Muscarinic Receptor Subtypes In Smooth Muscle
DOWNLOAD
Download Muscarinic Receptor Subtypes In Smooth Muscle PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Muscarinic Receptor Subtypes In Smooth Muscle book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page
Muscarinic Receptor Subtypes In Smooth Muscle
DOWNLOAD
Author : Richard M. Eglen
language : en
Publisher: CRC Press
Release Date : 2020-10-08
Muscarinic Receptor Subtypes In Smooth Muscle written by Richard M. Eglen and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-10-08 with Medical categories.
This book explores several subtypes of muscarinic receptors that modulate smooth muscle activity. Main topics include a classification of muscarinic receptors, biochemical responses that occur in smooth muscle, the role of muscarinic receptors in the function of gastrointestinal and genitourinary smooth muscle, and prejunctional muscarinic receptors in smooth muscle. Discussions cover the current state of research and are intended to generate further research into the design of novel therapeutics for disorders of smooth muscle function.
Colonic Motility
DOWNLOAD
Author : Sushil K. Sarna
language : en
Publisher: Morgan & Claypool Publishers
Release Date : 2010
Colonic Motility written by Sushil K. Sarna and has been published by Morgan & Claypool Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Three distinct types of contractions perform colonic motility functions. Rhythmic phasic contractions (RPCs) cause slow net distal propulsion with extensive mixing/turning over. Infrequently occurring giant migrating contractions (GMCs) produce mass movements. Tonic contractions aid RPCs in their motor function. The spatiotemporal patterns of these contractions differ markedly. The amplitude and distance of propagation of a GMC are several-fold larger than those of an RPC. The enteric neurons and smooth muscle cells are the core regulators of all three types of contractions. The regulation of contractions by these mechanisms is modifiable by extrinsic factors: CNS, autonomic neurons, hormones, inflammatory mediators, and stress mediators. Only the GMCs produce descending inhibition, which accommodates the large bolus being propelled without increasing muscle tone. The strong compression of the colon wall generates afferent signals that are below nociceptive threshold in healthy subjects. However, these signals become nociceptive; if the amplitudes of GMCs increase, afferent nerves become hypersensitive, or descending inhibition is impaired. The GMCs also provide the force for rapid propulsion of feces and descending inhibition to relax the internal anal sphincter during defecation. The dysregulation of GMCs is a major factor in colonic motility disorders: irritable bowel syndrome (IBS), inflammatory bowel disease (IBD), and diverticular disease (DD). Frequent mass movements by GMCs cause diarrhea in diarrhea predominant IBS, IBD, and DD, while a decrease in the frequency of GMCs causes constipation. The GMCs generate the afferent signals for intermittent short-lived episodes of abdominal cramping in these disorders. Epigenetic dysregulation due to adverse events in early life is one of the major factors in generating the symptoms of IBS in adulthood. Table of Contents: Introduction / Regulatory Mechanisms / Colonic Motility in Health / Colonic Motility Dysfunction / References
Animal Models Of Cognitive Impairment
DOWNLOAD
Author : Edward D. Levin
language : en
Publisher: CRC Press
Release Date : 2006-06-22
Animal Models Of Cognitive Impairment written by Edward D. Levin and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-06-22 with Medical categories.
The costs associated with a drug's clinical trials are so significant that it has become necessary to validate both its safety and efficacy in animal models prior to the continued study of the drug in humans. Featuring contributions from distinguished researchers in the field of cognitive therapy research, Animal Models of Cognitive Impairmen
Functional Neurobiology Of Aging
DOWNLOAD
Author : Patrick R. Hof
language : en
Publisher: Elsevier
Release Date : 2001-01-11
Functional Neurobiology Of Aging written by Patrick R. Hof and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-01-11 with Medical categories.
