Muscarinic Receptor
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The Muscarinic Receptors
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Author : Joan Heller Brown
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
The Muscarinic Receptors written by Joan Heller Brown and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Research on muscarinic receptors is advancing at an extraordinary rate. Ten years ago, the existence of muscarinic receptor sub types was a logical assumption with only scattered experimen tal support. The discovery that pirenzepine recognized apparent heterogeneity in muscarinic binding sites infused new life into the problem of subclassifying muscarinic receptors. Simultaneous advances in molecular biology created a frenzy to clone cell sur face receptors. The muscarinic receptor succumbed surprisingly quickly, revealing its structure and that of at least four closely related gene products within a year. Our hope of obtaining clear evidence for muscarinic receptor subtypes was answered with a vengeance. Now a family of muscarinic receptors sits before us, asking to be understood. The bounty is as attractive to those who have not previously studied muscarinic receptors as to those who have dedicated their research careers to this subject. The goal of this book is to ensure that the new generation of research will profit from the wisdom of the past. The tools of molecular biology are well suited to the tasks of characteriz ing the pharmacology, function, and regulation of the distinct muscarinic receptor subtypes. However, efficient and intelligent use of these tools is not possible, unless one understands the properties of the receptor, the molecular mechanisms by which it couples to effectors, and the ways that it is regulated.
Muscarinic Receptor Subtypes In Smooth Muscle
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Author : Richard M. Eglen
language : en
Publisher: CRC Press
Release Date : 2020-10-08
Muscarinic Receptor Subtypes In Smooth Muscle written by Richard M. Eglen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.
Muscarinic Receptors
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Author : Allison D. Fryer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-06
Muscarinic Receptors written by Allison D. Fryer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-06 with Medical categories.
Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Muscarinic Receptor
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Author : Jaromir Myslivecek
language : en
Publisher: Springer Nature
Release Date :
Muscarinic Receptor written by Jaromir Myslivecek and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on with categories.
Muscarinic Receptors In Airways Diseases
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Author : Johan Zaagsma
language : en
Publisher: Springer
Release Date : 2013-03-08
Muscarinic Receptors In Airways Diseases written by Johan Zaagsma and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-03-08 with Medical categories.
What are the different muscarinic acetylcholine receptor subtypes and how are they distributed in the airways and molecular signalling mechanisms? What is their function in neurogenic and non-neurogenic control of the airways and in inflammatory mechanisms? How is their gene expression regulated? The great importance of muscarinic acetylcholine receptors for the pathophysiology and treatment of chronic inflammatory obstructive airways diseases calls for a comprehensive and integrated overview of the current knowledge to address such questions, to discuss the role of these receptor subtypes in diseases such as asthma and COPD, and to present novel perspectives on antimuscarinic drug development. The present book is the worthy result of this need. It points out innovative insights into the hitherto poorly understood role of postjunctional muscarinic M2 receptors in airway smooth muscle contraction and sheds some light on the novel concepts of antimuscarinic drug development, with special reference to the l
Muscarinic Receptor Subtypes In The Gi Tract
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Author : G. Lux
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Muscarinic Receptor Subtypes In The Gi Tract written by G. Lux and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
The differentiation between the muscarinic and the nicotinic ef fects of acetylcholine led to the subdivision of the cholinergic ner vous system into two categories. Further studies showed that stimu lating and inhibiting muscarinic effects could be demonstrated in different organs. For instance, gastric secretion and gastrointestinal motility are stimulated, while heart rate and the vascular muscula ture are inhibited. For decades, it could not be determined whether the various ef fects were mediated by different subgroups of muscarinic receptors, but eventually, with the availability of agonists and antagonists to muscarinic receptors, and using various techniques, the existence of at least two such subgroups could be ascertained . . Mt receptors are defined by their high affinity for the antagonist pirenzipine in comparison to M2 receptors. This subdivision of muscarinic receptors has since been proved beyond doubt by experi ments in vivo and in vitro, by receptor binding studies, by histoauto radiography, and by electrophysiological studies. However, these different classes of muscarinic receptors have not been found to relate to different types of effects; instead both excit atory and inhibitory effects appear to be linked to each class. For ex ample, excitation of gut motility and inhibition of cardiac contrac tile activities both appear to be mediated by M2 receptors, while ex citation of some nerves in sympathetic ganglia and inhibition of some myenteric nerves may be mediated by M receptors.
The Muscarinic Receptors
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Author : Joan Heller Brown
language : en
Publisher:
Release Date : 1989-09-05
The Muscarinic Receptors written by Joan Heller Brown and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1989-09-05 with categories.
Molecular Mechanisms Of Muscarinic Acetylcholine Receptor Function
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Author : Jürgen Wess
language : en
Publisher:
Release Date : 1995-01-01
Molecular Mechanisms Of Muscarinic Acetylcholine Receptor Function written by Jürgen Wess and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-01-01 with Cellular signal transduction categories.
This book describes the molecular mechanisms governing the function of muscarinic acetylcholine receptors. Detailed knowledge about these processes is essential to understand the complex roles that muscarinic receptors play under physiological and pathophysiological conditions. The volume is written by the leaders in the field and provides concise, up-to-date, comprehensive information.
Characterization And Regulation Of Muscarinic Acetylcholine Receptor Signaling By Calmodulin
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Author : Julie Lynn Lucas
language : en
Publisher:
Release Date : 2004
Characterization And Regulation Of Muscarinic Acetylcholine Receptor Signaling By Calmodulin written by Julie Lynn Lucas and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Acetylcholine categories.
Pharmacology Of Antimuscarinic Agents
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Author : Laszlo Gyermek
language : en
Publisher: CRC Press
Release Date : 1997-11-25
Pharmacology Of Antimuscarinic Agents written by Laszlo Gyermek and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997-11-25 with Medical categories.
The theoretical and practical significance of antimuscarinic drugs is more obvious today than ever before. Antimuscarinics have helped to explore the pathomechanisms of of Alzheimer's disease, and to treat the symptoms of Parkinson's, cardiovascular problems, gastrointestinal diseases, and even nerve gas poisoning. No other drug class can claim as long a history with so many therapeutic applications, yet the most significant developments in this broad chapter of pharmacology come from the discovery of different muscarinic receptor sites in the peripheral and central nervous system and from the availability of many new selective agents, notably antagonists, for these different receptor types. Pharmacology of Antimuscarinic Agents, written by an expert in anesthesiology and drug research, focuses on the basic principles of antimuscarinic drugs, their therapeutic value, how they work, and what versions are now available in the U.S. and abroad. This is the first time in decades an author has reviewed historical and current literature to present a comprehensive, standard reference on the antimuscarinic family.