Neuroanatomy And Transgenic Technologies
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Neuroanatomy And Transgenic Technologies
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Author : Laurent Gautron
language : en
Publisher: Frontiers Media SA
Release Date : 2015-04-21
Neuroanatomy And Transgenic Technologies written by Laurent Gautron and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2015-04-21 with Brain categories.
Neuroanatomists increasingly rely on techniques enabling them to manipulate genes in defined brain cell populations. In particular, engineered transgenes, which encode a variety of fluorescent reporter proteins can be inserted into the genome or delivered into desired brain regions using viral vectors, thereby allowing the labeling of molecularly-defined populations of neurons and/or glial cells. Transgenic technology can also be used to selectively delete genes in targeted neuronal populations or bi-directionally modulate their electrical excitability using optogenetic or chemogenetic techniques. One of the primary advantages of using transgenic reagents is to simplify the identification and tracing of targeted population of brain cells, which can be laborious using traditional techniques in neuroanatomy. In this research topic, we assembled up-to-date reviews and original articles that demonstrate the versatility and power of transgenic tools in advancing our knowledge of the nervous system, with a special emphasis on the application of transgenic technology to neuroanatomical questions.
Transgenic Animal Technology
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Author : Carl A. Pinkert
language : en
Publisher: Academic Press
Release Date : 2012-12-02
Transgenic Animal Technology written by Carl A. Pinkert and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-02 with Technology & Engineering categories.
Transgenic animal technologies and the ability to introduce functional genes into animals have revolutionized our ability to address complex biomedical and biological questions, as well as to make practical applications to production agriculture. This well-illustrated handbook covers the technical aspects of gene transfer in animals--from molecular methods to whole animal considerations--for the important laboratory and domestic animal species. It describes methodologies as employed by leading laboratories and is a key resource for researchers, as well as a tool for training technicians and students. Contains a comprehensive collection of transgenic animal and gene transfer methods Discusses background and introduction to techniques and animal systems Teaches practical step-by-step protocols Describes mouse model systems Covers laboratory and domestic animal species Illustrated with diagrams and photographs Includes useful tables and charts
Neuroanatomy Of The Mouse
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Author : Hannsjörg Schröder
language : en
Publisher: Springer Nature
Release Date : 2020-02-28
Neuroanatomy Of The Mouse written by Hannsjörg Schröder and has been published by Springer Nature this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-02-28 with Medical categories.
This textbook describes the basic neuroanatomy of the laboratory mouse. The reader will be guided through the anatomy of the mouse nervous system with the help of abundant microphotographs and schemata. Learning objectives and summaries of key facts at the beginning of each chapter provide the reader with an overview on the most important information. As transgenic mice are one of the most widely used paradigms when it comes to modeling human diseases, a basic understanding of the neuroanatomy of the mouse is of considerable value for all students and researchers in the neurosciences and pharmacy, but also in human and veterinary medicine. Accordingly, the authors have included, whenever possible, comparisons of the murine and the human nervous system. The book is intended as a guide for all those who are about to embark on the structural, histochemical and functional phenotyping of the mouse’s central nervous system. It can serve as a practical handbook for students and early researchers, and as a reference book for neuroscience lectures and laboratories.
Frontiers In Neuroanatomy Editor S Pick 2021
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Author : Javier DeFelipe
language : en
Publisher: Frontiers Media SA
Release Date : 2021-07-28
Frontiers In Neuroanatomy Editor S Pick 2021 written by Javier DeFelipe and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2021-07-28 with Science categories.
Neuroanatomy For The Xxist Century
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Author : Kathleen S. Rockland
language : en
Publisher: Frontiers Media SA
Release Date : 2016-08-15
Neuroanatomy For The Xxist Century written by Kathleen S. Rockland and has been published by Frontiers Media SA this book supported file pdf, txt, epub, kindle and other format this book has been release on 2016-08-15 with Neurosciences. Biological psychiatry. Neuropsychiatry categories.
An explosion of new techniques with vastly improved visualization and sensitivity is leading a veritable revolution in modern neuroanatomy. Basic questions related to cell types, input localization, and connectivity are being re-visited and tackled with significantly more accurate and higher resolution experimental approaches. A major goal of this e-Book is thus to highlight in one place the impressive range of available techniques, even as these are fast becoming routine. This is not meant as a technical review, however, but rather will project the technical explosion as indicative of a field now in a vibrant state of renewal. Thus, contributions will be mainly research articles using the newer techniques. A second goal is to showcase what has become the conspicuous interdisciplinary reach of the field: neuroanatomical standards and the close association of structure-function and underlying circuitry mechanisms are increasingly relevant to investigations in development, physiology, and disease. Another feature of this Research Topic is that it includes a breadth of cross-species contributions from investigators working with rodent, nonhuman primate, and human brains. This is important since most of our current knowledge of brain structure has been obtained from experimental animals. However, recent technical advances, coupled with researcher willingness to use the human tissue available, will undoubtedly lead to major advances in the near future regarding human brain mapping and connectomes. Thus, of particular interest will be the methods that can help to define general wiring principles in the brain, both structural and functional. Overall, the state of the field is: exciting.
