Mutation Cancer And Malformation

DOWNLOAD

Download Mutation Cancer And Malformation PDF/ePub or read online books in Mobi eBooks. Click Download or Read Online button to get Mutation Cancer And Malformation book now. This website allows unlimited access to, at the time of writing, more than 1.5 million titles, including hundreds of thousands of titles in various foreign languages. If the content not found or just blank you must refresh this page

Mutation Cancer And Malformation

DOWNLOAD

Author : Ernest H.Y. Chu
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Mutation Cancer And Malformation written by Ernest H.Y. Chu and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

During the early 1930s, when I was a graduate student and later a post-doctoral researcher at the National Research Council for the University of Wisconsin at Madison, we had the opportunity to get acquainted with many graduate students from China who were sent to the University for training in modern basic sciences as well as social sciences. The University of Wisconsin continues to graduate a large number of Chinese students. Economic conditions in the 1930s were very precarious for the United States and other parts of the world. Many of us students grew closer together because we were living on similarly tight budgets. As a matter of fact, we subleased a part of our apartment in Madison to some Chinese graduate students. This was a very nice opportunity for us to learn about the scientific and cultural back ground of our Chinese friends. Many of them came from the interior of China and had had very little opportunity to become acquainted with people from a western culture. Living with these students was a very pleasant and educational experience which gave us a good pic ture of the cultural life and educational system of China at that time--an intimate picture that one normally would not see without travelling in that country.

Mutation Cancer And Malformation

DOWNLOAD

Author : Ernest H y Chu
language : en
Publisher:
Release Date : 1985-01-01

Mutation Cancer And Malformation written by Ernest H y Chu and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985-01-01 with categories.

Abnormal Chromosomes

DOWNLOAD

Author : Sverre Heim
language : en
Publisher: John Wiley & Sons
Release Date : 2022-03-21

Abnormal Chromosomes written by Sverre Heim and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-03-21 with Medical categories.

Explore the past, present, and future of cancer cytogenetics In Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics, globally renowned researchers Drs. Sverre Heim and Felix Mitelman deliver a state-of-the-art review of how cancer cytogenetic analyses have contributed to an improved understanding of tumorigenesis as well as to the diagnosis and treatment of cancer patients. The book also discusses how cytogenetics – the study of chromosomes - meets, interacts with, and cross-fertilizes other investigative technologies, including molecular somatic cell genetics. The book provides an impetus to think more deeply about the role chromosomes, and their abnormalities, play in health and disease, especially in neoplastic disorders. From which origins did cytogenetics develop? How did the finding of acquired chromosomal abnormalities in cells of leukemias and solid tumors influence our understanding of cancer as a biological process? How was information of this nature put to good use in the clinical management of cancer patients? Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics offers readers: A thorough introduction to ancient theories of disease, the advent of cellular pathology, and how a scientific interest in chromosomes developed Comprehensive exploration of the conceptual importance of Theodor Boveri and his somatic mutation theory of cancer A detailed chronological resume of cancer cytogenetic discoveries during the 20th century In-depth discussions of the role of chromosome abnormalities, oncogenes, and tumor suppressor genes in leukemias, lymphomas, and solid tumors, together with a survey of what chromosome analyses have revealed about the clonal evolution of neoplastic cell populations A discussion of the importance of pathogenetic classifications of neoplastic diseases, the role chromosome abnormalities play in this context, and which technological breakthroughs can be expected in chromosome-oriented cancer research Abnormal Chromosomes: The Past, Present, and Future of Cancer Cytogenetics was written for everyone with a scientific or clinical interest in cancer, especially how acquired chromosome abnormalities lead to neoplastic transformation. The book teaches how cytogenetic analyses contribute to a better understanding of tumorigenesis, but also how the finding of specific chromosome aberrations can be crucial for the diagnosis, prognosis, and management of cancer patients.

Vascular Tumors And Developmental Malformations

DOWNLOAD

Author : Paula E. North
language : en
Publisher: Springer
Release Date : 2016-02-04

Vascular Tumors And Developmental Malformations written by Paula E. North and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-04 with Medical categories.

This book comprehensively covers the classification, histopathology, pathogenesis, and molecular diagnosis of vascular tumors and malformations, correlating these with current approaches to clinical management. It offers a new multidisciplinary resource for clinicians, pathologists, molecular diagnosticians, and scientists in the field of vascular medicine and biology, fostering cross-cutting collaboration in clinical practice and research. Fundamental background information on vascular tumors and malformation is provided, while also including the most current information available on pathogenic mechanisms underlying this heterogenous group of disorders and the implications for molecular diagnosis and therapeutic intervention. Written by experts in the field, Vascular Tumors and Developmental Malformations: Pathogenic Mechanisms and Molecular Diagnosis provides the medical and scientific community with an essential, practical resource to guide accurate diagnosis, well-targeted therapies, and informed investigation of specific clinicopathological entities within the spectrum of vascular anomalies.

Health Effects Of Exposure To Low Levels Of Ionizing Radiation

DOWNLOAD

Author : National Research Council
language : en
Publisher: National Academies
Release Date : 1990-02-01

Health Effects Of Exposure To Low Levels Of Ionizing Radiation written by National Research Council and has been published by National Academies this book supported file pdf, txt, epub, kindle and other format this book has been release on 1990-02-01 with Science categories.

