Multi Scale Modeling In Human Systems Pharmacology Physiology
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Multi Scale Modeling In Human Systems Pharmacology Physiology
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Author : Henrik Cordes
language : en
Publisher:
Release Date : 2019
Multi Scale Modeling In Human Systems Pharmacology Physiology written by Henrik Cordes and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Multiscale modeling categories.
Multiscale Modelling In Biomedical Engineering
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Author : Dimitrios I. Fotiadis
language : en
Publisher: John Wiley & Sons
Release Date : 2023-06-07
Multiscale Modelling In Biomedical Engineering written by Dimitrios I. Fotiadis and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-07 with Science categories.
Multiscale Modelling in Biomedical Engineering Discover how multiscale modeling can enhance patient treatment and outcomes In Multiscale Modelling in Biomedical Engineering, an accomplished team of biomedical professionals delivers a robust treatment of the foundation and background of a general computational methodology for multi-scale modeling. The authors demonstrate how this methodology can be applied to various fields of biomedicine, with a particular focus on orthopedics and cardiovascular medicine. The book begins with a description of the relationship between multiscale modeling and systems biology before moving on to proceed systematically upwards in hierarchical levels from the molecular to the cellular, tissue, and organ level. It then examines multiscale modeling applications in specific functional areas, like mechanotransduction, musculoskeletal, and cardiovascular systems. Multiscale Modelling in Biomedical Engineering offers readers experiments and exercises to illustrate and implement the concepts contained within. Readers will also benefit from the inclusion of: A thorough introduction to systems biology and multi-scale modeling, including a survey of various multi-scale methods and approaches and analyses of their application in systems biology Comprehensive explorations of biomedical imaging and nanoscale modeling at the molecular, cell, tissue, and organ levels Practical discussions of the mechanotransduction perspective, including recent progress and likely future challenges In-depth examinations of risk prediction in patients using big data analytics and data mining Perfect for undergraduate and graduate students of bioengineering, biomechanics, biomedical engineering, and medicine, Multiscale Modelling in Biomedical Engineering will also earn a place in the libraries of industry professional and researchers seeking a one-stop reference to the basic engineering principles of biological systems.
Quantitative Physiology
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Author : Shangbin Chen
language : en
Publisher: Springer Nature
Release Date : 2021-02-09
Quantitative Physiology written by Shangbin Chen and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-02-09 with Medical categories.
Stephen Hawking says that the 21st century will be the century of complexity and indeed now systems biology or medicine means dealing with complexity. Both the genome and physiome have emerged in studying complex physiological systems. Computational and mathematical modeling has been regarded as an efficient tool to boost the understanding about living systems in normal or pathophysiological states. Covering applied methodology, basic case studies and complex applications, this volume provides researchers with an overview of modeling and computational studies of physiology (i.e. quantitative physiology), which is becoming an increasingly important branch of systems biology. This book aims to build multi-scale models to investigate functions in living systems and explain how biomolecules, cells, organs, organ systems and organisms carry out the chemical or physical functions. Some of the models addressed are related to gene expression, calcium signalling, neural activity, blood dynamics and bone mechanics. Combining theory and practice, with extensive use of MATLAB, this book is designed to establish a paradigm for quantitative physiology by integrating biology, mathematics, physics and informatics etc. To benefit from this book, the readers are expected to have a background in general physiology and mathematics
Multiscale Modeling Of Vascular Dynamics Of Micro And Nano Particles
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Author : Huilin Ye
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2020-01-02
Multiscale Modeling Of Vascular Dynamics Of Micro And Nano Particles written by Huilin Ye and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-02 with Science categories.
Recent advances witness the potential to employ nanomedicine and game-changing methods to deliver drug molecules directly to diseased sites. To optimize and then enhance the efficacy and specificity, the control and guidance of drug carriers in vasculature has become crucial. Current bottlenecks in the optimal design of drug carrying particles are the lack of knowledge about the transport of particles, adhesion on endothelium wall and subsequent internalization into diseased cells. To study the transport and adhesion of particle in vasculature, the authors have made great efforts to numerically investigate the dynamic and adhesive motions of particles in the blood flow. This book discusses the recent achievements from the establishment of fundamental physical problem to development of multiscale model, and finally large scale simulations for understanding transport of particle-based drug carriers in blood flow.
Modelling Methodology For Physiology And Medicine
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Author : Ewart Carson
language : en
Publisher: Newnes
Release Date : 2013-12-05
Modelling Methodology For Physiology And Medicine written by Ewart Carson and has been published by Newnes this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-12-05 with Science categories.
