More Than Human Aging

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More Than Human Aging

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Author : Cristina Douglas
language : en
Publisher: Rutgers University Press
Release Date : 2024-10-11

More Than Human Aging written by Cristina Douglas and has been published by Rutgers University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-10-11 with Social Science categories.

What does later life look like when it is lived in the companionship of other species? Similarly, how do other species age (or not) with humans, and what sort of (a)symmetries, if any, are brought to light around how we understand and think about aging? So far, aging has been investigated in the social sciences in purely human terms. This is the first collection of original work that considers aging as taking place in relation to other species. This volume aims to start a conversation about aging by taking its more-than-human participants seriously—that is, not only as a support for or context of human aging but also, more symmetrically, as agents and subjects in the process of aging. The contributors draw upon richly descriptive ethnographic accounts, including moments of connection between seniors and dogs in a long-term care facility, human care for aging laboratory animals, and robotic companionship in later life. The ethnographies in this volume not only enrich our understanding of more-than-human companionship during the human aging process but also challenge and urge us to rethink what it means to live later in life in ecologically entangled social and moral worlds.

Human Aging

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Author : Calogero Caruso
language : en
Publisher: Elsevier
Release Date : 2021-05-13

Human Aging written by Calogero Caruso and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-13 with Medical categories.

Intro -- Human Aging: From Cellular Mechanisms to Therapeutic Strategies -- Copyright -- Contents -- Contributors -- About the editors -- Preface -- Chapter 1: Aging and longevity: An evolutionary approach -- 1.1. Introduction -- 1.2. Why does aging occur? -- 1.3. Mechanisms of aging -- 1.4. Causality and chance in aging and longevity -- 1.5. Conclusions and future perspectives -- References -- Chapter 2: Demographic aspects of aging -- 2.1. Introduction -- 2.2. Understanding the process: Browsing around the demographic transition theories -- 2.3. Aging inequalities -- 2.3.1. Differences by gender, education, and cause of death -- 2.3.2. Does having a longer life also mean having a better life? -- 2.3.3. Economics of population aging -- 2.4. Conclusions and perspectives -- References -- Chapter 3: Pathobiology of aging: An introduction to age-related diseases -- 3.1. Introduction -- 3.2. Complexity -- 3.3. Hallmarks of aging -- 3.4. Genomic instability -- 3.5. Epigenetic alteration -- 3.6. Deregulated nutrient sensing pathways -- 3.6.1. FOXO3 -- 3.6.2. Insulin/IGF-1 pathway -- 3.6.3. mTOR pathway -- 3.6.4. Sirtuin pathway -- 3.6.5. Autophagy -- 3.7. Loss of proteostasis -- 3.8. Mitochondrial dysfunction -- 3.9. Telomere attrition -- 3.10. Cellular senescence -- 3.11. Stem cell exhaustion -- 3.12. Altered intercellular communication -- 3.13. Cancer and aging -- 3.14. Conclusion and future perspectives -- References -- Chapter 4: Cellular senescence and senescence-associated secretory phenotype (SASP) in aging process -- 4.1. Introduction -- 4.2. Signaling pathway stimulating the appearance of SASP -- 4.3. SASP components -- 4.4. MiRNA and extracellular vesicles as new regulators and components of SASP -- 4.5. SASP profile in different cell types -- 4.6. Cellular senescence, SASP, and aging -- 4.7. Conclusions and future perspectives -- References.

More Than Human

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Author : Ramez Naam
language : en
Publisher: Broadway
Release Date : 2005

More Than Human written by Ramez Naam and has been published by Broadway this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Genetic engineering categories.

What if you could be smarter, stronger, and have a better memory just by taking a pill? What if we could alter our genes to cure Alzheimer’s and Parkinson’s? What if we could halt or even reverse the human aging process? What if we could communicate with each othersimply by thinking about it? These questions were once the stuff of science fiction. Today, advances in biotechnology have shown that they’re plausible, even likely to be accomplished in the near future. In labs around the world, researchers looking for ways to help the sick and injured have stumbled onto techniques that enhance healthy animals—making them stronger, faster, smarter, and longer-lived—in some cases, even connecting their minds to robots and computers across the Internet. Now science is on the verge of applying this knowledge to healthy men and women, allowing us to alter humanity in ways we’d previously only dreamed possible. The same research that could cure Alzheimer’s is leading to drugs and genetic techniques that could boost human intelligence. The techniques being developed to stave off heart disease and cancer have the potential to slow or even reverse human aging. And brain implants that restore motion to the paralyzed and sight to the blind are already allowing a small set of patients to control robots and computers simply by thinking about it. Not everyone welcomes this scientific progress. Cries of “against nature” arise from skeptics even as scientists break new ground at an astounding pace. Across the political spectrum, the debate roils: Should we embrace the power to alter our minds and bodies, or should we restrict it? Distilling the most radical accomplishments being made in labs worldwide, including gene therapy, genetic engineering, stem cell research, life extension, brain-computer interfaces, and cloning,More Than Humanoffers an exciting tour of the impact biotechnology will have on our lives. Throughout this remarkable trip, author Ramez Naam shares an impassioned vision for the future with revealing insight into the ethical dilemmas posed by twenty-first-century science. Encouraging us to celebrate rather than fear these innovations, Naam incisively separates fact from myth, arguing that these much-maligned technologies have the power to transform the human race for the better, so long as individuals and families are left free to decide how and if to use them. If you’ve ever wondered about the boundaries of humanity,More Than Humanoffers a vision of a world where we use our knowledge to improve ourselves, unhindered by the fear of change.

