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Murine Homeobox Gene Control Of Embryonic Patterning And Organogenesis


Murine Homeobox Gene Control Of Embryonic Patterning And Organogenesis
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Murine Homeobox Gene Control Of Embryonic Patterning And Organogenesis


Murine Homeobox Gene Control Of Embryonic Patterning And Organogenesis
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Author : Thomas Lufkin
language : en
Publisher: Elsevier
Release Date : 2003-12-03

Murine Homeobox Gene Control Of Embryonic Patterning And Organogenesis written by Thomas Lufkin and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003-12-03 with Science categories.


The first homeobox gene was molecular cloned nearly two decades ago, and since that time tremendous progress has been made in our understanding of the distribution of homeobox genes in the genomes of many animal species and the common functional role the encoded homeodomains play in cell-type specification, morphogenesis and development.The amino acid sequence of the homeodomain, as well as the presence of other conserved protein domains, has allowed the classification of homeodomain-containing proteins (homeoproteins) into over thirty separate families (e.g. Hox, Dlx, Msx, Otx, Hmx, Cdx etc.). In many cases a single gene has been shown to fully direct the morphogenesis and development of a complex tissue, organ or even an entire body segment. Yet how this "master" regulatory ability of homeoproteins functions at the molecular level to a large degree still remains a mystery, in part owing to our limited understanding of the nature of both homeoprotein transcriptional cofactors and even more elusively, the downstream targets of homeoprotein function. In the reviews presented here it is limited primarily to what has been learned in vertebrate systems, principally focusing on the mouse, owing to the strengths of the technical approaches currently existing in murine developmental genetics that are not yet available to the same degree in other vertebrate species. Despite this mammalian predilection, a common thread to each of these reviews is the underlying importance of what has been learned about homeoprotein function in other animal species, particularly arthropods like Drosophila.



Mouse Development


Mouse Development
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Author : Janet Rossant
language : en
Publisher: Gulf Professional Publishing
Release Date : 2002-03-21

Mouse Development written by Janet Rossant and has been published by Gulf Professional Publishing this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-03-21 with Science categories.


This book represents a classic compilation of current knowledge about mouse development and its correlates to research in cell biology, molecular biology, genetics, and neuroscience. Emphasis is placed on the research strategy, experimental design, and critical analysis of the data, disguishing this from other books that only focus on protocols for mouse developmental research. Selected chapters are indexed to electronic databases such as GeneBank, GenBank, Electronic Mouse Atlas, and Transgenic/Knockout, further increasing the utility of this book as a reference.*Broad-based overview of mouse development from fundamental to specialist levels*Extensive coverage of a wide range of developmental mutations of the mouse*Excellent benchmark illustrations of brain, craniofacial, gut and heart development*In-depth experiment-based assessment of concepts in mammalian development*Focus on models of specific relevance to human development*Comprehensive reference to key literature and electronic databases related to mouse development*High-quality full-color production



Cell Lineage And Fate Determination


Cell Lineage And Fate Determination
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Author : Sally A. Moody
language : en
Publisher: Elsevier
Release Date : 1998-10-29

Cell Lineage And Fate Determination written by Sally A. Moody and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1998-10-29 with Science categories.


Cell Lineage and Fate Determination provides a comprehensive view of the mechanisms regulating cell lineage and fate determination in an effort to understand how the fertilized egg is transformed into a complex of specialized tissues. It presents basic information on eight different animal models and recent developmental biological research done in each model. The book provides a focused forum presenting key information for researchers studying various aspects of developmental and cellular biology. Extensive use of tables and black-and-white and color figures helps illustrate each model. The book concludes by discussing future goals for bringing cellular, molecular, and genetic research to clinical applications and tissue replacement therapies.Key Features* Presents eight different animal models* Provides a focused forum on cell fate determination that provides comprehensive and key information for researchers* Illustrates the transitional relationship between researchers and clinicians* Includes the extensive use of tables and color figures



Human Fetal Growth And Development


Human Fetal Growth And Development
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Author : Niranjan Bhattacharya
language : en
Publisher: Springer
Release Date : 2016-05-17

Human Fetal Growth And Development written by Niranjan Bhattacharya and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-05-17 with Health & Fitness categories.


This unique book delves into the mysteries of human fetal growth and maturation. Growing knowledge in genetics indicates that factors that impact on/influence fetal growth and maturation may have a role in determining a person’s health and disease in later years. Placental, maternal, environmental, nutrient as well as fetal genome factors each play a role in producing a healthy, unhealthy or abnormal baby. A study of fetal growth and maturation is therefore basic to the understanding of why fetal growth problems occur, what implications these can have for adult disease, and how clinical intervention can help to reverse growth problems. The present study will be comprehensive and will be a major contribution to the fields of gynecology, genetics, obstetrics, biochemistry, molecular biology and clinical medicine. It will include cutting edge research in the field as well as explorations on clinical interventions in fetal growth, which will not only add to existing knowledge but also prompt future research. The two Editors are distinguished in their fields and both have extensive clinical and research experience. They felt that they could use their expertise to create a book that will help students, practitioners, researchers and others to understand the subject of gestation, growth and maturation and its implications from a multi-dimensional point of view, which will help them develop their own expertise in a cutting-edge and developing field. They have brought toget her medical scientists, clinical practitioners, embryologists, endocrinologists, immunologists, gynecologists, obstetricians, reproductive and molecular biologists, geneticists and many others to create a state-of-the-art book on a subject with increasing demand for further knowledge. It aims to integrates different disciplines to give a holistic view of human fetal growth maturation.



