Neural Transplantation In Cerebellar Ataxia
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Neural Transplantation In Cerebellar Ataxia
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Author : Lazaros Triarhou
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-11-11
Neural Transplantation In Cerebellar Ataxia written by Lazaros Triarhou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-11-11 with Science categories.
erebellar ataxia is a failure in muscular coordination that re C sults from a slow, progressive deterioration of neurons in the cerebellum. An estimated 150,000 people are affected by the he reditary ataxias and related disorders in the United States. At present, there is no known cure. In an experimental treatment aimed at reconstructing the damaged pathway through exog enous neuronal supplementation, genetically ataxic mice have been used for intracerebral grafting of genetically healthy cerebellar neuroblasts, and evidence has been obtained for graft-induced en hancement of behavioral responses after bilateral cerebellar grafts. Such results are encouraging and underscore the potential of the neural grafting technique in restoring cerebellar function. How ever, many of the pathological and biochemical mechanisms in the interaction between grafted tissue and the host brain need to be further elucidated in extensive experimental studies, and great cau tion must be used in contemplating the theoretical feasibility of a possible application in humans.
Neural Transplantation In Cerebellar Ataxia
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Author : Lazaros Constantinos Triarhou
language : en
Publisher:
Release Date : 1997
Neural Transplantation In Cerebellar Ataxia written by Lazaros Constantinos Triarhou and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Cerebellar ataxia categories.
Dopaminergic Neuron Transplantation In The Weaver Mouse Model Of Parkinson S Disease
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Author : Lazaros C. Triarhou
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Dopaminergic Neuron Transplantation In The Weaver Mouse Model Of Parkinson S Disease written by Lazaros C. Triarhou and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
This book is the culmination of fifteen years of research on the transplantation of dopaminergic neurons in the striatum of the weaver mouse (wv/wv), a neurological mutant characterized by genetically-determined degeneration of midbrain dopamine neurons. This mutant constitutes the only available laboratory model with a chronic disorder that mimics Parkinson's disease. Structural and functional aspects of intrastriatal mesencephalic neuron grafting into the weaver model are reviewed, including histochemical correlates of graft survival and integration, numerical aspects of donor cell survival, ultrastructural findings on synaptogenesis, neurochemical indices of dopamine uptake and receptor binding, gene expression of structural and neurotransmitter-receptor related molecules, levels of striatal amino acid receptors, and behavioural effects of unilateral and bilateral neuronal transplantations.
Translational Medicine
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Author : Robert A. Meyers
language : en
Publisher: John Wiley & Sons
Release Date : 2018-03-02
Translational Medicine written by Robert A. Meyers and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-02 with Science categories.
This reference work gives a compete overview of the different stages of drug development using a translational approach. The book is structured in different parts, following the different stages in drug development. Almost half of the work is dedicated to core of drug discovery using a translational approach, the identification of appropriate targets and screening methods for the identification of compounds interacting with these targets. The rest of book covers the whole downstream pipeline after the identification of lead compounds, such as bioavailability issues, identification of appropriate drug delivery venues, production and scaling issues and preclinical trials. As has been the case with other works in the encyclopedia, the book is made up of long, comprehensive and authoritative chapters, written by outstanding researchers in the field.
Neural Transplantation Cns Neuronal Injury And Regeneration
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Author : Joe Marwah
language : en
Publisher: CRC Press
Release Date : 1994-02-23
Neural Transplantation Cns Neuronal Injury And Regeneration written by Joe Marwah and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1994-02-23 with Medical categories.
This unique reference presents studies from leading laboratories that are studying the effects of CNS transplants on neuronal plasticity and recovery of function after CNS injury. Topics covered include tropic influences, reinnervation patterns, and prevention of cell death that range from pre-clinical models of Parkinson's disease in primates to studies of restoration of circadian rhythms in rats. Techniques of neurotransplantation are presented, including current limitations and future projections of advancement.
