Nanoparticles And The Immune System
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Nanoparticles And The Immune System
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Author : Diana Boraschi
language : en
Publisher: Academic Press
Release Date : 2013-11-29
Nanoparticles And The Immune System written by Diana Boraschi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-29 with Medical categories.
Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage for amplifying immune responses in certain diseases or preventive strategies (e.g. vaccination). - Identifies endpoints relevant for assessing hazardous situations, evaluating the impact on immunologically frail populations and how to gauge chronic/cumulative effects - Raises the awareness of the importance of knowing the effects of the new nanomaterials on our immune system
Interaction Of Nanomaterials With The Immune System Role In Nanosafety And Nanomedicine
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Author : Paola Italiani
language : en
Publisher: Frontiers Media SA
Release Date : 2018-04-10
Interaction Of Nanomaterials With The Immune System Role In Nanosafety And Nanomedicine written by Paola Italiani and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-04-10 with categories.
The immune system has the double role of maintaining tissue integrity and homeostasis and of protecting the organism from possible dangers, from invading pathogens to environmentally-borne dangerous chemicals. New chemicals recognisable by the immune system are engineered nanomaterials/ nanoparticles, new agents in our environment that are becoming common due to their presence in many products, from constructions and building material (e.g., solar cells, pigments and paints, tilesand masonry materials) to daily products (e.g., food packaging, cosmetics, and cigarettes). Human beings can be accidentally exposed to engineered nanomaterials when these are released from products containing them or during production in workplaces. Furthermore, intentional exposure occurs in medicine, as engineered nanoparticles are used as tools for improving delivery of drugs and vaccines, vaccine adjuvants and contrast agents in therapeutic, preventive and diagnostic strategies. Nanoparticles that come in contact with the immune system after unintentional exposure need to be eliminated from the organism as they represent a potential threat. In this case, however, due to their peculiar characteristics of size, shape, surface charge and persistence, nanoparticles may elicit undesirable reactions and have detrimental effects on the immune system, such as cytotoxicity, inflammation, anaphylaxis, immunosuppression. Conversely, nanomedicines need to escape immune recognition/elimination and must persist in the organism long enough for reaching their target and exerting their beneficial effects. Immune cells and molecules at the body surface (airway and digestive mucosae, skin) are the first that come in contact with nanomaterials upon accidental exposure, while immune effectors in blood are those that more easily come in contact with nanomedical products. Thus, evaluating the interaction of the immune system with nanoparticles/nanomaterials is a topic of key importance both in nanotoxicology and in nanomedicine. Immuno-nanosafety studies consider both accidental exposure to nanoparticles, which may occur by skin contact, ingestion or inhalation (at doses and with a frequency that are not known), and medical exposure, which takes place with a defined administration schedule (route, dose, frequency). Many studies focus on the interaction between the immune system and nanoparticles that, for medical purposes, have been specifically modified to stimulate immunity or to avoid immune recognition, as in the case of vaccine carriers/adjuvants or drug delivery systems, respectively. The aims of this Research Topic is to provide an overview of recent strategies: 1.for assessing the immunosafety of engineered nanomaterials/nanoparticles, in particular in terms of activation of inflammatory responses, such as complement activation and allergic reactions, based on the nanomaterial intrinsic characteristics and on the possible carry-over of bioactive contaminants such as LPS. Production of new nanoparticles taking into account their effects on immune responses, in order to avoid undesirable effects on one hand, and to design particles with desirable effects for medical applications on the other hand; 2.for designing more effective nanomedicines by either avoiding or exploiting their interaction with the immune systems, with particular focus on cancer diagnosis and therapy, and vaccination. This collection of articles gives a comprehensive view of the state-of-the-art of the interaction of nanoparticles with the immune system from the two perspectives of safety and medical use, and aims at providing immunologists with the relevant knowledge for designing improved strategies for immunologically safe nanomaterial applications.
Nanoscience And Technology A Collection Of Reviews From Nature Journals
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Author : Peter Rodgers
language : en
Publisher: World Scientific
Release Date : 2009-08-21
Nanoscience And Technology A Collection Of Reviews From Nature Journals written by Peter Rodgers and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-08-21 with Technology & Engineering categories.
