Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy
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Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy
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Author : Gilda Shayan
language : en
Publisher:
Release Date : 2010
Murine In Vitro Model Of The Blood Brain Barrier Using A Nanofabricated Poly Hydroxy Styrene Membrane And Identification Of Therapeutic Biomarkers Of Alzheimer S Disease In Relation To Intravenous Immunoglobulin Therapy written by Gilda Shayan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Currently, there are over 5.3 million people in the United States diagnosed with Alzheimer's disease, with the disease being the sixth leading cause of death in the country. Current drugs on the market for the treatment of Alzheimer's disease are lipophilic small molecules that cross the blood-brain barrier by passive diffusion and none have been clinically useful in reversing the symptoms of the disease. Immunotherapy with intravenous immunoglobulin (IVIg) is one of several treatment strategies now being studied as part of efforts to discover safe and more effective treatment paradigms for Alzheimer's disease. In 2005, Weill Cornell Medical College initiated the phase I clinical trial of IVIg for the treatment of Alzheimer's disease, and the clinical outcomes indicated improvements in the cognitive abilities of subjects beyond expectations. This dissertation will address combining proteomics and statistical approaches with novel designs for in vitro blood-brain barrier models with an attempt to understand the molecular basis for the disease-modifying effects of IVIg in Alzheimer's disease. The first part of the thesis focuses on the development of a new in vitro model of the blood-brain barrier based on a co-culture between primary mouse brain microvascular endothelial cells and primary rat astrocytes on commercially available polyester membranes and nanofabricated poly(hydroxyl styrene) membranes. This model serves as a successful platform technology for evaluating molecular transport across the blood-brain barrier. The permeability of central nervous system drugs across this in vitro model correlated well with in vivo data, with the correlation coefficient being 0.98. The second part of this thesis provides examples of proteomics approaches coupled with advanced statistical modeling that can be utilized to identify therapy induced biomarkers in the cerebrospinal fluid. Specifically, cerebrospinal fluid samples from Alzheimer's subjects who underwent IVIg immunotherapy were analyzed using gel-based proteomics and the results were analyzed using a statistical model to identify 25 therapeutically relevant biomarkers in response to IVIg. These proteins have been previously implicated in Alzheimer's disease and the changes in their concentration is consistent with previous reports regarding the expression of them in the brain of Alzheimer's subjects compared to normal individuals.
Nanobiotechnology In Diagnosis Drug Delivery And Treatment
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Author : Mahendra Rai
language : en
Publisher: John Wiley & Sons
Release Date : 2020-11-17
Nanobiotechnology In Diagnosis Drug Delivery And Treatment written by Mahendra Rai and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-17 with Science categories.
Presents nanobiotechnology in drug delivery and disease management Featuring contributions from noted experts in the field, this book highlights recent advances in the nano-based drug delivery systems. It also covers the diagnosis and role of various nanomaterials in the management of infectious diseases and non-infectious disorders, such as cancers and other malignancies and their role in future medicine. Nanobiotechnology in Diagnosis, Drug Delivery and Treatment starts by introducing how nanotechnology has revolutionized drug delivery, diagnosis, and treatments of diseases. It then focuses on the role of various nanocomposites in diagnosis, drug delivery, and treatment of diseases like cancer, Alzheimer's disease, diabetes, and many others. Next, it discusses the application of a variety of nanomaterials in the diagnosis and management of gastrointestinal tract disorders. The book explains the concept of nanotheranostics in detail and its role in effective monitoring of drug response, targeted drug delivery, enhanced drug accumulation in the target tissues, sustained as well as triggered release of drugs, and reduction in adverse effects. Other chapters cover aptamer-incorporated nanoparticle systems; magnetic nanoparticles; theranostics and vaccines; toxicological concerns of nanomaterials used in nanomedicine; and more. Provides a concise overview of state-of-the-art nanomaterials and their application like drug delivery in infectious diseases and non-infectious disorders Highlights recent advances in the nano-based drug delivery systems and role of various nanomaterials Introduces nano-based sensors which detect various pathogens Covers the use of nanodevices in diagnostics and theranostics Nanobiotechnology in Diagnosis, Drug Delivery and Treatment is an ideal book for researchers and scientists working in various disciplines such as microbiology, biotechnology, nanotechnology, pharmaceutical biotechnology, pharmacology, pharmaceutics, and nanomedicine.
