Neurochemistry Of Metabolic Diseases
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Neurochemistry Of Metabolic Diseases
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Author : Sankar Surendran
language : en
Publisher: Nova Science Publishers
Release Date : 2020-08-18
Neurochemistry Of Metabolic Diseases written by Sankar Surendran and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2020-08-18 with Brain categories.
Metabolic disorder caused by altered levels of metabolism resulting pathophysiological abnormalities often leads to childhood death. Several new developments on metabolic diseases research have been emerging. Gaucher disease is a lysosomal storage disorder caused by glucocerebrosidase gene mutations resulting glucocerebrosidase deficiency. Current studies show that the same gene mutations also contribute to the Parkinson's disease. Tetrahydrobiopterin (BH4) has been widely used in treating patients with Phenylketonuria over a decade. Recent studies reveal that patients treated with BH4 over one-year period showed reduced levels of serum B12, folate and iron intake and therefore patients under chronic BH4 treatment needed to be advised to have additional micronutrients along with BH4. Macrocephaly was used as one of the important features to diagnose Canavan disease. However, a recent study showing a child with aspartoacylase gene mutation developed microcephaly. Hence, Canavan disease phenotype can be either macrocephaly or microcephaly. These are a few examples of recent developments on metabolic diseases research. Therefore, this book was aimed to compose current developments on metabolic diseases research for the use by broad spectrum of experts including Physicians, Neuroscientists, Neurologists, Biomedical researchers, Biochemists, Molecular biologists, Basic Science Researchers and Medical Students.
Neurochemistry Of Metabolic Diseases
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Author : Sankar Surendran
language : en
Publisher: Nova Science Publishers
Release Date : 2012
Neurochemistry Of Metabolic Diseases written by Sankar Surendran and has been published by Nova Science Publishers this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012 with Brain categories.
Neurochemistry Of Metabolic Diseases
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Author : Sankar Surendran
language : en
Publisher:
Release Date : 2007-01-01
Neurochemistry Of Metabolic Diseases written by Sankar Surendran and has been published by this book supported file pdf, txt, epub, kindle and other format this book has been release on 2007-01-01 with Brain categories.
Metabolic disorder caused by genetic defect is a major problem. Abnormal metabolism caused by this defect affects normal function of various organs including brain. Brain is the most complex organ of the body, regulating various vital functions. Therefore it is important to study monogenic defect resulting metabolic changes and pathophysiological abnormalities. This book provides critical, comprehensive overview of monogenic defects causing neurological abnormalities on lysosomal storage diseases, Phenylketonuria and Canavan disease. Therefore this book was compiled to understand how a single gene defect impedes normal metabolic activity to result in pathophysiological abnormalities. In addition, therapeutical approaches in treating monogenic traits have also been presented. The articles assembled in this book will bring the reader thoughtful appraisals of past accomplishments, fresh concepts on monogenic traits and an exciting glimpse of future developments in the field of metabolic disorder. It is hoped that the text will primarily interest advanced biomedical scientists, neuroscientists and pathologists interested in Lysosomal storage diseases, Phenylketonuria and Canavan disease.
Central Nervous System
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Author : E. Genazzani
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-12-06
Central Nervous System written by E. Genazzani and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-12-06 with Medical categories.
This book is based on the Symposium "Metabolic Regulation and Functional Activity in the Central Nervous System" which was held on September 16 and 17, 1972, at Saint Vincent (Aosta)/Italy, and was sponsored by the Accademia di Medicina di Torino with the scientific cooperation of the Istituto di Farmacologia, Universita di Torino, and the Pharmakologisches Institut der Freien Universitat Berlin. Its purpose was to give a greater number of scientists from different countries an opportunity to report their latest results under a heading concerning general relationships between metabolism and function. We quite deliberately refrained from pursuing the partly heterogenous subjects into details. Thus, the organizers hoped to be able to interest a greater circle of readers for the manifold subjects from various fields dealing with the investigation of metabolic processes in the central nervous system. The discussion remarks to the lectures could not be considered for printing. The Accademia di Medicina di Torino and all others concerned do not only thank Dr. R. Di Carlo and other members of the Istituto di Farmacologia, Universita di Torino, for the excellent work they performed in preparing this Symposium, but also the Amministrazione Regionale della Valle di Aosta and SIT A V di Saint-Vincent for their generous support and their kind hospitality which made the stay at Saint-Vincent most agreeable for all participants.
Metabolic And Degenerative Diseases Of The Central Nervous System
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Author : Jorge Cervos-Navarro
language : en
Publisher: Academic Press
Release Date : 1995-09-28
Metabolic And Degenerative Diseases Of The Central Nervous System written by Jorge Cervos-Navarro and has been published by Academic Press this book supported file pdf, txt, epub, kindle and other format this book has been release on 1995-09-28 with Medical categories.
This reference work is intended to provide an optimal basis for the understanding of metabolic and degenerative diseases of the central nervous system, and presents a synthesis for investigations into neuropathology, neurology, neuroradiology, neurosurgery and neuropaediatrics.
