Development And Engineering Of Dopamine Neurons
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Development And Engineering Of Dopamine Neurons
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Author : Jeroen Pasterkamp
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-12-16
Development And Engineering Of Dopamine Neurons written by Jeroen Pasterkamp and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-12-16 with Medical categories.
Theneurotransmitter dopamine has just celebrated its 50thbirthday. The discovery of dopamine as a neuronal entity in the late 1950s and the notion that it serves in neurotransmission has been a milestone in the field of neuroscience research. This milestone marked the beginning of an era that explored the brain as an integrated collection of neuronal systems that one could distinguish on basis of neurotransm- ter identities, and importantly, in which one started to be able to pinpoint the seat of brain disease. The mesodiencephalic dopaminergic (mdDA) system, previously designated as midbraindopaminergic system, has received much attention since its discovery. The initial identification of dopamine as a neurotransmitter in the central nervous system (CNS) and its relevance to psychiatric and neurological disorders have stimulated a plethora of neurochemical, pharmacological and genetic studies into the function of dopamine neurons and theirprojections. In the last decade, studies on gene expression and development have further increased the knowledge of this neuronal population and have unmasked a new level of complexity. The start of the molecular dissection of the mdDA system has been marked by the cloning and characterization ofNurrl and Pitx3. These transcription factors were shown to have a critical function during mdDA development. These initial studies have been followed by the identification of many other proteins, which have a crucial function in the creation of a dopamine neuron permissive region, induction of precursors, induction of terminaldifferent- tion and finally maintenance of the mdDA neuronal pool.
Discovering The Brain
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Author : National Academy of Sciences
language : en
Publisher: National Academies Press
Release Date : 1992-01-01
Discovering The Brain written by National Academy of Sciences and has been published by National Academies Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1992-01-01 with Medical categories.
The brain ... There is no other part of the human anatomy that is so intriguing. How does it develop and function and why does it sometimes, tragically, degenerate? The answers are complex. In Discovering the Brain, science writer Sandra Ackerman cuts through the complexity to bring this vital topic to the public. The 1990s were declared the "Decade of the Brain" by former President Bush, and the neuroscience community responded with a host of new investigations and conferences. Discovering the Brain is based on the Institute of Medicine conference, Decade of the Brain: Frontiers in Neuroscience and Brain Research. Discovering the Brain is a "field guide" to the brainâ€"an easy-to-read discussion of the brain's physical structure and where functions such as language and music appreciation lie. Ackerman examines: How electrical and chemical signals are conveyed in the brain. The mechanisms by which we see, hear, think, and pay attentionâ€"and how a "gut feeling" actually originates in the brain. Learning and memory retention, including parallels to computer memory and what they might tell us about our own mental capacity. Development of the brain throughout the life span, with a look at the aging brain. Ackerman provides an enlightening chapter on the connection between the brain's physical condition and various mental disorders and notes what progress can realistically be made toward the prevention and treatment of stroke and other ailments. Finally, she explores the potential for major advances during the "Decade of the Brain," with a look at medical imaging techniquesâ€"what various technologies can and cannot tell usâ€"and how the public and private sectors can contribute to continued advances in neuroscience. This highly readable volume will provide the public and policymakersâ€"and many scientists as wellâ€"with a helpful guide to understanding the many discoveries that are sure to be announced throughout the "Decade of the Brain."
Imaging Dopamine
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Author : Paul Cumming
language : en
Publisher: Cambridge University Press
Release Date : 2009-04-02
Imaging Dopamine written by Paul Cumming and has been published by Cambridge University Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-04-02 with Medical categories.
An illustrated biography of the dopamine molecule, with each chapter presenting a specific stage in the biochemical pathway for dopamine.
The Neurobiology Of Olfaction
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Author : Anna Menini
language : en
Publisher: CRC Press
Release Date : 2009-11-24
The Neurobiology Of Olfaction written by Anna Menini and has been published by CRC Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-11-24 with Science categories.
Comprehensive Overview of Advances in OlfactionThe common belief is that human smell perception is much reduced compared with other mammals, so that whatever abilities are uncovered and investigated in animal research would have little significance for humans. However, new evidence from a variety of sources indicates this traditional view is likely
Birth Life And Death Of Dopaminergic Neurons In The Substantia Nigra
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Author : Giuseppe di Giovanni
language : en
Publisher: Springer Science & Business Media
Release Date : 2009-09-02
Birth Life And Death Of Dopaminergic Neurons In The Substantia Nigra written by Giuseppe di Giovanni and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2009-09-02 with Medical categories.
This book provides a unique and timely multidisciplinary synthesis of our current knowledge of the anatomy, pharmacology, physiology and pathology of the substantia nigra pars compacta (SNc) dopaminergic neurons. The single chapters, written by top scientists in their fields, explore the life cycle of dopaminergic neurons from their birth to death, the cause of Parkinson's disease, the second most common and disabling condition in the elderly population. Nevertheless, the intracellular cascade of events leading to dopamine cell death is still unknown and, consequently, treatment is symptomatic rather than preventive. The mechanisms by which alterations cause neuronal death, new therapeutic approaches and the latest evidence of a possible de novo neurogenesis in the SNc are reviewed and singled out in different chapters. This book bridges basic science and clinical practice and will prepare the reader for the next few years, which will surely be eventful in terms of the progress of dopamine research.
