Neonatal Sepsis
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Neonatal Sepsis
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Author : Mathur
language : en
Publisher: Elsevier Health Sciences
Release Date : 2009
Neonatal Sepsis written by Mathur and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009 with categories.
Neonatal Sepsis Ecab
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Author : N B Mathur
language : en
Publisher: Elsevier Health Sciences
Release Date : 2013-01-10
Neonatal Sepsis Ecab written by N B Mathur and has been published by Elsevier Health Sciences this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-01-10 with Medical categories.
Neonatal sepsis contributes significantly to neonatal morbidity and mortality. The incidence of neonatal sepsis as per National Neonatal Perinatal Database (NNPD 2002-2003) is 30 per 1,000 live births among intramural neonates. Among extramural neonates, sepsis accounts for nearly 40% of admissions to the NICU. It accounts for 18% of neonatal mortality among intramural neonates and nearly 40% of mortality among extramural neonates. The incidence and mortality is much higher in VLBW neonates as compared to term neonates. Neonatal sepsis is a clinical syndrome characterized by systemic signs of infection and accompanied by bacteremia in the first month of life. Once bacteria gains access to the bloodstream, mechanisms are activated by the host to eliminate it. Usually, the bacteria are efficiently cleared by the monocyte macrophage system after opsonization by antibody and complement. Sometimes, however, a systemic inflammatory response syndrome is established and can progress independently of the original infection. In many patients with sepsis, it is difficult to document a bacterial cause. The term "systemic inflammatory response syndrome" includes several stages of infection ranging from sepsis, sepsis syndrome, and early septic shock to refractory septic shock, which can eventuate in multiple organ dysfunction syndrome (MODS) and death. Prevention of sepsis is probably the best management strategy as far as neonatal sepsis is concerned. Strategies include prevention of early-onset sepsis and prevention of late-onset sepsis. For the former, appropriate obstetric care is the key; for the latter, decreasing interventions, promoting breast feeding, and maintaining proper hand hygiene are essential.
Neonatal Sepsis Current Insights And Challenges
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Author : Rozeta Sokou
language : en
Publisher: Frontiers Media SA
Release Date : 2024-06-05
Neonatal Sepsis Current Insights And Challenges written by Rozeta Sokou and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2024-06-05 with Medical categories.
Despite the continuous progress in perinatal and neonatal care, sepsis is still a leading cause of morbidity and mortality in neonates accounting for approximately 15% of deaths during the neonatal period globally. Additionally, despite being a life-threatening situation, sepsis in the neonatal population, and especially in very preterm neonates, is a potential source for short- and long-term morbidity and neurodevelopmental outcomes. Initial clinical signs and symptoms of sepsis are subtle and often non-specific in neonates, representing substantial impediments to the institutionalization of an international definition for sepsis in this population. Early diagnosis of neonatal sepsis is crucial and remains a major challenge for neonatologists due to nonspecific symptoms and laboratory tests with limited diagnostic value, resulting in the empirical and non-prudent antibiotics use, a common practice in Neonatal Intensive Care Units (NICUs). Nevertheless, this practice is largely responsible for a high rate of antibiotic resistance in NICUs, a major issue for global healthcare systems, as it has been estimated that 31% of neonatal deaths related to sepsis can be attributed to antimicrobial resistance.
Sepsis In Neonates And Children
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Author : Luregn J. Schlapbach
language : en
Publisher: Frontiers Media SA
Release Date : 2021-01-04
Sepsis In Neonates And Children written by Luregn J. Schlapbach and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-01-04 with Medical categories.
Early Onset Neonatal Sepsis
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Author : Richard A. Polin
language : en
Publisher: Clinics: Internal Medicine
Release Date : 2010
Early Onset Neonatal Sepsis written by Richard A. Polin and has been published by Clinics: Internal Medicine this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.
Early Onset Neonatal Sepsis is covered in this issue of Clinics in Perinatology, guest edited by Drs. Karen Fairchild and Richard Polin. Authorities in the field have come together to pen articles on Innate host defenses and risk for EONS, Group B streptococcus, Diagnosis and management of clinical chorioamnionitis, Molecular diagnostics of sepsis, Use of proteomics in the diagnosis of chorioamnionitis and neonatal sepsis, Adjunct laboratory tests in the diagnosis of EONS, Ureaplasma: role in diseases of prematurity, Meningitis in neonates, Adjunct immunologic therapies in neonatal sepsis, Pathophysiology and treatment of septic shock in neonates, and International perspective on EONS.
Neonatal Bacterial Infection
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Author : Bernhard Resch
language : en
Publisher: BoD – Books on Demand
Release Date : 2013-04-30
Neonatal Bacterial Infection written by Bernhard Resch and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-04-30 with Medical categories.
Neonatal sepsis still remains a significant cause of morbidity and mortality in the newborn, particularly in preterm, low birth weight infants. Despite advances in neonatal care, overall case-fatality rates from sepsis may be as high as 50%. Clinical signs of bacterial infection are vague and non-specific, and up to now there exists no easily available, reliable marker of infection despite a large bulk of studies focussing on inflammatory indices in neonatology. Every neonatologist is faced with the uncertainty of under- or over- diagnosing bacterial infection. In this book three topics will be discussed: clinical presentation including a general approach to sepsis neonatorum and two distinct diagnoses pneumonia and osteomyelitis diagnostic approaches including C-reactive protein and the immature myeloid information, and prevention and treatment of bacterial infection with immunoglobulins.
Neonatal Sepsis And Meningitis
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Author : Alistair G. S. Philip
language : en
Publisher:
Release Date : 1985
Neonatal Sepsis And Meningitis written by Alistair G. S. Philip and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
Early Onset Neonatal Sepsis
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Author :
language : en
Publisher:
Release Date : 2010
Early Onset Neonatal Sepsis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with categories.
Phagocytosis Kinetic During Neonatal Sepsis
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Author :
language : en
Publisher:
Release Date : 2017
Phagocytosis Kinetic During Neonatal Sepsis written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017 with categories.
Neonatal sepsis is the third cause of death in neonatal population. Host specific recognition of bacteria is one of the mechanism that active immune system. In preterm and term infants phagocytosis and opsonophagocytosis dysfunction increase the risk of septic shock. Data on this regulation during sepsis are insufficient. The main objective of our work is to study phagocytosis evolution of neutrophils and monocytes during sepsis initiation and to evaluate the kinetics of opsonophagocytosis function in neonates during sepsis. Phagocytosis test was performed on whole blood of neonates (term and preterm 36 wks GA) during sepsis. The results were compared to cord blood from healthy newborns. Monocytes and neutrophils phagocytosis of Escherichia coli (EC) were measured using cytometric flow with characterization of surface activation marker expression. EC Phagocytosis is decreased in healty and septic low birth weight than in 1500 gr neonatal population. EC phagocytosis is decreased in non survivors septic newborn than in survivors septic newborn. EC kinetic of phagocytosis is different according to bacteria type during neonatal sepsis.
Target Product Profile For Therapy Of Neonatal Sepsis In High Resistance Settings
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Author :
language : en
Publisher: World Health Organization
Release Date : 2020-04-30
Target Product Profile For Therapy Of Neonatal Sepsis In High Resistance Settings written by and has been published by World Health Organization this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-04-30 with Medical categories.