Neural Transplantation And Regeneration
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Author : Gopal D. Das
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neural Transplantation And Regeneration written by Gopal D. Das and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
Four years ago the first international symposium dealing with neural transplan tation was organized as a satellite conference to the annual meeting of the Society for Neuroscience in Los Angeles, California. The expanded proceed ings of that symposium were published by Springer-Verlag in 1983 in a volume entitled Neural Tissue Transplantation Research. We were sufficiently pleased with the results of that effort to organize a second satellite international sympo sium on Neural Transplantation and Regeneration in conjunction with the 13th Annual Meeting of the Society for Neuroscience in Boston in the fall of 1983. Paralleling the growing body of research dealing with various aspects of neural transplantation, the scope of this second symposium was broadened to include not only transplantation but also regeneration. Additionally, topics of clinical interest were addressed as well as issues of basic research. The promise apparent in that first conference is still seen in the second as more and more investigators apply their talents in an attempt to understand this infant field of research. The present volume represents an expanded version of the material presented at the second symposium. We wish to thank all of the contributors to the conference and to this volume for their insight and their assistance.
The Cerebellum Disorders And Treatment
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Author :
language : en
Publisher: Elsevier
Release Date : 2018-06-08
The Cerebellum Disorders And Treatment written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-06-08 with Medical categories.
The Cerebellum: Disorders and Treatment, Volume 155 updates readers on the latest and clinically relevant advances in the study of cerebellar diseases in children and adults. It is organized into sections detailing: (1) Disorders (starting from the fetal cerebellum, to adult cerebellum) encountered during daily practice, and (2) Therapy (including insights into innovative drug and rehabilitative approaches). The book's innovative structure discusses cerebellar disorders in children and adults as a continuum, with its companion volume, The Cerebellum: From Embryology to Diagnostic Investigations detailing embryology, anatomy, function and diagnostic investigations and neuroimaging, including conventional sequences, diffusion tensor imaging, functional MRI, and connectivity studies. - Provides an in-depth understanding of the cerebellum and its involvement in a wide variety of diseases - Explores long-term outcome data of pediatric cerebellar diseases and potential problems in adult life for patients with pediatric cerebellar diseases - Features chapters co-authored by two experts, combining expertise in both pediatric and adult cerebellar diseases
Development Of The Cerebellum From Molecular Aspects To Diseases
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Author : Hassan Marzban
language : en
Publisher: Springer
Release Date : 2017-07-27
Development Of The Cerebellum From Molecular Aspects To Diseases written by Hassan Marzban and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2017-07-27 with Medical categories.
The authors present the most current and cutting-edge knowledge regarding the molecular basis of cerebellar development, focusing on information relevant to laboratory scientists and clinicians providing service to patients with cerebellar disorders. Knowledge obtained from advanced neuroimaging techniques that are used during development, and from molecular- and genetic-based studies has provided rapidly-growing evidence that the cerebellum is a brain region that is highly impacted by developmental defects. Cerebellar defects result in significant intellectual and motor function impairment that affects both the patients and their families.
The Berlin Ophthalmologist Bernhard Pollack
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Author : Lazaros C. Triarhou
language : en
Publisher: Lulu.com
Release Date : 2011
The Berlin Ophthalmologist Bernhard Pollack written by Lazaros C. Triarhou and has been published by Lulu.com this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011 with Biography & Autobiography categories.
Based on original research, this monograph is the first to portray the fascinating life of Bernhard Pollack (1865-1928), a pioneer neurohistologist, ophthalmologist, and world-class pianist. In doing so, it revives important scientists and musicians of fin-du-si cle Berlin. Pollack wrote the first standard reference on the staining methods for the nervous system (1897). Born into a Prussian-Jewish family, he received his piano education from Moritz Moszkowski and his pathology education from Carl Weigert. Pollack worked at the Institutes of W. Waldeyer (anatomy), E. Mendel (neuropsychiatry), Nobel laureate R. Koch (infectious diseases), and the Eye Clinic of P. Silex, before becoming Professor of Ophthalmology at Friedrich-Wilhelms-Universit t in 1919. English translations of two articles by Pollack, on musical memory and on Moszkowski, are included. The book also chronicles the founding by Pollack of the Berliner rzte-Orchester, who in 2011 celebrate their centennial.
The Cerebellum And Its Disorders
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Author : Mario Manto
language : en
Publisher: Cambridge University Press
Release Date : 2002
The Cerebellum And Its Disorders written by Mario Manto and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002 with Medical categories.
The first comprehensive text on the cerebellum and its disorders for many years.