Molecular Neuroanatomy
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Author : Fred W. Leeuwen
language : en
Publisher: Elsevier Publishing Company
Release Date : 1988
Molecular Neuroanatomy written by Fred W. Leeuwen and has been published by Elsevier Publishing Company this book supported file pdf, txt, epub, kindle and other format this book has been release on 1988 with Medical categories.
For a thorough study of the dynamics of particular brain compounds it is now possible to use and combine various molecular neuroanatomical methods (e.g. in situ hybridization, receptor localisation and immunocytochemistry) in a quantitative way on whole brain sections maintaining morphological details. Molecular Neuroanatomy deals with the many practical aspects and recent developments in these areas. The theoretical background of many techniques is presented, as well as clear, step-by-step instructions on the preparation and application of all the methods and techniques described in this book. It will be invaluable to all those working in the field of neuroscience. Available in both hardback and paperback, with colour illustrations.
Encyclopedia Of Neuroscience Volume 1
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Author : Larry R. Squire
language : en
Publisher: Academic Press
Release Date : 2009-06-12
Encyclopedia Of Neuroscience Volume 1 written by Larry R. Squire and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-06-12 with Medical categories.
The Encyclopedia of the Neuroscience explores all areas of the discipline in its focused entries on a wide variety of topics in neurology, neurosurgery, psychiatry and other related areas of neuroscience. Each article is written by an expert in that specific domain and peer reviewed by the advisory board before acceptance into the encyclopedia. Each article contains a glossary, introduction, a reference section, and cross-references to other related encyclopedia articles. Written at a level suitable for university undergraduates, the breadth and depth of coverage will appeal beyond undergraduates to professionals and academics in related fields.
Development Of The Cerebellar System
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Author : Joseph Altman
language : en
Publisher: CRC Press
Release Date : 1997
Development Of The Cerebellar System written by Joseph Altman and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1997 with Medical categories.
This book is an outstanding presentation of what happens during normal cerebellar development.
Dopamine
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Author : S.B. Dunnett
language : en
Publisher: Elsevier
Release Date : 2004-12-18
Dopamine written by S.B. Dunnett and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-12-18 with Medical categories.
Dopamine is a major neurotransmitter of the brain involved in the control of movement, emotion, and cognition; disturbance in dopamine function is associated with disorders like Parkinson’s disease, schizophrenia and attention deficit hyperactivity disorder. This volume of the Handbook of Chemical Neuroanatomy provides a series of in depth critical reviews of our present understanding of the most important aspects of dopamine’s organisation and disturbed function in the animal and human brain.
Computational Neuroanatomy
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Author : Moo K Chung
language : en
Publisher: World Scientific
Release Date : 2012-09-05
Computational Neuroanatomy written by Moo K Chung and has been published by World Scientific this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-09-05 with Computers categories.
Computational neuroanatomy is an emerging field that utilizes various non-invasive brain imaging modalities, such as MRI and DTI, in quantifying the spatiotemporal dynamics of the human brain structures in both normal and clinical populations. This discipline emerged about twenty years ago and has made substantial progress in the past decade. The main goals of this book are to provide an overview of various mathematical, statistical and computational methodologies used in the field to a wide range of researchers and students, and to address important yet technically challenging topics in further detail. Contents:Statistical PreliminaryDeformation-Based MorphometryTensor-Based MorphometryVoxel-Based MorphometryGeometry of Cortical ManifoldsSmoothing on Cortical ManifoldsSurface-Based MorphometryWeighted Fourier RepresentationStructural Brain ConnectivityTopological Data Analysis Readership: Researchers and graduate students in the fields of computational neuroscience and brain imaging, medical image analysis and pattern recognition. Keywords:Computational Neuroanatomy;Brain Image Analysis;NeuroimageKey Features:Includes necessary and very practical mathematical and statistical methodologiesAccessible to a wide range of readers and provides methodological understanding in a manner immediately usable to researchersCovers various topics in great detail without sacrificing readability; it can be used as both a textbook for graduate students and a reference for researchers Reviews: "The book is a comprehensive treatise on computational neuroanatomy — an area that has emerged with the enormous advancements of magnetic resonance imaging (MRI). The book is a solid and evidently needed testimony to the recent developments in the area of computational neuroanatomy. It is a welcome publication, which may appeal to senior graduate students, researchers and practitioners." Zentralblatt MATH