Some well-known age-related neurological diseases include Parkinson's disease, Alzheimer's disease, deafness, and blindness. Even more common are the problems of aging which are not due to disease but to more subtle impairments in neurobiological systems, including impairments in vision, memory loss, muscle weakening, and loss of reproductive functions, changes in body weight, and sleeplessness. As the average age of our society increases, diseases of aging continue to become more common, and conditions associated with aging need more attention by doctors and researchers. In 1991, patients over the age of 65 saw their doctors an average of eight times per year. Research funding is provided by the Neuroscience and Neuropsychology of Aging (NNA) Program, which is run by the National Institute on Aging. This book offers a comprehensive overview of all topics related to functional impairments which are related to the aging brain and nervous system. It is organized according to four general functions: movement, senses, memory, and neuroendocrine regulation. Written by the leading researchers in the field, this comprehensive work addresses both impairments associated with diseases and not associated with diseases, making it easier to understand the mechanisms involved. Functional Neurobiology of Aging is an important reference for professionals and students involved in aging research, as well as physicians who need to recognize and understand age-related impairments. - Organized by function, making it easy to find and understand the material - Addresses impairments both associated with diseases and not associated with diseases - Written by leading researchers in the field - Most comprehensive source of information on the neurobiology of aging
Keynes Aidley S Nerve And Muscle
DOWNLOAD
Author : Christopher L.-H. Huang
language : en
Publisher: Cambridge University Press
Release Date : 2020-11-19
Keynes Aidley S Nerve And Muscle written by Christopher L.-H. Huang and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-19 with Medical categories.
A complete, yet accessible and up-to-date, introduction to the cellular physiology of nerve, and skeletal, cardiac and smooth muscle.
Muscarinic Receptors
DOWNLOAD
Author : Allison D. Fryer
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-01-06
Muscarinic Receptors written by Allison D. Fryer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-01-06 with Medical categories.
Muscarinic acetylcholine receptors have played a key role in the advancement of knowledge of pharmacology and neurotransmission since the inception of studies in these fields, and the effects of naturally occurring drugs acting on muscarinic receptors were known and exploited for both therapeutic and non-therapeutic purposes for hundreds of years before the existence of the receptors themselves was recognized. This volume presents a broad yet detailed review of current knowledge of muscarinic receptors that will be valuable both to long-time muscarinic investigators and to those new to the field. It describes the detailed insights that have been obtained on the structure, function, and cell biology of muscarinic receptors. This volume also describes physiological analyses of muscarinic receptors and their roles in regulating the function of the brain and of a variety of peripheral tissues. This volume shows how the study of muscarinic receptors continues to provide new and surprising insights not just to the cholinergic system but to the broad areas of neurobiology, cell biology, pharmacology, and therapeutics.
Receptor Desensitization And Ca2 Signaling
DOWNLOAD
Author : M. K. Uchida
language : en
Publisher: Karger Medical and Scientific Publishers
Release Date : 1996-04-25
Receptor Desensitization And Ca2 Signaling written by M. K. Uchida and has been published by Karger Medical and Scientific Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-04-25 with Medical categories.
The last decade has witnessed a wealth of new information on the mechanisms underlying cell signaling. Molecular approaches have revealed the identity and structure of many of the receptor proteins which permit cells to respond to different chemical signals. An important mechanism regulating receptor function is desensitization, i.e. the suppression of a cellular response induced by the continuous presence of a constant agonist stimulus. This book features selected studies on receptor-mediated desensitization in various cells and tissues triggered by Ca2+. Post-receptor mechanisms are also considered. The contributions focus on muscarinic, histamine and adrenergic receptor systems as well as the phosphoinositidase C signaling pathway. The authoritative information compiled in this book will not only prove of great value to researchers interested in signal transduction but is also crucial for the development of new drugs.
Physiology Of The Gastrointestinal Tract
DOWNLOAD
Author : Kim E. Barrett
language : en
Publisher: Elsevier
Release Date : 2006-05-10
Physiology Of The Gastrointestinal Tract written by Kim E. Barrett and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-05-10 with Medical categories.
