Multiple Sclerosis Bench To Bedside

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Multiple Sclerosis Bench To Bedside

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Author : Alexzander A. A. Asea
language : en
Publisher: Springer
Release Date : 2017-01-16

Multiple Sclerosis Bench To Bedside written by Alexzander A. A. Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-16 with Medical categories.

Multiple Sclerosis (MS) is one of the main causes of disability in young adult population. The estimated burden of the disease worldwide is about three million people. The pathogenic mechanism of MS involves both auto immune and degenerative processes. These two mechanisms are thought to determine a combination of events leading to several clinical pattern of disease onset and course. Multiple Sclerosis: Bench to Bedside provides the most up-to-date and concise reviews on the critical issues of multiple sclerosis from around the world. This book is written by leaders and experts in the field of multiple sclerosis research and is divided into easy to read sections. Section I focuses on basic science aspects of Multiple Sclerosis, including potential biomarkers, molecular biology, heat shock proteins, oxidative stress, genetic and epigenetics. Section II focuses on clinical and epidemiological aspects of Multiple Sclerosis, including remyelination therapy, neuroplasticity-based technologies and interventions. This is an important reference book and a must-read for Postgraduate Medical Scholars, Basic Science Researchers and Neurologists in Clinical Practice.

Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients

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Author : Paulus Stefan Rommer
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-13

Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients written by Paulus Stefan Rommer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-13 with categories.

Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients

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Author : Paulus Stefan Rommer
language : en
Publisher:
Release Date : 2020

Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients written by Paulus Stefan Rommer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.

Research and advances in the treatment of Multiple Sclerosis (MS) is a story of growing success. Great progress has been made in identifying the molecular mechanisms that can be utilized to develop highly efficacious treatments for MS patients. Since the middle of the last century, when studies using an inflammatory autoimmune model of MS i.e. experimental autoimmune encephalitis (EAE) were initiated, research on MS has since led to an enormous growth of knowledge. The limitations arising from these animal models have been partially compensated by insights generated from histopathological, immunological, genetic, imaging and clinical studies of MS. The importance of T cells and, recently of B cells, in MS has been elucidated and the significance of CNS resident cells, particularly in the progressive course of MS has been highlighted. The importance of environmental factors and genetic predisposition have also been recognized and the interaction between th e individual and its environment seems to play key roles in the pathogenesis of this disease. However, definite causative agent(s) or single gene(s) involved in MS still remain unidentified. A deeper understanding of the immunological pathways involved goes hand in hand with further improving therapy for MS. Focal inflammation in MS, caused by de novo CNS infiltration, can be prevented effectively using peripherally-acting drugs. However, diffuse CNS intrinsic inflammation and neurodegeneration are not targeted by the current arsenal of therapeutics and patients with progressive disease courses remain difficult to treat. Generating insights into pathophysiological processes and the clinical translation of this knowledge have been a formula of success for treating inflammatory diseases. The future will show whether this will hold true for CNS-trapped inflammation and neurodegeneration and whether the ultimate goal - truly curing MS - will be possible.

Translational Neuroimmunology Volume 8

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Author : Nima Rezaei
language : en
Publisher: Elsevier
Release Date : 2023-06-16

Translational Neuroimmunology Volume 8 written by Nima Rezaei and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-06-16 with Medical categories.

Translational Neuroimmunology: Multiple Sclerosis provides an update on bench to bedside studies on Multiple Sclerosis as an autoimmune disease. Divided into twelve chapters, the book begins with an in-depth introduction to the neuroimmunology and immunopathology of multiple sclerosis. Sections also provide content on genetics and epigenetics, the microbiome, diagnosis, and treatment of multiple sclerosis. Finally, various precision treatments are covered. All information is presented in an accessible, practical format, making this volume a valuable resource for immunologists, neurologists and researchers in translational biomedical research. Provides an introduction on multiple sclerosis as an autoimmune disease, from bench to bedside Encourages the development of immunologic approaches to analyze the interaction and specific properties of nervous tissue elements during development and disease Focuses on understanding and therapeutically manipulating immunological responses to injury, degeneration and autoimmunity in the central nervous system Shows the changes in relevant immune and inflammatory reactions at the cellular and molecular level during the development of nervous system diseases

Neuroinflammation From Bench To Bedside

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Author : H. Kettenmann
language : en
Publisher: Springer
Release Date : 2012-12-25

Neuroinflammation From Bench To Bedside written by H. Kettenmann and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-25 with Medical categories.

