Nanotechnology Enabled Biomedical Fluorescence Imaging In The Second Near Infrared Window
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Nanotechnology Enabled Biomedical Fluorescence Imaging In The Second Near Infrared Window
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Author : Guosong Hong
language : en
Publisher:
Release Date : 2014
Nanotechnology Enabled Biomedical Fluorescence Imaging In The Second Near Infrared Window written by Guosong Hong and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014 with categories.
Fluorescence imaging in the second near-infrared window (NIR-II, 1.0-1.7 microns) has many salient advantages over the visible (400-750 nm) and the traditional near-infrared (NIR-I, 750-900 nm) windows owing to the reduced photon scattering and negligible tissue autofluorescence. However, NIR-II fluorescence imaging has been limited by the scarcity of materials with sufficient NIR-II fluorescence quantum efficiency, and single-walled carbon nanotube (SWNT) had been the only fluorophore for biological imaging in the NIR-II window. This work aims to enhance the intrinsic NIR-II fluorescence of SWNTs, apply SWNTs for in vivo imaging of real-world medical problems in animal models and develop new NIR-II fluorophores other than SWNTs. First, a plasmonic gold substrate is used to enhance the intrinsically low NIR-II fluorescence of SWNTs and to improve the sensitivity of cancer cell imaging using SWNTs as molecular targeting probes. The sensitive distance dependence of fluorescence enhancement of SWNTs is then exploited to probe the trans-membrane motion of single nanotube molecules and reveal the internalization pathway as receptor-mediated endocytosis. The biocompatible SWNTs are further applied to an in vivo animal model of lower limb ischemia, where we demonstrate microvascular imaging and hemodynamic measurement using NIR-II fluorescence, with improved spatial resolution over X-ray computer tomography (CT) and broader dynamic range of blood flowmetry than ultrasound. In a rationally chosen sub-region of NIR-II in the 1.3-1.4 micron range, chemically separated SWNTs allow for non-invasive brain vascular imaging through intact scalp and skull with sub-10 micron resolution at millimeter depth of penetration. Lastly, two new materials, Ag2S quantum dots (QDs) and conjugated copolymers are developed to expand the toolbox of NIR-II fluorophores. The Ag2S QDs afford in vitro targeted cancer cell imaging and in vivo mouse imaging with high tumor uptake. The high fluorescence quantum yield of the conjugated copolymer allows for ultrafast dynamic NIR-II imaging of the arterial blood flow with waveform cardiac cycles revealed in hemodynamic analysis. The many benefits of NIR-II fluorescence imaging demonstrated in this work based on the development of a handful of biocompatible NIR-II nanomaterials bode well for future biological research and clinical applications with this new imaging technique.
Near Infrared Emitting Nanoparticles For Biomedical Applications
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Author : Antonio Benayas
language : en
Publisher: Springer Nature
Release Date : 2020-04-13
Near Infrared Emitting Nanoparticles For Biomedical Applications written by Antonio Benayas and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-13 with Technology & Engineering categories.
This book analyzes and evaluates the growing field of light-emitting nanoprobes as contrast agents for in vivo imaging and sensing. It is a comprehensive resource that critically analyzes the state of the art in an interdisciplinary manner, with a special focus on the shift of emission wavelengths into the near-infrared (NIR) spectral region (ranging from 0.7 to 2 microns), which has greatly contributed to the latest advances in biomedical imaging and sensing. This book discusses merits of different contrast agents at nanoscale, and how their unique chemical and structural properties lead to the emission and interaction of light within the NIR window. Both the NIR-emitting materials and various surface modification strategies governing their interactions with the biological system at the “nano” level are discussed. Furthermore, different experimental techniques and protocols for NIR-light-based in vivo imaging and sensing are addressed to shed light on further understanding of the advantages and limitations of each category of these nanoprobes. Assembles the state of the art heretofore appearing in scientific literature into a comprehensive, multi-perspective guidebook on near infrared-emitting nanomaterials in an assortment of biomedical applications; Explains the physical, chemical, and biological phenomena underlying near infrared-emitting nanomaterials for biomedical applications; Presents conceptual and experimental approaches surrounding a unique spectral range of light emission from nanosized contrast agents, while offering a clear explanation of basic and general phenomena regarding the interaction between light and biological tissues, such as absorption, scattering and autofluorescence.