This book contains 35 review articles on nanoscience and nanotechnology that were first published in Nature Nanotechnology, Nature Materials and a number of other Nature journals. The articles are all written by leading authorities in their field and cover a wide range of areas in nanoscience and technology, from basic research (such as single-molecule devices and new materials) through to applications (in, for example, nanomedicine and data storage).
Nanotechnology Based Microbicides And Immune Stimulators
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Author : Suriya Rehman
language : en
Publisher: Springer Nature
Release Date : 2025-02-18
Nanotechnology Based Microbicides And Immune Stimulators written by Suriya Rehman and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-18 with Technology & Engineering categories.
This book reviews the use of nano-based drug delivery systems and biomaterials to enhance the immune system against infectious diseases. It focusses on the inbuilt immunoreactive properties of nanomaterials and the advancement in its engineering to modulate the immune system either via immune-stimulation or immunosuppression. The book further discusses the use of nanoparticle-based vaccines to improve vaccine efficacy, immunization strategies, and targeted delivery to achieve desired immune responses at the cellular level against infectious diseases. Perhaps, book focusses on nanoscale diagnostics that offer new approaches for sensitive health monitoring that are potable and can guide the use of nanoscale therapies. This book explores the potential of immunomodulatory nanotechnologies, focusing not only on their benefits, but also on biocompatibility, and toxicity concerns, while highlighting promising innovations in Interferon-based immune therapies and addressing key challenges in achieving safe, scalable nanotech products. The book would encompass broad topics to attract the diverse specialty of physicians, health professionals, students, faculty, and researchers of nanotechnology, nanomedicine, infectious diseases, public health, immunology, bacteriology, virology, pathology, biotechnology, toxicology, and biomedical technology.
Biochemical Toxicology
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Author : Muharrem Ince
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-07-29
Biochemical Toxicology written by Muharrem Ince and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-07-29 with Medical categories.
Biochemical Toxicology - Heavy Metals and Nanomaterials provides an overview of biochemical contamination, nanomaterials and toxic metals, and measurement techniques. It explains and clarifies important studies and compares and develops new and groundbreaking measurement techniques in the fields of organic and inorganic pollution and nanoscience. It is highly recommended for professionals and readers interested in the environment and human health.
Characterization Of Nanoparticles Intended For Drug Delivery
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Author :
language : en
Publisher: Springer
Release Date : 2011-08-14
Characterization Of Nanoparticles Intended For Drug Delivery written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-08-14 with categories.
Interaction Of Nanomaterials With The Immune System
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Author : James C. Bonner
language : en
Publisher: Springer Nature
Release Date : 2020-01-30
Interaction Of Nanomaterials With The Immune System written by James C. Bonner and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-01-30 with Medical categories.
This book covers the latest information related to understanding immune responses to engineered nanomaterials (ENMs). Many ENMs used in both the consumer and biomedical fields have been reported to elicit adverse immune responses ranging from innate immune responses such as complement activation to changes in adaptive immunity that influence pathogen responses and promote disease states such as asthma. Interaction of Nanomaterials with the Immune System covers the most up to date information on our understanding of immune responses to ENMs across a wide range of topics including innate immunity, allergic immune responses, adaptive provides the reader with (1) up to date understanding of immune responses to ENMs; (2) current testing methods; and (3) appropriate models including alternative testing strategies for evaluating immunotoxicity of ENMs.
Nanoparticle Mediated Immunotherapy
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Author : Tuan Vo-Dinh
language : en
Publisher: Springer Nature
Release Date : 2021-10-12
Nanoparticle Mediated Immunotherapy written by Tuan Vo-Dinh and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-12 with Science categories.