Current Topics In Developmental Biology
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Author :
language : en
Publisher: Elsevier
Release Date : 2004-09-28
Current Topics In Developmental Biology written by and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004-09-28 with Science categories.
Current Topics in Developmental Biology provides a comprehensive survey of the major topics in the field of developmental biology. The volumes are valuable to researchers in animal and plant development, as well as to students and professionals who want an introduction to cellular and molecular mechanisms of development. The series has recently passed its 30-year mark, making it the longest-running forum for contemporary issues in developmental biology. This volume contains eight important contributions from leading minds in developmental biology.* Hepatic Oval Cells: Helping Redefine a Paradigm in Stem Cell Biology * Meiotic DNA Replication * Pollen Tube Guidance: the Role of Adhesion and Chemotropic Molecules * The biology and diagnostic applications of fetal DNA and RNA in maternal plasma * Advances in Tissue Engineering * Directions in cell migration along the rostral migratory stream: the pathway for migration in the brain * Retinoids in Lung Development and Regeneration * Structural Organization and Functions of the Nucleus in Development, Aging and Disease* Series Editor Gerald Schatten is one of the leading minds in reproductive and developmental science * Presents major issues and astonishing discoveries at the forefront of modern developmental biology and developmental medicine * The longest-running forum for contemporary issues in developmental biology with over 30 years of coverage
Neural Cell Specification
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Author : Bernhard H.J. Juurlink
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Neural Cell Specification written by Bernhard H.J. Juurlink and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Science categories.
The last decades have witnessed a radical change in our views on central nervous system damage and repair. This change is not only due to the emergence of new powerful tools for the analysis of the brain and its reactions to insults, but it also reflects a conceptual change in the way we approach these problems. As an illustration to this development, it is instructive to go back to the proceedings of a meeting at the NIH in 1955 edited by William F. Windle, which summarizes the disillusioned and pessimistic view on CNS regeneration prevailing at the time. While this generation of researchers were well aware of the issues at stake, they felt they had reached the end of the road; the approaches they had pursued had got stuck and the tools available could not take them any further. I can very well imagine that the participants, most of them leaders in the field, left that conference feeling they had heard their field being sentenced to death.
Parkinson S Disease
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Author :
language : en
Publisher:
Release Date : 2004
Parkinson S Disease written by and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2004 with Parkinson's disease categories.
Cellular Transplantation
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Author : Craig Halberstadt
language : en
Publisher: Elsevier
Release Date : 2011-10-10
Cellular Transplantation written by Craig Halberstadt and has been published by Elsevier this book supported file pdf, txt, epub, kindle and other format this book has been release on 2011-10-10 with Science categories.
There have been tremendous strides in cellular transplantation in recent years, leading to accepted practice for the treatment of certain diseases, and use for many others in trial phases. The long history of cellular transplantation, or the transfer of cells from one organism or region of the body to another, has been revolutionized by advances in stem cell research, as well as developments in gene therapy. Cellular Transplants: From Lab to Clinic provides a thorough foundation of the basic science underpinning this exciting field, expert overviews of the state-of-the-art, and detailed description of clinical success stories to date, as well as insights into the road ahead. As highlighted by this timely and authoritative survey, scale-up technologies and whole organ transplantation are among the hurdles representing the next frontier. The contents are organized into four main sections, with the first covering basic biology, including transplant immunology, the use of immunosuppressive drugs, stem cell biology, and the development of donor animals for transplantation. The next part looks at peripheral and reconstructive applications, followed by a section devoted to transplantation for diseases of the central nervous system. The last part presents efforts to address the key challenges ahead, such as identifying novel transplantable cells and integrating biomaterials and nanotechnology with cell matrices. - Provides detailed description of clinical trials in cell transplantation - Review of current therapeutic approaches - Coverage of the broad range of diseases addressed by cell therapeutics - Discussion of stem cell biology and its role in transplantation
Stem Cells In Birth Defects Research And Developmental Toxicology
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Author : Theodore P. Rasmussen
language : en
Publisher: John Wiley & Sons
Release Date : 2018-03-27
Stem Cells In Birth Defects Research And Developmental Toxicology written by Theodore P. Rasmussen and has been published by John Wiley & Sons this book supported file pdf, txt, epub, kindle and other format this book has been release on 2018-03-27 with Science categories.
This book contains material contributed by forward-looking scientists who work at the interface of stem cell research and applied science with the aim to improve human fetal safety and the understanding of human developmental and degenerative disorders. Provides important platforms and contemporary accounts of the state of stem cell research in the fields of toxicology and teratology Considers both in vitro uses of stem cells as platforms for teratology and also stem cellopathies, which are in vivo developmental and degenerative disorders Helps the pharmaceutical industry and safety and environmental authorities validate the status quo of in vitro toxicity test systems based on human pluripotent stem cells and their derivatives