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Neo Adjuvant Chemotherapy


Neo Adjuvant Chemotherapy
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Neoadjuvant Chemotherapy


Neoadjuvant Chemotherapy
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Author : Maurie Markman
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-05-22

Neoadjuvant Chemotherapy written by Maurie Markman and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.


In the chapters of this excellent text, the authors have described advances in the neoadjuvant chemotherapeutic management of a number of tumor types. Based on the extensive experience with this management concept in breast cancer, several chapters are devoted to this important topic (Section 1). Section 2 deals with the administration of neoadjuvant chemotherapy in non-breast malignancies. Those who read and study the content of the chapters in this book will come away with a far greater understanding of the rationale supporting neoadjuvant chemotherapy, the existing evidence-based data regarding its use, limitations of the approach, and required future investigative efforts to learn how to optimize the benefits of this innovative management concept.



Proceedings Of The 3rd International Congress On Neo Adjuvant Chemotherapy


Proceedings Of The 3rd International Congress On Neo Adjuvant Chemotherapy
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Author : Pierre Banzet
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29

Proceedings Of The 3rd International Congress On Neo Adjuvant Chemotherapy written by Pierre Banzet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.


This book includes some selected presentations given at the 3rd International Congress on Neo-Adjuvant Chemotherapy which was held in Paris from February 6th to February 9th, 1991. It was attended by over 2000 physicians from around the world and by 700 nurses. Its organisation was saddened by the untimely death of Professor Claude Jacquillat on October 12th, 1990. It was further complicated in January and February 1991 by the gulf events which led some guests to cancel their participation. However with the outstanding help of the two presidents cho sen by Claude Jacquillat before his death, Pierre Banzet from Paris and James F. Holland from New York, the organizers could set up an exciting meeting confirming the impact of neo-adjuvant chemotherapy on relatively new indi cations such as non-small lung cancers, bladder cancer, esophagal cancer, cer vix cancer, etc ... It is noteworthy that a contradictory debate on primary chemotherapy in non-small lung cancer turned into a consensus conference. In breast cancer, the downstaging induced by primary chemotherapy is ack nowledged by all and the conviction that Jacquillat defended so heartily that breast preservation should be proposed to all patients with breast cancer what ever their tumour size is shared now by more and more people. A special emphasis was given to new drugs, new combination, new access (locoregional therapy) and new developments such as that of growth factors and of interleukin 2.



Neo Adjuvant Chemotherapy


Neo Adjuvant Chemotherapy
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Author : Claude Jacquillat
language : en
Publisher: John Libbey Eurotext
Release Date : 1988

Neo Adjuvant Chemotherapy written by Claude Jacquillat and has been published by John Libbey Eurotext this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.


This book presents the Proceedings of the Second International Congress on Neo-Adjuvant Chemotherapy which took place on 19 to 21 February 1988 in Paris.



Preoperative Neoadjuvant Chemotherapy


Preoperative Neoadjuvant Chemotherapy
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Author : Joseph Ragaz
language : en
Publisher:
Release Date : 1986-04-01

Preoperative Neoadjuvant Chemotherapy written by Joseph Ragaz and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1986-04-01 with categories.




Neoadjuvant Chemotherapy


Neoadjuvant Chemotherapy
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Author : Oliver Bathe
language : en
Publisher: BoD – Books on Demand
Release Date : 2012-02-01

Neoadjuvant Chemotherapy written by Oliver Bathe and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-02-01 with Medical categories.


The most significant advances in cancer therapy in recent years have involved the development of systemic therapeutics. With improvements in response rates in solid tumors, opportunities have arisen to enhance the effectiveness of surgery. Administration of systemic therapy prior to surgery - neoadjuvant chemotherapy - represents one approach by which clinicians have successfully reduced the extent of surgery and, in some instances, positively impacted on clinical outcomes. This collection of works by expert clinicians from a variety of disciplines represents an exploration of the current knowledge of the role of neoadjuvant chemotherapy in diverse tumor types.



