Natural And Synthetic Neurotoxins
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Natural And Synthetic Neurotoxins
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Author : Alan L. Harvey
language : en
Publisher:
Release Date : 1993
Natural And Synthetic Neurotoxins written by Alan L. Harvey and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993 with Medical categories.
Very Good,No Highlights or Markup,all pages are intact.
Neurotoxins
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Author : J. Eric McDuffie
language : en
Publisher: BoD – Books on Demand
Release Date : 2018-05-23
Neurotoxins written by J. Eric McDuffie and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-05-23 with Medical categories.
Toxicologists seek to better understand the myriad of mechanisms responsible for neurotoxins. Because the incidence of neurobehavioral hazards and risks of exogenous compounds (e.g., natural toxins, synthetic molecules, and therapeutic agents) remain a subject matter of interest, predictive tools have evolved, including but not limited to novel translational in vitro models, biomarkers, newer epidemiological research tools, and well-accepted best practices for diagnosing neurotoxins in clinical practice. Taken together, the foreseen need to highlight some of the more appreciated and/or emerging tactical approaches in neurotoxicology results in a "one-stop reference" book, Neurotoxins.
Environmental Neurotoxicology
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Author : National Research Council
language : en
Publisher: National Academies Press
Release Date : 1992-02-01
Environmental Neurotoxicology written by National Research Council and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-02-01 with Science categories.
Scientists agree that exposure to toxic agents in the environment can cause neurological and psychiatric illnesses ranging from headaches and depression to syndromes resembling parkinsonism. It can even result in death at high exposure levels. The emergence of subclinical neurotoxicity-the concept that long-term impairments can escape clinical detection-makes the need for risk assessment even more critical. This volume paves the way toward definitive solutions, presenting the current consensus on risk assessment and environmental toxicants and offering specific recommendations. The book covers: The biologic basis of neurotoxicity. Progress in the application of biologic markers. Reviews of a wide range of in vitro and in vivo testing techniques. The use of surveillance and epidemiology to identify neurotoxic hazards that escape premarket screening. Research needs. This volume will be an important resource for policymakers, health specialists, researchers, and students.
Neurotoxins In Neurobiology
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Author : Keith F. Tipton
language : en
Publisher: CRC Press
Release Date : 1994-03-01
Neurotoxins In Neurobiology written by Keith F. Tipton and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-03-01 with Medical categories.
Natural Toxins 2
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Author : Bal Ram Singh
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Natural Toxins 2 written by Bal Ram Singh and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
From beach encounters, aquaculture perils, and processed-food poisoning to snake bites and biological warfare, natural toxins seem never to be far from the public's sight. A better understanding of toxins in terms of their origin, structure, structure-function relation ships, mechanism of action, and detection and diagnosis is of utmost importance to human and animal food safety, nutrition, and health. In addition, it is now clear that many of the toxins can be used as scientific tools to explore the molecular mechanism of several biological processes, be it a mechanism involved in the function of membrane channels, exocytosis, or cytotoxicity. Several of the natural toxins have also been approved as therapeutic drugs, which has made them of interest to several pharmaceutical companies. For example, botulinum neurotoxins, which have been used in studies in the field of neurobiology, have also been used directly as therapeutic drugs against several neuromus cular diseases, such as strabismus and blepherospasm. Toxins in combination with modem biotechnological approaches are also being investigated for their potential use against certain deadly medical problems. For example, a combination of plant toxin ricin and antibodies is being developed for the treatment of tumors. The great potential of natural toxins has attracted scientists of varying backgrounds-pure chemists to cancer biologists-to the study of fundamental aspects of the actions of these toxins.
Clostridial Neurotoxins
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Author : Cesare Montecucco
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Clostridial Neurotoxins written by Cesare Montecucco and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Medical categories.
