Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis
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Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis
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Author : Cecilia Battistelli
language : en
Publisher: Frontiers Media SA
Release Date : 2020-02-10
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis written by Cecilia Battistelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-10 with categories.
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis Volume Ii
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Author : Cecilia Battistelli
language : en
Publisher: Frontiers Media SA
Release Date : 2022-10-17
Molecular Mechanisms And New Therapeutic Targets In Epithelial To Mesenchymal Transition Emt And Fibrosis Volume Ii written by Cecilia Battistelli and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-10-17 with Science categories.
Molecular Mechanism In Epithelial Mesenchymal Transition Emt And Fibrosis
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Author : Sabrina Lisi
language : en
Publisher:
Release Date : 2024-03-29
Molecular Mechanism In Epithelial Mesenchymal Transition Emt And Fibrosis written by Sabrina Lisi and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-03-29 with Science categories.
This Special Issue of the International Journal of Molecular Sciences (IJMS), entitled "Molecular Mechanism in Epithelial-Mesenchymal Transition (EMT) and Fibrosis", collected 15 original research papers (5 reviews and 10 articles) written by a panel of experts from different countries who highlight recent advances in the EMT process. Navigating the complex field of EMT, this Special Issue introduces the current understanding of the underlying mechanisms of EMT in the evolution and progression of fibrogenesis and discusses potential strategies for attenuating EMT to prevent and/or inhibit fibrosis. Overall, the 15 scientific articles in this Special Issue of the International Journal of Molecular Sciences provide valuable insights into the complex mechanisms governing the EMT process linked to fibrosis and have highlighted the potential of novel therapeutic strategies. In the last few years, the field of EMT has shown considerable promise, and there is still much to be learned. As our understanding continues to grow, we hope that this Special Issue serves as a catalyst for further research and innovation in this developing field.
The Epithelial To Mesenchymal Transition Emt In Cancer
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Author : Joëlle Roche
language : en
Publisher: MDPI
Release Date : 2018-04-09
The Epithelial To Mesenchymal Transition Emt In Cancer written by Joëlle Roche and has been published by MDPI this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-09 with Electronic book categories.
This book is a printed edition of the Special Issue "The Epithelial-to-Mesenchymal Transition (EMT) in Cancer" that was published in Cancers
Epithelial Mesenchymal Transitions New Advances In Development Fibrosis And Cancer
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Author : Erik W. Thompson
language : en
Publisher:
Release Date : 2010-12-13
Epithelial Mesenchymal Transitions New Advances In Development Fibrosis And Cancer written by Erik W. Thompson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-13 with categories.
This special issue represents a progression through signaling processes, development, fibrosis and cancer, illustrating common underlying mechanisms and highlighting the growing recognition of therapeutic possibilities. Novel molecular pathways are shown in the context of known regulators, and many articles offer specific insights into therapeutic targeting. Not surprisingly, several articles relate to the signaling pathways activated by the common anchor transforming growth factor (TGF)-beta in relation to epithelial-mesenchymal transition (EMT). A number of new mechanisms with therapeutic implications are described, specifically the interplay between the non-Smad PI3 kinase-Akt-mTOR axis and EMT-associated invasion in response to TGF-beta, the unexpected role of c-Abl in repressing TGF-beta1-induced EMT, the cooperativity between oncostatin M, hepatocyte growth factor and TGF-beta1 in lung carcinoma EMT, and the roles of dystroglycan and periostin in developmental EMT associated with gastrulation and palate fusion, respectively. Collectively, the issue presents the full spectrum of interest in EMT today.
Rise And Fall Of Epithelial Phenotype
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Author : Pierre Savagner
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-07-05
Rise And Fall Of Epithelial Phenotype written by Pierre Savagner and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-07-05 with Science categories.
Epithelial phenotype is a dynamic stage of differentiation that can be modulated during several physiological or pathological events. The rapid conversion to a mesenchymal-like phenotype is called an epithelial-mesenchymal transition (EMT). The Rise and Fall of Epithelial Phenotype is the first book to comprehensively introduce the concept of EMT. The first part of this volume describes main examples and models and explains their physiological relevance. These examples include hydra morphogenesis, gastrulation in mouse, drosophila and sea urchin, as well as neural crest cell migration and heart morphogenesis in vertebrates. Part two reviews in detail, specific EMT molecular pathways covering extracellular induction, transduction and transcription response and modulation of cell-cell adhesion structures. It emphasizes new specific pathways with potential medical applications. EMTs can also be linked to pathological events such as wound healing and cancer progression, as detailed in this section of the book.
Targeting Cell Survival Pathways To Enhance Response To Chemotherapy
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Author :
language : en
Publisher: Academic Press
Release Date : 2018-03-28
Targeting Cell Survival Pathways To Enhance Response To Chemotherapy written by and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-28 with Medical categories.