Near Infrared Nanomaterials
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Author : Professor Fan Zhang
language : en
Publisher: Royal Society of Chemistry
Release Date : 2016
Near Infrared Nanomaterials written by Professor Fan Zhang and has been published by Royal Society of Chemistry this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016 with Medical categories.
In the last decade, bioimaging and therapy based on near-infrared (NIR) nanomaterials have played an important role in biotechnology due to their intrinsic advantages when compared with the traditional imaging probe and medicine. NIR nanomaterials allow deeper penetration depth, low detection threshold concentration and better targeted performance. This book systematically summarises the recent progress in the fabrication and application of NIR nanomaterials for biomedical imaging and therapy, and discusses the advantages, challenges and opportunities available. Near-infrared Nanomaterials contains a chapter highlighting the outlook of these materials, detailing novel ideas for the further application of NIR nanomaterials in bioimaging and medicine. Written by leading experts working in the field, this title will have broad appeal to those working in chemistry, materials science, nanotechnology, biology and bioengineering, biomedical science and biophysics.
Metal Enhanced Fluorescence
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Author : Chris D. Geddes
language : en
Publisher: John Wiley & Sons
Release Date : 2010-06-22
Metal Enhanced Fluorescence written by Chris D. Geddes and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-06-22 with Science categories.
Discover how metal-enhanced fluorescence is changing traditional concepts of fluorescence This book collects and analyzes all the current trends, opinions, and emerging hot topics in the field of metal-enhanced fluorescence (MEF). Readers learn how this emerging technology enhances the utility of current fluorescence-based approaches. For example, MEF can be used to better detect and track specific molecules that may be present in very low quantities in either clinical samples or biological systems. Author Chris Geddes, a noted pioneer in the field, not only explains the fundamentals of metal-enhanced fluorescence, but also the significance of all the most recent findings and models in the field. Metal-enhanced fluorescence refers to the use of metal colloids and nanoscale metallic particles in fluorescence systems. It offers researchers the opportunity to modify the basic properties of fluorophores in both near- and far-field fluorescence formats. Benefits of metal-enhanced fluorescence compared to traditional fluorescence include: Increased efficiency of fluorescence emission Increased detection sensitivity Protect against fluorophore photobleaching Applicability to almost any molecule, including both intrinsic and extrinsic chromophores Following a discussion of the principles and fundamentals, the author examines the process and applications of metal-enhanced fluorescence. Throughout the book, references lead to the primary literature, facilitating in-depth investigations into particular topics. Guiding readers from the basics to state-of-the-technology applications, this book is recommended for all chemists, physicists, and biomedical engineers working in the field of fluorescence.
Nanotechnology Characterization Tools For Biosensing And Medical Diagnosis
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Author : Challa S.S.R. Kumar
language : en
Publisher: Springer
Release Date : 2018-05-02
Nanotechnology Characterization Tools For Biosensing And Medical Diagnosis written by Challa S.S.R. Kumar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-02 with Technology & Engineering categories.
Eighth volume of a 40 volume series on nanoscience and nanotechnology, edited by the renowned scientist Challa S.S.R. Kumar. This handbook gives a comprehensive overview about Nanotechnology Characterization Tools for Biosensing and Medical Diagnosis. Modern applications and state-of-the-art techniques are covered and make this volume an essential reading for research scientists in academia and industry.
Cancer Nanotechnology
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Author : Ângela Maria Almeida de Sousa
language : en
Publisher: Springer Nature
Release Date : 2022-12-13
Cancer Nanotechnology written by Ângela Maria Almeida de Sousa and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-12-13 with Medical categories.
