Mosaicism In Human Skin
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Mosaicism In Human Skin
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Author : Rudolf Happle
language : en
Publisher: Springer Nature
Release Date : 2022-11-24
Mosaicism In Human Skin written by Rudolf Happle and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-11-24 with Medical categories.
This second edition offers a fully revised and updated work on a rapidly growing field of knowledge, and was prepared by two experts whose goal was to explain the molecular basis of mosaic skin disorders in a language that is accessible for practicing physicians and medical students alike. It presents a timely and comprehensive overview of the strikingly manifold patterns and peculiarities of mosaic skin disorders in a straightforward, reader-friendly way that will help physicians to further improve genetic counseling and treatment outcomes. The first two parts of the book are devoted to the mechanisms and patterns of cutaneous mosaicism, and include an explanation of genomic and epigenetic mosaicism and a description of the archetypical segmental patterns including the lines of Blaschko and the flag-like, phylloid and lateralization pattern, the non-segmental pattern of large congenital melanocytic nevi, and the sash-like arrangement as noted in a particular type of cutis tricolor. The concept of lethal mutations surviving as mosaics has now been confirmed by molecular analysis in many sporadically occurring phenotypes. The difference between monoallelic and biallelic traits has deepened our understanding of hereditary mosaics, especially of multiple benign skin tumors. Moreover, recognition of the fundamental difference between the simple segmental and the superimposed types of mosaicism is important for the purpose of genetic counseling. In the third part, the various mosaic skin disorders are examined in depth, including nevi, didymotic disorders, other binary genodermatoses, mosaic manifestations of autosomal skin disorders, and nevoid skin disorders such as phenotypes reflecting functional X-chromosome mosaicism or a superimposed mosaic manifestation of common skin diseases with a polygenic background. Reader-friendly and clearly structured, Mosaicism in Human Skin will appeal to both experienced dermatologists and residents in training, as well as to medical geneticists and pediatricians.
Mosaicism In Human Skin
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Author : Rudolf Happle
language : en
Publisher: Springer
Release Date : 2013-11-30
Mosaicism In Human Skin written by Rudolf Happle and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-30 with Medical categories.
Mosaicism is a powerful biologic concept, originally developed from studying plants and animals. All cutaneous neoplasms, both benign and malignant, reflect mosaicism, which is the necessary basis to explain numerous human skin disorders. For example, various mosaic patterns visualize the embryonic development of human skin and X-linked skin disorders explain why women live longer than men, and so on. This book presents, for the first time, a comprehensive overview on the strikingly manifold patterns and peculiarities of mosaic skin disorders. This reader-friendly structured and straightforward publication will help the dermatologist to understand the underlying molecular mechanisms of skin disorders in order to further improve the treatment outcome.
Harper S Textbook Of Pediatric Dermatology
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Author : Peter H. Hoeger
language : en
Publisher: John Wiley & Sons
Release Date : 2019-12-04
Harper S Textbook Of Pediatric Dermatology written by Peter H. Hoeger and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-12-04 with Medical categories.
A consummate classic with a fresh approach to pediatric dermatology Children ́s skin is different. Maturation affects the epidermal barrier, the cutaneous microbiome, adnexal structures, vasculature, and transcutaneous absorption of drugs. The immature skin is more susceptible to pathogens and environmental disruption. Many genetic disorders are either present at birth or manifest early in childhood. Skin diseases thus present differently in children than in adults. Pediatric dermatology has seen significant advances over the last decade, particularly in the field of molecular genetics research, which has furthered our understanding of the pathogenesis of many skin diseases and the development of new approaches to treatment. This fourth edition of the Harper classic provides state-of-the-art information on all aspects of skin disease in children. It covers the diagnosis and treatment of all conditions - both common and rare - with a consistently evidence-based approach. Existing content has been refreshed and fully updated to reflect emerging thinking and to incorporate the latest in research and clinical data - especially at the genetic level. This new fourth edition includes: Greater focus on the genetics behind skin disease, including new genes/genodermatoses, progress in genetic analysis, and stem cell transplants Increased coverage of lasers and other technologies used to treat skin disease More summary tables, learning points, tables of differential diagnosis, and clinical algorithms for diagnosis and management Additional online features, including patient information links and multiple choice questions Harper's Textbook of Pediatric Dermatology delivers crucial clinical insights and up-to-date research information that spans the breadth of the field. As the most comprehensive reference book on this subject available, this revised fourth edition will support and guide the daily practice of both dermatologists and pediatricians across the world.
An Early Description Of A Human Mosaic Involving The Skin A Story From 1945
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Author : Rudolf Happle
language : en
Publisher:
Release Date : 2020
An Early Description Of A Human Mosaic Involving The Skin A Story From 1945 written by Rudolf Happle and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Abstract: In 1945, the Journal of Heredity published an impressive article entitled "A human mosaic: bilaterally asymmetrical noevus pigmentosus pilosus et mollusciformis unilateralis." The author was M. Zlotnikoff, a Russian physician working in Ivanovo, a city located approximately 250 km northeast of Moscow. Zlotnikoff described a 24-year-old woman with a congenital linear epidermal naevus in a systematized and strictly unilateral arrangement. For the first time, the author explained this disorder as a mosaic resulting from a somatic mutation that occurred at an early stage of embryonic development. However, because this article was published immediately after the war, it fell into oblivion, despite the fact that it was of utmost importance in clinical dermatology. Zlotnikoff's work is all the more remarkable as the author had never heard of the lines of Blaschko
Braun Falco S Dermatology
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Author : Walter Burgdorf
language : en
Publisher: Springer
Release Date : 2008-11-28
Braun Falco S Dermatology written by Walter Burgdorf and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-11-28 with Medical categories.
