Nephrotoxicity
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Nephrotoxicity In The Experimental And Clinical Situation
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Author : P.H. Bach
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nephrotoxicity In The Experimental And Clinical Situation written by P.H. Bach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Nephrotoxicity
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Author : Peter H. Bach
language : en
Publisher:
Release Date : 1991
Nephrotoxicity written by Peter H. Bach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1991 with Medical categories.
Papers presented at the Fourth International Symposium on Nephrotoxicity, held at Guildford, Surrey, England in 1989. Life scientists and clinicians focus on understanding the mechanistic basis of toxic nephropathies as a means for developing new and sensitive markers for the early diagnosis of neph
Nephrotoxicity In The Experimental And Clinical Situation
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AUDIOBOOK
Author : P.H. Bach
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Nephrotoxicity In The Experimental And Clinical Situation written by P.H. Bach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
Nephrotoxicity
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Author : Peter Bach
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Nephrotoxicity written by Peter Bach and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or immunological changes. The weaknesses in diagnosing nephropathies arises because of the effective role the kidney plays in maintaining homeostasis, despite the fact that it has been extensively damaged. The frequencies of some type of chemically-induced acute renal failure is well documented, but the causes of chronic renal failure, malignancy, and other nephropathies are far more difficult to associate with a chemical aetiology. Many of the new therapeutic agents have important beneficial effects, but they are found to have marked nephrotoxic effects. Thus there is a growing urgency to increase the stringency of chemical safety evaluation for their potential nephrotoxic effects. This is strongly countered by the increased financial pressure to identify potentially nephrotoxic chemicals earlier in their development and humanitarian considerations to more closely relate animal test to the clinical situation. Part of the challenge may be achieved by the increasing use of in vitro techniques.
Clinical Nephrotoxins
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Author : Marc E. de Broe
language : en
Publisher: Springer Science & Business Media
Release Date : 2008-09-15
Clinical Nephrotoxins written by Marc E. de Broe and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2008-09-15 with Medical categories.
Clinical Nephrotoxins: Renal Injury from Drugs and Chemicals, Third Edition is a comprehensive text on all aspects of adverse effects by drugs, chemical substances and radiation on the kidneys. The importance of the toxicity of drugs and other substances for the kidneys is increasingly recognized. The book consists of themes such as clinical relevance, renal handling and cellular mechanisms of nephrotoxicity, as well as animal and cell culture models. In addition, the volume highlights specific types of drugs, such as anti-infectious agents and anti-inflammatory, cardiovascular and anti-cancer drugs. The last section deals with prevention and focuses on urinary biomarkers, pharmacological aspects and drug dosage in renal failure. In this third and completely revised edition, several new topics were added and additional figures and tables will be included. The book is of interest for the nephrologist, internist, general practitioner, toxicologist, pharmacologist, anesthesiologist, epidemiologist, public health official, pharmaceutical industry, and national drug safety committees, among others.
Toxicology Of The Kidney
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Author : Jerry B. Hook
language : en
Publisher: CRC Press
Release Date : 1993-06-30
Toxicology Of The Kidney written by Jerry B. Hook and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1993-06-30 with Medical categories.
This second edition provides a synthesis of recent research on the mechanisms of chemically-induced kidney injury. The text includes a review of current concepts of clinical nephrotoxicity and renal failure, and mechanisms of specific classes of nephrotoxic drugs and environmental chemicals.
Nephrotoxicity In The Experimental And Clinical Situation
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Author : Peter H. Bach
language : en
Publisher:
Release Date : 1987
Nephrotoxicity In The Experimental And Clinical Situation written by Peter H. Bach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1987 with Kidneys categories.
Nephrotoxic Mechanisms Of Drugs And Environmental Toxins
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Author : George A. Porter
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Nephrotoxic Mechanisms Of Drugs And Environmental Toxins written by George A. Porter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
The majority of the offending toxicants to be reviewed in this volume were devel oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip tion drugs, there has been an attempt to identify the adverse effects in advance and incorporate these risks into the decision of approval for human consumption. Unfortunately, for those drugs in which recognized injury occurs only after prolonged use, such appraisals are made in retrospect. Despite this, most renal injury induced by drugs or toxicants can be either prevented by excluding drugs with unacceptable side effects or interrupted by eliminating the offending agent once damage is manifested. The fact that prevention, reversibility, or arrest of renal injury is possible provided a major impetus for this publication. Since no international registry for nephrotoxic injury exists, estimates of incidence must rely on less than ideal sources. Recently I, together with Dr. William Bennett, summarized a survey of the frequency of various categories of nephrologic disease (Porter and Bennett, 1981). Based on this survey, we projected that in nearly one of ten patients seeking nephrologic consultation a nephrotoxic etiology may be involved. Of cases of end-stage renal disease, between 3 and 4% are due to drug nephrotoxicity, according to recent published results(European Dialysis and Transplant Association, 1979). For acute renal failure, antibiotics and contrast agents persist as major offending agents, while for chronic renal failure, analgesics remain a worldwide problem.
Nephrotoxicity
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Author : Jean-Paul Fillastre
language : en
Publisher: Presses universitaires de Rouen et du Havre
Release Date : 1978
Nephrotoxicity written by Jean-Paul Fillastre and has been published by Presses universitaires de Rouen et du Havre this book supported file pdf, txt, epub, kindle and other format this book has been release on 1978 with Political Science categories.
L'utilisation d'antibiotiques contenant notamment des aminoglycosides pour com¬battre les affections bactériennes, est très répandue. Or, à long terme, elle pose sou¬vent des complications dont la néphrotoxicité est la plus fréquente. Si les manifes¬tations de ces complications rénales sont connues, les mécanismes de ces altérations le sont moins. Ces communications apportent donc des éclaircissements sur ces mécanismes et les effets de ces substances dans les néphrons, le transport et la pénétration dans les cellules labyrinthiques du rein, l'influence sur la structure cellulaire, les effets au niveau de l'appareil de Colgi et notamment les réactions des organites intracellulaires : lysosomes-mitochendria.
Nephrotoxicity
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Author : P. H. Bach
language : en
Publisher:
Release Date : 1982-12-03
Nephrotoxicity written by P. H. Bach and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982-12-03 with Medical categories.
Brings together reviews by experts in many related fields of nephrotoxicity. Discusses renal physiology and biochemistry, and current hypotheses concerning nephrotoxicity induced by heavy metals, antibodies, anaesthetics, therapeutically administered drugs, and industrial chemicals. Examines isolated renal cell preparations, the perfused kidney and micropuncture techniques. Covers methods for detecting renal damage in man and animals.