Molecular Mechanisms Of Neuronal Responsiveness
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Molecular Mechanisms Of Neuronal Responsiveness
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Author : Yigal H. Ehrlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-13
Molecular Mechanisms Of Neuronal Responsiveness written by Yigal H. Ehrlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-13 with Science categories.
The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
Molecular Mechanisms Of Neuronal Responsiveness
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Author : Yigal H. Ehrlich
language : en
Publisher: Springer
Release Date : 2012-05-18
Molecular Mechanisms Of Neuronal Responsiveness written by Yigal H. Ehrlich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-05-18 with Science categories.
The interaction of neurotransmitters, neuromodulators and neuroactive drugs with receptors localized at the cell surface initiates a chain of molecular events leading to integrated neuronal responses to the triggering stimuli. Major advancements in the characterization and isolation of recep tor molecules have answered many quest ions regarding the nature of the ele ments that determine the specificity in these interactions. At the same time, recent studies have provided evidence that delicate regulation by intracellular enzymatic systems determines the efficiency of the stimulus response coupling process, mediates the interaction between receptors, operates in feedback control mechanisms and transduces signals from the receptors to various effector sites in a highly coordinated fashion. These studies are at the focus of the present volume, which is an outcome of a symposium held at the University of Vermont College of Medicine on March 21-23, 1986, in conjunction with the seventeenth annual meeting of the Amer ican Society for Neurochemistry. The symposium has demonstrated clearly that the concerted efforts of investigators in neurophysiology, biochemis try, pharmacology, cell-biology, molecular genetics, neurology, and psy chiatry are required to achieve better understanding of the processes under lying neuronal responsiveness. This volume includes contributions provided by prominent investigators in all these research areas. We hope that the readers will find here a useful source of information and ideas for stimu lating further studies which may serve to narrow the gap between basic neuroscience research and its clinical implications.
Molecular And Cellular Mechanisms Of Neuronal Plasticity
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Author : Yigal H. Ehrlich
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Molecular And Cellular Mechanisms Of Neuronal Plasticity written by Yigal H. Ehrlich and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Numerous studies have proven the biological basis of memory formation and have begun to identify the biochemical traces and cellular circuits that are formed by experience, and which participate int the storage of information in the brain, its retention for long durations, and its retrieval upon demand. Cells in the nervous system have the capability of undergoing extremely long-lasting alterations in response to hormonal, pharmacological, and environmental stimulations. The mechanisms underlying this neuronal plasticity are activated by experiential inputs and operate in the process of learning and the formation of memories in the brain. This volume presents research areas which have not been highlighted in the past. In addition to studies on the involement of functional proteins in neuronal adaptation, this volume presents recent developments on the critical roles of bioactive lipids and nucleotides in these processes. In addition to the widely studied role of second messengers, a review of studies on extracellular phosphorylation systems operating on the surface of brain neurons is presented.The first section of the volume presents studies of basic mechanisms operating in a wide range of adaptive processes. The second section presents recent advances in investigations that have demonstrated the clinical implications of this research. These include: state of the art use of transgenic models in studies of molecular and cellular mechanisms implicated in familial Alzheimer's disease and Amyotrophic Lateral Sclerosis; studies of specific proteins implicated in Alzheimer's disease, including an adapter that binds to the beta-amyloid precurser protein (beta-APP) and the microtubular protein Tau and its membrane-bound counterpart. The advantages of using cell culture models for elucidating the causes of neuronal degeneration and for identifying mechanisms of neuroprotection are also presented among the chapters in the section on clinical implications.
Molecular Mechanisms Of Neurotransmitter Release
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Author : Zhao-Wen Wang
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-11-16
Molecular Mechanisms Of Neurotransmitter Release written by Zhao-Wen Wang and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-16 with Medical categories.
Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.
Neural Cell Specification
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Author : Bernhard H.J. Juurlink
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neural Cell Specification written by Bernhard H.J. Juurlink and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.
Molecular Mechanisms Of Neurotransmitter Release
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Author : Zhao-Wen Wang
language : en
Publisher: Humana Press
Release Date : 2010-11-16
Molecular Mechanisms Of Neurotransmitter Release written by Zhao-Wen Wang and has been published by Humana Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-16 with Medical categories.
