Navigating Endophytic Research For Next Generation Therapeutics

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Navigating Endophytic Research For Next Generation Therapeutics

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Author : Vagish Dwibedi
language : en
Publisher: Academic Press
Release Date : 2025-02-17

Navigating Endophytic Research For Next Generation Therapeutics written by Vagish Dwibedi and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2025-02-17 with Science categories.

Navigating Endophytic Research for Next-Generation Therapeutics explores the evolving field of endophytic fungal research and applications in combating diseases, addressing environmental challenges, and in shaping the future of therapeutics. The book starts off with a discussion on the biodiversity and biogeography of endophytic fungal communities and describes the bioprospecting of endophytes for drug discovery. In addition, it covers the therapeutic application of endophytic fungi to treat and manage specific diseases and investigates the innovative use of technologies such as genome editing, genetic engineering for enhanced bioactivity, multi-omics-based exploration, and the use of big data and machine learning in endophytic drug discovery.Featuring contributions from experts across fields like mycology, pharmacology, biotechnology, and environment science, this comprehensive, practical, and insightful resource guides those engaged in endophytic fungal research and its transformative potential in next-generation therapeutics. - Explores diverse research techniques for isolating, culturing, and characterizing endophytic fungi - Demonstrates how endophytic fungi have been successfully utilized in drug discovery and therapeutic applications - Recognizes the importance of responsible research practices and ethical considerations in bioprospecting and drug development

Advances In Endophytic Fungal Research

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Author : Bhim Pratap Singh
language : en
Publisher: Springer
Release Date : 2019-02-12

Advances In Endophytic Fungal Research written by Bhim Pratap Singh and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-02-12 with Science categories.

Plant endophytes are a potential source for the production of bioactive compounds that can fight against devastating diseases in both plants and humans. Among these endophytic microorganisms, endophytic fungi are one of the dominant group of microorganisms with a potential role in plant growth promotion and the discovery of noble bioactive natural products. Endophytic fungi possess several bioactivities like anticancer, antimicrobial, insecticidal, plant growth stimulants, crop protection, phytoremediation, etc. Presence of modular biosynthetic genes clusters like PKS and NRPS in several endophytic fungi underscores the need to understand and explore such organisms. This volume presents and demonstrates the applied aspects of endophytic fungi. Practical applications of such endophytes are discussed in detail, including studies in pharmaceutical development and agricultural management of important microbial diseases. The beneficial effects that endophytic fungi provide to host plants—enhancing growth, increasing fitness, strengthening tolerance to abiotic and biotic stresses through secondary metabolites—are also discussed. The reader is provided with a comprehensive and detailed understanding of such relationships between endophytic fungi and their host.

Anticancer Plants Natural Products And Biotechnological Implements

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Author : Mohd Sayeed Akhtar
language : en
Publisher: Springer
Release Date : 2018-07-02

Anticancer Plants Natural Products And Biotechnological Implements written by Mohd Sayeed Akhtar and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-07-02 with Science categories.

This volume provides summarized scientific evidence of the different classes of plant-derived phytocompounds, their sources, chemical structures, anticancer properties, mechanisms of action, methods of extraction, and their applications in cancer therapy. It also discusses endophyte-derived compounds as chemopreventives to treat various cancer types. In addition, it provides detailed information on the enhanced production of therapeutically valuable anticancer metabolites using biotechnological interventions such as plant cell and tissue culture approaches, including in vitro-, hairy root- and cell-suspension culture; and metabolic engineering of biosynthetic pathways. Anticancer Plants: Natural Products and Biotechnological Implements – Volume 2” explores the natural bioactive compounds isolated from plants as well as fungal endophytes, their chemistry, and preventive effects to reduce the risk of cancer. Moreover, it highlights the genomics/proteomics approaches and biotechnological implementations. Providing solutions to deal with the challenges involved in cancer therapy, the book benefits a wide range of readers including academics, students, and industrial experts working in the area of natural products, medicinal plant chemistry, pharmacology, and biotechnology.

Endophytes And Secondary Metabolites

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Author : Sumita Jha
language : en
Publisher: Springer
Release Date : 2019-07-24

Endophytes And Secondary Metabolites written by Sumita Jha and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-07-24 with Science categories.

This reference work presents an authoritative review of endophytes and their applications to human welfare. Endophytes have become a class of interesting and curious microorganisms due to their intimate intra- and intercellular association with plants for competence, survival and reproduction. They can be bacteria or fungi, and they are usually non-pathogenic to their host. Endophytes have important applications in agriculture and industry, namely, they can help with plant growth, act as biocontrol agents and biosurfactant and secondary metabolite producers, and they are also rich sources of bioactive natural products. Novel and beneficial effects of endophytes are constantly emerging, and this book, divided into four sections, provides readers with the latest developments in this fast expanding field. In the first section, readers will discover the biology of the major groups of endophytes, followed by a summary of conventional and molecular tools for endophytes’ identification in Section II. The production of high-value metabolites by endophytes will be explored in the third section of this book, and in the final section, readers will find several case studies, examples and prospects for endophytes’ application in agriculture and industry. Written by leading international authors, this reference work will appeal to a wide readership, from students and researchers in the field of botany, biotechnology and agriculture to professionals interested in the production and applications of endophytic metabolites.

Microbial Ecology Of Leaves

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Author : John H. Andrews
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Microbial Ecology Of Leaves written by John H. Andrews and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

The leaf surface or phyllosphere is a major habitat for microorganisms. Microbes on or within leaves play important roles in plant ecology, and these microbes can be manipulated to enhance plant growth or reduce plant disease. This book presents a number of critical reviews by internationally recognized experts on the microbial ecology of leaves. Topics include methods of assessment of microbial populations on leaf surfaces, leaves as reservoirs of ice nucleation phenomenon, and leaves as microbial habitats in both aquatic and terrestrial environments. The book will be of interest to students and scientists in numerous disciplines, including botany, aerobiology, meteorology, ecology, agriculture, and microbiology.

