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Nanoengineered Implantable Devices For Controlled Drug Delivery


Nanoengineered Implantable Devices For Controlled Drug Delivery
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Nanoengineered Implantable Devices For Controlled Drug Delivery


Nanoengineered Implantable Devices For Controlled Drug Delivery
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Author : Piyush Mohan Sinha
language : en
Publisher:
Release Date : 2005

Nanoengineered Implantable Devices For Controlled Drug Delivery written by Piyush Mohan Sinha and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Controlled release technology categories.


Abstract: Considerable advances have been made in the field of drug delivery technology over the last three decades, resulting in many breakthroughs in clinical medicine. However, important classes of drugs have yet to benefit from these technological successes. One of the major requirements for an implantable drug delivery device is controlled release of therapeutic agents, especially biological molecules, at a constant rate over an extended period of time (i.e. a zero order release kinetics). Another significant challenge in drug delivery is to engineer a delivery system that can deliver drug in a manipulated non-zero order fashion such as pulsatile, ramp or delivery on demand. The goal of this research is to deliver technological innovations to address these requirements. Silicon was chosen as a carrier vehicle and nanochannel delivery systems (nDS) of progressively increasing degrees of functionality were conceived. The fundamental embodiment of the first device, nDS1, employs high-precision nanoengineered clefts to yield the long-term zero-order release of therapeutic agents. This device was designed and fabricated targeting four nanochannel sizes. These were 20 nm, 40 nm, 60 nm and 100 nm. The achieved nanochannel heights measured by Atomic Force Microscope (AFM) were 18 nm, 43 nm, 70 nm, and 108 nm, respectively. Glucose diffusion through a nominal 100 nm channel for a period of 15 days, through a nominal 60 nm channel for a period of 5 days and interferon-alpha (IFN-alpha) release through a nominal 100 nm channel for a period of 7 days showed a zero order release profile through this device. Further, it was proved that IFN-alpha preserves its functional activity after being released through this device. Next, the top substrate of the nDS1 device was replaced with a glass substrate (nDS1g) for improved bonding and a visual observation of fluid flow through the nanochannels of the device. Another implantable drug delivery system (nDS2) that is capable of being integrated with an external electronic circuit of interest was designed and a fabrication process flow was developed. This device has integrated electrodes and the concept of drug delivery is based upon electrokinetic flow of molecules through the nanochannels of the device.



Biomimetic Nanoengineered Materials For Advanced Drug Delivery


Biomimetic Nanoengineered Materials For Advanced Drug Delivery
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Author : Afeesh Rajan Unnithan
language : en
Publisher: Elsevier
Release Date : 2019-11-05

Biomimetic Nanoengineered Materials For Advanced Drug Delivery written by Afeesh Rajan Unnithan and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-11-05 with Technology & Engineering categories.


Biomimetic Nanoengineered Materials for Advanced Drug Delivery is an indispensable guide for new developments in biomimetic nanoengineering for advanced drug delivery applications. Focusing on the fundamentals of a new type of nanocarriers for drug delivery in the most recent miRNA therapeutics, the book provides readers with detailed knowledge from the basics, to the most recent innovations. Early chapters of the book discuss a range of drug delivery techniques, including nanofibers, biomimetic polymers, 3D bioprinting, nanotechnology and radiofrequency sensitive nanocarriers. Later chapters explore miRNA therapeutics, magnetic nanoparticles, nanogel-based and ROS-mediated drug delivery systems. The book is a vital reference for biomaterials and nanomedicine researchers and clinicians with an interest in advanced drug delivery. Analyzes nanoparticle-plasma protein interactions, making it one of the first books on this topic Includes the latest trends in nanotherapeutic drug delivery Presents comprehensive chapters that cover a specific drug delivery carrier and its mode of operation, stimuli and the target site of action Provides an essential tool for researchers in nanomedicine and nanobiomaterials



Stem Cell Nanoengineering


Stem Cell Nanoengineering
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Author : H. Baharvand
language : en
Publisher: John Wiley & Sons
Release Date : 2014-12-30

Stem Cell Nanoengineering written by H. Baharvand and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-12-30 with Science categories.


