Molecular Mechanisms Underlying Polycystic Kidney Disease From The Smallest Bricks To The Big Scenario
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Molecular Mechanisms Underlying Polycystic Kidney Disease From The Smallest Bricks To The Big Scenario
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Author : Annarita Di Mise
language : en
Publisher: Frontiers Media SA
Release Date : 2024-05-29
Molecular Mechanisms Underlying Polycystic Kidney Disease From The Smallest Bricks To The Big Scenario written by Annarita Di Mise and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-05-29 with Science categories.
Cystogenesis
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Author : Jong Hoon Park
language : en
Publisher: Springer
Release Date : 2016-10-12
Cystogenesis written by Jong Hoon Park and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-12 with Medical categories.
Autosomal Dominant Polycystic Kidney Disease (ADPKD) is a highly prevalent hereditary renal disorder in which fluid-filled cysts are appeared in both kidneys. Main causative genes of ADPKD are PKD1 and PKD2, encoding for polycystin-1 (PC1) and polycystin-2 (PC2) respectively. Those proteins are localized on primary cilia and function as mechanosensor in response to the fluid flow, translating mechanistic stimuli into calcium signaling. With mutations either of PKD1 or PKD2, hyper-activated renal tubular epithelial cell proliferation is observed, followed by disrupted calcium homeostasis and aberrant intracellular cyclic AMP (cAMP) accumulation. Increased cell proliferation with fluid secretion leads to the development of thousands of epithelial-lined, fluid-filled cysts in kidneys. It is also accompanied by interstitial inflammation, fibrosis, and finally reaching end-stage renal disease (ESRD). In human ADPKD, the age at which renal failure typically occurs is later in life, however no specific targeted medications are available to cure ADPKD. Recently, potential therapeutic targets or surrogate diagnostic biomarkers for ADPKD are proposed with the advances in the understanding of ADPKD pathogenesis, and some of them were attempted for clinical trials. Herein, we will summarize genetic and epi-genetic molecular mechanisms in ADPKD progression, and overview the currently available biomarkers or potential therapeutic reagents suggested.
The Metabolic Ghetto
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Author : Jonathan C. K. Wells
language : en
Publisher: Cambridge University Press
Release Date : 2016-07-21
The Metabolic Ghetto written by Jonathan C. K. Wells and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-07-21 with Business & Economics categories.
A multidisciplinary analysis of the role of nutrition in generating hierarchical societies and cultivating a global epidemic of chronic diseases.
Porth
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Author : Carol Mattson Porth
language : en
Publisher:
Release Date : 2009
Porth written by Carol Mattson Porth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Exercise Genomics
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Author : Linda S. Pescatello
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-03-23
Exercise Genomics written by Linda S. Pescatello and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-03-23 with Medical categories.
Exercise Genomics encompasses the translation of exercise genomics into preventive medicine by presenting a broad overview of the rapidly expanding research examining the role of genetics and genomics within the areas of exercise performance and health-related physical activity. Leading researchers from a number of the key exercise genomics research groups around the world have been brought together to provide updates and analysis on the key discoveries of the past decade, as well as lend insights and opinion about the future of exercise genomics, especially within the contexts of translational and personalized medicine. Clinicians, researchers and health/fitness professionals will gain up-to-date background on the key findings and critical unanswered questions across several areas of exercise genomics, including performance, body composition, metabolism, and cardiovascular disease risk factors. Importantly, basic information on genomics, research methods, and statistics are presented within the context of exercise science to provide students and professionals with the foundation from which to fully engage with the more detailed chapters covering specific traits. Exercise Genomics will be of great value to health/fitness professionals and graduate students in kinesiology, public health and sports medicine desiring to learn more about the translation of exercise genomics into preventive medicine.
Concepts And Principles Of Pharmacology
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Author : James E. Barrett
language : en
Publisher: Springer Nature
Release Date : 2019-12-24
Concepts And Principles Of Pharmacology written by James E. Barrett and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-24 with Medical categories.
Celebrating 100 years of HEP, this volume will discuss key pharmacological discoveries and concepts of the past 100 years. These discoveries have dramatically changed the medical treatment paradigms of many diseases and these concepts have and will continue to shape discovery of new medicinies. Newly evolving technologies will similarly be discussed as they will shape the future of the pharmacology and, accordingly, medical therapy.
