Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition
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Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition
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Author : Markus Rudin
language : en
Publisher: World Scientific
Release Date : 2020-04-04
Molecular Imaging Basic Principles And Applications In Biomedical Research 3rd Edition written by Markus Rudin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-04 with Technology & Engineering categories.
The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied.The third edition has been extended considerably. This holds for the chapter on imaging modalities, which now includes sections on intravital microscopy and mass spectrometric imaging. All chapters have been updated and a new chapter on the challenges of translating molecular imaging solutions for clinical use has been added.
Molecular Imaging Basic Principles And Applications In Biomedical Research 2nd Edition
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Author : Markus Rudin
language : en
Publisher: World Scientific
Release Date : 2013-07-04
Molecular Imaging Basic Principles And Applications In Biomedical Research 2nd Edition written by Markus Rudin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-07-04 with Technology & Engineering categories.
The area of molecular imaging has matured over the past decade and is still growing rapidly. Many concepts developed for molecular biology and cellular imaging have been successfully translated to in vivo imaging of intact organisms. Molecular imaging enables the study of processes at a molecular level in their full biological context. Due to the high specificity of the molecular readouts the approach bears a high potential for diagnostics. It is fair to say that molecular imaging has become an indispensable tool for biomedical research and drug discovery and development today.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities, and the design of targeted probes are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events in the living organism. Topics covered include the studies of the biodistribution of reporter probes and drugs, visualization of the expression of biomolecules such as receptors and enzymes, and how imaging can be used for analyzing consequences of the interaction of a ligand or a drug with its molecular target by visualizing signal transduction, or assessing the metabolic, physiological, or structural response of the organism studied. The final chapter deals with visualization of cell migration, for example in the context of cell therapies.The second edition covers novel developments over recent years, in particular regarding imaging technologies (hybrid techniques) and novel reporter concepts. Novel biomedical applications have been included, where appropriate. All the chapters have been thoroughly reworked and the artwork updated.
Molecular Imaging Basic Principles And Applications In Biomedical Research
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Author : Markus Rudin
language : en
Publisher: World Scientific
Release Date : 2005-09-29
Molecular Imaging Basic Principles And Applications In Biomedical Research written by Markus Rudin and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-09-29 with Science categories.
Molecular imaging is a rapidly emerging field that translates many concepts developed for molecular biology and cellular imaging to the in vivo imaging of intact organisms. The technique allows the study of molecular biological events in their full context and will therefore become an indispensable tool for biomedical research and drug discovery and development.This volume familiarizes the reader with the concepts of imaging and molecular imaging in particular. Basic principles of imaging technologies, reporter moieties for the various imaging modalities and the design of target reporter constructs are described in the first part. The second part illustrates how these tools can be used to visualize relevant molecular events: the biodistribution of drugs/ligands, the expression of drug targets (receptors, enzymes), and the consequences of the molecular drug-target interactions (pathway activations, system responses). A final chapter deals with visualization of cell migration (cell therapies).
Organic Trace Analysis
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Author : Reinhard Nießner
language : en
Publisher: Walter de Gruyter GmbH & Co KG
Release Date : 2024-09-23
Organic Trace Analysis written by Reinhard Nießner and has been published by Walter de Gruyter GmbH & Co KG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-23 with Technology & Engineering categories.
Organic contaminants even in very low concentrations can have toxic and ecotoxic effects on exposed organisms. Detection and quantification of such trace amounts in diverging matrices (e.g., water, air, soil, food, tissue, organisms) is challenging and great carefulness and strategic thinking is needed to get reliable results along the way from taking samples up to the final analysis. In the 2nd edition, besides revisions of existing chapters, new analytical technologies and recent application examples are presented: non-target mass spectrometric analysis, trace analysis of per- and polyfluoroalkylated "forever chemicals", organophosphorus esters (nerve agents), and micro- and nanoplastic particles in the environment. Students will learn about peculiarities and state of the art organic trace analysis and acquire basic and advanced principles of statistical evaluation of analytical results quality control strategies and good laboratory practices sampling techniques from various matrices sample treatment, enrichment and clean-up techniques chromatographic analyses including hyphenated techniques, and spectroscopy as well mass spectrometry and bioanalytical tools. An extended chapter on selected applications will transfer the theoretical understanding into applied scientific problems. Students will profit from a comprehensive and state of the art overview of organic trace analyses and from an extensive collection of relevant literature.
Molecular Imaging
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Author : Brian D. Ross
language : en
Publisher: Elsevier
Release Date : 2021
Molecular Imaging written by Brian D. Ross and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021 with Diagnostic imaging categories.
"The detection and measurement of the dynamic interactions of proteins within the living cell are critical to the understanding of cell physiology and pathophysiology. The field of molecular imaging of living subjects continues to expand and has seen dramatic advances in chemistry, engineering and biomedical applications. Molecular Imaging: Principles and Practice, Second Edition provides the first point of entry to the research for all scientists interested in this multi-disciplinary field. Molecular imaging is very diverse: new investigators, collaborators, and students entering this field need an authoritative reference to bring this field together. Editors Brian Ross and Sam Gambhir designed this revision precisely to fill this need"--
Comprehensive Systems Biomedicine
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Author : Pietro Lio
language : en
Publisher: Frontiers E-books
Release Date : 2014-12-03
Comprehensive Systems Biomedicine written by Pietro Lio and has been published by Frontiers E-books this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-03 with Genetics categories.
