Mutation Driven Evolution
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Mutation Driven Evolution
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Author : Masatoshi Nei
language : en
Publisher: OUP Oxford
Release Date : 2013-05-02
Mutation Driven Evolution written by Masatoshi Nei and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-02 with Science categories.
The purpose of this book is to present a new theory of mutation-driven evolution, which is based on recent advances in genomics and evolutionary developmental biology. This theory asserts that the driving force of evolution is mutation and natural selection is of secondary importance.
Crumbling Genome
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Author : Alexey S. Kondrashov
language : en
Publisher: John Wiley & Sons
Release Date : 2017-07-12
Crumbling Genome written by Alexey S. Kondrashov and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-12 with Science categories.
A thought-provoking exploration of deleterious mutations in the human genome and their effects on human health and wellbeing Despite all of the elaborate mechanisms that a cell employs to handle its DNA with the utmost care, a newborn human carries about 100 new mutations, originated in their parents, about 10 of which are deleterious. A mutation replacing just one of the more than three billion nucleotides in the human genome may lead to synthesis of a dysfunctional protein, and this can be inconsistent with life or cause a tragic disease. Several percent of even young people suffer from diseases that are caused, exclusively or primarily, by pre ]existing and new mutations in their genomes, including both a wide variety of genetically simple Mendelian diseases and diverse complex diseases such as birth anomalies, diabetes, and schizophrenia. Milder, but still substantial, negative effects of mutations are even more pervasive. As of now, we possess no means of reducing the rate at which mutations appear spontaneously. However, the recent flood of genomic data made possible by next-generation methods of DNA sequencing, enabled scientists to explore the impacts of deleterious mutations on humans with previously unattainable precision and begin to develop approaches to managing them. Written by a leading researcher in the field of evolutionary genetics, Crumbling Genome reviews the current state of knowledge about deleterious mutations and their effects on humans for those in the biological sciences and medicine, as well as for readers with only a general scientific literacy and an interest in human genetics. Provides an extensive introduction to the fundamentals of evolutionary genetics with an emphasis on mutation and selection Discusses the effects of pre-existing and new mutations on human genotypes and phenotypes Provides a comprehensive review of the current state of knowledge in the field and considers crucial unsolved problems Explores key ethical, scientific, and social issues likely to become relevant in the near future as the modification of human germline genotypes becomes technically feasible Crumbling Genome is must-reading for students and professionals in human genetics, genomics, bioinformatics, evolutionary biology, and biological anthropology. It is certain to have great appeal among all those with an interest in the links between genetics and evolution and how they are likely to influence the future of human health, medicine, and society.
Genetics Of Adaptation
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Author : Rodney Mauricio
language : en
Publisher: Springer Science & Business Media
Release Date : 2005-07-20
Genetics Of Adaptation written by Rodney Mauricio and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-07-20 with Science categories.
An enduring controversy in evolutionary biology is the genetic basis of adaptation. Darwin emphasized "many slight differences" as the ultimate source of variation to be acted upon by natural selection. In the early 1900’s, this view was opposed by "Mendelian geneticists", who emphasized the importance of "macromutations" in evolution. The Modern Synthesis resolved this controversy, concluding that mutations in genes of very small effect were responsible for adaptive evolution. A decade ago, Allen Orr and Jerry Coyne reexamined the evidence for this neo-Darwinian view and found that both the theoretical and empirical basis for it were weak. Orr and Coyne encouraged evolutionary biologists to reexamine this neglected question: what is the genetic basis of adaptive evolution? In this volume, a new generation of biologists have taken up this challenge. Using advances in both molecular genetic and statistical techniques, evolutionary geneticists have made considerable progress in this emerging field. In this volume, a diversity of examples from plant and animal studies provides valuable information for those interested in the genetics and evolution of complex traits.
Mutation Driven Evolution
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Author : Masatoshi Nei
language : en
Publisher: OUP Oxford
Release Date : 2013-05-02
Mutation Driven Evolution written by Masatoshi Nei and has been published by OUP Oxford this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-02 with Science categories.
The purpose of this book is to present a new mechanistic theory of mutation-driven evolution based on recent advances in genomics and evolutionary developmental biology. The theory asserts, perhaps somewhat controversially, that the driving force behind evolution is mutation, with natural selection being of only secondary importance. The word 'mutation' is used to describe any kind of change in DNA such as nucleotide substitution, gene duplication/deletion, chromosomal change, and genome duplication. A brief history of the principal evolutionary theories (Darwinism, mutationism, neo-Darwinism, and neo-mutationism) that preceded the theory of mutation-driven evolution is also presented in the context of the last 150 years of research. However, the core of the book is concerned with recent studies of genomics and the molecular basis of phenotypic evolution, and their relevance to mutation-driven evolution. In contrast to neo-Darwinism, mutation-driven evolution is capable of explaining real examples of evolution such as the evolution of olfactory receptors, sex-determination in animals, and the general scheme of hybrid sterility. In this sense the theory proposed is more realistic than its predecessors, and gives a more logical explanation of various evolutionary events. Mutation-Driven Evolution is suitable for graduate level students as well as professional researchers (both empiricists and theoreticians) in the fields of molecular evolution and population genetics. It assumes that the readers are acquainted with basic knowledge of genetics and molecular biology.
