Monoclonal Antibodies And Their Functional Fragments In Research Diagnosis And Therapy
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Monoclonal Antibodies And Their Functional Fragments In Research Diagnosis And Therapy 2 0
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Author : Menotti Ruvo
language : en
Publisher: Mdpi AG
Release Date : 2022-02-11
Monoclonal Antibodies And Their Functional Fragments In Research Diagnosis And Therapy 2 0 written by Menotti Ruvo and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-11 with Science categories.
Monoclonal antibodies (mAbs) are among the most specialised molecules for the recognition and capture of specific analytes. Hundreds of thousands of mAbs have been generated for a large number of different antigens with increasing affinity and specificity and are available for the most diverse purposes. Many of them have been validated as irreplaceable agents for diagnosis and therapy or as unique reagents for research. Others have been developed using emerging technologies that avoid the need for animal immunisation. This short book strives to gather the perspective view of the various contributing authors and to survey the new strategic assets adopted to generate novel monoclonal antibodies or surrogates, such as Fab, Fab2, ScFv and nanobodies, which have an increasing impact in biomedicine as therapeutic or diagnostic assets in various diseases.
Monoclonal Antibodies And Their Functional Fragments In Research Diagnosis And Therapy
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Author : Menotti Ruvo
language : en
Publisher:
Release Date : 2022-02-11
Monoclonal Antibodies And Their Functional Fragments In Research Diagnosis And Therapy written by Menotti Ruvo and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-02-11 with categories.
The Pharmacology Of Monoclonal Antibodies
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Author : Martin Rosenberg
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Pharmacology Of Monoclonal Antibodies written by Martin Rosenberg and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
A sample of the most exciting developments in the cloning, manipulation, expression and application of genetically-engineered monoclonal antibodies. This rapidly-evolving field has witnessed the PCR combinatorial cloning of vast immunological diversity, in vitro mutagenesis of MAbs, MAbs created by transgenic animals, novel expression systems in plants, animals and lower systems, as well as a rich variety of genetically modified MAbs as potential therapeutic agents. Leading scientists from academia and industry present their own findings as well as short reviews of these research areas.
Applications And Engineering Of Monoclonal Antibodies
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Author : David J. King
language : en
Publisher: CRC Press
Release Date : 1998-11-27
Applications And Engineering Of Monoclonal Antibodies written by David J. King and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-11-27 with Medical categories.
A valuable resource for researchers and workers in the fields of both pharmaceuticals and biotechnology as well as undergraduates in biochemistry, applied biology, biomedical sciences and pharmacy, this book compares established techniques of antibody production with the new. Antibody structure and the implications of antibody engineering are fully discussed, and a case study approach illustrates how antibodies are finding increasing use in the diagnosis and treatment of disease. The volume ends with commercial expression, purification and large-scale manufacture of antibodies and their future potential, particularly as therapeutic agents.
Therapeutic Monoclonal Antibodies
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Author : Zhiqiang An
language : en
Publisher: John Wiley & Sons
Release Date : 2011-09-20
Therapeutic Monoclonal Antibodies written by Zhiqiang An and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-20 with Science categories.
70-chapter authoritative reference that covers therapeutic monoclonal antibody discovery, development, and clinical applications while incorporating principles, experimental data, and methodologies. First book to address the discovery and development of antibody therapeutics in their entirety. Most chapters contain experimental data to illustrate the principles described in them. Authors provide detailed methodologies that readers can take away with them and use in their own laboratories.
Therapeutic Monoclonal Antibodies And Antibody Products Their Optimization And Drug Design In Cancers
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Author : Veysel Kayser
language : en
Publisher: Mdpi AG
Release Date : 2022-01-25
Therapeutic Monoclonal Antibodies And Antibody Products Their Optimization And Drug Design In Cancers written by Veysel Kayser and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-25 with categories.
The book broadly deals with therapeutic monoclonal antibodies (mAbs) and various relevant topics, including different antibody formats such as Antibody-Drug Conjugates (ADC), bispecifics, nanoparticle-based mAbs and HER2+ cancers, immune checkpoint inhibitors and other closely related topics. Each paper was written by leading active research groups in their fields both from academia and industry. The book should be of interest to those scientists and researchers who develop or use biologics, biotherapeutics, biosimilars and biobetters in cancer treatment.