Toxic Chemical And Biological Agents
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Author : Giovanni Sindona
language : en
Publisher: Springer Nature
Release Date : 2020-10-19
Toxic Chemical And Biological Agents written by Giovanni Sindona and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-19 with Science categories.
This book critically assesses the current state of knowledge on new and important detection technologies, e.g. mass spectrometry, tandem mass spectrometry, biosensor detection and tissue imaging, in connection with toxic chemical and biological agents. In general, the main topics discussed concern the risks and consequences of chemical and biological agents for human health in general, with special emphasis on all biochemical and metabolic pathways including the reproductive system. The exposome, genetic risks and the environment, various health hazard agents, risk assessment, environmental assessment and preparedness, and analysis of sub-lethal effects at the molecular level are also discussed. In closing, the book provides comprehensive information on the diagnosis of exposure, and on health concerns related to toxic chemical and biological agents.
Medical Surgical Nursing
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Author : Sharon Mantik Lewis
language : en
Publisher: Mosby Incorporated
Release Date : 2003-12-01
Medical Surgical Nursing written by Sharon Mantik Lewis and has been published by Mosby Incorporated this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-01 with Medical categories.
Package includes Medical-Surgical Nursing: Assessment and Management of Clinical Problems Two Volume text and Virtual Clinical Excursions 2.0
The Pentose Phosphate Pathway
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Author : Terry Wood
language : en
Publisher: Elsevier
Release Date : 2012-12-02
The Pentose Phosphate Pathway written by Terry Wood and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Science categories.
The Pentose Phosphate Pathway aims to explore the pentose phosphate cycle and the practical techniques applied in its investigation. The main focus of the book is the pentose phosphate cycle in animals as well as microorganisms, and does not discuss the one related to photosynthesis. The book covers the formulation of the pathway, its types, and its alternative formulations; the preparation, processes, and analysis of the pathway; and the enzymes involved. Also covered in the book are the intermediates in intact cells and tissues; distribution of enzymes among different tissues and species; the operation, regulation, and overall control of the pathway; and the clinical, nutritional, and metabolic aspects of the pathway. The text is recommended for biologists and biochemists who would like to understand further the pentose phosphate pathway and the processes related to it.
Jubb Kennedy Palmer S Pathology Of Domestic Animals E Book
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Author : Grant Maxie
language : en
Publisher: Elsevier Health Sciences
Release Date : 2015-08-16
Jubb Kennedy Palmer S Pathology Of Domestic Animals E Book written by Grant Maxie and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-08-16 with Medical categories.
With an emphasis on the disease conditions of dogs, cats, horses, swine, cattle and small ruminants, Jubb, Kennedy, and Palmer's Pathology of Domestic Animals, 6th Edition continues its long tradition of being the most comprehensive reference book on common domestic mammal pathology. Using a body systems approach, veterinary pathology experts provide overviews of general system characteristics, reactions to insult, and disease conditions that are broken down by type of infectious or toxic insult affecting the anatomical subdivisions of each body system. The sixth edition now boasts a new full-color design, including more than 2,000 high-resolution images of normal and abnormal organs, tissues, and cells. Updated content also includes evolved coverage of disease agents such as the Schmallenberg virus, porcine epidemic diarrhea virus, and the porcine deltacoronavirus; plus new information on molecular-based testing, including polymerase chain reaction (PCR) and in-situ hybridization, keep you abreast of the latest diagnostic capabilities. Updated content includes new and evolving pathogens and diagnostic techniques. Updated bibliographies give readers new entry points into the rapidly expanding literature on each subject. NEW! High-resolution color images clearly depict the diagnostic features of hundreds of conditions. NEW! Introduction to the Diagnostic Process chapter illustrates the whole animal perspective and details the approaches to systemic, multi-system, and polymicrobial disease. NEW! Coverage of camelids is now included in the reference’s widened scope of species. NEW! Team of 30+ expert contributors offers the latest perspective on the continuum of issues in veterinary pathology. NEW! Expanded resources on the companion website include a variety of helpful tools such as full reference lists with entries linked to abstracts in Pub Med and bonus web-only figures. NEW! Full-color design improves the accessibility of the text.