Metabolic Syndrome
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Author : Akhlaq A. Farooqui
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-14
Metabolic Syndrome written by Akhlaq A. Farooqui and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-14 with Medical categories.
Metabolic syndrome as an important risk factor for stroke, Alzheimer disease, and depression presents readers with cutting edge and comprehensive information on relationship among metabolic syndrome, stroke, Alzheimer disease, and depression. It is hoped that this monograph will be useful to postgraduate students, faculty, research scientists, pharmacologists, nutritionists, and physicians, who are curious about the molecular mechanisms that link metabolic syndrome with stroke, Alzheimer disease, and depression.
The Chemistry Of Brain Metabolism In Health And Disease
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Author : Juda Hirsch Quastel
language : en
Publisher: Springfield, Ill. : Thomas
Release Date : 1961
The Chemistry Of Brain Metabolism In Health And Disease written by Juda Hirsch Quastel and has been published by Springfield, Ill. : Thomas this book supported file pdf, txt, epub, kindle and other format this book has been release on 1961 with Biochemistry categories.
Neural Metabolism In Vivo
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Author : In-Young Choi
language : en
Publisher: Springer Science & Business Media
Release Date : 2012-03-14
Neural Metabolism In Vivo written by In-Young Choi and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2012-03-14 with Medical categories.
From the preface: “Neural Metabolism In Vivo aims to provide a comprehensive overview of neurobiology by presenting the basic principles of up-to-date and cutting-edge technology, as well as their application in assessing the functional, morphological and metabolic aspects of the brain. Investigation of neural activity of the living brain via neurovascular coupling using multimodal imaging techniques extended our understanding of fundamental neurophysiological mechanisms, regulation of cerebral blood flow in connection to neural activity and the interplay between neurons, astrocytes and blood vessels. Constant delivery of glucose and oxygen for energy metabolism is vital for brain function, and the physiological basis of neural activity can be assessed through measurements of cerebral blood flow and consumption of glucose and oxygen.... This book presents the complex physiological and neurochemical processes of neural metabolism and function in response to various physiological conditions and pharmacological stimulations. Neurochemical detection technologies and quantitative aspects of monitoring cerebral energy substrates and other metabolites in the living brain are described under the “Cerebral metabolism of antioxidants, osmolytes and others in vivo” section. Altogether, the advent of new in vivo tools has transformed neuroscience and neurobiology research, and demands interdisciplinary approaches as each technology could only approximate a very small fraction of the true complexity of the underlying biological processes. However, translational values of the emerging in vivo methods to the application of preclinical to clinical studies cannot be emphasized enough. Thus, it is our hope that advances in our understanding of biochemical, molecular, functional and physiological processes of the brain could eventually help people with neurological problems, which are still dominated by the unknowns.” -- In-Young Choi and Rolf Gruetter
Neurochemical Mechanisms In Disease
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Author : John P. Blass
language : en
Publisher: Springer Science & Business Media
Release Date : 2010-12-01
Neurochemical Mechanisms In Disease written by John P. Blass and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2010-12-01 with Medical categories.
This newest volume of Advances in Neurobiology deals with the Neurochemistry of disease, with chapters covering both human diseases and animal “model” diseases.
Cytochrome Oxidase In Neuronal Metabolism And Alzheimer S Disease
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Author : Francisco Gonzalez-Lima
language : en
Publisher: Springer Science & Business Media
Release Date : 2013-06-29
Cytochrome Oxidase In Neuronal Metabolism And Alzheimer S Disease written by Francisco Gonzalez-Lima and has been published by Springer Science & Business Media this book supported file pdf, txt, epub, kindle and other format this book has been release on 2013-06-29 with Medical categories.
This book is based on an international symposium titled "Cytochrome oxidase in energy metabolism and Alzheimer's disease," held as a satellite to the 27th meeting of the Society for Neuroscience, New Orleans, 1997. The symposium was dedicated in honor of Dr. Margaret T. T. Wong-Riley because, in our opinion, the cytochrome oxidase histo chemical method introduced by Dr. Wong-Riley in 1979 was the most significant break through to map energy metabolism in the entire brain since the 2-deoxyglucose method introduced by Dr. Louis Sokoloff and colleagues in 1977. Both of these metabolic map ping techniques have made monumental contributions to brain research by allowing an integral view of brain activity. They have also developed into various specialized tech niques, including applications to the human brain. One of these new applications, which is described in detail in this book, is the quantitative cytochrome oxidase cytochemical method used to study Alzheimer's disease. The objective of this book is to describe the role of cytochrome oxidase in neuronal metabolism and Alzheimer's disease. Whether genetic or environmental, the pathogenesis of Alzheimer's disease involves a cascade of multiple intracellular events, eventually re sulting in failure of oxidative energy metabolism. Could impairment of cytochrome oxi dase in energy metabolism initiate the degenerative process? Cytochrome oxidase function and dysfunction are discussed in relationship to neuronal energy metabolism, neurodegen eration, and Alzheimer's disease. The book is made up of 10 chapters, divided into three major parts.