Morphological Mouse Phenotyping
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Morphological Mouse Phenotypin
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Author : Jesus Ruberte
language : en
Publisher: Academic Press
Release Date : 2016-12-15
Morphological Mouse Phenotypin written by Jesus Ruberte and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-12-15 with Medical categories.
Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypothesis has encouraged the development of massive global projects making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans. However, a mouse is not a man. Here we present a complete and integrative description of mouse normal morphology. This book, basically an atlas, but also containing explanatory diagrams and text, guides the reader through normal mouse anatomy, histology and imaging, and is aimed for mouse researchers as well as veterinarian and human pathologists. More than 2,200 original images showing the anatomy, histology and cellular structure of mouse organs have been specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autonoma de Barcelona) In addition, correlative X-ray, Computed Tomography, Magnetic Resonance and Ultrasound images complete this integrative vision of the mouse morphology Classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, as well as histological, immunohistochemical and electron microscopy techniques have been employed to characterize the mouse morphology "
Morphological Mouse Phenotyping
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Author : Jesus Ruberte
language : en
Publisher: Elsevier
Release Date : 2017-01-27
Morphological Mouse Phenotyping written by Jesus Ruberte and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-27 with Medical categories.
Morphological Mouse Phenotyping: Anatomy, Histology and Imaging is an atlas of explanatory diagrams and text that guides the reader through normal mouse anatomy, histology, and imaging. The book is targeted for mouse researchers and veterinarian and human pathologists, and presents a complete, integrative description of normal mouse morphology. Disease animal models are fundamental in research to improve human health. The success of using genetically engineered mice to evaluate molecular disease hypotheses has encouraged the development of massive global projects, making the mouse the most used animal disease model. Laboratory mouse populations are straining the housing capacity of pharmaceutical and biotechnology companies, as well as public research institutions. However, the scientific community lacks sufficient expertise in morphological phenotyping to effectively characterize and validate these animal models. The mouse displays fundamental morphological similarities to humans; however, a mouse is not a man. Features more than 2,200 original images showing the anatomy, histology, and cellular structure of mouse organs Includes images specifically produced for this book in the Mouse Imaging Platform (Center for Animal Biotechnology and Gene Therapy, Universitat Autònoma de Barcelona) Offers an integrative vision of mouse morphology using correlative X-ray, computed tomography, magnetic resonance, and ultrasound images Employs classical anatomical techniques such as conventional dissection, skeletal preparations, vascular injections, and histological, immunohistochemical, and electron microscopy techniques to characterize mouse morphology
Morphological Mouse Phenotyping Anatomy Histology And Imaging
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Author :
language : en
Publisher:
Release Date :
Morphological Mouse Phenotyping Anatomy Histology And Imaging written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on with Medical categories.
Mouse Retinal Phenotyping
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Author : Naoyuki Tanimoto
language : en
Publisher: Humana
Release Date : 2019-04-05
Mouse Retinal Phenotyping written by Naoyuki Tanimoto and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-04-05 with Science categories.
The aim of this volume is to provide a wide range of techniques and aspects of mouse retinal phenotyping and characterization. Chapters guide readers through morphological and functional properties of the mouse retina and techniques for the analysis of outer to mid-retina and mid- to inner retina. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and cutting-edge, Mouse Retinal Phenotyping: Methods and Protocols aims to ensure successful results in the further study of this vital field.
Comparative Anatomy And Histology
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Author : Piper M. Treuting
language : en
Publisher: Academic Press
Release Date : 2012
Comparative Anatomy And Histology written by Piper M. Treuting and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Medical categories.
1. Introduction -- 2. Phenotyping -- 3. Necropsy and histology -- 4. Mammary Gland -- 5. Skeletal System -- 6. Nose, sinus, pharynx and larynx -- 7. Oral cavity and teeth -- 8. Salivary glands -- 9. Respiratory -- 10. Cardiovascular -- 11. Upper GI -- 12. Lower GI -- 13. Liver and gallbladder -- 14. Pancreas -- 15. Endocrine System -- 16. Urinary System -- 17. Female Reproductive System -- 18. Male Reproductive System -- 19. Hematopoietic and Lymphoid Tissues -- 20. Nervous System -- 21. Special senses, eye -- 22. Special senses, ear -- 23. Skin and adnexa -- Index.
Comparative Anatomy And Histology
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Author : Piper M. Treuting
language : en
Publisher: Academic Press
Release Date : 2017-08-29
Comparative Anatomy And Histology written by Piper M. Treuting and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-08-29 with Science categories.