In The Light Of Evolution
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Author : National Academy of Sciences
language : en
Publisher: National Academies Press
Release Date : 2007-12-28
In The Light Of Evolution written by National Academy of Sciences and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-12-28 with Science categories.
In December 2006, the National Academy of Sciences sponsored a colloquium (featured as part of the Arthur M. Sackler Colloquia series) on "Adaptation and Complex Design" to synthesize recent empirical findings and conceptual approaches toward understanding the evolutionary origins and maintenance of complex adaptations. Darwin's elucidation of natural selection as a creative natural force was a monumental achievement in the history of science, but a century and a half later some religious believers still contend that biotic complexity registers conscious supernatural design. In this book, modern scientific perspectives are presented on the evolutionary origin and maintenance of complex phenotypes including various behaviors, anatomies, and physiologies. After an introduction by the editors and an opening historical and conceptual essay by Francisco Ayala, this book includes 14 papers presented by distinguished evolutionists at the colloquium. The papers are organized into sections covering epistemological approaches to the study of biocomplexity, a hierarchy of topics on biological complexity ranging from ontogeny to symbiosis, and case studies explaining how complex phenotypes are being dissected in terms of genetics and development.
The Neutral Theory Of Molecular Evolution
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Author : Motoo Kimura
language : en
Publisher: Cambridge University Press
Release Date : 1983
The Neutral Theory Of Molecular Evolution written by Motoo Kimura and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1983 with Science categories.
This book is the first comprehensive treatment of this subject.
Evolution A Very Short Introduction
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Author : Brian Charlesworth
language : en
Publisher: Oxford University Press
Release Date : 2017-06-15
Evolution A Very Short Introduction written by Brian Charlesworth and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-15 with Science categories.
Less than 450 years ago, all European scholars believed that the Earth was at the centre of a Universe that was at most a few million miles in extent, and that the planets, sun, and stars all rotated around this centre. Less than 250 years ago, they believed that the Universe was created essentially in its present state about 6000 years ago. Even less than 150 years ago, the view that living species were the result of special creation by God was still dominant. The recognition by Charles Darwin and Alfred Russel Wallace of the mechanism of evolution by natural selection has completely transformed our understanding of the living world, including our own origins. In this Very Short Introduction Brian and Deborah Charlesworth provide a clear and concise summary of the process of evolution by natural selection, and how natural selection gives rise to adaptations and eventually, over many generations, to new species. They introduce the central concepts of the field of evolutionary biology, as they have developed since Darwin and Wallace on the subject, over 140 years ago, and discuss some of the remaining questions regarding processes. They highlight the wide range of evidence for evolution, and the importance of an evolutionary understanding for instance in combating the rapid evolution of resistance by bacteria to antibiotics and of HIV to antiviral drugs. This reissue includes some key updates to the main text and a completely updated Further Reading section. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.
Understanding Evolution
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Author : Kostas Kampourakis
language : en
Publisher: Cambridge University Press
Release Date : 2014-04-03
Understanding Evolution written by Kostas Kampourakis and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-04-03 with Science categories.
Bringing together conceptual obstacles and core concepts of evolutionary theory, this book presents evolution as straightforward and intuitive.
The Cooperative Gene
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Author : Mark Ridley
language : en
Publisher: Simon and Schuster
Release Date : 2001
The Cooperative Gene written by Mark Ridley and has been published by Simon and Schuster this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001 with Chromosome replication categories.
"Why isn's all life pond-scum? Why are there multimillion-celled, long-lived monsters like us, built from tens of thousands of cooperating genes? Mark Ridley presents a new explanation of how complex large life forms like ourselves came to exist, showing that the answer to the greatest mystery of evolution for modern science is not the selfish gene; it is the cooperative gene." "In this thought-provoking book, Ridley breaks down how two major biological hurdles had to be overcome in order to allow living complexity to evolve: the proliferation of genes and gene-selfishness. Because complex life has more genes than simple life, the increase in gene numbers poses a particular problem for complex beings."--BOOK JACKET.
Chance In Evolution
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Author : Grant Ramsey
language : en
Publisher: University of Chicago Press
Release Date : 2016-10-25
Chance In Evolution written by Grant Ramsey and has been published by University of Chicago Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-10-25 with Science categories.
This illuminating volume explores the effects of chance on evolution, covering diverse perspectives from scientists, philosophers, and historians. The evolution of species, from single-celled organisms to multicellular animals and plants, is the result of a long and highly chancy history. But how profoundly has chance shaped life on earth? And what, precisely, do we mean by chance? Bringing together biologists, philosophers of science, and historians of science, Chance in Evolution is the first book to untangle the far-reaching effects of chance, contingency, and randomness on the evolution of life. The book begins by placing chance in historical context, starting with the ancients and moving through Darwin to contemporary biology. It documents the shifts in our understanding of chance as Darwin’s theory of evolution developed into the modern synthesis, and how the acceptance of chance in Darwinian theory affected theological resistance to it. Other chapters discuss how chance relates to the concepts of genetic drift, mutation, and parallel evolution—as well as recent work in paleobiology and the experimental evolution of microbes. By engaging in collaboration across biology, history, philosophy, and theology, this book offers a comprehensive overview both of the history of chance in evolution and of our current understanding of the impact of chance on life.