Stem Cell Nanoengineering reviews the applications of nanotechnology in the fields of stem cells, tissue engineering, and regenerative medicine. Topics addressed include various types of stem cells, underlying principles of nanobiotechnology, the making of nano-scaffolds, nano tissue engineering, applications of nanotechnology in stem cell tracking and molecular imaging, nano-devices, as well as stem cell nano-engineering from bench to bedside. Written by renowned experts in their respective fields, chapters describe and explore a wide variety of topics in stem cell nanoengineering, making the book a valuable resource for both researchers and clinicians in biomedical and bioengineering fields.



Nanoengineered Biomaterials For Advanced Drug Delivery


Nanoengineered Biomaterials For Advanced Drug Delivery
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Author : Masoud Mozafari
language : en
Publisher: Elsevier
Release Date : 2020-06-17

Nanoengineered Biomaterials For Advanced Drug Delivery written by Masoud Mozafari and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-06-17 with Technology & Engineering categories.


Nanoengineered Biomaterials for Advanced Drug Delivery explores the latest advances in the applications of nanoengineered biomaterials in drug delivery systems. The book covers a wide range of biomaterials and nanotechnology techniques that have been used for the delivery of different biological molecules and drugs in the human body. It is an important resource for biomaterials scientists and engineers working in biomedicine and those wanting to learn more on how nanoengineered biomaterials are being used to enhance drug delivery for a variety of diseases. Nanoengineered biomaterials have enhanced properties that make them more effective than conventional biomaterials as both drug delivery agents, and in the creation of new drug delivery systems. As nanoengineering becomes more cost-effective, nanoengineered biomaterials have become more widely used within biomedicine. Offers an informed overview on how nanoengineering biomaterials enhance their properties for drug delivery applications Discusses the major applications of nanoengineered biomaterials for drug delivery Outlines the major challenges for successfully implementing nanoengineered biomaterials into existing drug delivery systems



Nanotechnology In Tissue Engineering And Regenerative Medicine


Nanotechnology In Tissue Engineering And Regenerative Medicine
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Author : Ketul Popat
language : en
Publisher: CRC Press
Release Date : 2010-11-22

Nanotechnology In Tissue Engineering And Regenerative Medicine written by Ketul Popat and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-11-22 with Mathematics categories.


Although nanotechnology applied to medicine has a potentially huge impact on drug delivery and tissue engineering, significant challenges need to be resolved before clinically viable nanomedicine or nanobiomedicine therapies will be available. Skillfully edited, with contributions from an expert panel of researchers, Nanotechnology in Tissue Engine



Nanostructures For The Engineering Of Cells Tissues And Organs


Nanostructures For The Engineering Of Cells Tissues And Organs
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Author : Alexandru Mihai Grumezescu
language : en
Publisher: William Andrew
Release Date : 2018-02-14

Nanostructures For The Engineering Of Cells Tissues And Organs written by Alexandru Mihai Grumezescu and has been published by William Andrew this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-02-14 with Science categories.


Nanostructures for the Engineering of Cells: Tissues and Organs showcases recent advances in pharmaceutical nanotechnology, with particular emphasis on tissue engineering, organ and cell applications. The book provides an up-to-date overview of organ targeting and cell targeting using nanotechnology. In addition, tissue engineering applications, such as skin regeneration are also discussed. Written by a diverse range of international academics, this book is a valuable research resource for researchers working in the biomaterials, medical and pharmaceutical industries. Explains how nanomaterials regulate different cell behavior and function as a carrier for different biomolecules Shows how nanobiomaterials and nanobiodevices are used in a range of treatment areas, such as skin tissue, wound healing and bone regeneration Discusses nanomaterial preparation strategies for pharmaceutical application and regenerative medicine



Nanoengineering


Nanoengineering
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Author : Patricia I. Dolez
language : en
Publisher: Elsevier
Release Date : 2015-05-26

Nanoengineering written by Patricia I. Dolez and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-05-26 with Technology & Engineering categories.