Adjuvant Therapy Of Breast Cancer


Adjuvant Therapy Of Breast Cancer
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Author : I. Craig Henderson
language : en
Publisher: Springer
Release Date : 1992-08-31

Adjuvant Therapy Of Breast Cancer written by I. Craig Henderson and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-08-31 with Health & Fitness categories.


The results of randomized trials evaluating the use of early or adjuvant systemic treatment for patients with resectable breast cancer provide an eloquent rebuttal to those who would argue that we have made no progress in the treatment of cancer. Many of the tumors that we have been most successful in curing with chemotherapy and other newer forms of treatment are relatively uncommon. In contrast, breast cancer continues to be the single most common malignancy among women in the western world, is increasingly a cause of death throughout Asia and Third-World countries, and remains one of the most substantial causes of cancer mortality world wide. The use of mammography as a means of early detection has been shown to reduce breast cancer mortality by 25-35% among those popu lations in which it is utilized. The use of adjuvant systemic treatment in appropriate patients provides a similar (and additional) reduction in breast cancer mortality. Few subjects have been so systematically studied in the history of medicine, and it seems fair to conclude that the value to adjuvant systemic therapy in prolonging the lives of women with breast cancer is more firmly supported by empirical evidence than even the more conventional or primary treatments using various combinations ofsurgery and radiotherapy.



Preoperative Neoadjuvant Chemotherapy


Preoperative Neoadjuvant Chemotherapy
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Author : Joseph Ragaz
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Preoperative Neoadjuvant Chemotherapy written by Joseph Ragaz and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.


Despite recent advances in adjuvant therapies of cancer, the regi mens of postoperative adjuvant chemotherapy treatment which are presently available fail to cure the majority of cancer patients. Pre operative (neoadjuvant) chemotherapy represents a new approach in drug scheduling, based on sound theoretical, pharmacokinetic, and experimental principles. The preoperative timing of chemotherapy before definitive sur gery is not a minor change in the therapy of cancer. To be successful, large numbers of practitioners and their patients must participate. Substantial alterations of many aspects of the present management of cancer will have to follow. Therefore, before such therapy can be fully and routinely implemented, results of the novel treatment and its rationale have to be carefully evaluated. In preoperative treatment, other features will likely gain impor tance. For the first time, clinicians have a chance to follow the in vivo response of the tumor exposed to preoperative chemotherapy. The subsequent histological assessment of the tumor sample may likely become an important prognostic guide, permitting more re fined individual approaches to the planning of postoperative adju vant treatment. The value of such a treatment strategy can already be appreciated in the clinical setting, as seen from the therapy of osteosarcoma. Furthermore, preoperative chemotherapy might render previously inoperable tumors operable and hence resectable with a curative intention. The preoperative reduction of tumor bulk may also effectively decrease the need for more radical operations, permitting a more uniform adoption of conservative surgery.



Management Of The Breast And Axilla In The Neoadjuvant Setting


Management Of The Breast And Axilla In The Neoadjuvant Setting
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Author : Atilla Soran
language : en
Publisher: Springer Nature
Release Date : 2021-12-14

Management Of The Breast And Axilla In The Neoadjuvant Setting written by Atilla Soran and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-12-14 with Medical categories.