Inflammatory processes have been implicated in the pathophysiology of a variety of neurodegenerative diseases such as Alzheimer's disease, stroke and mUltiple sclerosis. It is now widely accepted that the brain, considered to be an "immunologically privileged" organ, can exhibit immune and autoimmune responses, and it is these responses that may in fact be responsible for many neural pathologies. The participants of the workshop VI Preface Research over the past decade has demonstrated the pivotal role of the microglia in the neuroinflammatory process, and more recent work in the field of chemokines has firmly established their important role in the pathogenesis of inflammatory disease states. Inevitably with the wealth of research being conducted in the field of neuroinflammation comes the hope of identifying novel targets for therapeutic intervention in the inflammatory process which may im pact on neurodegenerative diseases. The meeting "Neuroinflammation - From Bench to Bedside" aimed to cover the whole spectrum of research currently being pursued in this exciting field, literally taking the participants from the bench - study ing the importance of the microglia in the inflammatory process and the involvement, in particular, of the rapidly expanding chemokine family in the pathophysiology of neurodegenerative diseases - to the bedside - and the possibilities for novel treatment of disorders as di verse as multiple sclerosis, Alzheimer's disease, stroke and variant Creutzfeldt-Jakob disease (vCJD).

Burger S Medicinal Chemistry Drug Discovery And Development 8 Volume Set

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Author :
language : en
Publisher: John Wiley & Sons
Release Date : 2021-04-20

Burger S Medicinal Chemistry Drug Discovery And Development 8 Volume Set written by and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-20 with Science categories.

Burger’s Medicinal Chemistry, Drug Discovery and Development Explore the freshly updated flagship reference for medicinal chemists and pharmaceutical professionals The newly revised eighth edition of the eight-volume Burger’s Medicinal Chemistry, Drug Discovery and Development is the latest installment in this celebrated series covering the entirety of the drug development and discovery process. With the addition of expert editors in each subject area, this eight-volume set adds 35 chapters to the extensive existing chapters. New additions include analyses of opioid addiction treatments, antibody and gene therapy for cancer, blood-brain barrier, HIV treatments, and industrial-academic collaboration structures. Along with the incorporation of practical material on drug hunting, the set features sections on drug discovery, drug development, cardiovascular diseases, metabolic diseases, immunology, cancer, anti-Infectives, and CNS disorders. The text continues the legacy of previous volumes in the series by providing recognized, renowned, authoritative, and comprehensive information in the area of drug discovery and development while adding cutting-edge new material on issues like the use of artificial intelligence in medicinal chemistry. Included: Volume 1: Methods in Drug Discovery, edited by Kent D. Stewart Volume 2: Discovering Lead Molecules, edited by Kent D. Stewart Volume 3: Drug Development, edited by Ramnarayan S. Randad and Michael Myers Volume 4: Cardiovascular, Endocrine, and Metabolic Diseases, edited by Scott D. Edmondson Volume 5: Pulmonary, Bone, Immunology, Vitamins, and Autocoid Therapeutic Agents, edited by Bryan H. Norman Volume 6: Cancer, edited by Barry Gold and Donna M. Huryn Volume 7: Anti-Infectives, edited by Roland E. Dolle Volume 8: CNS Disorders, edited by Richard A. Glennon Perfect for research departments in the pharmaceutical and biotechnology industries, Burger’s Medicinal Chemistry, Drug Discovery and Development can be used by graduate students seeking a one-stop reference for drug development and discovery and deserves its place in the libraries of biomedical research institutes, medical, pharmaceutical, and veterinary schools.

Conditions In Occupational Therapy

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Author : Ben Atchison
language : en
Publisher: Lippincott Williams & Wilkins
Release Date : 2023-04-03

Conditions In Occupational Therapy written by Ben Atchison and has been published by Lippincott Williams & Wilkins this book supported file pdf, txt, epub, kindle and other format this book has been release on 2023-04-03 with Medical categories.

