Natural Killer T Cells
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Natural Killer T Cells
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Author : Nathan V. Fournier
language : en
Publisher: Nova Publishers
Release Date : 2008
Natural Killer T Cells written by Nathan V. Fournier and has been published by Nova Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with Medical categories.
Natural killer T (NKT) cells are a heterogeneous group of T cells that share properties of both T cells and natural killer (NK) cells. Many of these cells recognize the non-polymorphic CD1d molecule, an antigen-presenting molecule that binds self- and foreign lipids and glycolipids. Upon activation, NK T cells are able to produce large quantities of interferon-gamma, IL-4, and granulocyte-macrophage colony-stimulating factor, as well as multiple other cytokines and chemokines (such as IL-2 and TNF-alpha). NKT cells seem to be essential for several aspects of immunity because their dysfunction or deficiency has been shown to lead to the development of autoimmune diseases (such as diabetes or atherosclerosis) and cancers. NKT cells have recently been implicated in the disease progression of human asthma. The clinical potential of NKT cells lies in the rapid release of cytokines (such as IL-2, IFN-gamma, TNF-alpha, and IL-4) that promote or suppress different immune responses.
Natural Killer T Cells
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Author : Masaki Terabe
language : en
Publisher: Springer Science & Business Media
Release Date : 2011-09-22
Natural Killer T Cells written by Masaki Terabe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with Medical categories.
This book will cover primary roles of NKT cells in immunity to cancer, in both mouse tumor models and cancer patients. There are several chapters describing general aspects of NKT cells.
Natural Killer Cells
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Author : Jacques Zimmer
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-01-12
Natural Killer Cells written by Jacques Zimmer and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-01-12 with Medical categories.
Natural killer (NK) cells have been at the forefront of immunology for two decades. During that time, a great amount of information about these cells has been obtained. They are important in antiinfectious and antitumoral defense and shape the adaptive immune response. In addition, they can act as immunoregulatory cells. In recent years, the therapeutic potential of NK cells in cancer immunotherapy has become increasingly evident. This book describes in detail current knowledge about NK cells and covers a broad range of NK cell-related topics, including those that are not frequently reviewed, e.g. NK cells and allergy or NK cells and skin diseases.
Invariant Natural Killer T Cells
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Author : Chaohong Liu
language : en
Publisher: Humana
Release Date : 2021-10-16
Invariant Natural Killer T Cells written by Chaohong Liu and has been published by Humana this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-16 with Medical categories.
This detailed book focuses on various aspects of Invariant Natural Killer T-Cells (iNKT), which are known to contribute to homeostasis and autoimmunity and can also cause various pathological responses such as allergy, infection, excessive autoimmune response, and cancer. The volume explores techniques for identification and isolation of iNKT cells, iNKT cell activation and transformation, as well as proliferation and differentiation and much more. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Invariant Natural Killer T-Cells: Methods and Protocols is an ideal guide for researchers working with and studying iNKT cells, perhaps to provide a deeper knowledge of the human immune system.
Signaling Mechanisms Regulating T Cell Diversity And Function
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Author : Jonathan Soboloff
language : en
Publisher: CRC Press
Release Date : 2017-03-27
Signaling Mechanisms Regulating T Cell Diversity And Function written by Jonathan Soboloff and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-27 with Medical categories.
T cells play a vital role mediating adaptive immunity, a specific acquired resistance to an infectious agent produced by the introduction of an antigen. There are a variety of T cell types with different functions. They are called T cells, because they are derived from the thymus gland. This volume discusses how T cells are regulated through the operation of signaling mechanisms. Topics covered include positive and negative selection, early events in T cell receptor engagement, and various T cell subsets.
A Role For Transcriptional Regulator Id2 In Natural Killer T Cells
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Author : Laurel Anne Monticelli
language : en
Publisher:
Release Date : 2008
A Role For Transcriptional Regulator Id2 In Natural Killer T Cells written by Laurel Anne Monticelli and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008 with categories.