Biomimicked Biomaterials
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Author : Heung Jae Chun
language : en
Publisher: Springer Nature
Release Date : 2020-06-29
Biomimicked Biomaterials written by Heung Jae Chun and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-29 with Medical categories.
This book is the second of two volumes that together offer a comprehensive account of cutting-edge advances in the development of biomaterials for use within tissue engineering and regenerative medicine. In this volume, which is devoted to biomimetic biomaterials, the opening section discusses bone regeneration by means of duck’s feet-derived collagen scaffold and the use of decellularized extracellular matrices. The role of various novel biomimetic hydrogels in regenerative medicine is then considered in detail. The third section focuses on the control of stem cell fate by biomimetic biomaterials, covering exosome-integrated biomaterials for bone regeneration, cellular responses to materials for biomedical engineering, and the regulation of stem cell functions by micropatterned structures. Finally, the use of nano-intelligent biocomposites in regenerative medicine is addressed, with discussion of, for example, recent advances in biphasic calcium phosphate bioceramics and blood-contacting polymeric biomaterials. The authors are recognized experts in the interdisciplinary field of regenerative medicine and the book will be of value for all with an interest in regenerative medicine based on biomaterials.
Biobased Nanotechnology For Green Applications
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Author : Hemen Sarma
language : en
Publisher: Springer Nature
Release Date : 2021-05-02
Biobased Nanotechnology For Green Applications written by Hemen Sarma and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-05-02 with Technology & Engineering categories.
Investigation on biobased nanomaterials has provided new insights into the rapidly advancing fields of the biomedical and environmental sciences by showing how these nanomaterials are effective in biomedicine and environmental remediation. These particles hold tremendous prospective applications, and are likely to become the next generation of particles in these areas. As such, research is ongoing and the data generated should have the potential for a sustainable future in both the environmental and biomedical fields. This book presents important findings on the role of and identification of novel applications of biobased nanomaterials. Unlike other books in this field, this book focuses entirely on sustainable application and remediation in biomedicine and environmental science. The chapters are written in such a way as to make them accessible to the reader, and furthermore, the volume can be readily adopted as a reference, or used as a guide for further research. This project was based on recent research (the last 5 years) and developed through an extensive literature search. The editors have also compiled some advanced, outstanding texts that should be of benefit to graduate students in their research.
Nanobiotechnology
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Author : Oded Shoseyov
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-02-07
Nanobiotechnology written by Oded Shoseyov and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-02-07 with Science categories.
NanoBiotechnology is a groundbreaking text investigating the recent advances and future direction of nanobiotechnology. It will assist scientists and students in learning the fundamentals and cutting-edge nature of this new and emerging science. Focusing on materials and building blocks for nanotechnology, leading scientists from around the world share their knowledge and expertise in this authoritative volume.
Nanopharmaceuticals Principles And Applications Vol 1
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Author : Vinod Kumar Yata
language : en
Publisher: Springer Nature
Release Date : 2020-07-14
Nanopharmaceuticals Principles And Applications Vol 1 written by Vinod Kumar Yata and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-14 with Technology & Engineering categories.
This book discusses the biological, technical and study-design challenges of Nanopharmaceuticals. Chapters of this book are dedicated to supermagentic iron oxide nanoparticles for the diagnosis of brain, breast, gastric, ovarian, liver, colorectal, lung and pancreatic cancers. It also includes a brief introduction to magnetic resonance imaging and ends with the future prospective of iron oxide nanoparticles in cancer detection. The book also provides a critical discussion on ‘Computational sequence design for DNA nanostructures’ and gives a brief introduction about the skin delivery. A detailed discussion has been included about the different types of nanocarriers such as micells, microemulsions, nanoemulsions, polymeric and lipid based nanoparticles. Focussing on the safety concerns of nanomedicine it also covers the safety issues, clinical benefits, ecotoxicity and regulatory frame work of nanopharmaceuticals.
