomes And Sex Determination In Vertebrates written by Alberto J. Solari and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-10-22 with Nature categories.
The cloning of the SRY gene and the attainment of XX mice transgenic for the Sry gene opened a new era in research on sex determination. This book surveys current knowledge of sex chromosomes and sex determination in all vertebrate classes, relying on the restriction of genetic recombination in sex chromosomes as the unifying concept of this subject. The book's interdisciplinary approach integrates contributions from the fields of cytogenetics, molecular biology, developmental biology, and evolutionary genetics. A detailed treatment of the meiotic behavior of sex chromosomes is featured, and the entire text is supplemented by numerous schemes, drawings, and electron micrographs. The book will be valuable to general cytogeneticists, vertebrate zoologists, and veterinarian and medical practitioners interested in the foundations of sex determination and the current knowledge of sex chromosomes. It will also interest students in advanced undergraduate and graduate courses in these areas.
Molecular Genetic Mechanisms Of Sex Determination In Animals
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Author : F. Smirnov Aleksandr
language : en
Publisher:
Release Date : 2017-09
Molecular Genetic Mechanisms Of Sex Determination In Animals written by F. Smirnov Aleksandr and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-09 with categories.
The Molecular Genetics Of Mammalian Sex Determination
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Author : James Michael Smith
language : en
Publisher:
Release Date : 2003
The Molecular Genetics Of Mammalian Sex Determination written by James Michael Smith and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with Sexual determination, Genetic categories.