Natural Killer T (NKT) cells are a critical component of the body's immune system and function to activate both innate and adaptive immune cells. NKT cells are T lymphocyte lineage cells that develop in the thymus and express a variety of both NK and T cell surface markers. Mice deficient in the inhibitor of DNA binding protein-2 (Id2) fail to develop natural killer cells, CD8[alpha] dendritic cells, [alpha][beta] IELs, Langerhans cells, and lack lymph nodes. Absence of Id2 also affects the CD8 T cell immune response to infection, resulting in reduced survival of effector CD8 T cells and impaired memory formation. The role of Id2 in NKT cell physiology has not been addressed. Here, I show that bone marrow chimeras reconstituted with Id2-deficient hematopoietic stem cells have fewer NKT cells in the liver, spleen, thymus, and bone marrow compared to chimeras generated with Id2-sufficient HSCs, with the most severe defect (10-fold reduction) occurring in the liver. Despite their diminished numbers, Id2-deficient NKT cells produce cytokines after activation with [alpha]-galactocsylceramide, suggesting normal functional activity, and have similar expression levels of multiple maturation markers compared to Id2-suficient chimeras. However, Id2-deficient NKT cells have lower mRNA and cell surface expression of the chemokine receptor CXCR6, which is thought to have a critical role in NKT cell accumulation in the liver. The NKT cell defect in Id2-deficient chimeras is not due to an inability of cells to migrate to the peripheral tissues, but could be the result of increased cell death. Early NKT cell development is not affected by Id2 deficiency, possibly due to compensation by Id3, but maturation in the periphery is impaired. These experiments point to a role for Id2 in regulating a CXCR6-mediated survival/maturation signal essential for accumulation of NKT cells in the liver.
Natural Killer Cells
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Author : Michael T. Lotze
language : en
Publisher: Academic Press
Release Date : 2009-11-12
Natural Killer Cells written by Michael T. Lotze and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-12 with Medical categories.
Natural Killer Cells explains the importance of killer cells and how they are produced. It mentions that the most likely explanation for killer cell production is that they serve as a complementary system for T cells as a primary defense against viruses. However, these cells defend against certain viruses only, such as herpes viruses and influenza viruses. The book also explains the primary functions of killer cells, and it discusses how these cells help recognize damaged tissues, limit further damage to tissues, and regenerate damaged tissues. It discusses how these cells mature and develop, and it covers the different isolation, culture, and propagation methods of these cells. Furthermore, it focuses on the different killer cells that are present in various parts of the human body. The book concludes by explaining that natural killer cells are utilized for clinical therapy of malignancies, and that they have led to positive outcomes in the field of biology and medicine. Provides a broad, detailed coverage of the biology and interactions of NK cells for students, fellows, scientists, and practitioners Includes figures, histologic sections, and illustrations of the ontogeny of NK cells
Natural Killer Cells
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Author : Eric Vivier
language : en
Publisher: Springer
Release Date : 2016-02-15
Natural Killer Cells written by Eric Vivier and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-02-15 with Medical categories.
To celebrate the 40th anniversary of the discovery of Natural Killer (NK) cells, this volume focuses on the recent advances in our understanding of NK cell development and differentiation and their acquisition of functional properties, as well as the latest models for NK-cell analysis in mice and applications in clinical medicine. NK cells have travelled a circuitous path from their initial description as ‘spontaneous killers’ (for some simply an experimental artifact) to being a bona fide subset of innate lymphoid cells with a complementary mode of action in immune defense and an important mediator of immune reactivity in health and disease. Together, these reviews provide a timely and concise picture of the evolution of NK cells as essential agents in immunity and as potent weapons against disease. This book offers an appealing and insightful resource for scientists and clinicians.
Natural Killer T Cells
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Author :
language : en
Publisher:
Release Date : 2011-09-22
Natural Killer T Cells written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-09-22 with categories.
Killer Lymphocytes
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Author : Gideon Berke
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-30
Killer Lymphocytes written by Gideon Berke and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-30 with Medical categories.
This extensively documented, comprehensive survey of cell-mediated cytotoxicity (CMC) traces the history of killer lymphocytes from 1960 to the present, providing a definitive resource for specialists and non-specialists alike. It offers an advanced analysis of CMC, including a comprehensive examination of key papers underlying its evolution, and provides a thorough discussion of the most recent advances in the field.