Also the 3rd edition of "Dermatology" covers all the classical and related fields of dermatology, providing a wealth of information on diagnostic methods, clinical features, pathophysiology, and differential diagnosis. About 950 excellent photos and diagrams help the reader become acquainted with the immense variety of dermatological diseases. The contents of all chapters have been updated. New chapters have been included covering numerous subjects, e.g. dermatopathology, sonography, disorders of chromosomal instability and defective DNA repair, aging skin, sport dermatology, aesthetic therapy. The book is a must for every doctor confronted with dermatological problems.
Cassidy And Allanson S Management Of Genetic Syndromes
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Author : John C. Carey
language : en
Publisher: John Wiley & Sons
Release Date : 2021-01-27
Cassidy And Allanson S Management Of Genetic Syndromes written by John C. Carey and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-27 with Science categories.
MANAGEMENT OF GENETIC SYNDROMES THE MOST RECENT UPDATE TO ONE OF THE MOST ESSENTIAL REFERENCES ON MEDICAL GENETICS Cassidy and Allanson’s Management of Genetic Syndromes, Fourth Edition is the latest version of a classic text in medical genetics. With newly covered disorders and cutting-edge, up-to-date information, this resource remains the most crucial reference on the management of genetic syndromes in the field of medical genetics for students, clinicians, caregivers, and researchers. The fourth edition includes current information on the identification of genetic syndromes (including newly developed diagnostic criteria), the genetic basis (including diagnostic testing), and the routine care and management for more than 60 genetic disorders. Written by experts, each chapter includes sections on: Incidence Diagnostic criteria Etiology, pathogenesis and genetics Diagnostic testing Differential diagnosis Manifestations and Management (by system) The book focuses on genetic syndromes, primarily those involving developmental disabilities and congenital defects. The chapter sections dealing with Manifestations and Management represents the centerpiece of each entry and is unmatched by other genetic syndrome references. Management of Genetic Syndromes is perfect for medical geneticists, genetic counselors, primary care physicians and all healthcare professionals seeking to stay current on the routine care and management of individuals with genetic disorders.
Atlas Of Skin Disorders
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Author : Wen-Yuan Zhu
language : en
Publisher: Springer
Release Date : 2018-07-31
Atlas Of Skin Disorders written by Wen-Yuan Zhu and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-31 with Medical categories.
This book was written to assist the dermatologists and practitioners in the management of rare and challenging skin disorders. It is the most valuable collection of such skin disorders from more than 274 outstanding contributors over 4 decades in China. In this book, a comprehensive coverage of about 387 conditions are illustrated by 1215 superb images, and each is introduced with an initial summary of clinical characters. This atlas incorporates a wide range of skin disorders from the mildest and common conditions to the most severe conditions. The objective of this book is to provide readers with a clinical reference, which can be easily approachable and possesses the necessary expertise to sharpen a dermatologist’s diagnostic and clinical acumen.
Neurocutaneous Disorders
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Author : Martino Ruggieri
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-10-01
Neurocutaneous Disorders written by Martino Ruggieri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-10-01 with Medical categories.
The book provides an authoritative source of knowledge about these problematic disorders. It bridges the gap between clinical recognition and the new molecular medicine. The editors, distinguished clinicians and geneticists, assembled an internationally renowned group of collaborators, many of them the experts who first described a particular disorder or established its present accepted definition. They have written a practical, comprehensive guide to the recognition, investigation and management of more than 60 recognised phakomatoses.
Genetic Mosaicism
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Author : János Szabad
language : en
Publisher: Cambridge Scholars Publishing
Release Date : 2021-06-17
Genetic Mosaicism written by János Szabad and has been published by Cambridge Scholars Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-06-17 with Science categories.
The presence of green and yellow ornamental plants around us, dark spots on our skin, people with brown and blue mosaic irises, and white-spotted dogs and horses are all well-known phenomena of life, and are recognisable genetic mosaics. Although such genetics mosaics live with us (and, in fact, we are all a genetic mosaics), little is known about the genetic bases of their origin. This book provides a general overview of the mechanisms that lead to the formation of different types of mosaics, listing an ample collection of examples to illustrate the impact of the genetic mosaics on our life. The book will appeal to the reader interested in understanding the relationship between genetic events and mosaicism, especially undergraduate and graduate students and medical doctors, as well as experts engaged in horticulture and animal breeding.
Paediatric Dermatology
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Author : Susan Lewis-Jones
language : en
Publisher: Oxford University Press
Release Date : 2020-03-07
Paediatric Dermatology written by Susan Lewis-Jones and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-07 with Medical categories.
Paediatric Dermatology is an indispensable and highly-accessible practical guide for all healthcare professionals faced with the assessment, diagnosis, and treatment of children with skin diseases. The second edition has been fully revised and updated to take into account new advances in therapies including biologics and genetics, and emerging problems such as rashes associated with transplantation and immunosuppression. Divided into 39 comprehensive chapters written by experts in both dermatology and paediatrics, the book is organised according to presentation and body site rather than diagnosis, making it ideal for quick reference in the clinical setting, as well as general study. It contains over 325 full-colour, high-quality clinical photographs of skin conditions, as well as simple algorithms to aid diagnosis of common presentations such as itchy red rashes, blistering disorders, bruising, and nail disorders. Features of more rare dermatological conditions are listed under the relevant clinical signs for easy reference and to aid diagnosis. Advice is given on when to refer to a dermatologist, while short descriptions of approved treatment modalities are given where appropriate.