This book reevaluates the health risks of ionizing radiation in light of data that have become available since the 1980 report on this subject was published. The data include new, much more reliable dose estimates for the A-bomb survivors, the results of an additional 14 years of follow-up of the survivors for cancer mortality, recent results of follow-up studies of persons irradiated for medical purposes, and results of relevant experiments with laboratory animals and cultured cells. It analyzes the data in terms of risk estimates for specific organs in relation to dose and time after exposure, and compares radiation effects between Japanese and Western populations.

Mulliken And Young S Vascular Anomalies

DOWNLOAD

Author : John B. Mulliken
language : en
Publisher: Oxford University Press
Release Date : 2013-05-01

Mulliken And Young S Vascular Anomalies written by John B. Mulliken and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-01 with Medical categories.

The field of vascular anomalies has grown rapidly in last 25 years. Molecular genetics has led to discovery of genes that cause vascular anomalies. Interventional radiology has become a major contributor to accurate diagnosis and management of previously untreatable disorders. New pharmacologic therapies are under investigation and surgical protocols have been established. Vascular Anomalies: Hemangiomas and Malformations is a comprehensive and interdisciplinary textbook ideal for dermatologists, interventional radiologists, surgical specialists, ophthalmologists, pathologists, geneticists, pediatricians, hematologic-oncologists, and vascular biologists. With a central motif of the biologic dichotomy of vascular tumors and vascular malformations, this book is organized into chapters which address clinical presentation, diagnostic imaging, molecular genetics, pathogenesis, histopathology, and management of vascular anomalies. Generous, full-color images compliment this extensive volume written by three colleagues and their teammates from Children's Hospital Boston and Harvard Medical School, with leading specialists from other centers.

Cavernous Malformations

DOWNLOAD

Author : Issam A. Awad
language : en
Publisher: Thieme
Release Date : 1993

Cavernous Malformations written by Issam A. Awad and has been published by Thieme this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.

The massive convergence of information about cavernous malformations has been synthesized in this volume by experts in the field of pathology, neuroradiology and neurosurgery. Cavernous Malformations represents state-of-the-art knowledge about this lesion and the spectrum of opinion about its nature, clinical behavior and management strategies. Highlights of Cavernous Malformations: Definition and pathologic features Epidemiology Diagnostic imaging Epilepsy Hemorrhage Conservative management Surgical intervention Microsurgical treatments Spinal cavernous malformations Pediatrics Radiotherapy (Distributed by Thieme for the American Association of Neurological Surgeons)

Inborn Errors Of Development

DOWNLOAD

Author : Charles J. Epstein
language : en
Publisher: Oxford University Press, USA
Release Date : 2004

Inborn Errors Of Development written by Charles J. Epstein and has been published by Oxford University Press, USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Medical categories.

In this book, the clinical chapters are organized into sections by defined developmental pathways or gene families, and each section is preceded by a general overview. For each disorder the authors cover the disease-causing genes, the role of these genes in development as elucidated in model organisms, the human mutations that have been identified, and the developmental pathogenesis of the condition. Clinical descriptions, along with discussions of therapy and counseling, are provided. This book will be an invaluable resource for physicians, dentists, and other health professionals and for basic scientists interested in developmental processes and genetic perturbations that affect them.

Path Proliferation Accumulation Tumor Hypothesis

DOWNLOAD

Author : Thomas Wascher
language : en
Publisher: Thomas Wascher
Release Date : 2018-08-15

Path Proliferation Accumulation Tumor Hypothesis written by Thomas Wascher and has been published by Thomas Wascher this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-08-15 with categories.

What is or what does a gene mutation do? A gene mutation, i.e. the damage of a gene, leads to a gene expressing more, less or modified proteins. These altered proteins alter the behaviour of the cell. And this is how cancer is ultimately to develop: Changed proteins due to changes in the genes. But what would happen if these changes in the proteins were not caused by mutations in the genes, but by direct damage to the proteins? Then the result "cancer" would be the same, but otherwise everything would be different. And cancer could be curable. We cannot reverse a mutation, but we can reverse a mechanical process such as protein accumulation. At least we could considerably influence such a carcinogenesis. The proliferation-accumulation-tumour-hypothesis describes how this might be possible. According to PATH, cancer is not a mutation disease, but a protein accumulation disease. But a protein accumulation (protein oxidation / protein aggregation) in immortal stem cells. And a protein accumulation that affecting 400 protein types (mainly cell cycle proteins) and millions of protein copies simultaneously. A protein accumulation in which autophagocytosis in the G0 phase - as the most important proteolysis factor - is no longer sufficiently effective. PATH is based on the latest findings on the ubiquitin proteasome system, cyclins (in particular Cyclin-D-CDK4,6) and autophagy (according to Ohsumi's findings) and their role in the development of tumours. And PATH also shows why certain forms of treatment and substances (e.g. acetylsalicylic acid [aspirin], metformin, 2-deoxy-2-glucose, methadone, terfenadine, etc.) have a certain effect in studies. And how cancer could possibly be hindered in its development to such an extent that a lethal effect is omitted. For example, PATH also explains better why a person has a 50% chance of developing cancer or at least a 25% chance of dying from it. The most important basis for the development of PATH was the rigorous detachment from the cancer multimutation principle, which has not been effective to date, and the exclusive reorientation towards the most probable and logical facts and conclusions. And the realization: „What is the cause of death for at least 25% of all people cannot be something that has to be caused by a rare, undirected coincidence (mutation).“

Genomic Medicine

DOWNLOAD

Author : Dhavendra Kumar
language : en
Publisher: Oxford Monographs on Medical G
Release Date : 2014-10-15

Genomic Medicine written by Dhavendra Kumar and has been published by Oxford Monographs on Medical G this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-10-15 with Medical categories.

Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.