Tetanus has been known from the very beginning of medical literature since it was first described by Hyppocrates of Cos in the fifth century B.C. For 24 centuries it was considered a neuro logical disease until the breakthrough of CARLE and RATIONE (1884) who demonstrated its infectious etiology. Following the establishment of purified cultures of Clostridium tetani(KITASATO 1889), FABER (1890), and TIZZONI and CATIANI (1890) demon strated that the disease is actually an intoxication caused by a proteic neurotoxin. This toxin was shown by BRUSHCHETIINI (1892) to move retroaxonally and to act at the spinal cord level. Soon thereafter VAN ERMENGEN (1897) demonstrated that botu lism is also due to intoxication with a protein toxin produced by bacteria of the genus Clostridium. These bacteria and their spores and ubiquitous, and the majority of them do not produce neurotoxins. The selective advantage of producing such potent toxin is still a matter of speculation (see Popoff, this volume). The next major advance was the discovery that tetanus neurotoxin 1 can be converted by formaldehyde treatment to a nonpathogenic but still fully immunogenic form, and that this can be used successfully as a vaccine to prevent tetanus (RAMON and DESCOMBEY 1925). Similar vaccines (toxoids) can be prepared with botulism neurotoxins (see MiDDLEBROOK and BROWN, this volume). The prevention oftetanus by vaccination (see Galatzka and Gasse, this volume) is one of the great successes of basic research coupled with an efficient public medicine service.
Handbook Of Neurotoxicology
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Author : Edward J. Massaro
language : en
Publisher: Springer Science & Business Media
Release Date : 2001-11-12
Handbook Of Neurotoxicology written by Edward J. Massaro and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-12 with Medical categories.
Neurotoxicology is a broad and burgeoning field of research. Its growth in recent years can be related, in part, to increased interest in and concern with the fact that a growing number of anthropogenic agents with neurotoxic potential, including pesticides, lead, mercury, and the polytypic bypro ducts of combustion and industrial production, continue to be spewed into and accumulate in the environment. In addition, there is great interest in natural products, including toxins, as sources of therapeutic agents. Indeed, it is well known that many natural toxins of broadly differing structure, produced or accumulated for predatory or defensive purposes, and toxic agents, accumulated incidentally by numerous species, function to perturb nervous tissue. Components of some of these toxins have been shown to be useful therapeutic agents and/or research reagents. Unfor tunately, the environmental accumulation of some neurotoxic ants of anthropogenic ori gin, especially pesticides and metals, has resulted in incidents of human poisoning, some of epidemic proportion, and high levels of morbidity and mortality. Furthermore, an increasing incidence of neurobehavioral disorders, some with baffling symptoms, is confronting clinicians. It is not clear whether this is merely the result of increased vigi lance and/or improved diagnostics or a consequence of improved health care. In any case, the role of exposure to environmental and occupational neurotoxic ants in the etiology of these phenomena, as well as neurodegenerative diseases, is coming under increasing scrutiny and investigation.
Protein Engineering And Design
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Author : Paul R. Carey
language : en
Publisher: Elsevier
Release Date : 1996-06-21
Protein Engineering And Design written by Paul R. Carey and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-06-21 with Science categories.
The design and production of novel peptides and proteins occupy pivotal positions in science and technology and will continue to do so in the 21st century. Protein Engineering and Design outlines the rapid advances in computer-based modeling, protein engineering, and methods needed for protein and peptide preparation and characterization. This indispensable reference lays the groundwork for understanding this multidisciplinary activity while providing an introduction for researchers and students to the field of protein design. Introduces and defines the techniques involved in protein engineering and design Provides a concise overview of key technologies involved and demonstrates their contributions to the specialized design and production of novel proteins and peptides
Neurotransmitter Release And Its Modulation
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Author : David A. Powis
language : en
Publisher: Cambridge University Press
Release Date : 1995-08-24
Neurotransmitter Release And Its Modulation written by David A. Powis and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-08-24 with Medical categories.
A uniquely comprehensive and integrated account of neurotransmitter modulation. Suitable for neuroscientists and non-specialists alike.
Neuronal Nicotinic Receptors
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Author : F. Clementi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neuronal Nicotinic Receptors written by F. Clementi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Neuronal nicotinic receptors are key molecules for signal transduction in a number of neuronal pathways. They are widely distributed in the brain and are known to be involved in cognitive tasks, including learning and memory, in smoking addiction and in several brain diseases, such as Alzheimer's and Parkinson's dementias, schizophrenia, and epilepsy. This book provides a comprehensive review of the field, starting with a historical perspective and dealing with the molecular structure of these receptors, their biophysical and pharmacological properties, their distribution in central and peripheral nervous systems, and their major involvement in brain functions. Particular emphasis is paid to drugs (both new and old) that are useful in the diagnosis and treatment of diseases involving neuronal nicotinic receptors. Finally, the relevance of these receptors in smoking addiction is carefully evaluated, together with future trends and the latest results.