Bioresource Utilization And Management

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Author : Hrudayanath Thatoi
language : en
Publisher: CRC Press
Release Date : 2021-10-14

Bioresource Utilization And Management written by Hrudayanath Thatoi and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-10-14 with Nature categories.

The need for exploration, conservation, and sustainable utilization of bioresources is undeniable for the survival and growth of mankind. This new book throws light on new and recent research on and development of effective strategies for sustainable utilization of bioresources using modern tools and techniques to help meet this challenge. This volume addresses the utilization of bioresources in therapeutics, in biofuel, in agriculture, and in environmental protection. Beginning with the diverse potential applications of bioresources in food, medicine, and cosmetics, the volume goes on to address the various different underutilized bioresources and their sustainable uses. It discusses important advances in biofuel and patents that highlight recent developments that address the energy crises and the continuously fluctuating cost of petroleum. It explores new renewable energy sources from bioresources and their sustainable utilization in the bioenergy and biofuel industry. Several chapters focus on the sustainable utilization of bioresources in the agricultural sector. The volume considers that developing countries have huge agricultural resources that could be employed for production of value-added byproducts for the sustainable development of a bio-based economy. The book discusses efficient use of underexploited natural bioresources, new chemical approaches for the generation of novel biochemicals, and the applications of genetics approaches for bioresource conservation and production of value-added products. Further, strategies for the production of biopesticides utilizing bioresources are also discussed.

Modern Phytomedicine

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Author : Iqbal Ahmad
language : en
Publisher: John Wiley & Sons
Release Date : 2006-12-13

Modern Phytomedicine written by Iqbal Ahmad and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2006-12-13 with Medical categories.

This timely and original handbook paves the way to success in plant-based drug development, systematically addressing the issues facing a pharmaceutical scientist who wants to turn a plant compound into a safe and effective drug. Plant pharmacologists from around the world demonstrate the potentials and pitfalls involved, with many of the studies and experiments reported here published for the first time. The result is a valuable source of information unavailable elsewhere.

Endophytes

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Author : Ravindra H. Patil
language : en
Publisher: Springer Nature
Release Date : 2021-03-25

Endophytes written by Ravindra H. Patil and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-03-25 with Science categories.

This book describes the various therapeutic and commercial applications of compounds produced by endophytes. Endophytes are microorganisms that reside in the living internal tissues of plants without showing any apparent symptom of their presence. During their life cycle, they establish a symbiotic or parasitic relationship with the host plant. The book discusses different kinds of compounds that these endophytes produce, and their potential properties such as antimicrobial, anti-oxidative, anti-inflammatory, anticancer, neutraceutical, immunomodulatory etc. Other prospects of entophytic biology such as fungi of wild and domesticated crop plants and their applications in sustainable agriculture have also been included. The book also provides details about various techniques used in endophyte research, metabolite detection and bioactivity-based assays to explore endophytes. Endophytes with phytohormones‐producing potential and their role in plant —microbial interactions under stress are also discussed. The book also highlights novel strategies to tap into the hidden potential of endophytic fungi for the production of novel biomolecules using an integrated approach. These microorganisms have attracted a lot of scientific attention worldwide because of their huge potential for novel phytochemicals, pharmaceuticals and lead compounds. Hundreds of new novel endophytic fungi have been isolated, identified and systematically studied in last decade. However, this is the first of its kind, systematic compilation of potential biotechnological applications of endophytic compounds. Chapter contributions from groups across the globe make this book very up-to-date and informative. This book is very useful and interesting for students and researchers in the field of microbiology, plant sciences, mycology and pharmacology. It is also helpful for industry experts working on developing novel compounds.

Therapeutic Enzymes Function And Clinical Implications

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Author : Nikolaos Labrou
language : en
Publisher: Springer Nature
Release Date : 2019-09-03

Therapeutic Enzymes Function And Clinical Implications written by Nikolaos Labrou and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-09-03 with Science categories.

Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This volume aims to overview these therapeutic enzymes, focusing in particular on more recently approved enzymes produced by recombinant DNA technology. This volume is composed of four sections. Section 1 provides an overview of the production process and biochemical characterization of therapeutic enzymes, while Section 2 focuses upon the engineering strategies and delivery methods of therapeutic enzymes. Section 3 highlights the clinical applications of approved therapeutic enzymes, including aspects on their structure, indications and mechanisms of action. Together with information on these mechanisms, safety and immunogenicity issues and various adverse events of the recombinant enzymes used for therapy are discussed. Section 4, provides discussion on the prospective and future developments of new therapeutic enzymes. This book is aimed at academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

Plant Associated Bacteria

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Author : Samuel S. Gnanamanickam
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-09-29

Plant Associated Bacteria written by Samuel S. Gnanamanickam and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-09-29 with Science categories.

This volume is envisioned as a resource for researchers working with beneficial and harmful groups of bacteria associated with crop plants. The book is divided into two parts, with Part I on beneficial bacteria including chapters on symbiotic nitrogen fixers and rhizosphere bacteria. The second part consists of detailed descriptions of 8 genera of plant pathogenic bacteria, including Agrobacterium and Herbaspirillum. Each chapter covers terminology, molecular phylogeny and more. soft-rot, Pseudomonas, Xanthomonas, Ralstonia, Burkholderia and Acidovorax There is an opening chapter on the plant-associated bacteria survey, molecular phylogeny, genomics and recent advances. And each chapter includes terminology/definitions, molecular phylogeny, methods that can be used (both traditional and latest molecular tools) and applications