Molecular Targeting In Oncology
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Molecular Targeting In Oncology
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Author : Howard L. Kaufman
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-12-26
Molecular Targeting In Oncology written by Howard L. Kaufman and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-26 with Medical categories.
This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.
Molecular Targeted Therapy In Oncology Lessons From Pharmacogenetics And Pharmacoepigenetics
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Author : Saber Imani
language : en
Publisher: Frontiers Media SA
Release Date : 2022-04-06
Molecular Targeted Therapy In Oncology Lessons From Pharmacogenetics And Pharmacoepigenetics written by Saber Imani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-06 with Science categories.
Molecular Targets In Oncological And Hematological Disease Management Innovations In Precision Medicine
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Author : Adrian Bogdan Tigu
language : en
Publisher: Frontiers Media SA
Release Date : 2024-10-01
Molecular Targets In Oncological And Hematological Disease Management Innovations In Precision Medicine written by Adrian Bogdan Tigu and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-01 with Science categories.
Targeted therapies use specific therapeutic agents that specifically target a molecule that is involved in disease progression. By targeting these specific molecules, the molecular pathway of the disease development could be modulated thus inhibiting the disease progression. By specifically targeting a molecule involved in disease development, we can overcome potential side effects, increasing the precision of the treatment. Precision medicine approaches have been particularly successful in the field of oncology, where targeted therapies have been tested and developed for specific mutations or molecules that promote tumor growth. This Research Topic is centered around the use of therapeutic agents which specifically target molecules involved in disease progression, the novel therapeutic approaches which are focused on specific molecular pathways that are responsible for disease development, resistance to therapy, and the use of cutting-edge techniques that may put well-known therapies and novel therapies under the same spotlight of precision medicine. We aim to create a collection of research papers that lead to a better understanding of how oncological and hematological diseases develop and to improve disease management.
Targeted Therapies In Oncology
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Author : Giuseppe Giaccone
language : en
Publisher: CRC Press
Release Date : 2007-09-25
Targeted Therapies In Oncology written by Giuseppe Giaccone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-25 with Medical categories.
Targeted therapy is one of the most burgeoning areas of development in cancer research. Increasing knowledge in tumor formation and growth at the molecular level has generated a broad array of therapeutic options, including signal transduction inhibition, anti-angiogenic and anti-vascular agents, cell cycle inhibitors, telomerase and telomere inter
Cancer Metabolism Molecular Targeting And Implications For Therapy
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Author : Shanmugasundaram Ganapathy-Kanniappan
language : en
Publisher: Frontiers Media SA
Release Date : 2017-11-03
Cancer Metabolism Molecular Targeting And Implications For Therapy written by Shanmugasundaram Ganapathy-Kanniappan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-11-03 with categories.
Development of an effective anticancer therapeutic necessitates the selection of cancer-related or cancer-specific pathways or molecules that are sensitive to intervention. Several such critical yet sensitive molecular targets have been recognized, and their specific antagonists or inhibitors validated as potential therapeutics in preclinical models. Yet, majority of anticancer principles or therapeutics show limited success in the clinical translation. Thus, the need for the development of an effective therapeutic strategy persists.
