Multiple Sclerosis And Pregnancy
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Multiple Sclerosis And Pregnancy
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Author : June R. Wyman
language : en
Publisher:
Release Date : 1987
Multiple Sclerosis And Pregnancy written by June R. Wyman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Multiple sclerosis categories.
Multiple Sclerosis And Having A Baby
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Author : Judy Graham
language : en
Publisher: Simon and Schuster
Release Date : 1999-06-01
Multiple Sclerosis And Having A Baby written by Judy Graham and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-06-01 with Health & Fitness categories.
An essential resource for anyone with MS who is considering having a child. • Firsthand advice from a woman with multiple sclerosis who has successfully borne and raised a child. • Contains information that can change the lives of many of the 250,000 women in the United States suffering from MS. • Highly readable format puts the facts at your fingertips. Diagnosed with MS at twenty-eight, author Judy Graham gave birth for the first time at the age of thirty-eight. Her new book Multiple Sclerosis and Having a Baby provides other women who are considering starting a family with the kind of genuine and useful insight that comes only from firsthand experience. Multiple Sclerosis and Having a Baby makes available not only the medical answers prospective parents need, but also the practical suggestions and sound advice that will help them meet the many unique and sometimes difficult challenges that face couples living with MS. In this highly informative and readable book, Graham asks and provides answers for nearly every question a woman with multiple sclerosis might want to consider before having a baby. With the latest medical facts and valuable data culled from hundreds of interviews with women who have multiple sclerosis and are currently raising a child, Graham straightforwardly addresses such issues as the possibility of relapse, genetic predisposition to MS, sexuality and fertility, pregnancy, postnatal care, and breastfeeding as they relate to women with MS.
Multiple Sclerosis And Pregnancy
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Author : June R. Wyman
language : en
Publisher:
Release Date : 1987
Multiple Sclerosis And Pregnancy written by June R. Wyman and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Multiple sclerosis categories.
Effects Of Pregnancy And Hormones On T Cell Immune Regulation In Multiple Sclerosis
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Author : Sandra Hellberg
language : en
Publisher: Linköping University Electronic Press
Release Date : 2019-10-22
Effects Of Pregnancy And Hormones On T Cell Immune Regulation In Multiple Sclerosis written by Sandra Hellberg and has been published by Linköping University Electronic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-22 with categories.
Multiple sclerosis (MS) is characterized by a dysregulated immune system leading to chronic inflammation in the central nervous system. Despite increasing number of treatments, many patients continue to deteriorate. A better understanding of the underlying disease mechanisms involved in driving disease is a pre-requisite for finding new biomarkers and new treatment targets. The improvement of MS during pregnancy, comparable to the beneficial effects of the most effective treatment, suggests that the transient and physiological immune tolerance established during pregnancy could serve as a model for successful immune regulation. Most likely the immune-endocrine alterations that take place during pregnancy to accommodate the presence of the semi-allogenic fetus contribute to the observed disease improvement. The aim of this thesis was to characterize the dysregulated immune system in MS and define potential factors and mechanisms established during pregnancy that could be involved in the pregnancy-induced effects in MS, focusing on CD4+ T cells as one of the main drivers in immunity and in the MS pathogenesis. Using a network-based modular approach based on gene expression profiling, we could show that CD4+ T cells from patients with MS displayed an altered dynamic gene response to activation, in line with a dysregulated immune system in MS. The resulting gene module disclosed cell activation and chemotaxis as central components in the deviating response, results that form a basis for further studies on its modulation during pregnancy. Moreover, a combination of secreted proteins (OPN+CXCL1-3+CXCL10-CCL2), identified from the module, could be used to separate patients and controls, predict disease activity after 2 years and discriminate between high and low responders to treatment, highlighting their potential use as biomarkers for predicting disease activity and response to treatment. The pregnancy hormone progesterone (P4), a potential factor involved in the pregnancy-induced amelioration of MS, was found to significantly dampen CD4+ T cell activation. Further detailed transcriptomic profiling revealed that P4 almost exclusively down-regulated immune-related pathways in activated T cells, several related to or downstream of T cell activation such as JAKSTAT signaling, T cell receptor signaling and cytokine-cytokine receptor interaction. In particular, P4 significantly affected genes of relevance to diseases known to be modulated during pregnancy, where genes associated to MS were most significantly affected, supporting a role for P4 in the pregnancy-induced immunomodulation. By using another approach, the role of thymus in T cell regulation during pregnancy was assessed. Two established measures of thymic output, CD31 expression and TREC content, were used and showed that thymic output of T cells is maintained during human pregnancy, or even possibly increased in terms of regulatory T cells. This thesis further supports a pivotal role for CD4+ T cells and T cell activation in the MS pathogenesis and adds to the knowledge of how they could be involved in driving disease. We identified a novel strategy for capturing central aspects of the deviating response to T cell activation that could be translated into potentially clinically relevant biomarkers. Further, P4 is emerging as a promising candidate for the pregnancy-induced immunomodulation that could be of importance as a future treatment option. Lastly, maintained thymic output of T cells during human pregnancy challenges the rodent-based dogma of an inactive thymus during pregnancy. Thymic dysfunction has been reported not only in MS but also in rheumatoid arthritis, another inflammatory disease that improves during pregnancy, which highlights a potential role for thymus in immune regulation that could be involved in the pregnancy-induced amelioration.
