Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients
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Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients
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Author : Paulus Stefan Rommer
language : en
Publisher: Frontiers Media SA
Release Date : 2020-03-13
Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients written by Paulus Stefan Rommer and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-03-13 with categories.
Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients
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Author : Paulus Stefan Rommer
language : en
Publisher:
Release Date : 2020
Multiple Sclerosis From Bench To Bedside Currents Insights Into Pathophysiological Concepts And Their Potential Impact On Patients written by Paulus Stefan Rommer and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020 with categories.
Research and advances in the treatment of Multiple Sclerosis (MS) is a story of growing success. Great progress has been made in identifying the molecular mechanisms that can be utilized to develop highly efficacious treatments for MS patients. Since the middle of the last century, when studies using an inflammatory autoimmune model of MS i.e. experimental autoimmune encephalitis (EAE) were initiated, research on MS has since led to an enormous growth of knowledge. The limitations arising from these animal models have been partially compensated by insights generated from histopathological, immunological, genetic, imaging and clinical studies of MS. The importance of T cells and, recently of B cells, in MS has been elucidated and the significance of CNS resident cells, particularly in the progressive course of MS has been highlighted. The importance of environmental factors and genetic predisposition have also been recognized and the interaction between th e individual and its environment seems to play key roles in the pathogenesis of this disease. However, definite causative agent(s) or single gene(s) involved in MS still remain unidentified. A deeper understanding of the immunological pathways involved goes hand in hand with further improving therapy for MS. Focal inflammation in MS, caused by de novo CNS infiltration, can be prevented effectively using peripherally-acting drugs. However, diffuse CNS intrinsic inflammation and neurodegeneration are not targeted by the current arsenal of therapeutics and patients with progressive disease courses remain difficult to treat. Generating insights into pathophysiological processes and the clinical translation of this knowledge have been a formula of success for treating inflammatory diseases. The future will show whether this will hold true for CNS-trapped inflammation and neurodegeneration and whether the ultimate goal - truly curing MS - will be possible.
Multiple Sclerosis Bench To Bedside
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Author : Alexzander A. A. Asea
language : en
Publisher: Springer
Release Date : 2017-01-16
Multiple Sclerosis Bench To Bedside written by Alexzander A. A. Asea and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-16 with Medical categories.
Multiple Sclerosis (MS) is one of the main causes of disability in young adult population. The estimated burden of the disease worldwide is about three million people. The pathogenic mechanism of MS involves both auto immune and degenerative processes. These two mechanisms are thought to determine a combination of events leading to several clinical pattern of disease onset and course. Multiple Sclerosis: Bench to Bedside provides the most up-to-date and concise reviews on the critical issues of multiple sclerosis from around the world. This book is written by leaders and experts in the field of multiple sclerosis research and is divided into easy to read sections. Section I focuses on basic science aspects of Multiple Sclerosis, including potential biomarkers, molecular biology, heat shock proteins, oxidative stress, genetic and epigenetics. Section II focuses on clinical and epidemiological aspects of Multiple Sclerosis, including remyelination therapy, neuroplasticity-based technologies and interventions. This is an important reference book and a must-read for Postgraduate Medical Scholars, Basic Science Researchers and Neurologists in Clinical Practice.
Porth
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Author : Carol Mattson Porth
language : en
Publisher:
Release Date : 2009
Porth written by Carol Mattson Porth and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
The Impact Of Active And Passive Smoking Upon Health And Neurocognitive Function
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Author : Thomas Heffernan
language : en
Publisher: Frontiers Media SA
Release Date : 2016-09-14
The Impact Of Active And Passive Smoking Upon Health And Neurocognitive Function written by Thomas Heffernan and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-09-14 with Medicine (General) categories.
Tobacco smoking is a major risk factor for a number of chronic diseases, including a variety of cancers, lung disease and damage to the cardiovascular system. The World Health Organization recently calculated that there were 6 million smoking-attributable deaths per year and that this number is due to rise to about eight million per year by the end of 2030. Recent work has demonstrated that habitual smoking in adults is not only associated with a range of health problems, but may also contribute to a number of neurocognitive deficits, including deficits in memory and attention. One area of growing concern is the health and neurocognitive consequences of exposure to second-hand smoke or “passive smoking” (where a non-smoker inhales another person’s smoke, mainly in the form of side-stream smoke). In terms of tackling smoking-related problems, there has been a rise in the amount and range of smoking cessation and interventions techniques, including the emergence of e-cigarettes as one of the most popular forms of nicotine replacement therapies. The present book comprises a collection of manuscripts discussing (1) the impact of active and passive smoking upon health and neurocognitive function, (2) smoking cessation techniques and interventions used to tackle smoking-related problems, and (3) a critical consideration of current issues surrounding the use of e-cigarettes as nicotine-replacement therapy. This collection of papers includes empirical, theoretical, and review papers. This Research Topic demonstrates the broad nature of research currently being undertaken in this field and should pave the way for future work.
