Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation Volume Ii
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Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation Volume Ii
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Author : Michael Schrader
language : en
Publisher: Frontiers Media SA
Release Date : 2022-12-02
Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation Volume Ii written by Michael Schrader and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-02 with Science categories.
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation
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Author : Michael Schrader
language : en
Publisher: Frontiers Media SA
Release Date : 2017-02-28
Molecular Mechanisms And Physiological Significance Of Organelle Interactions And Cooperation written by Michael Schrader and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-02-28 with categories.
Eukaryotic cells contain distinct membrane-bound organelles, which compartmentalise cellular proteins to fulfil a variety of vital functions. Many organelles have long been regarded as isolated and static entities (e.g., peroxisomes, mitochondria, lipid droplets), but it is now evident that they display dynamic changes, interact with each other, share certain proteins and show metabolic cooperation and cross-talk. Despite great advances in the identification and characterisation of essential components and molecular mechanisms associated with the biogenesis and function of organelles, information on how organelles interact and are incorporated into metabolic pathways and signaling networks is just beginning to emerge. Organelle cooperation requires sophisticated targeting systems which regulate the proper distribution of shared proteins to more than one organelle. Organelle motility and membrane remodeling support organelle interaction and contact. This contact can be mediated by membrane proteins residing on different organelles which can serve as molecular tethers to physically link different organelles together. They can also contribute to the exchange of metabolites and ions, or act in the assembly of signaling platforms. In this regard organelle communication events have been associated with important cellular functions such as apoptosis, antiviral defense, organelle division/biogenesis, ROS metabolism and signaling, and various metabolic pathways such as breakdown of fatty acids or cholesterol biosynthesis. In this research topic we will focus on recent novel findings on the underlying molecular mechanisms and physiological significance of organelle interaction and cooperation with a particular focus on mitochondria, peroxisomes, endoplasmic reticulum, lysosomes and lipid droplets and their impact on the regulation of cellular homeostasis. Our understanding of how organelles physically interact and use cellular signaling systems to coordinate functional networks between each other is still in its infancy. Nevertheless recent discoveries of defined membrane structures such as the mitochondria-ER associated membranes (MAM) are revealing how membrane domains enriched in specific proteins transmit signals across organelle boundaries, allowing one organelle to influence the function of another. In addition to its role as a mediator between mitochondria and the ER, contacts between the MAM and peroxisomes contribute to antiviral signaling, and specialised regions of the ER are supposed to initiate peroxisome biogenesis, whereas intimate contacts between peroxisomes, lipid droplets and the ER mediate lipid metabolism. In line with these observations it is tempting to speculate that further physical contact sites between other organelles exist. Alternatively, novel regulated vesicle trafficking pathways between organelles (e.g., mitochondria to peroxisomes or lysosomes) have been discovered implying another mode of organelle communication. Identifying the key molecular players of such specialised membrane structures will be a prerequisite to understand how organelle communication is physically accomplished and will lead to the identification of new regulatory networks. In addition to the direct transmission of interorganellar information, cytosolic messenger systems (e.g., kinase/phosphatase systems or redox signaling) may contribute to the coordination of organelle functions. This research topic will integrate new findings from both modes of communication and will provide new perspectives for the functional significance of cross-talk among organelles. We would like to thank all the researchers who contributed their valuable work to this research topic. Furthermore, we are grateful to the reviewers and Associate Editors who contributed valuable comments and positive criticism to improve the contributions.
Biomembranomics
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Author : Hongda Wang
language : en
Publisher: CRC Press
Release Date : 2023-11-23
Biomembranomics written by Hongda Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-11-23 with Science categories.