Modelling Methodology for Physiology and Medicine, Second Edition, offers a unique approach and an unprecedented range of coverage of the state-of-the-art, advanced modeling methodology that is widely applicable to physiology and medicine. The second edition, which is completely updated and expanded, opens with a clear and integrated treatment of advanced methodology for developing mathematical models of physiology and medical systems. Readers are then shown how to apply this methodology beneficially to real-world problems in physiology and medicine, such as circulation and respiration. The focus of Modelling Methodology for Physiology and Medicine, Second Edition, is the methodology that underpins good modeling practice. It builds upon the idea of an integrated methodology for the development and testing of mathematical models. It covers many specific areas of methodology in which important advances have taken place over recent years and illustrates the application of good methodological practice in key areas of physiology and medicine. It builds on work that the editors have carried out over the past 30 years, working in cooperation with leading practitioners in the field. Builds upon and enhances the reader's existing knowledge of modeling methodology and practice Editors are internationally renowned leaders in their respective fields Provides an understanding of modeling methodologies that can address real problems in physiology and medicine and achieve results that are beneficial either in advancing research or in providing solutions to clinical problems
Anatomy And Physiology Of The Circulatory And Ventilatory Systems
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Author : Marc Thiriet
language : en
Publisher: Springer
Release Date : 2013-11-27
Anatomy And Physiology Of The Circulatory And Ventilatory Systems written by Marc Thiriet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-27 with Science categories.
Together, the volumes in this series present all of the data needed at various length scales for a multidisciplinary approach to modeling and simulation of flows in the cardiovascular and ventilatory systems, especially multiscale modeling and coupled simulations. The cardiovascular and respiratory systems are tightly coupled, as their primary function is to supply oxygen to, and remove carbon dioxide from, the body's cells. Because physiological conduits have deformable and reactive walls, macroscopic flow behavior and prediction must be coupled to nano- and microscopic events in a corrector scheme of regulated mechanism. Therefore, investigation of flows of blood and air in physiological conduits requires an understanding of the biology, chemistry, and physics of these systems, together with the mathematical tools to describe their functioning in quantitative terms. The present volume focuses on macroscopic aspects of the cardiovascular and respiratory systems in normal conditions, i.e., anatomy and physiology, as well as the acquisition and processing of medical images and physiological signals.
Patterns Of Dynamics
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Author : Pavel Gurevich
language : en
Publisher: Springer
Release Date : 2018-02-07
Patterns Of Dynamics written by Pavel Gurevich and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-07 with Mathematics categories.
Theoretical advances in dynamical-systems theory and their applications to pattern-forming processes in the sciences and engineering are discussed in this volume that resulted from the conference Patterns in Dynamics held in honor of Bernold Fiedler, in Berlin, July 25-29, 2016.The contributions build and develop mathematical techniques, and use mathematical approaches for prediction and control of complex systems. The underlying mathematical theories help extract structures from experimental observations and, conversely, shed light on the formation, dynamics, and control of spatio-temporal patterns in applications. Theoretical areas covered include geometric analysis, spatial dynamics, spectral theory, traveling-wave theory, and topological data analysis; also discussed are their applications to chemotaxis, self-organization at interfaces, neuroscience, and transport processes.
Signaling At The Cell Surface In The Circulatory And Ventilatory Systems
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Author : Marc Thiriet
language : en
Publisher: Springer
Release Date : 2016-05-01
Signaling At The Cell Surface In The Circulatory And Ventilatory Systems written by Marc Thiriet and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-01 with categories.
This multidisciplinary review of signaling pathways that regulate circulatory and respiratory function focuses on those involved in cell signaling, from sensors and receptors on the cell surface to intracellular effectors that trigger molecule synthesis.
Systems Pharmacology And Pharmacodynamics
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Author : Donald E. Mager
language : en
Publisher: Springer
Release Date : 2016-11-29
Systems Pharmacology And Pharmacodynamics written by Donald E. Mager and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-11-29 with Medical categories.
While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.
Modeling Human Atrial Patho Electrophysiology From Ion Channels To Ecg Substrates Pharmacology Vulnerability And P Waves
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Author : Loewe, Axel
language : en
Publisher: KIT Scientific Publishing
Release Date : 2016-08-03
Modeling Human Atrial Patho Electrophysiology From Ion Channels To Ecg Substrates Pharmacology Vulnerability And P Waves written by Loewe, Axel and has been published by KIT Scientific Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-03 with categories.