Ending Aging

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Author : Aubrey de Grey
language : en
Publisher: Macmillan + ORM
Release Date : 2007-09-04

Ending Aging written by Aubrey de Grey and has been published by Macmillan + ORM this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-04 with Science categories.

MUST WE AGE? A long life in a healthy, vigorous, youthful body has always been one of humanity's greatest dreams. Recent progress in genetic manipulations and calorie-restricted diets in laboratory animals hold forth the promise that someday science will enable us to exert total control over our own biological aging. Nearly all scientists who study the biology of aging agree that we will someday be able to substantially slow down the aging process, extending our productive, youthful lives. Dr. Aubrey de Grey is perhaps the most bullish of all such researchers. As has been reported in media outlets ranging from 60 Minutes to The New York Times, Dr. de Grey believes that the key biomedical technology required to eliminate aging-derived debilitation and death entirely—technology that would not only slow but periodically reverse age-related physiological decay, leaving us biologically young into an indefinite future—is now within reach. In Ending Aging, Dr. de Grey and his research assistant Michael Rae describe the details of this biotechnology. They explain that the aging of the human body, just like the aging of man-made machines, results from an accumulation of various types of damage. As with man-made machines, this damage can periodically be repaired, leading to indefinite extension of the machine's fully functional lifetime, just as is routinely done with classic cars. We already know what types of damage accumulate in the human body, and we are moving rapidly toward the comprehensive development of technologies to remove that damage. By demystifying aging and its postponement for the nonspecialist reader, de Grey and Rae systematically dismantle the fatalist presumption that aging will forever defeat the efforts of medical science.

Lifespan

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Author : David A. Sinclair
language : en
Publisher: Simon and Schuster
Release Date : 2019-09-10

Lifespan written by David A. Sinclair and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-10 with Science categories.

A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.”​ —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Time Of Our Lives The Science Of Human Aging

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Author : Tom Kirkwood Professor of Biological Gerontology University of Manchester
language : en
Publisher: Oxford University Press, USA
Release Date : 1999-06-23

Time Of Our Lives The Science Of Human Aging written by Tom Kirkwood Professor of Biological Gerontology University of Manchester and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-06-23 with Social Science categories.

As recent articles about "the graying of America" suggest, a demographic revolution is well underway. The number of people living into extreme old age is increasing dramatically. By the year 2050 one in five of the world's population, including the developing countries, will be 65 or older, a fact which presages profound medical, biological, philosophical, and political changes in the coming century. In Time of Our Lives, Tom Kirkwood unfolds some of the deepest mysteries of medical science while demolishing some of the most persistent misconceptions. He overturns the almost universally held belief that aging is either necessary or inevitable--it isn't--and debunks the idea that there exists a "death gene" that evolved to inhibit population growth. Instead, Kirkwood shows that we age because our genes, evolving at a time when life was "nasty, brutish, and short," placed little priority on the long-term maintenance of our bodies. With such knowledge, along with new insights from genome research, we can devise ways to target the root causes of aging and of age-related diseases such as Alzheimer's and osteoporosis. Expanding his thesis of the "disposable soma," developed over twenty years of research, Kirkwood makes sense of the evolution of aging, explains how aging occurs, and answers fundamental questions like why women live longer than men. He even considers the possibility that human beings will someday have greatly extended life spans or even be free from senescence altogether. Beautifully written by one of the world's pioneering researchers into the science of aging, Time of Our Lives is a clear, original and, above all, inspiring investigation of a process all of us experience but few of us understand.

Aging

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Author : Carsten Carlberg
language : en
Publisher: Springer Nature
Release Date : 2024-07-22

Aging written by Carsten Carlberg and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-07-22 with Science categories.