Monoclonal Antibodies
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Author : Harleen Kaur
language : en
Publisher: Elsevier
Release Date : 2021-08-03
Monoclonal Antibodies written by Harleen Kaur and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-08-03 with Medical categories.
Monoclonal antibodies (mAbs) are naturally occurring complex biomolecules. New engineering methods have turned mAbs into a leading therapeutic modality for addressing immunotherapeutic challenges and led to the rise of mAbs as the dominant class of protein therapeutics. mAbs have already demonstrated a great potential in developing safe and reliable treatments for complex diseases and creating more affordable healthcare alternatives. Developing mAbs into well-characterized antibody therapeutics that meet regulatory expectations, however, is extremely challenging. Obstacles to overcome include the determination and development of physiochemical characteristics such as aggregation, fragmentation, charge variants, identity, carbohydrate structure, and higher-order structure (HOS). This book dives deep into mAbs structure and the array of physiochemical testing and characterization methods that need to be developed and validated to establish a mAb as a therapeutic molecule. The main focus of this book is on physiochemical aspects, including the importance of establishing quality attributes such as glycosylation, primary sequence, purity, and HOS and elucidating the structure of new antibody formats by mass spectrometry. Each of the aforementioned quality attributes has been discussed in detail; this will help scientists in researching and developing biopharmaceuticals and biosimilars to find practical solutions to physicochemical testing and characterization. Describes the spectrum of analytical tests and characterization methods necessary for developing and releasing mAb batches Details antibody heterogeneity in terms of size, charge, and carbohydrate content Gives special focus to the structural analysis of mAbs, including mass spectrometry analysis Presents the basic structure of mAbs with clarity and rigor Addresses regulatory guidelines - including ICH Q6B - in relation to quality attributes Lays out characterization and development case studies including biosimilars and new antibody formats
Radiolabeled Monoclonal Antibodies For Imaging And Therapy
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Author : Suresh C. Srivastava
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-03-14
Radiolabeled Monoclonal Antibodies For Imaging And Therapy written by Suresh C. Srivastava and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-14 with Medical categories.
The advent of hybridoma technology leading to the successful produc tion of monoclonal antibodies against a variety of tumor-associated antigens has, during the last decade, provided a very powerful tool for research and clinical investigations. These highly specific reagents have essentially replaced the polysera of the earlier days. The successful demonstration of the many wide ranging capabilities of the monoclonal antibody technique has already begun to exert an enormous impact on diverse areas of research in basic science and medicine. In particular, the potential of monoclonal antibodies to serve as carriers for selective targeting of radionuclides to tumors for diagnosis or therapy, has stimulated an intense surge of research interest and even revived hopes of realizing Ehrlich's concept of the "magic bullet". Indeed, the technology appears to be on the threshold of a revolution in diagnosing and treating malignant disease. Much work remains to be done, however, and even though the progress has been impressive, results to date have shown only moderate success. There is no question that the limited success we have achieved thus far is merely a prelude to the many more exciting developments yet to come.
Monoclonal Antibodies
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Author : Maher Albitar
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Monoclonal Antibodies written by Maher Albitar and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
This book examines a collection of state-of-the-art methods that employ monoclonal antibodies in a clinical setting. The chapters offer in-depth description for generating mouse and recombinant humanized antibodies, and a comprehensive review of how antibodies are being used in bead-based methods for measuring proteins. This field will continue to expand and provide new and innovative techniques in the laboratory and as a basis that complements targeted therapy.
Monoclonal Antibody Directed Therapy
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Author : Veysel Kayser
language : en
Publisher: Mdpi AG
Release Date : 2022-01-28
Monoclonal Antibody Directed Therapy written by Veysel Kayser and has been published by Mdpi AG this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-28 with Science categories.
The book deals with therapeutic monoclonal antibodies (mAbs) broadly, and relevant topics such as challenges and opportunities, next-generation antibody products, Antibody-Drug-Conjugates (ADC), bispecifics, glycosylation, and T-cell engagers are covered. Each topic has been written by leading groups around the world and the book should be of interest to researchers from both academia and industry.