Neural Cell Specification

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Progenitor Diversity And Neural Cell Specification In The Central Nervous System

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Author : Marcos R. Costa
language : en
Publisher: Frontiers Media SA
Release Date : 2015-12-18

Progenitor Diversity And Neural Cell Specification In The Central Nervous System written by Marcos R. Costa and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-12-18 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.

The central nervous system continuously perceives, integrates, processes and generates information. These complex functions rely on the detailed elaboration of its cellular network and on the myriads of individual, highly differentiated and specialized cell types, classically subdivided into neurons, astrocytes and oligodendrocytes. The specification of these individual populations begins early during development with less differentiated, yet already partly restricted, progenitor cells. Anatomically located in dedicated germinative niches, neural progenitors perceive the influence of diffusible molecules of various natures and concentrations. These signals result in the initial specialization of cohorts of progenitors that express unique combinations of transcription factors. It is now clearly established that both extrinsic and intrinsic signals act in concert to determine the fate potentials of these progenitor cohorts. This limitation increases over time, adult neural progenitors being more restricted than their developmental counterparts. Nevertheless, recent data have shown that the fate restriction of neural progenitors, as well as that of their progenies, can be overwritten upon selected intrinsic factor expression, not only during development but also in adulthood. This e-book is a collection of original research studies along with review articles that, together, provide insights into the vast spatiotemporal diversity of neural progenitors, and the various factors that govern their fate potential.

Neural Cell Specification

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Author : Bernhard H.J. Juurlink
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

Neural Cell Specification written by Bernhard H.J. Juurlink and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.

The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.

Neural Cell Specification

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Author : Bernhard H J Juurlink
language : en
Publisher:
Release Date : 1995-10-01

Neural Cell Specification written by Bernhard H J Juurlink and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-10-01 with categories.

Mechanisms Underlying Neural Cell Fate Specification In The Drosophila Sensory Organ Precursor Lineage

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Author : Nicholas John Justice
language : en
Publisher:
Release Date : 2003

Mechanisms Underlying Neural Cell Fate Specification In The Drosophila Sensory Organ Precursor Lineage written by Nicholas John Justice and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2003 with categories.

Neural Cell Biology

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Author : Cheng Wang
language : en
Publisher: CRC Press
Release Date : 2017-06-26

Neural Cell Biology written by Cheng Wang and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-06-26 with Medical categories.

This book delineates how systems biology, pharmacogenomic, and behavioral approaches, as applied to neurodevelopmental toxicology, provide a structure to arrange information in a biological model. The text reviews and discusses approaches that can be used as effective tools to dissect mechanisms underlying pharmacological and toxicological phenomena associated with the exposure to drugs or environmental toxicants during development. The book intends to elaborate functional outcomes of component-to-component relationships using rodent and nonhuman primate in vitro and in vivo models that allow for the directional and quantitative description of the complete organism in response to environmental perturbations. In addition, attention has also been directed to some of the more recent methodologies, including genomics, proteomics and metabolomics, applied in the evolutionary neurobiological field.

Handbook Of Stem Cells

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Author : Anthony Atala
language : en
Publisher: Academic Press
Release Date : 2012-10-08

Handbook Of Stem Cells written by Anthony Atala and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-10-08 with Medical categories.

This is a complete overview of the field of stem cells, providing the background, tools, methods and experimental protocols needed for further research.

Developmental Neurobiology

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Author : Greg Lemke
language : en
Publisher: Academic Press
Release Date : 2010-05-22

Developmental Neurobiology written by Greg Lemke and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-05-22 with Science categories.

Developmental Neuroscience is one of the six core disciplines in Neuroscience, and yet no single volume, non-textbook reference exists on the market that provides researchers with more in-depth, high-level information on developmental neurobiology. Currently, anyone interested in the field at a higher level must sift through review articles published frequently and the more specific handbooks that focus on aspects of development rather than the field as a whole. This reference is the first of its kind to fill this need. It pulls together the relevant articles on the topic from the 10-volume Encyclopedia of Neuroscience (Academic Press, 2008) and serves as an affordable and immediate resource for scientists, postdocs, graduate students with an interest beyond the basic textbook materials on the subject. - The first and only comprehensive, single-volume reference for developmental neuroscience that goes beyond the basic textbook information - The 93 chapters cover topics ranging from cell fate determination, path finding, synapse generation, neural stem cells, to neurodegeneration and regeneration, carefully selected from the Encyclopedia of Neuroscience by one of the great developmental neuroscientists, Greg Lemke - The best researchers in the field provide their conclusions in the context of the latest experimental results

Molecular And Cellular Approaches To Neural Development

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Author : W. Maxwell Cowan
language : en
Publisher:
Release Date : 1997

Molecular And Cellular Approaches To Neural Development written by W. Maxwell Cowan and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.

Comprehensive, up-to-date and authoritative, this volume covers all the recent advances in understanding the early events of neural development at the molecular and cellular levels. The authors detail the applications of molecular genetic methods to the study of neural induction, neuronal phenotypes and processes, and the formation of specific patterns of connections. They analyze the new information generated through modern techniques for identifying, cloning, deleting and introducing specific genes, for labeling neuronal or glial precursors, and for imaging individual neurons or parts of neurons. Other chapters focus on the increasing use of a variety of model organisms: fruit flies, nematode worms, zebra fish, xenopus frogs, chicks, and mice. The improved conservation of DNA and protein sequences, and the availability of gene and protein databases have made it possible to rapidly identify gene homologues in organisms sometimes separated by hundreds of millions of years of evolution. This volume features several chapters co-authored by investigators one of whom works on vertebrates and the other on invertebrates. They demonstrate clearly that although the nervous systems of a fruit fly and a mouse, for example, are quite different in appearance and organization, many of the same molecular players and cellular processes are involved in their assembly. Molecular and Cellular Approaches to Neural Development will be of great practical interest to researchers, graduate students and post-doctoral fellows in developmental, cell and molecular biology, genetics, and neuroscience.

Transcriptional And Translational Regulation Of Stem Cells

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Author : Gary Hime
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-05-22

Transcriptional And Translational Regulation Of Stem Cells written by Gary Hime and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-05-22 with Medical categories.

This volume describes the latest findings on transcriptional and translational regulation of stem cells. Both transcriptional activators and repressors have been shown to be crucial for the maintenance of the stem cell state. A key element of stem cell maintenance is repression of differentiation factors or developmental genes – achieved transcriptionally, epigenetically by the Polycomb complex, and post-transcriptionally by RNA-binding proteins and microRNAs. This volume takes two approaches to this topic – (1) illustrating the general principles outlined above through a series of different stem cell examples – embryonic, iPS and adult stem cells, and (2) describing several molecular families that have been shown to have roles in regulation of multiple stem cell populations.

Neural Crest Induction And Differentiation

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Author : Jean-Pierre Saint-Jeannet
language : en
Publisher: Springer Science & Business Media
Release Date : 2007-08-10

Neural Crest Induction And Differentiation written by Jean-Pierre Saint-Jeannet and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-08-10 with Science categories.

Neural Crest Induction and Differentiation, written by an international panel of recognized leaders in the field, discusses all aspects of modern neural crest biology from its evolutionary significance, to its specification, migration, plasticity and contribution to multiple lineages of the vertebrate body, to the pathologies associated with abnormal neural crest development and function. Each chapter provides an invaluable resource for information on the most current advances in the field, with discussion of controversial issues and areas of emerging importance.