Aminoglycoside Ototoxicity
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Ototoxicity
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Author : Peter S. Roland
language : en
Publisher: PMPH-USA
Release Date : 2004
Ototoxicity written by Peter S. Roland and has been published by PMPH-USA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Aminoglycosides categories.
CD-ROM features complete text and full-color illustrations in searchable PDF files.
Aminoglycoside Ototoxicity
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Author : Stephen A. Lerner
language : en
Publisher: Little, Brown Medical Division
Release Date : 1981
Aminoglycoside Ototoxicity written by Stephen A. Lerner and has been published by Little, Brown Medical Division this book supported file pdf, txt, epub, kindle and other format this book has been release on 1981 with Medical categories.
Cellular Mechanisms In Ototoxicity
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Author : Peter S. Steyger
language : en
Publisher: Frontiers Media SA
Release Date : 2018-06-12
Cellular Mechanisms In Ototoxicity written by Peter S. Steyger and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-12 with categories.
The auditory perception of sounds (environmental, vocal or music) is one of the 5 principal senses consciously monitored by our brains, and is crucial for many human endeavors as well as quality of life. Loss of optimal performance in this principal sensory system leads to loss of effective communication and intimacy, as well as increased risk of isolation, depression, cognitive decline, and greater vulnerability to predators. The vestibular system ensures that individuals remain upright and effectively monitor their posture within their spatial surroundings, move effectively, and remain focused on visual targets during motion. The loss of vestibular sensitivity results in postural instability, falls, inability to observe the environment during motion, and a debilitating incapacity to function effectively. The sensory cells for both auditory and vestibular systems are located within the inner ear of the temporal bulla. There are many causes of auditory and vestibular deficits, including congenital (or genetic) events, trauma, aging and loud sound exposures. Ototoxicity refers to damage of the auditory or vestibular structures or functions, as the result of exposure to certain pharmaceuticals, chemicals, and/or ionizing radiation exposure that damage the inner ear. Ototoxicity is a major contributor to acquired hearing loss and vestibular deficits, and is entirely preventable. In 2009, the United States Department of Defense initiated the Hearing Center of Excellence (HCE), headquartered in San Antonio, Texas, in response to the prevalence of acquired auditory and vestibular deficits in military and veteran populations. The knowledge shared in this eBook supports the HCE’s mandate to improve aural protection of military and civilian populations worldwide. The last few years have seen significant advances in understanding the cellular mechanisms underlying ototoxic drug-induced hearing loss and vestibular deficits. In this eBook, we present some of these advances and highlight gaps where further research is needed. Selected articles discuss candidate otoprotective agents that can ameliorate the effects of ototoxicity in the context of how they illustrate cellular mechanisms of ototoxicity. Our goal in illustrating these advances in mechanisms of ototoxicity is to accelerate the development of clinical therapies that prevent or reverse this debilitating disorder.
Ototoxicity
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Author : Donald Henderson
language : en
Publisher:
Release Date : 1999
Ototoxicity written by Donald Henderson and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1999 with Medical categories.
This work presents an integrated look at research suggesting that many ototoxic and ototraumatic reactions in the inner ear from drugs and trauma (noise) can be prevented or reduced with pharmacological interventions. The papers, by international authorities, address both the basic science background and the clinical applications of new therapies involving neurotrophins, free-radical scavengers, and other compounds that reduce the risk of hearing loss. A contextual framework is provided by three tutorial papers on free-radical scavengers, neurotrophins, and the role of the kidney in ototoxic reactions.
Ototoxicity
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Author : Gregg Colon
language : en
Publisher:
Release Date : 2019-08-30
Ototoxicity written by Gregg Colon and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-08-30 with categories.
This compilation focuses on Ototoxicity, the adverse pharmacological reaction affecting the inner ear or auditory nerve, characterised by cochlear or vestibular dysfunction. Although ototoxic medications play an essential role in modern medicine, they can cause harm and lead to significant morbidity. The authors discuss aminoglycoside antibiotics, loop diuretics, platinum-based chemotherapeutic agents, macrolide antibiotics and antimalarial medications which are among the 600 frequently used ototoxic drugs. Next, an overview of cisplatin-associated ototoxicity, namely its clinical features, incidence rates, molecular and cellular mechanisms and risk factors is provided for health care practitioners managing patients with cancer. Ototoxicity and neurotoxicity are defined from the perspective of chemical agents, nicotine and cotinine, that individuals experience through cigarette smoking and environmental tobacco smoke exposure. Mechanisms for toxicity are described by review of animal and human studies revealing changes in peripheral and central auditory structures after exposure to nicotine. The mechanisms of ototoxicity induced by aminoglycoside are also discussed, as well as the usage of these drugs for treatment of several disorders such as Meniere disease, and possible protective agents. In closing, the authors highlight the serious issue of aminoglycoside mediated hearing loss in cystic fibrosis patients, and also discuss alternative approaches for avoiding aminoglycoside-induced cochleotoxicity.
The Aminoglycosides Microbiology Clinical Use And Toxicology
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Author : Andrew Whelton
language : en
Publisher:
Release Date : 1982
The Aminoglycosides Microbiology Clinical Use And Toxicology written by Andrew Whelton and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Science categories.
Handbook Of Ototoxicity
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Author : Julian J. Miller
language : en
Publisher: CRC Press
Release Date : 2019
Handbook Of Ototoxicity written by Julian J. Miller and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019 with Medical categories.
Published in 1985: This publication will serve as a useful guide to all those involved in Otology either in a clinical or research environment.
Pharmacology And Ototoxicity For Audiologists
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Author : Kathleen Campbell
language : en
Publisher: Cengage Learning
Release Date : 2007
Pharmacology And Ototoxicity For Audiologists written by Kathleen Campbell and has been published by Cengage Learning this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007 with Medical categories.
This book is written specifically for audiologists. It is designed as a one semester course for AuD students but is also ideal for practicing professionals. It is also appropriate for other professionals wishing to know more about this area, such as clinical trials coordinators.
Nephrotoxicity Ototoxicity Of Drugs
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Author : Jean-Paul Fillastre
language : en
Publisher: Presses de l'Université de Rouen et du Havre
Release Date : 1982
Nephrotoxicity Ototoxicity Of Drugs written by Jean-Paul Fillastre and has been published by Presses de l'Université de Rouen et du Havre this book supported file pdf, txt, epub, kindle and other format this book has been release on 1982 with Drugs categories.
Aminoglycoside Antibiotics A Guide To Therapy
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Author : William G. Barnes
language : en
Publisher: CRC Press
Release Date : 2019-06-04
Aminoglycoside Antibiotics A Guide To Therapy written by William G. Barnes and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2019-06-04 with Medical categories.
First Published in 1984, this book offers a full, comprehensive guide into the applications of Aminoglycoside Antibiotics in therapy. Carefully compiled and filled with a vast repertoire of notes, diagrams, and references this book serves as a useful reference for Students of Medicine, and other practitioners in their respective fields.