Human Embryonic Stem Cells


Human Embryonic Stem Cells
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Author : Jon Odorico
language : en
Publisher: Garland Science
Release Date : 2004-02-01

Human Embryonic Stem Cells written by Jon Odorico and has been published by Garland Science this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-02-01 with Science categories.


Since the first successful isolation and cultivation of human embryonic stem cells at the University of Wisconsin, Madison in 1998, there has been high levels of both interest and controversy in this area of research. This book provides a concise overview of an exciting field, covering the characteristics of both human embryonic stem cells and pluripotent stem cells from other human cell lineages. The following chapters describe state-of-the-art differentiation and characterization of specific ectoderm, mesoderm and endoderm-derived lineages from human embryonic stem cells, emphasizing how these can be used to study human developmental mechanisms. A further chapter discusses genetic manipulation of human ES cells. The concluding section covers therapeutic applications of human ES cells, as well as addressing the ethical and legal issues that this research have raised.



Cumulated Index Medicus


Cumulated Index Medicus
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Author :
language : en
Publisher:
Release Date : 1994

Cumulated Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994 with Medicine categories.




Index Medicus


Index Medicus
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Author :
language : en
Publisher:
Release Date : 2004

Index Medicus written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medicine categories.


Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.



Principles Of Developmental Genetics


Principles Of Developmental Genetics
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Author : Sally A. Moody
language : en
Publisher: Academic Press
Release Date : 2014-09-02

Principles Of Developmental Genetics written by Sally A. Moody and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-09-02 with Science categories.


Providing expert coverage of all major events in early embryogenesis and the organogenesis of specific systems, and supplemented with representative clinical syndromes, Principles of Developmental Genetics, Second Edition discusses the processes of normal development in embryonic and prenatal animals, including humans. The new edition of this classic work supports clinical researchers developing future therapies with its all-new coverage of systems biology, stem cell biology, new technologies, and clinical disorders. A crystal-clear layout, exceptional full-color design, and bulleted summaries of major takeaways and clinical pathways assist comprehension and readability of the highly complex content. - All-new coverage of systems biology and stem cell biology in context of evolving technologies places the work squarely on the modern sciences - Chapters are complemented with a bulleted summary for easy digestion of the major points, with a clinical summary for therapeutic application - Clinical highlights provides a bridge between basic developmental biology and clinical sciences in embryonic and prenatal syndromes



Seldin And Giebisch S The Kidney


Seldin And Giebisch S The Kidney
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Author : Robert J. Alpern
language : en
Publisher: Academic Press
Release Date : 2012-12-31

Seldin And Giebisch S The Kidney written by Robert J. Alpern and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-31 with Science categories.


A classic nephrology reference for over 25years, Seldin and Giebisch's The Kidney, is the acknowledged authority on renal physiology and pathophysiology. In this 5th edition, such new and powerful disciplines as genetics and cell biology have been deployed to deepen and widen further the explanatory framework. Not only have previous chapters been extensively updated, but new chapters have been added to incorporate additional disciplines. Individual chapters, for example, now provide detailed treatment of the significance of cilia; the role of stem cells is now given special consideration. Finally, there has been a significant expansion of the section of pathophysiology, incorporating the newer findings of cell biology and genetics. If you research the development of normal renal function or the mechanisms underlying renal disease, Seldin and Giebisch's The Kidney is your number one source for information. - Offers the most comprehensive coverage on the market of fluid and electrolyte regulation and dysregulation in 85 completely revised chapters and 10 new chapters - Includes 4sections, 62 chapters, devoted to regulation and disorders of acid-base homeostasis, and epithelial and nonepithelial transport regulation - Includes foreword by Donald Seldin and Gerhard Giebisch, world renowned names in nephrology and editors of the previous three editions



Hypothalamic Pituitary Development


Hypothalamic Pituitary Development
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Author : Raphaël Rappaport
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 2001-01-01

Hypothalamic Pituitary Development written by Raphaël Rappaport and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-01 with Medical categories.


In recent years dramatic progress has been made in understanding the pathophysiology of pituitary diseases by a combination of experimental studies, molecular genetics and clinical research. This book presents an updated overview of normal and pathological hypothalamic-pituitary development. Several chapters include experimental data and describe brain and facial defects associated with various conditions of pituitary insufficiency. A major part is devoted to the still increasing number of molecular and genetic defects which are responsible for various clinical presentations of pituitary insufficiency: diseases due to genetic defects of growth hormone, TSH, gonadotropins and corticotropin secretion are extensively described. These diseases present as metabolic (diabetes insipidus and adrenal insufficiency), growth and reproductive (including puberty) disorders. A distinct chapter emphasizes the contribution of a multidisciplinary comprehensive approach including the most recent molecular and genetic tools. Finally in most chapters an effort was made to address phenotypic and genotypic presentations in affected patients including valuable information provided by magnetic resonance imaging of the pituitary and brain. This book will help endocrinologists and paediatricians by providing unique models of genetic and developmental defects of the pituitary region which bear ultimate consequences on metabolic control, growth and reproduction.