Molecular Pathology Of Htlv 1

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Molecular Pathology Of Htlv 1

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Author : Umberto Bertazzoni
language : en
Publisher: Frontiers Media SA
Release Date : 2019-03-25

Molecular Pathology Of Htlv 1 written by Umberto Bertazzoni and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-25 with categories.

Human T-cell leukemia virus type 1 (HTLV-1) was the first human retrovirus discovered, in 1980, by Gallo and co-workers. About 5-10% of HTLV-1-infected individuals are at risk of developing either a fatal malignancy, adult T-cell leukemia (ATL), or a chronic neuroinflammatory syndrome, HTLV-associated myelopathy/tropical spastic paraparesis (HAM/TSP). Both diseases are incurable at present. Many issues concerning HTLV-1’s life cycle and pathobiology are still unsolved or controversial, and new approaches for prognostic stratification of patients and eradication of HTLV-1 infection are in high demand. In this Research Topic, the focus has been centered on discussing two main themes: the functional analysis and oncogenic potential of HTLV-1 regulatory proteins and the control of HTLV-1-associated diseases. The 22 articles in this eBook cover many different aspects of HTLV-1 infection and pathogenesis, providing new perspectives and groundwork for future studies.

Human T Cell Leukemia Virus 1 Htlv 1 Infection Associated Pathology And Response Of The Host

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Author : Roberto S. Accolla
language : en
Publisher: Frontiers Media SA
Release Date : 2023-06-30

Human T Cell Leukemia Virus 1 Htlv 1 Infection Associated Pathology And Response Of The Host written by Roberto S. Accolla and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-30 with Medical categories.

Advances In Adult T Cell Leukemia And Htlv I Research

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Author : Kiyoshi Takatsuki
language : en
Publisher: CRC PressI Llc
Release Date : 1992

Advances In Adult T Cell Leukemia And Htlv I Research written by Kiyoshi Takatsuki and has been published by CRC PressI Llc this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992 with Medical categories.

Provides an examination of the epidemiology, molecular biology, immunology, pathology and genetics of the HTLV-1 virus. The text reflects the advances in research conducted in Japan over the last 10 years and includes information on the molecular mechanisms of viral replication and leukemogenesis.

Htlv Molecular Biology And Pathogenesis

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Author : Zwi N Berneman
language : en
Publisher:
Release Date : 2000

Htlv Molecular Biology And Pathogenesis written by Zwi N Berneman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2000 with categories.

Molecular Mechanisms Of Monocyte Depletion And Cd4 T Cell Persistence During Human T Cell Leukemia Virus Infection

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Author : Alexandre Sze
language : en
Publisher:
Release Date : 2018

Molecular Mechanisms Of Monocyte Depletion And Cd4 T Cell Persistence During Human T Cell Leukemia Virus Infection written by Alexandre Sze and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018 with categories.

"Human T-cell Leukemia Virus type 1 (HTLV-1) was the first human retrovirus discovered in 1980. It is the causal agent of two well characterized human diseases, Adult T-cell Leukemia (ATL) and HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis (HAM/TSP). Few treatment options have been developed for ATL and HAM/TSP; the median survival times for ATL remains under a year, and treatment options of HAM/TSP remain palliative in nature. Thankfully the incidence of disease in HTLV-1 infected patients is relatively low, with only approximately 5% of individuals developing ATL and 2% HAM/TSP. One major obstacle in the development of effective therapies is a lack of understanding regarding the factors that determine HTLV-1 associated pathology. The route of transmission, contaminated breast milk and blood, almost exclusively lead to ATL or HAM/TSP development respectively, but it is unclear as to why. This suggests that the early events of HTLV-1 infection may be key in discerning pathological outcomes. Unfortunately this time point is understudied, in part due to the fact that de novo infection is asymptomatic. The activity of cytotoxic T-cell lymphocytes seems to be vital in controlling viral replication, and is likely a key determinant in disease progression. We thus set out to study the early events of HTLV-1 infection in two important immunologically relevant peripheral blood mononuclear cell populations, monocytes and CD4+ T-cells. HTLV-1 infection of primary human monocytes resulted in the depletion of this cell type. This was not mediated by viral accessory proteins, as host restriction factor SAMHD1 prevented the completion of reverse transcription. The DNA by-products of this inhibition induced a potent STING-mediated immunological response, that triggered Bax and IRF3 activation and complex formation that led to apoptosis. Infection of activated CD4+ T-cells on the other hand, resulted in persistent cellular survival. This was mediated by the viral accessory protein Tax, known to have oncogenic properties. Tax expression activated the AKT pathway, which resulted in the inactivation of the pro-apoptotic FOXO3a transcription factor. This led to the long-term survival of an activated CD4+ T-cell population that was capable of viral transmission. Overall this work has demonstrated the molecular consequences of HTLV-1 infection in two important cell types, monocytes and CD4+ T-cells. These events likely shape the subsequent immunological events that control viral replication and likely influence HTLV-1 disease pathology." --

Molecular Pathology Of Hematolymphoid Diseases

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Author : Cherie H. Dunphy
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-06-16

Molecular Pathology Of Hematolymphoid Diseases written by Cherie H. Dunphy and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-16 with Medical categories.

