Nephrotoxicity Ototoxicity Of Drugs
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N Phrotoxicity Interaction Of Drugs With Membranes Systems
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Author : Jean-Paul Fillastre
language : en
Publisher: Presses universitaires de Rouen et du Havre
Release Date : 1982
N Phrotoxicity Interaction Of Drugs With Membranes Systems written by Jean-Paul Fillastre and has been published by Presses universitaires de Rouen et du Havre this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Medical categories.
Nephrotoxicity : Otoxicity of Drugs. Ce livre rassemble les textes des communications présentées au symposium de Rouen (mai 1981) ayant pour thème l'étude de la néphrotoxicité des antibiotiques. La majeure partie de l'ouvrage est réservée à la néphrotoxicité des aminoglycosides. Sont détaillés les aspects morphologiques, les résultats d'études autoradiographiques, d'études de fractionnement cellulaires permettant l'analyse du comportement des mitochondries ou des lysosomes. Une large part est réservée aux variations de multiples enzymes urinaires excrétées sous l'action des médicaments. Le rôle de nombreux facteurs est largement discuté : influence des doses injectées, du rythme d'administration, de la durée du traitement, de l'âge, de l'existence d'une néphropathie antérieure. À la lecture des différentes études présentées, le clinicien pourra juger des différences de potentiel néphrotique des antibiotiques qui lui sont proposés pour le traitement des infections sévères. La place consacrée à l'otoxicité des aminoglycosides est plus restreinte mais les études de variations de potentiels pour détecter les signes d'otoxicité, les études de pharmacocinétique des aminogly¬cosides sont des contributions fort intéressantes et très originales.
Nephrotoxicite Ototoxicite Medicamenteuses
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Author : Jean Paul FILLASTRE
language : un
Publisher:
Release Date : 1981
Nephrotoxicite Ototoxicite Medicamenteuses written by Jean Paul FILLASTRE and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with categories.
Ototoxicity
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Author : Peter S. Roland
language : en
Publisher: PMPH-USA
Release Date : 2004
Ototoxicity written by Peter S. Roland and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Aminoglycosides categories.
CD-ROM features complete text and full-color illustrations in searchable PDF files.
Nephrotoxic Mechanisms Of Drugs And Environmental Toxins
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Author : George A. Porter
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-21
Nephrotoxic Mechanisms Of Drugs And Environmental Toxins written by George A. Porter and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-21 with Science categories.
The majority of the offending toxicants to be reviewed in this volume were devel oped to help mankind, and it is only with prolonged or widespread application that their adverse effects have been recognized. Conversely, in the case of pre scrip tion drugs, there has been an attempt to identify the adverse effects in advance and incorporate these risks into the decision of approval for human consumption. Unfortunately, for those drugs in which recognized injury occurs only after prolonged use, such appraisals are made in retrospect. Despite this, most renal injury induced by drugs or toxicants can be either prevented by excluding drugs with unacceptable side effects or interrupted by eliminating the offending agent once damage is manifested. The fact that prevention, reversibility, or arrest of renal injury is possible provided a major impetus for this publication. Since no international registry for nephrotoxic injury exists, estimates of incidence must rely on less than ideal sources. Recently I, together with Dr. William Bennett, summarized a survey of the frequency of various categories of nephrologic disease (Porter and Bennett, 1981). Based on this survey, we projected that in nearly one of ten patients seeking nephrologic consultation a nephrotoxic etiology may be involved. Of cases of end-stage renal disease, between 3 and 4% are due to drug nephrotoxicity, according to recent published results(European Dialysis and Transplant Association, 1979). For acute renal failure, antibiotics and contrast agents persist as major offending agents, while for chronic renal failure, analgesics remain a worldwide problem.
Aminoglycoside Ototoxicity
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Author : Stephen A. Lerner
language : en
Publisher: Little, Brown Medical Division
Release Date : 1981
Aminoglycoside Ototoxicity written by Stephen A. Lerner and has been published by Little, Brown Medical Division this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Medical categories.
Hdbk Of Ototoxicity
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Author : Julian J. Miller
language : en
Publisher: Springer
Release Date : 1985
Hdbk Of Ototoxicity written by Julian J. Miller and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 1985 with Medical categories.
The Aminoglycosides Microbiology Clinical Use And Toxicology
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Author : Andrew Whelton
language : en
Publisher:
Release Date : 1982
The Aminoglycosides Microbiology Clinical Use And Toxicology written by Andrew Whelton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Science categories.
Nephrotoxicity Ototoxicity Of Drugs
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Author : Jean-Paul Fillastre
language : en
Publisher: Presses de l'Université de Rouen et du Havre
Release Date : 1982
Nephrotoxicity Ototoxicity Of Drugs written by Jean-Paul Fillastre and has been published by Presses de l'Université de Rouen et du Havre this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Drugs categories.
Transporters And Drug Metabolizing Enzymes In Drug Toxicity
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Author : Albert P. Li
language : en
Publisher: John Wiley & Sons
Release Date : 2021-07-27
Transporters And Drug Metabolizing Enzymes In Drug Toxicity written by Albert P. Li and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-27 with Medical categories.
TRANSPORTERS AND DRUG-METABOLIZING ENZYMES IN DRUG TOXICITY Explore up-to-date coverage on the interaction between drug metabolism enzymes, transporters, and drug toxicity with this leading resources Transporters and Drug-Metabolizing Enzymes in Drug Toxicity delivers a comprehensive and updated review of the relationship between drug metabolism, transporters, and toxicity, providing insights into a major challenge in drug development – accurate assessment of human drug toxicity. Combining two disciplines frequently considered independently of one another, the book combines drug metabolism and toxicology with a focus on the role of biotransformation on drug toxicity and as a major factor for species and individual differences. Mechanism and species differences in drug metabolizing enzymes and transporters are discussed, as are the methods used to investigate the role of drug metabolizing enzymes and transporters in drug toxicity. Finally, the distinguished authors describe promising new experimental approaches to accurately assessing human drug toxicity via the consideration of human-specific drug metabolism in toxicity assays. In addition to topics as diverse as extended clearance models, experimental approaches for the estimation of DILI potential of drug candidates and roles of transporters in renal drug toxicity, readers will also enjoy the inclusion of such subjects as: A thorough overview of and introduction to drug metabolism and transporters and drug toxicity An exploration of drug metabolism enzymes and transporter activities as risk factors of marketed drugs associated with drug-induced fatalities A discussion of human-based in vitro experimental models for the evaluation of metabolism-dependent drug toxicity A treatment of mechanism-based experimental models for the evaluation of BSEP inhibition and DILI An examination of transporters and cochlea toxicity Perfect for scientists, students, and practitioners with interests in metabolism, toxicology, and drug development in the pharmaceutical industry, Transporters and Drug-Metabolizing Enzymes in Drug Toxicity will also earn a place in the libraries of medicinal chemists, pharmacologists, biochemists, toxicologists, and regulators in the pharmaceutical and health industries.
Advances In Clinical Audiology
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Author : Stavros Hatzopoulos
language : en
Publisher: BoD – Books on Demand
Release Date : 2017-03-29
Advances In Clinical Audiology written by Stavros Hatzopoulos and has been published by BoD – Books on Demand this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-03-29 with Medical categories.
Advances in Clinical Audiology is an excursus on the latest findings in clinical audiology with a strong emphasis in new emerging technologies which facilitate and optimize a better assessment of the human patient. The book has been edited with a strong educational perspective (all chapters include an extensive introduction to their corresponding topic and an extensive glossary of terms). The book contains material suitable for graduate students in audiology, ENT, hearing science, and neuroscience.