Neurons in the nervous system organize into complex networks and their functions are precisely controlled. The most important means for neurons to communicate with each other is transmission through chemical synapses, where the release of neurotransmitters by the presynaptic nerve terminal of one neuron influences the function of a second neuron. Since the discovery of chemical neurotransmission by Otto Loewi in the 1920s, great progress has been made in our understanding of mol- ular mechanisms of neurotransmitter release. The last decade has seen an explosion of knowledge in this field. The aim of Molecular Mechanisms of Neurotransmitter Release is to provide up-to-date, in-depth coverage of essentially all major mole- lar mechanisms of neurotransmitter release. The contributors have made great efforts to write concisely but with sufficient background information, and to use figures/diagrams to present clearly key concepts or experiments. It is hoped that this book may serve as a learning tool for neuroscience students, a solid reference for neuroscientists, and a source of knowledge for people who have a general interest in neuroscience. I was fortunate to be able to gather contributions from a group of outstanding scientists. I thank them for their efforts. In particular, I want to thank Dr. Erik Jorgensen who offered valuable suggestions about the book in addition to contrib- ing an excellent chapter. I thank US National Science Foundation and National Institute of Health for their supports.
Cellular And Molecular Mechanisms Underlying Higher Neural Functions
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Author : A. I. Selverston
language : en
Publisher:
Release Date : 1994-06-30
Cellular And Molecular Mechanisms Underlying Higher Neural Functions written by A. I. Selverston and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-06-30 with Medical categories.
Despite the remarkable advances made in molecular neurobiology over the last ten years, very little progress has been made towards understanding how the brain performs higher functions: cognition, behavior, learning, and memory. One of the greatest challenges facing modern neurobiology, therefore, is the integration of data that comes from disparate levels of analysis. This volume presents the results of the Dahlem conference convened to address these issues. The purpose of the conference was to bring together brain researchers, who approach their work at different conceptual levels, to consider how their results might be synthesized into a more integrated view of how the brain works. To try and accomplish this, two specific examples were chosen: the modulation of neural circuits and the phenomena of long-term potentiation (LTP). Neuromodulation has been studied from the molecular to the behavioral level with dramatic breakthroughs at the circuit level over the last five years. Due to the possibility that it may be the cellular mechanism for certain types of learning and memory, LTP has also been studied at different levels. To assist in understanding LTP and neuromodulation at the molecular, cellular, circuit, and behavioral levels, the background papers written for the meeting are included in this volume. The conference itself was devoted to discussing LTP and neuromodulation from the perspective of each of the different levels, and the results of these discussions are presented in the group reports. Particular emphasis was given to a consideration of how the rapid progress in molecular and cellular neurobiology can be integrated into systems and behavioral neurobiology. Specific suggestions for future research in both areas were discussed thoroughly. This volume presents what is most probably the most authoritative, up-to-date assessment of LTP and neuromodulation currently available. Goal of this Dahlem Workshop: to apply new cellular and molecular concepts to the understanding of plasticity in synapses, cells, local circuits, and defined systems in the mature brain.
Molecular Biology Of The Neuron
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Author : Brian Morris
language : en
Publisher: Oxford University Press
Release Date : 2004-04-08
Molecular Biology Of The Neuron written by Brian Morris and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-04-08 with Medical categories.
This book is a valuable compendium of up-to-date reviews of neuronal molecular biology by leading researchers in the field. It covers all aspects of neuron structure and function, with the emphasis on genetic and molecular analysis.
Neural Plasticity And Memory
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Author : Federico Bermudez-Rattoni
language : en
Publisher: CRC Press
Release Date : 2007-04-17
Neural Plasticity And Memory written by Federico Bermudez-Rattoni and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-04-17 with Psychology categories.
A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq
Molecular Mechanisms Of Neuronal Communication
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Author : Kjell Fuxe
language : en
Publisher: Pergamon
Release Date : 1996
Molecular Mechanisms Of Neuronal Communication written by Kjell Fuxe and has been published by Pergamon this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Medical categories.
Hardbound. This volume represents the state of the art of the understanding of many aspects of neural and humoral communication with focus on molecular mechanisms. The book emphasizes the importance of histochemical techniques such as fluorescence histochemistry, immunocytochemistry and receptor autoradiography together with quantitative neuroanatomy to reach new insight into the functions of the endocrine and the nervous systems. The localization and expression of transmitters and high affinity G protein coupled receptors, especially in relation to monoaminergic and peptidergic transmission, have been analyzed with regard to different modes of neuronal communication, namely wiring transmission and volume transmission within both the autonomic nervous system and the central nervous system. Some of the most advance research on the molecular mechanisms underlying transmitter storage and release and signal transduction at the G protein coupled receptors is p