This updated 6th Edition is fully aligned with the most current DSM-5 and Occupational Therapy Practice Framework, 4th Edition, and adds new chapters reflecting recent advances in the management of infectious diseases, general deconditioning, musculoskeletal pain, amputations, and sickle cell anemia. Each chapter follows a consistent format, presenting an opening case followed by descriptions and definitions, etiology, incidence and prevalence, signs and symptoms, diagnosis, course and prognosis, medical/surgical management, impact on occupational performance, and two case illustrations. Rounded out with robust instructor resources and new full-color imagery, this bestselling resource is an essential tool for today’s occupational therapy and occupational therapy assistant students.

There S No Pill For This

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Author : Michaël Friedman
language : en
Publisher: Chelsea Green Publishing
Release Date : 2020-11-06

There S No Pill For This written by Michaël Friedman and has been published by Chelsea Green Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-06 with Health & Fitness categories.

"I truly recommend There’s No Pill for This because it contains the wisdom of a health care professional who also has the experience of being a patient."—Bernie Siegel, MD, author of No Endings, Only Beginnings and Love, Medicine & Miracles From a doctor living with MS: how to radically improve your quality of life with diet, hormones, supplements, exercise, and other lifestyle adjustments Most of us take for granted the little things in life—like walking out to the mailbox, socializing with friends, or enjoying a mug of hot coffee. But what if each daily activity required intensive planning and effort? That’s what living with multiple sclerosis is like, and author Michaël Friedman knows this from first-hand experience. Since his diagnosis of multiple sclerosis a decade ago, Dr. Friedman has been searching for a cure for the disease. After years of research, he realized that he had some of the answers right in his naturopathic medicine toolbox, and others, surprisingly, lay in the realm of conventional medicine. There’s No Pill for This tells his story and offers treatment advice and hope to those who suffer from MS. He does not promise a miracle cure but instead provides the personal prescriptions he follows that are delaying the disease process and radically improving his quality of life, including dietary measures and supplements to support a healthy microbiome and hormone therapies that can reduce neuroinflammation and possibly promote neurorestoration. Dr. Friedman presents a daily protocol for MS patients, including diet, supplement, detoxification, and hormone strategies; mindfulness therapy; physical therapy; and a wide range of beneficial lifestyle adjustments related to exercise, sleep routines, time management, stress management, and more. He also offers special advice for supporting healthy bladder and bowel function and improving oxygen supply. In the book’s conclusion, Dr. Friedman reflects on what this complicated chronic disease has taught him, and continues to teach him, about the value of humility and about what is truly important in life.

Role Of Oxidative Stress In Chronic Diseases

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Author : Isaias Dichi
language : en
Publisher: CRC Press
Release Date : 2014-03-14

Role Of Oxidative Stress In Chronic Diseases written by Isaias Dichi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-03-14 with Medical categories.

This book presents recent findings on the role of oxidative stress in chronic diseases. Understanding the mechanisms behind it enables readers to comprehend the rationale which underlies intervention in such conditions. The book places special emphasis on genetic polymorphism-an important issue related to this field of study. It covers the role of

Hematopoietic Stem Cell Transplantation For Neurologic Diseases

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Author :
language : en
Publisher: Elsevier
Release Date : 2024-08-05

Hematopoietic Stem Cell Transplantation For Neurologic Diseases written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-08-05 with Medical categories.

Intense immunosuppression followed by Hematopoietic Stem Cell Transplantation for Neurological Diseases (HSCT) has been evaluated as a possible therapeutic tool in severe autoimmune diseases for the last 20 years. In the neurological field, HSCT has been widely investigated for the treatment of multiple sclerosis and evidence is accumulating about its potential use in neuromyelitis optica, stiff person syndrome, myasthenia gravis and many immune neuropathies. This volume summarizes that research. Besides their strong clinical relevance, studies on HSCT in neurological diseases have contributed to mew insights on the pathological mechanisms underlying CNS autoimmunity. Reviews immunological mechanisms of HSCT and CNS autoimmunity Identifies neurological diseases showing treatment efficacy with HSCT Includes MS, myasthenia gravis, neuromyelitis optica, and more Covers early and late side effects of HSCT