Targeting Cell Survival Pathways to Enhance Response to Chemotherapy encompasses recently developed molecular targeting agents and approaches that suppress cell survival signaling. Cell survival signaling attenuates the effectiveness of conventional chemotherapy and numerous mechanisms have been described, and continue to be described, which contribute to cell survival in the face of chemotherapy treatment. Key pathways leading to chemoresistance emanate from growth factor receptors, PI3K, STAT3, anti-apoptotic Bcl-2 family members, autophagy, and the DNA damage response pathway. New advances have underscored the potential of targeting each of these cell survival mechanisms to improve responsiveness to chemotherapy. This book reviews these recent advances and provides a foundational background and hints of new opportunities for basic, translational, and clinical investigators focused on improving therapeutic responses to chemotherapy. Presents cutting-edge agents and approaches with proved success in different model systems that can be translated to a different type of cancer Brings updated information to be used to propose new clinical trials investigating innovative strategies for improving responses to chemotherapy Provides mechanistic details to help guide the design of laboratory studies associated with clinical trials
Network Pharmacology
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Author : Shao Li
language : en
Publisher: Springer Nature
Release Date : 2021-09-29
Network Pharmacology written by Shao Li and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-09-29 with Medical categories.
This book introduces “network pharmacology” as an emerging frontier subject of systematic drug research in the era of artificial intelligence and big data. Network Pharmacology is an original subject of fusion system biology, bioinformatics, network science and other related disciplines. It emphasizes on starting from the overall perspective of the system level and biological networks, the analysis of the laws of molecular association between drugs and their treatment objects, reveals the systematic pharmacological mechanisms of drugs, and guides the research and development of new drugs and clinical diagnosis and treatment. After it was proposed, network pharmacology has been paid attention by researchers, and it has been rapidly developed and widely used. In order to systematically reveal the biological basis of diagnosis and treatment in traditional Chinese medicine and modern medicine, we proposed a new concept of "network target" for the first time, which has become the core theory of "network pharmacology". The core principle of a network target is to construct a biological network that can be used to decipher complex diseases. The network is then used as the therapeutic target, to which multicomponent remedies are applied. This book mainly includes four parts: 1) The concept and theory of network pharmacology; 2) Common analysis methods, databases and software in network pharmacological research; 3) Typical cases of traditional Chinese medicine modernization and modern drug research based on network pharmacology; 4) Network pharmacology practice process based on drugs and diseases.
Renal Fibrosis Mechanisms And Therapies
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Author : Bi-Cheng Liu
language : en
Publisher: Springer
Release Date : 2019-08-09
Renal Fibrosis Mechanisms And Therapies written by Bi-Cheng Liu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-09 with Science categories.
This book systemically presents the latest research on renal fibrosis, covering all the major topics in the field, including the possible mechanisms, biomarkers, and strategies for prevention and treatment of chronic kidney disease (CKD). Due to its high prevalence, CKD represents a huge global economic and social burden. Irrespective of the initial causes, CKD progresses to end stage kidney disease (ESKD) due to renal fibrosis, which is characterized by glomerulosclerosis, tubule atrophy and atresia, and the excessive accumulation of extracellular matrix (ECM) in the kidney. Unfortunately, an estimated 1%-2% of the adult population living with CKD will need renal replacement therapy at some point as a result of ESKD. As such, strategies for preventing or slowing CKD progression to ESKD are of utmost importance, and studies aiming to understand the mechanisms of renal fibrosis have been the focus of intensive research. Recently, novel insights into the pathophysiological processes have furthered our understanding of the pathogenesis of renal fibrosis, and more importantly, promoted studies on the early diagnosis and treatment of CKD. This book draws lessons from the extensive, state-of-the-art research in this field, elaborating the new theories and new techniques to offer readers a detailed and comprehensive understanding of renal fibrosis and as well as inspiration for future research directions.
Colon Cancer Cells
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Author : Mary Moyer
language : en
Publisher: Elsevier
Release Date : 2012-12-02
Colon Cancer Cells written by Mary Moyer and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Medical categories.
Colon Cancer Cells brings together fundamental research and clinically relevant issues in the cell biology of colon cancer. This book is composed of five parts encompassing 21 chapters that specifically describe the initiation and progression of colon cancer cells. After briefly dealing with the major issues in colorectal carcinoma, this book goes on presenting the in vitro and in vivo models of colon carcinogenesis. This topic is followed by a discussion on the history of the development and characterization of commonly used colon cancer cell lines. The following parts describe the biochemical and immunological features and hormones in the colon. These parts also consider the studies on human colon tumors xenografted into nude mice and the biology and treatment of colorectal cancer metastasis. Discussions on the application of human monoclonal antibodies to tumor detection; the expression of blood group-related carbohydrates by normal, premalignant, and malignant colonic tissues; and the correlation of antigen variability in colon carcinoma with certain diagnostic and prognostic parameters are also included in these parts. The concluding part examines various therapeutic strategies and their potential in improving patient management with advanced colon carcinoma. Researchers, clinicians, and students interested in the biology of colon cancer development and in gastrointestinal cell biology will find this book invaluable.