The membrane is an intricately structured entity that performs numerous vital biological functions, including materials transport, signal transduction, energy transfer, and enzymatic reactions. Abnormal expression and distribution of certain membrane proteins are even associated with genetic disorders, neurodegenerative diseases, and malignant tumors. Despite the widely acknowledged significance of membranes, comprehensive and systematic research on membranes akin to genomics, proteomics, and metabolomics is still lacking. Furthermore, the broad concept of biomembranes is not confined to the plasma membrane alone; it also includes organelle membranes and membranes of endocytosis or exocytosis vesicles, which are also derived from the biomembrane system. This book introduces the concept of "omics" to membranes and proposes the term ‘biomembranomics.’ It compiles the latest advancements in structural analysis techniques for biomembranes, including single-molecule manipulation techniques, single-molecule fluorescence techniques, super-resolution fluorescence imaging, cryo-electron microscopy, mass spectrometry, molecular dynamics simulation, and hyphenated instrumental techniques. The book presents both classic and cutting-edge protocols in text and illustrative forms, serving as a valuable and applicable reference material. It provides a profound understanding of biomembrane organization at single-molecule level, paving new avenues for unveiling the relationship between membrane structure and function. Therefore, this book is essential reading for researchers across all related fields.
Molecular Biology Of The Cell
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Author :
language : en
Publisher:
Release Date : 2004
Molecular Biology Of The Cell written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Cells categories.
Impacts Of Agriculture On Human Health And Nutrition Volume Ii
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Author : Ismail Cakmak
language : en
Publisher: EOLSS Publications
Release Date : 2009-11-25
Impacts Of Agriculture On Human Health And Nutrition Volume Ii written by Ismail Cakmak and has been published by EOLSS Publications this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-25 with categories.
Impacts of Agriculture on Human Health and Nutrition is a component of Encyclopedia of Food and Agricultural Sciences, Engineering and Technology Resources in the global Encyclopedia of Life Support Systems (EOLSS), which is an integrated compendium of twenty one Encyclopedias. The Theme on Agriculture on Human Health and Nutrition provides the essential aspects and a number of issues of importance in human life: Global Prevalence of Micronutrient Malnutrition and Impacts on the Health of Children; Community-Centered Food-Based Strategies for Alleviating and Preventing Malnutrition; Influence of Mineral Fertilizers on Nutritional Quality of Staple Food Crops; Molecular Genetic Approaches to Improve the Nutritional Quality of Staple Food Crops; Nutritional Consequences of Using Organic Agricultural Methods in Developing Countries which are then expanded into multiple subtopics, each as a chapter. These two volumes are aimed at the following five major target audiences: University and College students Educators, Professional practitioners, Research personnel and Policy analysts, managers, and decision makers and NGOs.
Research Awards Index
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Author :
language : en
Publisher:
Release Date : 1989
Research Awards Index written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989 with Medicine categories.
The Biogenesis Of Cellular Organelles
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Author : Chris Mullins
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-03-06
The Biogenesis Of Cellular Organelles written by Chris Mullins and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-03-06 with Medical categories.
The Biogenesis of Cellular Organelles represents a comprehensive summary of recent advances in the study of the biogenesis and functional dynamics of the major organelles operating in the eukaryotic cell. This book begins by placing the study of organelle biogenesis in a historical perspective by describing past scientific strategies, theories, and findings and relating these foundations to current investigations. Reviews of protein and lipid mediators important for organelle biogenesis are then presented, and are followed by summaries focused on the endoplasmic reticulum, Golgi, lysosome, nucleus, mitochondria, and peroxisome.
Scientific And Technical Aerospace Reports
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Author :
language : en
Publisher:
Release Date : 1993
Scientific And Technical Aerospace Reports written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Aeronautics categories.
Research Grants Index
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Author : National Institutes of Health (U.S.). Division of Research Grants
language : en
Publisher:
Release Date : 1975
Research Grants Index written by National Institutes of Health (U.S.). Division of Research Grants and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1975 with Medicine categories.
The Liver
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Author : Irwin M. Arias
language : en
Publisher: John Wiley & Sons
Release Date : 2020-01-20
The Liver written by Irwin M. Arias and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-20 with Medical categories.
Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.