Cancer nanotechnology is a growing, emerging area of cross-disciplinary research that aims to develop efficient, specific and noninvasive approaches to restore the health and well-being of all cancer patients through more effective diagnosis and treatment. This new volume serves as a fundamental guide to cutting-edge topics in cancer nanotechnology, including advances in therapy, the use of nanoparticles and nanomaterials, future directions for nanocarriers in cancer therapy, and the application of DNA and RNA nanovaccines. Organized into four sections, the volume presents an overview of research and innovation in the emerging field of nanotechnology as a powerful tool in the diagnosis, imaging and treatment of cancer. International experts author chapters addressing targets of cancer therapy, materials for cancer nanotechnology, strategies for cancer therapy using nanotechnology, and innovative nanotechnologies for cancer diagnosis and treatment. The volume will be useful for a broad audience, including cross-disciplinary researchers, trainees, health professionals, and experts in industry.
Nanomedicine For Deep Tissue High Resolution Bio Imaging And Non Invasive Therapy
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Author : Michael Ming-Yuan Wei
language : en
Publisher: Frontiers Media SA
Release Date : 2020-11-12
Nanomedicine For Deep Tissue High Resolution Bio Imaging And Non Invasive Therapy written by Michael Ming-Yuan Wei and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-11-12 with Science categories.
Dr Ming-Yuan Wei currently holds a pending U.S. Patent Application entitled “Systems and Methods for High-Resolution Imaging”. All other Guest Editors have no other competing interests to declare with regards to the Topic subject.
Nanomaterials And Their Biomedical Applications
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Author : Tuhin Subhra Santra
language : en
Publisher: Springer Nature
Release Date : 2021-04-16
Nanomaterials And Their Biomedical Applications written by Tuhin Subhra Santra and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-04-16 with Science categories.
This book highlights the evolution of, and novel challenges currently facing, nanomaterials science, nanoengineering, and nanotechnology, and their applications and development in the biological and biomedical fields. It details different nanoscale and nanostructured materials syntheses, processing, characterization, and applications, and considers improvements that can be made in nanostructured materials with their different biomedical applications. The book also briefly covers the state of the art of different nanomaterials design, synthesis, fabrication and their potential biomedical applications. It will be particularly useful for reading and research purposes, especially for science and engineering students, academics, and industrial researchers.
Fluorescence Methods For Investigation Of Living Cells And Microorganisms
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Author : Natalia Grigoryeva
language : en
Publisher: BoD – Books on Demand
Release Date : 2020-09
Fluorescence Methods For Investigation Of Living Cells And Microorganisms written by Natalia Grigoryeva and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-09 with Cytofluorometry categories.
Fluorescence methods play a leading role in the investigation of biological objects. They are the only non-destructive methods for investigating living cells and microorganisms in vivo. Using intrinsic and artificial fluorescence methods provides deep insight into mechanisms underlying physiological and biochemical processes. This book covers a wide range of modern methods involved in experimental biology. It illustrates the use of fluorescence microscopy and spectroscopy, confocal laser scanning microscopy, flow cytometry, delayed fluorescence, pulse-amplitude-modulation fluorometry, and fluorescent dye staining protocols. This book provides an overview of practical and theoretical aspects of fluorescence methods and their successful application in the investigation of static and dynamic processes in living cells and microorganisms.
Frontiers In Biophotonics For Translational Medicine
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Author : Malini Olivo
language : en
Publisher: Springer
Release Date : 2015-07-15
Frontiers In Biophotonics For Translational Medicine written by Malini Olivo and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-07-15 with Technology & Engineering categories.
The present book provides recent developments in various in vivo imaging and sensing techniques such as photo acoustics (PA) imaging and microscopy, ultrasound-PA combined modalities, optical coherence tomography (OCT) and micro OCT, Raman and surface enhanced Raman scattering (SERS), Fluorescence lifetime imaging (FLI) techniques and nanoparticle enabled endoscopy etc. There is also a contributing chapter from leading medical instrumentation company on their view of optical imaging techniques in clinical laparoscopic surgery. The UN proclaimed 2015 as the International Year of Light and Light-based Technologies, emphasizing achievements in the optical sciences and their importance to human beings. In this context, this book focusses on the recent advances in biophotonics techniques primarily focused towards translational medicine contributed by thought leaders who have made cutting edge developments in various photonics techniques.