The past two decades have seen an ever-accelerating growth in knowledge about molecular pathology of human diseases, which received a large boost with the sequencing of the human genome in 2003. Molecular diagnostics, molecular targeted therapy and genetic therapy, are now routine in many medical centers. The molecular field now impacts every field in medicine, whether clinical research or routine patient care. There is a great need for basic researchers to understand the potential clinical implications of their research whereas private practice clinicians of all types (general internal medicine and internal medicine specialists, me- cal oncologists, radiation oncologists, surgeons, pediatricians, family practitioners), clinical investigators, pathologists and medical laboratory directors and radiologists require a basic understanding of the fundam- tals of molecular pathogenesis, diagnosis, and treatment for their patients. Traditional textbooks in molecular biology deal with basic science and are not readily applicable to the medical setting. Most medical textbooks that include a mention of molecular pathology in the clinical s- ting are limited in scope and assume that the reader already has a working knowledge of the basic science of molecular biology. Other texts emphasize technology and testing procedures without integrating the clinical perspective. There is an urgent need for a text that fills the gap between basic science books and clinical practice. In the Molecular Pathology Library series, the basic science and the technology is integrated with the medical perspective and clinical application.

Infections Of The Central Nervous System

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Author : Fabrice Chretien
language : en
Publisher: John Wiley & Sons
Release Date : 2020-01-08

Infections Of The Central Nervous System written by Fabrice Chretien and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-08 with Medical categories.

Der neue Band aus der Reihe International Society of Neuropathology wurde anlässlich der British Medical Association (BMA) Awards 2019 wärmstens empfohlen. Die Herausgeber sind Experten des Fachgebiets und beschreiben Infektionen des Nervensystems mit ihren klinischen, pathologischen und genetischen Eigenheiten. Auch seltene Erkrankungen werden in übersichtlichen Kapiteln erläutert, zusammen mit Definitionen, mikrobiologischen Eigenschaften, Epidemiologie, klinischen Ausprägungen, Labortests, Pathologie, Genetik und Behandlungsoptionen.

Molecular Pathology Of Human Retroviruses Htlv I And Endogenous Retroviruses

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Author : Takashi Yoshiki
language : en
Publisher:
Release Date : 2004

Molecular Pathology Of Human Retroviruses Htlv I And Endogenous Retroviruses written by Takashi Yoshiki and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with HTLV (Viruses) categories.

Viral And Immunological Malignancies

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Author : Paul Volberding
language : en
Publisher: PMPH-USA
Release Date : 2006

Viral And Immunological Malignancies written by Paul Volberding and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006 with AIDS (Disease) categories.

The precise relationship between viral infection and malignancy remains an epidemiologic association and the subject of active investigation. Nonmalignant hematologic disorders have a similarly complex relationship with cancer-associated viruses and may offer insight into the pathogenesis of oncogenesis. This book explores the relationships between viral infections, immune impairments and the hematologic and malignant diseases, particularly against the backdrop of the HIV epidemic. By extending the scope to all of viral oncology the editors provide an invaluable resource on tumors related to other viruses other than HIV, particularly carcinomas of the cervix and anus with HPV and tumors of the liver with the various hepatitis viruses.

Molecular Pathology

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Author : Antoni Horst
language : en
Publisher: CRC Press
Release Date : 2018-05-04

Molecular Pathology written by Antoni Horst and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-04 with Science categories.

This book provides modern views of developments in medical sciences based on advances in molecular pathology. Topics discussed include the molecule; the genome of eukaryotes and its function; gene regulation; the proteins; molecular aspects of inflammation, immunology, and carcinogenesis; molecular biology of the nervous system; molecular defects in the endocrine system; molecular diseases of the blood and blood-forming tissues; and diagnosis of molecular diseases. Four tables and 75 figures illustrate the concepts and provide a quick means to reference important data. Immunologists, pathologists, geneticists, and all other researchers in the biological and medical sciences will find a wealth of information in this ground-breaking new book.