Nanoengineering: Global Approaches to Health and Safety Issues provides a global vision on the impact of engineered nanomaterials both for the consumer/general public and in occupational settings. The book also presents a hint on what can be expected for the future from nanomaterials and their effects on our lives, both at home and at work. In addition, users will find valuable information on nanomaterials' irreplaceable value and their risks for health, safety, and environmental issues. Case studies illustrate key points and provide information on important processes. Provides a global vision on the different aspects related to nanosafety and a synthesis of the information available Gives all the information required for precision decision-making in a single book, offering both general public and occupational aspects Contains separate chapters on each subject written by world-renowned contributors Presents a complete vision of the problem, with perspectives on global approaches Includes case studies that illustrate important processes



Nanoengineering Of Biomaterials


Nanoengineering Of Biomaterials
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Author : Sougata Jana
language : en
Publisher: John Wiley & Sons
Release Date : 2022-04-18

Nanoengineering Of Biomaterials written by Sougata Jana and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-04-18 with Science categories.


A comprehensive discussion of various types of nanoengineered biomaterials and their applications In Nanoengineering of Biomaterials: Drug Delivery & Biomedical Applications, an expert team of chemists delivers a succinct exploration of the synthesis, characterization, in-vitro and in-vivo drug molecule release, pharmacokinetic activity, pharmacodynamic activity, and the biomedical applications of several types of nanoengineered biomaterials. The editors have also included resources to highlight the most current developments in the field. The book is a collection of valuable and accessible reference sources for researchers in materials chemistry and related disciplines. It uses a functions-directed approach to using organic and inorganic source compounds that translate into biological systems as scaffolds, micelles, dendrimers, and other delivery systems. Nanoengineering of Biomaterials offers readers up-to-date chemistry and material science insights that are readily transferrable to biomedical systems. The book also includes: Thorough introductions to alginate nanoparticle delivery of therapeutics and chitosan-based nanomaterials in biological applications Comprehensive explorations of nanostructured carrageenan as a drug carrier, gellan gum nanoparticles in drug delivery, and guar-gum nanoparticles in the delivery of bioactive molecules Practical discussions of protein-based nanoparticles for drug delivery, solid lipid nanoparticles as drug carriers, and pH-responsive nanoparticles in therapy In-depth examinations of stimuli-responsive nano carriers in drug targeting Perfect for pharmaceutical chemists, materials scientists, polymer chemists, life scientists, and medicinal chemists, Nanoengineering of Biomaterials: Drug Delivery and Biomedical Applications is also an indispensable resource for biologists and bioengineers seeking a one-stop reference on the transferability of materials chemistry and nanotechnology to biomedicine.



Nanoengineered Nanofibrous Materials


Nanoengineered Nanofibrous Materials
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Author : Selcuk Guceri
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-11-12

Nanoengineered Nanofibrous Materials written by Selcuk Guceri and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-11-12 with Technology & Engineering categories.


The combination of conductive polymer technology with the ability to produce nanofibres will facilitate major new developments in biotechnology and information technology, benefiting such areas as scaffolds for tissue engineering and drug delivery systems; wires, capacitors, transistors and diodes; sensor technology; biohazard protection; and energy transport, conversion and storage. The work on nanofibrous materials presented here is designed, first of all, to instruct scientists in the most advanced methods for the formation of nanofibres and nanotubes. The second section covers the physics and chemistry of nanofibres, while the third deals with computer simulation and modelling. The applications described in section 4 include biomedical applications, nanotube-based devices, electronic applications of nanotubes and nanofibres, nanofluidics, and composites. Finally, the fifth section discusses recent developments in nanomaterials, nanoparticles and nanostructures.



Dissertation Abstracts International


Dissertation Abstracts International
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Author :
language : en
Publisher:
Release Date : 2005

Dissertation Abstracts International written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005 with Dissertations, Academic categories.