This book is intended to serve as an authoritative reference source for a broad audience involved in the research, teaching, learning, and practice of nanotechnology in immunotherapy. The combination of nanotechnology and immunotherapy is recognized as a promising treatment modality. In particular, the use of nanoparticles in immunotherapy has attracted increased attention for their unique efficacy and specificity in cancer treatment. A wide variety of nanoparticles, such as polymeric and liposomal nanosystems, carbon nanotubes, and gold nanoparticles have provided important nanoplatforms for immunotherapeutic approaches. They have been shown to improve delivery and efficacy of immunotherapeutic agents such as vaccines or adjuvants. Nanoparticle-mediated thermal therapy has demonstrated the effectiveness for precise tumor cell ablation, radio-sensitization of hypoxic regions, enhancement of drug delivery, activation of thermosensitive agents, and enhancement of the immune system. Plasmonic nanoparticles are a special type of metallic nanoparticles that has received great interest due to their enhanced optical and electromagnetic properties and their superior capacity to convert photon energy into heat for selective photothermal therapy at the nanoscale level. Nanoparticle sizes can also be controlled such that they accumulate preferentially in tumors due to the enhanced permeability and retention effect of tumor vasculature. Various nanosystems such as gold nanoparticles have also been shown to stimulate the immune system. Immunotherapies could thus synergistically benefit from the combination with targeted nanoparticle-mediated photothermal therapies, especially when hyperthermia around immune-checkpoint inhibitors in the tumor bed is combined with precise thermal ablation of cancer cells. Of great importance is the possibility that such an approach can induce long-term immunological memory that can provide protection against tumor recurrence long after treatment of the initial tumors, like an ‘anticancer vaccine’. Nanoparticle-mediated immunotherapy could lead to an entirely new treatment paradigm that challenges traditional surgical resection approaches for many cancers and metastases.
Biomaterials And Immune Response
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Author : Nihal Engin Vrana
language : en
Publisher: CRC Press
Release Date : 2018-07-20
Biomaterials And Immune Response written by Nihal Engin Vrana and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-20 with Medical categories.
The interactions of the biomaterials with the host immune system is crucial for their functionality. This book aims to provide the reader with a better understanding of the role of the immune system in biomaterial applications. For this end, the book has dedicated chapters for i) explaining immune cells taking part in immune response to biomaterials/immune systems interface; ii) the effect of biomaterial shape, form and physicochemical properties on the response of immune system; iii) biofilm formation on implanted materials as a failure of immune system/biomaterial interactions; iv) tissue-specific effects of immune response and its consequences for tissue engineering and regenerative medicine; v) immune reaction in a clinical context (periodontology). In the field of biomaterials there are significant advances in using immunomodulation techniques to improve the success rates of implantable materials. For better understanding of such techniques it is required to have a full grasp of the biomaterial–immune system interactions. This would greatly enhance the understanding of why the human body reacts to implants in a certain way and how to improve the clinical outcomes by developing immune-instructive biomaterials. Provides keen insight into biomaterial–immune cell interactions Presents an explanation of state-of-the-art methodologies in immunomodulation Offers a concise and simple-to-understand treatment of biomaterial–immune cell interactions for materials scientists in a biology heavy topic Explores a comprehensive overview of biomaterial related complications Provides extensive references at the end of each chapter to enhance study for this very hot research area
Environmental Influences On The Immune System
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Author : Charlotte Esser
language : en
Publisher: Springer
Release Date : 2016-02-04
Environmental Influences On The Immune System written by Charlotte Esser and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-04 with Medical categories.
This book brings together articles on the overarching theme of how the environment shapes the immune system. The immune system is commonly assumed to respond to harmful pathogens such as bacteria and viruses. However, harmless bacteria, chemicals, stress, normal food and other factors can also trigger, shape or interfere with the immune system, often producing adverse effects. Yet, it is also becoming increasingly accepted that some of these interactions are physiological and necessary for a healthy immune system. Examples of negative effects include the immunosuppressive effects of UV irradiation, or the immunotoxic effects of man-made chemicals such as polycyclic aromatic hydrocarbons. Autoimmunity or allergies can be the adverse consequences of interaction between the immune system and chemical compounds such as drugs. Positive effects can come from natural exposure levels to bacteria, healthy life-style or the diet. There is a great need to understand how communication between the environment and the immune system works. This book addresses this need. It covers environmental factors (such as bacteria, sun exposure), human factors (such as age, exercise or stress), and important man-made factors (such as air pollution). A chapter on human rights complements the scientific chapters. The book is intended for immunologists, toxicologists and researchers who want to know how the immune system works and is triggered, as well as for medical doctors in environmental medicine and the general public interested in immunology.