FROM THE PREFACE:The original purpose of the First Edition of Physiology of the Gastrointestinal Tractto collect in one set of volumes the most current and comprehensive knowledge in our fieldwas also the driving force for the Fourth Edition. The explosion of information at the cellular level, made possible in part by the continued emergence of powerful molecular and cellular techniques, has resulted in a greater degree of revision than that of any other edition. The first section, now titled "Basic Cell Physiology and Growth of the Gl Tract" contains numerous new chapters on topics such as transcriptional regulation, signaling networks in development, apoptosis, and mechanisms in malignancies. Most of the chapters in this section were edited by Juanita L. Merchant. Section II has been renamed "Neural Gastroenterology and Motility" and has been expanded from seven chapters with rather classic titles to more than twenty chapters encompassing not only the movement of the various parts of the digestive tract but also cell physiology, neural regulation, stress, and the regulation of food intake. Almost all of the chapters were recruited and edited by Jackie D. Wood. The third section is entirely new and contains chapters on "Immunology and Inflammation" which were edited by Kim E. Barrett. The fourth section on the "Physiology of Secretion" consists of chapters with familiar titles, but with completely updated information to reflect the advances in our understanding of the cellular processes involved in secretion. The last section on "Digestion and Absorption" contains new chapters on the intestinal barrier, protein sorting and ion channels along with those focusing on the uptake of specific nutrients. These chapters were recruited and edited by Hamid M. Said and Fayez K. Ghishan.· Collected in one set - the most current and comprehensive coverage of gastrointestinal physiology· Information presented in a style that is both readable and understandable· Valuable to the specialized researcher, the clinical gastroenterologist, the teacher, and the student· Features an entirely new section on Immunology and Inflammation· Each section edited by the preeminent scientist in the field
Anticholinergic Agents In The Upper And Lower Airways
DOWNLOAD
Author : Sheldon Spector
language : en
Publisher: CRC Press
Release Date : 1999-06-04
Anticholinergic Agents In The Upper And Lower Airways written by Sheldon Spector and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999-06-04 with Medical categories.
This comprehensive collection discusses anticholinergic agents, integrating the treatment of rhinitis, the common cold, and asthma in the upper and lower airways, while updating the latest therapeutic practices. Features assessments of soon-to-be-available medications! Written by expert allergists and pulmonologists as an exploration of the clinical application of antimuscarinics, Anticholinergic Agents in the Upper and Lower Airways explores the common triggers and pathogenesis of the upper and lower airways, including pathogenic mechanisms that cause allergies covers hyperresponsiveness and the M2 and M3 receptors considers the interactions of muscarinic receptors with other substances such as protein kinase C, cytokines, and growth factors that magnify the receptors' effects analyzes bronchodilators, bronchomotor tone, and reflex bronchospastic mechanisms assesses antimuscarinic drugs as treatment for acute asthma attacks reviews the use of anticholinergic agents to treat rhinorrhea and upper respiratory infections surveys data regarding the combination of beta agonists and antimuscarinics evaluates the future of tiotropium bromide as a bronchodilator focuses on the subspecialties of allergy and chest medicine examines new work regarding the interaction of viruses and the muscarinic receptor and more! Containing over 700 references to facilitate further study, Anticholinergic Agents in the Upper and Lower Airways is a thorough, multidisciplinary reference especially relevant to clinical immunologists and allergists, pulmonologists, physiologists, lung biologists, family and general practitioners, internists, pediatricians, and medical students in these disciplines.
Neurourology
DOWNLOAD
Author : Limin Liao
language : en
Publisher: Springer
Release Date : 2019-03-11
Neurourology written by Limin Liao and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-03-11 with Medical categories.
This book introduce neurourology as an emerging interdisciplinary area that covers the basic and clinical studies of the neural control on the normal lower urinary tract and the lower/upper urinary tract dysfunction due to neuropathy disorders. It systematically describes all aspects of neurourology from the epidemiology of the neurogenic bladder; to the pathology and pathophysiology of the lower urinary tract; to the diagnosis and treatment of the neurogenic bladder by conservative therapies or surgeries. This book provides a useful resource for medical doctors, nurses and students in the field of neurourological conditions. All the topics are written by internationally recognized specialists in their field.