“Altered energy metabolism” in cancer is one of the earliest known biochemical phenotypes which dates back to the early 20th century. The German scientist, Otto Warburg and his team (Warburg, Wind, Negelein 1926; Warburg, Wind, Negelein 1927) provided the first evidence that the glucose metabolism of cancer cells diverge from normal cells. This phenomenal discovery on deregulated glucose metabolism or cellular bioenergetics is frequently witnessed in majority of solid malignancies. Currently, the altered glucose metabolism is used in the clinical diagnosis of cancer through positron emission tomography (PET) imaging. Thus, the “deregulated bioenergetics” is a clinically relevant metabolic signature of cancer cells, hence recognized as one of the hallmarks of cancer (Hanahan and Weinberg 2011). Accumulating data unequivocally demonstrate that, besides cellular bioenergetics, cancer metabolism facilitates several cancer-related processes including metastasis, therapeutic resistance and so on. Recent reports also demonstrate the oncogenic regulation of glucose metabolism (e.g. glycolysis) indicating a functional link between neoplastic growth and cancer metabolism. Thus, cancer metabolism, which is already exploited in cancer diagnosis, remains an attractive target for therapeutic intervention as well. The Frontiers in Oncology Research Topic “Cancer Metabolism: Molecular Targeting and Implications for Therapy” emphases on recent advances in our understanding of metabolic reprogramming in cancer, and the recognition of key molecules for therapeutic targeting. Besides, the topic also deliberates the implications of metabolic targeting beyond the energy metabolism of cancer. The research topic integrates a series of reviews, mini-reviews and original research articles to share current perspectives on cancer metabolism, and to stimulate an open forum to discuss potential challenges and future directions of research necessary to develop effective anticancer strategies. Acknowledgment I sincerely thank the Frontiers for providing the opportunity and constant support throughout the process of this research topic and eBook production. I gratefully acknowledge all the authors for their valuable contributions. Finally, I would like to thank my brother, Saravana Kumar, G.K., whose personal sacrifices and unflinching encouragement made my career in science possible. References: Hanahan D, Weinberg RA. 2011. Hallmarks of cancer: The next generation. Cell. 144(5):646-74. Warburg O, Wind F, Negelein E. 1926. Über den stoffwechsel der tumoren in körper. Klinische Wochenschrift. 5:829-32. Warburg O, Wind F, Negelein E. 1927. The metabolism of tumors in the body. J Gen Physiol. 8(6):519-30.
365 Days Of Progress In Cancer Molecular Targets And Therapeutics
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Author : Wafik S. El-Deiry
language : en
Publisher: Frontiers Media SA
Release Date : 2023-09-26
365 Days Of Progress In Cancer Molecular Targets And Therapeutics written by Wafik S. El-Deiry and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-09-26 with Medical categories.
Molecular Targets In Cancer Therapy
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Author : Anand Shankar Ramteke
language : en
Publisher: Springer Nature
Release Date : 2025-06-23
Molecular Targets In Cancer Therapy written by Anand Shankar Ramteke and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-06-23 with Medical categories.
Cancer continues to be a major global health challenge. Recent breakthroughs in molecular biology and multi-omics technologies have revolutionized the understanding of disease pathology and treatment modalities. Molecular Targets in Cancer Therapy is a cutting-edge resource that explores the rapidly evolving landscape of targeted cancer treatments, offering critical insights into the molecular mechanisms driving tumors growth and progression. This comprehensive book brings together contributions from leading cancer researchers who examine a wide range of molecular targets— that are involved in hallmarks of cancer, i.e. cell signalling pathways, angiogenesis, cell death pathways, epithelial mesenchymal transitions, telomerase, immune signalling, metabolic attributes etc. Each chapter delves into the biological rationale, current therapeutic strategies, and clinical implications of targeting these molecules, offering readers both foundational knowledge and the latest advances in the field.
Novel Molecular Targets And Treatments For Gastroesophageal Cancer
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Author : Bin Li
language : en
Publisher: Frontiers Media SA
Release Date : 2024-09-25
Novel Molecular Targets And Treatments For Gastroesophageal Cancer written by Bin Li and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-09-25 with Medical categories.
Gastroesophageal cancer is among the most common malignant diseases worldwide and is associated with high mortality rates, leading to a substantial burden on public health and healthcare systems around the world. Chemotherapeutic drugs have achieved great success in the treatment of esophageal cancer; however, they also bring cytotoxicity to other organs and often have serious side effects. With the development of molecular diagnostics and biomarker discovery, the application of precision medicine has emerged to improve clinical outcomes.
Targeted Cancer Therapies From Small Molecules To Antibodies
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Author : Zhe-Sheng Chen
language : en
Publisher: Frontiers Media SA
Release Date : 2020-07-22
Targeted Cancer Therapies From Small Molecules To Antibodies written by Zhe-Sheng Chen and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-22 with categories.
Advances In Nuclear Oncology
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Author : Emilio Bombardieri
language : en
Publisher: CRC Press
Release Date : 2007-10-15
Advances In Nuclear Oncology written by Emilio Bombardieri and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-10-15 with Medical categories.
The diagnostic and therapeutic achievements in radiopharmaceuticals and nuclear medicine instrumentation - PET, SPECT, MR, CT and their hypbrids PET-CT and SPECT-CT - are the result of the interdisciplinary research efforts of cell-biologists, chemists, pharmacologists, physicists, computer-scientists, engineers, nuclear medicine physicians, a