Neurobiology Of Dopa As A Neurotransmitter

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Neurobiology Of Dopa As A Neurotransmitter

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Author : Yoshimi Misu
language : en
Publisher: CRC Press
Release Date : 2005-11-01

Neurobiology Of Dopa As A Neurotransmitter written by Yoshimi Misu and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2005-11-01 with Science categories.

New research suggests it is highly probable that DOPA, in addition to being a precursor to dopamine, functions by itself as a neurotramsmitter and/or neuromodulator. Neurobiology of DOPA as a Neurotransmitter integrates background information about DOPA as an inert amino acid precursor of dopamine with the evidence showing that DOPA fulfills several criteria of neurotransmitters. Providing easy access to, and complete understanding of, the latest research on the subject, the book makes the case that DOPA meets many of the criteria of neurotransmitters and includes anti-evidence in some instances. The book begins with a historical review of current knowledge of DOPA. It characterizes DOPA as a prominent example showing transmutation from an inert substance to a gold drug in Parkinson's disease and further to a neurotransmitter in its own right. The next chapters cover the essential criteria of a neurotransmitter such as synthesis, existence, and competitive antagonism. The book describes metabolism composed of catecholamine synthesis and degradation products related to neuron death, physiological release of DOPA in the lower brainstem, striatum, and nucleus accumbens, and physiological or pharmacological responses involved in baroreflex neurotransmission and related to behavioral science including interactions with catecholamines, acetylcholine, glutamate, and GABA. The book explores recognition sites, transport sites, and therapeutic role and mechanisms for neuron death related to adverse influence in the treatment of Parkinson's Disease. Edited by experts in the field, the breadth and depth of information contained in this book is confirmed by a quick scan of the chapter authors. They summarize the issues surrounding DOPA neurotoxicity and explore the link between experimental studies and clinical relevance.

Development And Engineering Of Dopamine Neurons

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Author : Jeroen Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-16

Development And Engineering Of Dopamine Neurons written by Jeroen Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-16 with Medical categories.

Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.

Dopamine Handbook

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Author : Leslie L. Iversen
language : en
Publisher:
Release Date : 2010

Dopamine Handbook written by Leslie L. Iversen and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010 with Medical categories.

The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.

Cns Neurotransmitters And Neuromodulators

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Author : Trevor W. Stone
language : en
Publisher: CRC Press
Release Date : 1996-05-09

Cns Neurotransmitters And Neuromodulators written by Trevor W. Stone and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1996-05-09 with Science categories.

CNS Neurotransmitters and Neuromodulators: Dopamine is an indispensable single-volume resource for any researcher involved with dopamine in the central nervous system (CNS). Part of the CNS Neurotransmitters and Neuromodulators Series, it is destined to be the definitive reference work on this topic. This book is comprised of independently authored chapters dealing with biochemistry, molecular biology and localization of dopamine receptors and transporters, receptor interactions, growth factors, new antipsychotic drugs, and the neuroendocrinal and retinal functions of dopamine. The authors, an international group of well-known researchers from varied disciplines, have utilized the most up-to-date material in preparing their reviews. CNS Neurotransmitters and Neuromodulators: Dopamine is the perfect source for established researchers seeking the latest information or for students requiring an in-depth one-step introduction.

The Role Of Brain Dopamine

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Author :
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06

The Role Of Brain Dopamine written by and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.

As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.

Dopamine Handbook

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Author : Leslie Iversen
language : en
Publisher: Oxford University Press
Release Date : 2009-11-13

Dopamine Handbook written by Leslie Iversen and has been published by Oxford University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-13 with Medical categories.

The discovery of dopamine in 1957-1958 was one of the seminal events in the development of modern neuroscience, and has been extremely important for the development of modern therapies of neurological and psychiatric disorders. Dopamine has a fundamental role in almost all aspects of behavior: from motor control to mood regulation, cognition and addiction and reward, and dopamine research has been unique within the neurosciences in the way it has bridged basic science and clinical practice. Over the decades research into the role of dopamine in health and disease has been in the forefront of modern neuroscience. The Dopamine Handbook is the first single-volume publication to capture current progress and excitement in this dynamic research field.

Dopamine

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Author :
language : en
Publisher: Elsevier
Release Date : 2014-06-23

Dopamine written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2014-06-23 with Science categories.

Progress in Brain Research is a well-established international series examining major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields. This volume, concentrates on state-of-the-art of dopamine research: from basic science to clinical applications. It covers topics including thalamostriatal synapses as a substrate for dopamine action; the multilingual nature of dopamine neurons; ethanol-mechanisms along the mesolimbic dopamine system, and much more.Progress in Brain Research is the most acclaimed and accomplished series in neuroscience, firmly established as an extensive documentation of the advances in contemporary brain research. The volumes, some of which are derived from important international symposia, contain authoritative reviews and original articles by invited specialists. The rigorous editing of the volumes assures that they will appeal to all laboratory and clinical brain research workers in the various disciplines: neuroanatomy, neurophysiology, neuropharmacology, neuroendocrinology, neuropathology, basic neurology, biological psychiatry, and the behavioral sciences. The most acclaimed and accomplished series in neuroscience This volume looks at dopamine research in the light of the newest scholarly discoveries and insights

Neurotransmitters Drugs And Brain Function

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Author : Roy Webster
language : en
Publisher: John Wiley & Sons
Release Date : 2001-11-28

Neurotransmitters Drugs And Brain Function written by Roy Webster and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2001-11-28 with Medical categories.

Neurotransmitters, Drugs and Brain Function aims to link basic aspects of the activity of neurotransmitters at the receptor and synaptic level with their role in normal brain function, disease states, and drug action. Thus, the material considers to what extent our knowledge of the central synaptic action of certain drugs can explain their possible roles in the cause of diseases and in the modes of action of drugs effective in those conditions. It offers a working explanation of drug and neurotransmitter action in CNS function, with a clear, comprehensive, and challenging style of writing. The authors review the chemical basis for drugs and the conditions they treat. It also, includes numerous illustrations and schematic diagrams.

Dopamine In The Cns Ii

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Author : Gaetano Di Chiara
language : en
Publisher: Springer Science & Business Media
Release Date : 2002-06-27

Dopamine In The Cns Ii written by Gaetano Di Chiara and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2002-06-27 with Medical categories.

With contributions by numerous experts

The Role Of Brain Dopamine

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Author :
language : en
Publisher: Springer
Release Date : 2011-12-29

The Role Of Brain Dopamine written by and has been published by Springer this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-12-29 with Medical categories.

As in other volumes in the series, this newest volume conveys up-to-date knowledge in a clear and straightforward manner. It begins with a survey of the neurobiological functions of the brain, with the emphasis on Parkinson's disease. This is followed by a presentation of the role of dopamine in the regulation of human anterior pituitary function. The final two chapters concentrate on the dopamine receptors: first, the binding sites are characterized and the biochemical and physiological consequences of dopamine-receptor stimulation are discussed and, finally, there is a report on the topology of a dopamine-receptor model that can account comprehensively for agonists and antagonists.