Multiple Myeloma Mm
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Multiple Myeloma Mm
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Author : Ken Campbell (FIBMS.)
language : en
Publisher:
Release Date : 2005
Multiple Myeloma Mm written by Ken Campbell (FIBMS.) and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Multiple myeloma categories.
Multiple Myeloma Mm
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Author :
language : en
Publisher:
Release Date : 2013
Multiple Myeloma Mm written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Multiple myeloma categories.
Multiple Myeloma A New Era Of Treatment Strategies
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Author : Klaus Podar
language : en
Publisher: Bentham Science Publishers
Release Date : 2012-01-03
Multiple Myeloma A New Era Of Treatment Strategies written by Klaus Podar and has been published by Bentham Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-03 with Medical categories.
"Multiple Myeloma (MM), the second most common blood cancer in adults, is a clonal plasma cell malignancy within the bone marrow characterized by osteolytic bone lesions, renal disease, and immunodeficiency. It is now well established that MM cell- induced"
Multiple Myeloma Mm
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Author : Sics Editore
language : en
Publisher: SICS Editore
Release Date : 2014-10-01
Multiple Myeloma Mm written by Sics Editore and has been published by SICS Editore this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-01 with Medical categories.
Affects primarily middle-aged and elderly patients.Recognize complications that require prompt intervention.A symptomless patient is usually not treated, whereas a symptomatic patient is actively treated.
Fast Facts Multiple Myeloma And Plasma Cell Dyscrasias
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Author : Karthik Ramasamy
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2017-01-09
Fast Facts Multiple Myeloma And Plasma Cell Dyscrasias written by Karthik Ramasamy and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-09 with Medical categories.
Our understanding of multiple myeloma (MM) is growing at a formidable pace, particularly in terms of risk factors and potential drug targets. Minimal residual disease (MRD) negativity is set to become the new benchmark in treatment, and cytogenetic analysis is now paving the way for personalized therapies. This second edition of 'Fast Facts: Multiple Myeloma and Plasma Cell Dyscrasias' includes: - the new IMWG SLiM CRAB criteria - the latest advances in diagnostic tests and imaging - cytogenetics and genetic profiling - induction therapy prior to SCT - new lenalidomide- and bortezomib-based regimens - second-generation proteasome inhibitors, histone deacetylase inhibitors and monoclonal antibodies treatments. This Fast Facts handbook provides a comprehensive overview of MM and other plasma cell dyscrasias, from bench to bedside, presenting the pathogenesis, diagnosis and treatment in the context of daily clinical practice. Contents: • Epidemiology and etiology Predisposing conditions associated with MM • Pathophysiology of MM and MGUS • Diagnosis, staging and monitoring of multiple myeloma • Genetics and multiple myeloma • Treatment of newly diagnosed multiple myeloma • Stem cell transplantation in multiple myeloma • Relapsed and refractory multiple myeloma • Bone disease and renal complications • AL amyloidosis • Rare plasma cell dyscrasias • Supportive care
Advances In Biology And Therapy Of Multiple Myeloma
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Author : Nikhil C. Munshi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-11-15
Advances In Biology And Therapy Of Multiple Myeloma written by Nikhil C. Munshi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-11-15 with Medical categories.
Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Management Of Bone Disease And Kidney Failure In Multiple Myeloma
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Author : Elena Zamagni
language : en
Publisher: Springer Nature
Release Date : 2021-01-11
Management Of Bone Disease And Kidney Failure In Multiple Myeloma written by Elena Zamagni and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-11 with Medical categories.
This pocket guide provides a concise yet comprehensive overview of the two most prominent clinical features of multiple myeloma (MM), bone disease and renal failure. The first half of the text reviews critical aspects of bone disease in MM, including pathophysiology, the use of imaging modalities and drugs in treatment, and the role of orthopedic surgery. The latter half of the book reviews major components of kidney disease in MM, from pathophysiology to treatment. Written by experts in the field, Management of Bone Disease and Kidney Failure in Multiple Myeloma: A Pocket Guide is a valuable resource for clinicians and practitioners who manage patients afflicted with multiple myeloma.
Bortezomib In The Treatment Of Multiple Myeloma
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Author : Irene M. Ghobrial
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-10-20
Bortezomib In The Treatment Of Multiple Myeloma written by Irene M. Ghobrial and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-10-20 with Medical categories.
Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
Advances In Biology And Therapy Of Multiple Myeloma
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Author : Nikhil C. Munshi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-09
Advances In Biology And Therapy Of Multiple Myeloma written by Nikhil C. Munshi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-09 with Medical categories.
Despite the advances in conventional, novel agent and high dose chemotherapy multiple myeloma (MM) remains incurable. In order to overcome resistance to current therapies and improve patient outcome, novel biologically-based treatment approaches are being developed. Current translational research in MM focusing on the development of molecularly-based combination therapies has great promise to achieve high frequency and durable responses in the majority of patients. Two major advances are making this goal possible. First, recent advances in genomics and proteomics in MM have allowed for increased understanding of disease pathogenesis, identified novel therapeutic targets, allowed for molecular classification, and provided the scientific rationale for combining targeted therapies to increase tumor cell cytotoxicity and abrogate drug resistance. Second, there is now an increased understanding of how adhesion of MM cells in bone marrow (BM) further impacts gene expression in MM cells, as well as in BM stromal cells (BMSCs). As a result of these advances in oncogenomics on the one hand and increased understanding of the role of the BM in the pathogenesis of MM on the other, a new treatment paradigm targeting the tumor cell and its BM microenvironment to overcome drug resistance and improve patient outcome has now been developed. Thalidomide, lenalidomide, and Bortezomib are three agents which target the tumor cell in its microenvironment in both laboratory and animal models and which have rapidly translated from the bench to the bedside. Ongoing efforts are using oncogenomics and cell signaling studies to identify next generation of therapies in MM on the one hand, and to inform the design of combination trials on the other. This new paradigm for overcoming drug resistance and improving patient outcome in MM has great promise not only to change the natural history of MM, but also to serve as a model for targeted therapeutics directed to improve outcome of patients with MM.
Multiple Myeloma
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Author : Steve Holt
language : en
Publisher: Nova Science Publishers
Release Date : 2014-09
Multiple Myeloma written by Steve Holt and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09 with Multiple myeloma categories.
Multiple myeloma (MM) is a haematological malignancy characterised by the clonal expansion of monoclonal immunoglobulin-secreting plasma cells in the bone marrow (BM). MM is associated with lytic bone lesions, anaemia, immunodeficiency, and renal impairment. Multiple myeloma accounts for over 10% of all hematologic malignancies and about 1% of all cancers. Multiple myeloma remains mostly incurable despite conventional intensive high dose chemotherapy followed by hematopoietic stem cell transplant. The costs associated with multiple myeloma are among the highest. This book discusses the diagnosis of multiple myeloma along with the risk factors involved and the treatments available.