The second edition of Comparative Anatomy and Histology is aimed at the new rodent investigator as well as medical and veterinary pathologists who need to expand their knowledge base into comparative anatomy and histology. It guides the reader through normal mouse and rat anatomy and histology using direct comparison to the human. The side by side comparison of mouse, rat, and human tissues highlight the unique biology of the rodents, which has great impact on the validation of rodent models of human disease. Offers the only comprehensive source for comparing mouse, rat, and human anatomy and histology through over 1500 full-color images, in one reference work Enables human and veterinary pathologists to examine tissue samples with greater accuracy and confidence Teaches biomedical researchers to examine the histologic changes in their model rodents Experts from both human and veterinary fields take readers through each organ system in a side-by-side comparative approach to anatomy and histology - human Netter anatomy images along with Netter-style rodent images
Magnetic Resonance Imaging
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Author : Pottumarthi V. Prasad
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-02
Magnetic Resonance Imaging written by Pottumarthi V. Prasad and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-02 with Medical categories.
Leading experts in the use of MRI explain its basic principles and demonstrate its power to understand biological processes with numerous cutting-edge applications. To illustrate its capability to reveal exquisite anatomical detail, the authors discuss MRI applications to developmental biology, mouse phenotyping, and fiber architecture. MRI can also provide information about organ and tissue function based on endogenous cantrast mechanisms. Examples of brain, kidney, and cardiac function are included, as well as applications to neuro and tumor pathophysiology. In addition, the volume demonstrates the use of exogenous contrast material in functional assessment of the lung, noninvasive evaluation of tissue pH, the imaging of metabolic activity or gene expression that occur on a molecular level, and cellular labeling using superparamagnetic iron oxide contrast agents.
Advancing Disease Modeling In Animal Based Research In Support Of Precision Medicine
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Author : National Academies of Sciences, Engineering, and Medicine
language : en
Publisher: National Academies Press
Release Date : 2018-05-29
Advancing Disease Modeling In Animal Based Research In Support Of Precision Medicine written by National Academies of Sciences, Engineering, and Medicine and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-29 with Science categories.
Precision medicine is focused on the individual and will require the rapid and accurate identification and prioritization of causative factors of disease. To move forward and accelerate the delivery of the anticipated benefits of precision medicine, developing predictable, reproducible, and reliable animal models will be essential. In order to explore the topic of animal-based research and its relevance to precision medicine, the National Academies of Sciences, Engineering, and Medicine convened a 2-day workshop on October 5 and 6, 2017. The workshop was designed to focus on the development, implementation, and interpretation of model organisms to advance and accelerate the field of precision medicine. Participants examined the extent to which next-generation animal models, designed using patient data and phenotyping platforms targeted to reveal and inform disease mechanisms, will be essential to the successful implementation of precision medicine. This publication summarizes the presentations and discussions from the workshop.
Kaufman S Atlas Of Mouse Development Supplement
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Author : Richard Baldock
language : en
Publisher: Academic Press
Release Date : 2015-09-23
Kaufman S Atlas Of Mouse Development Supplement written by Richard Baldock and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-09-23 with Science categories.
Kaufman's Atlas of Mouse Development: With Coronal Sections continues the stellar reputation of the original Atlas by providing updated, in-depth anatomical content and morphological views of organ systems.The publication offers written descriptions of the developmental origins of the organ systems alongside high-resolution images for needed visualization of developmental processes. Matt Kaufman himself has annotated the coronal images in the same clear, meticulous style of the original Atlas. Kaufman's Atlas of Mouse Development: With Coronal Sections follows the original Atlas as a continuation of the standard in the field for developmental biologists and researchers across biological and biomedical sciences studying mouse development. Provides high-resolution images for best visualization of key developmental processes and structures Offers in-depth anatomy and morphological views of organ systems Written descriptions convey developmental origins of the organ systems
Pathology Of The Developing Mouse
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Author : Brad Bolon
language : en
Publisher: CRC Press
Release Date : 2015-04-24
Pathology Of The Developing Mouse written by Brad Bolon and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-24 with Medical categories.
Pathology of the Developing Mouse provides, in so far as feasible, one complete reference on the design, analysis, and interpretation of abnormal findings that may be detected in developing mice before and shortly after birth. In particular, this book is designed specifically to be not only a "how to do" manual for developmental pathology experimentation in mice but, more importantly, a "how to interpret" resource for pathologists and other biomedical scientists faced for the first or hundredth time with defining the significance of distorted features in some fantastic murine developmental monstrosity. The topics covered in this volume include a full range of subjects encountered when building and wielding a developmental pathology tool kit: baseline anatomic and physiologic traits of developing mice principles of good experimental design and statistical analysis for mouse developmental pathology studies procedures for anatomic pathology examinations, to evaluate structural changes at the macroscopic (gross), microscopic (cells and tissues), and ultrastructural (subcellular) levels, suing conventional autopsy-based or novel non-invasive imaging techniques; methods for clinical pathology testing, to assess the biochemical and cellular composition of tissues and fluids; options and protocols for in situ molecular pathology analysis, to undertake site-specific explorations of the various mechanisms responsible for producing adverse findings (i.e., "lesions") during development; and well-referenced and illustrated guides to the interpretation of anatomic pathology and clinical pathology changes in the animal (embryos, fetuses, neonates, and juveniles) and its support system (placenta).