Over the last several decades breast cancer management has made great strides in the improvement of oncologic treatment outcomes, particularly so in patients with early stage disease. While wide-spread access to screening resulting in early detection is undoubtedly to be credited for this trend, at the same time, the management of breast cancer has evolved to be an intricate multidisciplinary collaboration between breast imagers, surgeons, medical oncologists and radiation oncologist. As a result, with better mutual understanding of multidisplinary goals and challenges, the treatment strategies have become more individualized, with a great emphasis being placed on the intrinsic disease biology. Furthermore, the indications for neoadjuvant systemic therapy have significantly broadened, with a substantial number of patients with early stage breast cancer being able to take advantage of this strategy to decrease the extent of breast surgery they would undergo at its completion. As such, the management of the axilla in these patients has presented with new challenges as well as with new opportunities to scale down on the extent of local therapy and, consequently, its toxicity. This text will provide a comprehensive, state-of-the art review of this field, and will serve as a valuable resource for clinicians (surgeons, medical oncologists, radiation oncologists) and researchers with an interest in breast cancer. The book will review novel and evoling strategies in neoadjuvant systemic therapy forn early stage breast cancer, provide new perspectives about appropriate axillary imaging in anticipation of neoadjuvant systemic therapy, and describe new data on innovative surgical techniques and Radiation Oncology concepts designed to deescalate the extent and toxicity of local therapy while insuring oncologic safety. Several landmark clinical trials have been published in the last few years and will be placed in context with respect to current management. Integration of novel diagnostic and interventional breast imaging, local therapy (surgery and radiation) with contemporary systemic therapy will also be discussed. This text will serve as a very useful resource for physicians and researchers dealing with, and interested in, this challenging field. It will provide a concise yet comprehensive summary of the current status of the field that will help guide patient management and stimulate investigative efforts. All chapters will be written by experts in their fields and will include the most up to date scientific and clinical information.



Ondansetron And Chemotherapy Induced Emesis


Ondansetron And Chemotherapy Induced Emesis
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Author : M. Marty
language : en
Publisher: Springer
Release Date : 1991

Ondansetron And Chemotherapy Induced Emesis written by M. Marty and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.


During the 3rd International Congress on Neoadjuvant Chemotherapy (Paris 1991) a complete symposium was devoted to chemically induced nausea and vomiting and to the value of Ondansetron. This book comprises original articles dealing with the different topics discussed during this session. It provides fuller information on current practice in anti-emetic treatment during anti-cancerous chemotherapy and sets out the position of a new and important drug, ondansetron, in this pathology. Different international clinical studies made with ondansetron in various types of patients are analysed: specific studies in hematology or in pulmonary disease, evaluation against benzamide-corticoid as a combined reference standard, or further the additive effect of a corticoid combined with ondansetron. One article is devoted to the use of the drug in children. Finally, recent programmes dealing with both the intravenous and the oral use of ondansetron are assessed. The last article deals with the economic evaluation of the use of ondansetron. Thus the reader will findhere a recent and uo-to-date review of the results and possible uses of ondansetron, now the premier member of the class of 5 HT 3 antagonists, in chemically induced nausea and vomiting.



Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers


Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers
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Author : Andrea Necchi
language : en
Publisher: Springer Nature
Release Date : 2022-01-03

Neoadjuvant Immunotherapy Treatment Of Localized Genitourinary Cancers written by Andrea Necchi and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2022-01-03 with Medical categories.


This book aims to provide readers with a current overview of enrolling trials with immune-checkpoint inhibitors in the preoperative setting of localized bladder cancer, renal cell carcinoma, and prostate cancer. The advent of immunotherapy has revolutionized treatments of genitourinary malignancy and evolved strategies for multidisciplinary management. This book explains neoadjuvant checkpoint inhibitors in localized genitourinary cancers, providing insights into the mechanisms of response and development of resistance of cancer cells to immunotherapy. It debates optimal trial design of preoperative checkpoint inhibitors in GU tumors, including optimal endpoints and the role of pathologic response as a surrogate endpoint of survival. It also illuminates clinical management of patients with organ-confined GU tumors, such as side effect management and perioperative safety, before providing an overview of biomarker use for patient selection across the early-stage GU malignancies. Lastly, the book provides the reader with the most up-to-date data emerging from clinical trials involving immunotherapy in early-stage GU malignancies. Neoadjuvant Immunotherapy Treatment of Localized Genitourinary Cancers: Multidisciplinary Management provides a comprehensive review of the field, serving as a valuable resource for urologists, medical oncologists, pathologists, fellows in urologic oncology, upper-level residents training in urology and medical oncology, as well as pharmacists interested in RCC clinicians.