The Fourth Industrial Revolution
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Author : Klaus Schwab
language : en
Publisher: Penguin UK
Release Date : 2017-01-03
The Fourth Industrial Revolution written by Klaus Schwab and has been published by Penguin UK this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-01-03 with Business & Economics categories.
The founder and executive chairman of the World Economic Forum on how the impending technological revolution will change our lives We are on the brink of the Fourth Industrial Revolution. And this one will be unlike any other in human history. Characterized by new technologies fusing the physical, digital and biological worlds, the Fourth Industrial Revolution will impact all disciplines, economies and industries - and it will do so at an unprecedented rate. World Economic Forum data predicts that by 2025 we will see: commercial use of nanomaterials 200 times stronger than steel and a million times thinner than human hair; the first transplant of a 3D-printed liver; 10% of all cars on US roads being driverless; and much more besides. In The Fourth Industrial Revolution, Schwab outlines the key technologies driving this revolution, discusses the major impacts on governments, businesses, civil society and individuals, and offers bold ideas for what can be done to shape a better future for all.
Principles Of Regenerative Medicine
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Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2010-12-16
Principles Of Regenerative Medicine written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-16 with Science categories.
Virtually any disease that results from malfunctioning, damaged, or failing tissues may be potentially cured through regenerative medicine therapies, by either regenerating the damaged tissues in vivo, or by growing the tissues and organs in vitro and implanting them into the patient. Principles of Regenerative Medicine discusses the latest advances in technology and medicine for replacing tissues and organs damaged by disease and of developing therapies for previously untreatable conditions, such as diabetes, heart disease, liver disease, and renal failure. Key for all researchers and instituions in Stem Cell Biology, Bioengineering, and Developmental Biology The first of its kind to offer an advanced understanding of the latest technologies in regenerative medicine New discoveries from leading researchers on restoration of diseased tissues and organs
Index Medicus
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Author :
language : en
Publisher:
Release Date : 2001
Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Medicine categories.
Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.
Uremic Toxins
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Author : Severin Ringoir
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Uremic Toxins written by Severin Ringoir and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The present book contains the Proceedings of a two day Symposium on Uremic Toxins organized at the University of Ghent in Belgium. A series of guest lectures, free communications and posters have been presented. An international audience of 163 scientists from 16 nationalities listened to and discussed extensively a spectrum of topics brought forward by colleagues and researchers who worked for many years in the field of Uremic Toxins. There is a striking contrast between all the new dialysis strategies available in the work to "clean" the uremic patients and the almost non-progression of our knowledge on uremic toxins in the past decade. In this sense the symposium was felt by all participants as a new start for the research in the biochemical field of the definition of uremia. If the present volume would stimulate new work in this field in order to define uremia, or identify the uremic toxins, the purpose of the organizers would be maximally fulfilled.
White Matter Diseases
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Author : Massimo Filippi
language : en
Publisher: Springer Nature
Release Date : 2020-02-13
White Matter Diseases written by Massimo Filippi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-13 with Medical categories.
This book provides cutting-edge information on the epidemiology, etiopathogenesis, clinical manifestations, diagnostic procedures and treatment approaches for the main white matter (WM) disorders of the central nervous system (CNS). WM lesions are associated with many neurological conditions, and with aging. The diagnostic work-up of neurological diseases characterized by the presence of these lesions has changed dramatically over the past few years. This is mainly due on the one hand to the discovery of specific pathogenetic factors in some of these conditions, and on the order to the optimized use of diagnostic tools. All of this has resulted in new diagnostic algorithms, and in the identification of new neurological conditions. The book offers neurologists essential guidance in the diagnosis and treatment of the most frequent WM conditions, promoting their correct and cost-saving diagnosis and management. By integrating neurological, laboratory and imaging concepts with the demands of accurate diagnosis, this reference guide provides a state-of-the-art overview of the current state of knowledge on these conditions, as well as practical guidelines for their diagnosis and treatment.