Deciding On Motherhood
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Author : Multiple Sclerosis Limited
language : en
Publisher:
Release Date : 2011
Deciding On Motherhood written by Multiple Sclerosis Limited and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Motherhood categories.
Health Issues In Women With Multiple Sclerosis
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Author : Maria K. Houtchens
language : en
Publisher: Springer
Release Date : 2017-03-15
Health Issues In Women With Multiple Sclerosis written by Maria K. Houtchens and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-15 with Medical categories.
This book addresses specific concerns of females affected by multiple sclerosis, where women are disproportionally impacted by the disease. MS is an autoimmune disease of the central nervous system affecting young adults of reproductive age. This book presents the current understanding of genetic variables, hormonal influences, immunological milieu and neurological outcomes, discussing issues such as fertility, pregnancy management, and menopause, as well as end of life care and mortality in women with MS. With contributions by international experts, this interdisciplinary book will serve as a useful reference and guide for MS specialists, general neurologists, obstetricians/gynecologists, physicians in training, family practice doctors, clinical nurse specialists in multiple sclerosis, and all other healthcare professionals involved in the care and treatment of women affected by MS.
Fast Facts Multiple Sclerosis
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Author : Mary Rensel
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2016-08-29
Fast Facts Multiple Sclerosis written by Mary Rensel and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-29 with Medical categories.
Since the last edition of this book, 'no evidence of disease activity' (NEDA) has been proposed as a new treatment target, early data on the first pharmacological treatments for progressive MS have emerged, and the first remyelination trial has shown positive effects on nerve repair. It is with this sense of optimism that the authors of 'Fast Facts: Multiple Sclerosis' have detailed the latest developments for use in clinical practice by all members of the multidisciplinary team, including: • a concise overview of investigations and modern diagnostic criteria • a holistic approach to all signs and symptoms, and proactive relapse management • the latest disease-modifying drugs, including when to treat, choice of drug and risk versus benefit. With case histories that will help to guide treatment decisions, discussion of the special considerations for MS during pregnancy, and in children and the elderly, and a detailed outline of emerging therapies, this book will benefit all healthcare professionals involved in the care of patients with this complex disease.
Mechanisms Of Pregnancy Induced Tolerance In An Animal Model Of Multiple Sclerosis
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Author : Jan Broder Engler
language : en
Publisher:
Release Date : 2014
Mechanisms Of Pregnancy Induced Tolerance In An Animal Model Of Multiple Sclerosis written by Jan Broder Engler and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Multiple Sclerosis Pregnancy And Parenthood
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Author : Judy Graham
language : en
Publisher:
Release Date : 1996
Multiple Sclerosis Pregnancy And Parenthood written by Judy Graham and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996 with Motherhood categories.
Infertility And Impaired Fecundity In The United States 1982 2010
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Author : Anjani Chandra
language : en
Publisher:
Release Date : 2013
Infertility And Impaired Fecundity In The United States 1982 2010 written by Anjani Chandra and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013 with Fertility, Human categories.