Metal Enhanced Fluorescence
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Author : Chris D. Geddes
language : en
Publisher: John Wiley & Sons
Release Date : 2010-06-22
Metal Enhanced Fluorescence written by Chris D. Geddes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Science categories.
Discover how metal-enhanced fluorescence is changing traditional concepts of fluorescence This book collects and analyzes all the current trends, opinions, and emerging hot topics in the field of metal-enhanced fluorescence (MEF). Readers learn how this emerging technology enhances the utility of current fluorescence-based approaches. For example, MEF can be used to better detect and track specific molecules that may be present in very low quantities in either clinical samples or biological systems. Author Chris Geddes, a noted pioneer in the field, not only explains the fundamentals of metal-enhanced fluorescence, but also the significance of all the most recent findings and models in the field. Metal-enhanced fluorescence refers to the use of metal colloids and nanoscale metallic particles in fluorescence systems. It offers researchers the opportunity to modify the basic properties of fluorophores in both near- and far-field fluorescence formats. Benefits of metal-enhanced fluorescence compared to traditional fluorescence include: Increased efficiency of fluorescence emission Increased detection sensitivity Protect against fluorophore photobleaching Applicability to almost any molecule, including both intrinsic and extrinsic chromophores Following a discussion of the principles and fundamentals, the author examines the process and applications of metal-enhanced fluorescence. Throughout the book, references lead to the primary literature, facilitating in-depth investigations into particular topics. Guiding readers from the basics to state-of-the-technology applications, this book is recommended for all chemists, physicists, and biomedical engineers working in the field of fluorescence.
Nanotheranostics
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Author : Mahendra Rai
language : en
Publisher: Springer Nature
Release Date : 2019-11-22
Nanotheranostics written by Mahendra Rai and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-22 with Medical categories.
This book is specifically designed to provide information about various nanocarriers currently developed under the emerging field of nanotheranostics for a sustained, controlled, and targeted co-delivery of diagnostic and therapeutic agents. Diverse theranostic applications of nanotechnology and their limitations are also addressed. It integrates nanobiotechnology with theranostic applications. The combined term nanotheranostics has diverse application particularly in chemotherapy and other infectious diseases.Among other topics addressed are antimicrobial resistance, targeting intra-cellular pathogens, viruses and bacteria, chemotherapy, cancer therapeutics, and inflammatory disorders. This interdisciplinary volume is essential for a diverse group of readers including nanotechnologists, microbiologists, biotechnologists, bioengineering and bioprocess industry.
Sensors In Water Pollutants Monitoring Role Of Material
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Author : D. Pooja
language : en
Publisher: Springer Nature
Release Date : 2019-10-24
Sensors In Water Pollutants Monitoring Role Of Material written by D. Pooja and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-10-24 with Technology & Engineering categories.
This book discusses the sensitivity, selectivity, and response times of different sensor materials and their potential application in the design of portable sensor systems for monitoring water pollutants and remediation systems. Beginning with an overview on water pollutants and analytical methods for their detection, the book then moves on to describing the advances in sensor materials research, and the scope for their use in different types of sensors. The book lays emphasis on techniques such as colorimetric, fluorescence, electrochemical, and biological sensing of conventional and emerging pollutants. This book will serve as a handy guide for students, researchers, and professional engineers working in the field of sensor systems for monitoring water pollutants to address various challenges.
Dendritic Molecules
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Author : George R. Newkome
language : de
Publisher: John Wiley & Sons
Release Date : 2008-07-11
Dendritic Molecules written by George R. Newkome and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-07-11 with Science categories.
The first book on dendrimers! The authors, pioneers in this scientific field, describe basic principles and current developments in the rapidly evolving field of dendrimer research. All aspects of the subject are covered: the authors provide a historical overview, theoretical background, and discussions of the synthesis and applications of dendrimers. The book thus spans organic chemistry and more application-orientated disciplines like material science and pharmaceutical chemistry. The excellent, detailed list of references further increases the value of the book. The optimal presentation of the structural formulas of dendrimers - highly symmetrical giant molecules - helps the reader understand the sophisticated synthesis quickly. This book will set the standard for further monographs on this subject.