Aging is a topic that concerns all of us, since none of us can escape it. The molecular and cellular process is built in every of the billions of cells forming our body. Some of these cells, such as immune cells and red blood cells, live only for a few days to weeks and get life-long constantly replaced by cells produced in the bone marrow. In contrast, there are cells, such as neurons and memory lymphocytes, that get as old as we get. The process of aging limits our maximal life span, which is for us humans 120 years. However, only a very few individuals reached this age. How did their life differ from others that died decades earlier? Is it just the absence of life threatening disease paired with a more healthy life style? Or is it build in in our genome or epigenome? In this book we try to give answers to these questions from the perspectives of evolution, our genome, the epigenomes of our different tissues and cell types and the functionality of our cells. We should try to understand ourselves in detail as well as in a global setting. Basic biology explains cellular mechanisms, such as growth, differentiation, and cell death, which make life as a whole possible. Every (human) organism represents a complex interplay between hundreds of different cell types forming distinctive tissues and organs with specialized tasks. These processes need to be highly orchestrated especially during development, maintenance and aging. Studying the cellular and molecular basis of aging is one of the most fascinating areas but also a great challenge. Nevertheless, research made the biggest steps in elucidating biological processes via studying malfunctions of normal mechanisms leading to different diseases, such as progeroid syndrome and cancer. We will start this book with the understanding of the human genome in relation to principles of evolution. Then we will explain the basics of gene regulation and epigenetics, i.e., the interplay of transcription factors and chromatin. Next, we will shift to cellular mechanisms of aging and discuss then the impact of nutrition and immunity on the aging process. In the following the relation of aging to so-called aging-related common diseases, such as type 2 diabetes, atherosclerosis, cancer and Alzheimer. Do we get these diseases because we are aging or are we aging because we get one of these diseases? The book will end how we can slow down the aging process so that we can age healthy. In short, healthy aging is not an option but is a must. An ancient poem says “Teach us to number our days, that we may get a heart of wisdom.” It is up to each one of us and a daily decision to live a healthy lifestyle and to be aware of the unique gift of live we all have.

Exercise As A Countermeasure To Human Aging

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Author : Bradley Elliott
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-12

Exercise As A Countermeasure To Human Aging written by Bradley Elliott and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Science categories.

This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.

Human Aging

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Author : Calogero Caruso
language : en
Publisher: Academic Press
Release Date : 2021-05-11

Human Aging written by Calogero Caruso and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-11 with Science categories.

Human Aging: From Cellular Mechanisms to Therapeutic Strategies offers an exhaustive picture of all the biological aspects of human aging by describing the key mechanisms associated with human aging and covering events that could disrupt the normal course of aging. Each chapter includes a summary of the salient points covered, along with futures prospects. The book provides readers with the information they need to gain or deepen the skills needed to evaluate the mechanisms of aging and age-related diseases and to monitor the effectiveness of therapies aimed at slowing aging. The book encourages PhD and Postdoc students, researchers, health professionals and others interested in the biology of aging to explore the fascinating and challenging questions about why and how we age as well as what can and cannot be done about it. - Concentrates on different processes, e.g., oxidative stress, cellular senescence and Inflammaging - Offers the ability to access cross-sectional knowledge more easily - Written by expert researchers in biogerontology who are actively involved in various fields within aging research

Human Aging

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Author : Paul W. Foos
language : en
Publisher: Routledge
Release Date : 2016-01-08

Human Aging written by Paul W. Foos and has been published by Routledge this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-01-08 with Psychology categories.

This text offers a readable and friendly presentation of the important methods, findings, and theories of human aging, while actively involving the reader in meaningful exercises and critical thinking. Students are repeatedly challenged to apply information in the text to the older adults in their own lives. Specifically, suggestions for enhancing the lives of their older relatives are offered and encouraged. These include guidelines for discussions they might have regarding social, emotional, and environmental changes as well encouraging intellectual and social interaction. In this Edition: Emphasis on the science of the study of aging and why questions in aging are difficult to answer, how social scientists attempt to handle such difficulties, and the successes and failures social scientists have had thus far in answering those questions. The text also demonstrates how current research findings are now being applied in the real world and/or how they might be applied in the future. Cross-cultural comparisons and ethnic group comparisons are included wherever possible. Each chapter begins with "Senior View," which introduces students to a real person and gives them a chance to hear what older adults think and say about important issues related to the chapter and a chance to compare those opinions to the research findings. Each chapter ends with "Making Choices," emphasizing the important behavioral, emotional, and social choices that students can make now to prolong a healthy, happy life. "Chapter Projects" offer the opportunity for active learning, as students investigate for themselves an issue related to the chapter. Instructors can expand these projects for students who want to learn more, or for independent study. "Focus on Aging" boxes compliment the material in the text, providing additional insight and examples, and encouraging critical thinking. Every chapter includes discussion questions, study questions, chapter exercises, and related online resources.