Systems Biomedicine is a field in perpetual development. By definition a translational discipline, it emphasizes the role of quantitative systems approaches in biomedicine and aims to offer solutions to many emerging problems characterized by levels and types of complexity and uncertainty unmet before. Many factors, including technological and societal ones, need to be considered. In particular, new technologies are providing researchers with the data deluge whose management and exploitation requires a reinvention of cross-disciplinary team efforts. The advent of “omics” and high-content imaging are examples of advances de facto establishing the necessity of systems approaches. Hypothesis-driven models and in silico validation tools in support to all the varieties of experimental applications call for a profound revision. The focus on phases like mining and assimilating the data has substantially increased so to allow for interpretable knowledge to be inferred. Notably, to be able to tackle the newly generated data dimensionality, heterogeneity and complexity, model-free and data-driven intensive applications are increasingly shaping the computational pipelines and architectures that quant specialists set aside of the high-throughput genomics, transcriptomics, proteomics platforms. As for the societal aspects, in many advanced societies health care needs now more than in the past to address the problem of managing ageing populations and their complex morbidity patterns. In parallel, there is a growing research interest on the impact that cross-disciplinary clinical, epidemiological and quantitative modelling studies can have in relation to outcomes potentially affecting the quality of life of many people. Complex systems, including those characterizing biomedicine, are assessed in both their functionality and stability, and also relatively to the capacity of generating information from diversity, variation, and complexity. Due to the combined interactions and effects, such systems embed prediction power available for instance in both target identification or marker discovery, or more generally for conducting inference about patients’ pathological states, i.e. normal versus disease, diagnostic or prognostic analysis, and preventive assessment (e.g., risk evaluation). The ultimate goal, personalized medicine, will be achieved based on the confluence of the system’s predictive power to patient-specific profiling.
Molecular Imaging Probes For Cancer Research
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Author : Xiaoyuan Chen
language : en
Publisher: World Scientific
Release Date : 2012
Molecular Imaging Probes For Cancer Research written by Xiaoyuan Chen and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
This review volume integrates the advances in cancer biology, molecular imaging techniques and imaging probes for visualization and quantitative measurement of anatomical, functional, and molecular profiles of cancer. The volume also presents a comprehensive summary of the state-of-the-art technology in molecular imaging probe design and applications in radionuclide (PET and SPECT), magnetic resonance (MR), optical (fluorescence, Raman, photoacoustic), ultrasound, CT, and multimodality imaging. Bringing together the fundamentals of molecular imaging, and the basic principles of each molecular imaging modality in this volume, readers' understanding in this field is further enhanced. With a strong emphasis on the chemistry of the design of appropriate molecular imaging probes for early cancer detection, therapy-response monitoring, and anti-cancer drug development, the process of translating novel cancer imaging probes from bench to bedside is extensively discussed.
Optical Polarimetric Modalities For Biomedical Research
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Author : Nirmal Mazumder
language : en
Publisher: Springer Nature
Release Date : 2023-07-25
Optical Polarimetric Modalities For Biomedical Research written by Nirmal Mazumder and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-07-25 with Science categories.
This book focuses on polarization microscopy, a powerful optical tool used to study anisotropic properties in biomolecules, and its enormous potential to improve diagnostic tools for various biomedical research. The interaction of polarized light with normal and abnormal regions of tissue reveals structural information associated with its pathological condition. Diagnosis using conventional microscopy can be time-consuming, as pathologists require an hour to freeze and stain tissue slices from suspected patients. In comparison, polarization microscopy more quickly distinguishes abnormal tissue and provides better microstructural information of samples, even in the absence of staining. This book provides a basic understanding of the properties of polarized light, a description of the polarization microscope, and a mathematical formalism of Mueller matrix polarimetry. The authors discuss various advanced linear and nonlinear optical techniques such as optical coherence tomography (OCT), reflectance and transmission spectroscopy, fluorescence, multiphoton excitation, second harmonic generation, Raman microscopy, and more. They explore the exciting potential of integrating polarimetry with these techniques for possible applications in different areas of biomedical research, as well as the associated challenges. Including the most recent developments on the topic, this book serves as a modern guide to polarization microscopy and advancements in its use in biomedical research.
Principles Of Diffuse Light Propagation Light Propagation In Tissues With Applications In Biology And Medicine
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Author : Jorge Ripoll Lorenzo
language : en
Publisher: World Scientific
Release Date : 2012-03-23
Principles Of Diffuse Light Propagation Light Propagation In Tissues With Applications In Biology And Medicine written by Jorge Ripoll Lorenzo and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-23 with Science categories.
The main idea behind this book is to present a rigorous derivation of the equations that govern light propagation in highly scattering media, with an emphasis on their applications in imaging in biology and medicine. The equations and formulas for diffuse light propagation are derived from the very beginning, and all the necessary analytical expressions needed to complete a complex imaging or characterization problem are presented step by step.This book provides postgraduate and PhD students with the basic framework and sufficient knowledge in light transport and the related mathematical methods to solve most complex problems that may appear in biomedical applications involving multiple scattered light. All results presented are formal analytical derivations from the complete problem, presenting, in those cases which are relevant, approximations to these expressions.
Molecular Imaging In Oncology
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Author : Martin G. Pomper
language : en
Publisher: CRC Press
Release Date : 2008-10-13
Molecular Imaging In Oncology written by Martin G. Pomper and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-10-13 with Medical categories.
With molecular imaging becoming one the fastest growing topics in medical schools, Informa Healthcare presents Molecular Imaging in Oncology, the first comprehensive reference on molecular imaging in oncology.Giving clinicians and researchers a greater understanding of the current field, this text covers:instrumentation and techniquescancer imaging